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  • Biomaterials
  • To achieve this goal, the surface properties of biomaterials have been modified with mimetic functional molecules in order to enhance the biocompatibility of implantable devices by carrying specific cell signals or by preventing undesired biological events that occur at the interface of material surface and living tissues. (scielo.br)
  • metastasis
  • Galectin-3, a multifunctional member of the galectin family, binds specifically the poly-N-acetyllactosamine residues of laminin and has been implicated in tumor invasion and metastasis. (ac.be)
  • significance
  • Patients with high Lu/BCAM expression showed a trend toward larger tumor size ( p = 0.07) and lower disease-specific survival ( p = 0.08), although not reaching statistical significance. (biomedcentral.com)
  • globular
  • Each fiber monomer is comprised of an amino-terminus that is noncovalently anchored to the penton base, a carboxy-terminus globular domain that binds to the cell surface receptor, and a rod-like shaft that varies in length according to the Ad serotype. (pubmedcentralcanada.ca)
  • molecules
  • However, they all tend toward the genesis of a restricted repertoire of pathogen recognition molecules, named pattern-recognition receptors (PRRs), allowing to identify a determined diversity of pathogens ( 2 ). (frontiersin.org)
  • Several cell surface molecules have been identified as receptors for Ad attachment and entry. (pubmedcentralcanada.ca)
  • In this review, we discuss the various cell surface molecules that are implicated as receptors for virus attachment and internalization. (pubmedcentralcanada.ca)
  • or via binding and blocking growth-promoting effects of some extracellular matrix molecules, such as laminin and tenascin ( Sherman and Back, 2008 ). (jneurosci.org)
  • genes
  • Amastigotes mostly express membrane transporters and genes involved in regulation of cell cycle, and also express a specific subset of surface glycoprotein coding genes. (peerj.com)
  • accumulation
  • Laminin is a heterotrimer composed of an alpha (LanA or Wb), beta (LanB1) and gamma (LanB2) subunit and we demonstrate that LanB2 loss in glia results in accumulation of LanB1 leading to distended ER, ER stress and glial swelling in addition to decreased larval locomotion and lethality. (ubc.ca)
  • We conclude that it is the loss of one laminin subunit that leads to deleterious consequences through the accumulation of the remaining subunits. (ubc.ca)
  • Dystrophin
  • It is thought to link the LG modules of α1- and α2-laminins to the cytoskeleton through its interaction with cytoskeletal dystrophin and/or utrophin (reviewed by Henry and Campbell, 1996 ). (biologists.org)
  • biological
  • This analysis allowed us to delineate specific transcriptomic profiling for each stage, and also to identify those biological processes of major relevance in each state. (peerj.com)
  • peripheral
  • Together, the results in this thesis highlight the role of perineurial glia in secreting laminin, facilitating larval locomotion and regulating both central and peripheral nervous system morphology in Drosophila. (ubc.ca)
  • soluble
  • Oligopeptides containing the YIGSR sequence from the B1 chain of laminin and the water soluble oligopeptide containing the IKVAV sequence (CSRARKQAASIKVAVSADR) from the A chain were covalently bound to the hydroxylated FEP films. (epfl.ch)
  • attachment
  • The degree of receptor-specific cell attachment and the ability to spatially control neurite outgrowth by covalently patterning the oligopeptide sequences on the FEP film surface were assessed. (epfl.ch)
  • The degree of receptor mediated NG108-15 cell attachment on immobilized CDPGYIGSR films was determined using competitive binding media. (epfl.ch)
  • Human
  • Flow cytometry using fluorescein isothiocyanate-conjugated fibrinogen confirmed that binding of human fibrinogen to the conidia was dose dependent and specific. (asm.org)
  • Our study is the first demonstration that human galectin-3 is oligomerized by transglutaminase with, as a consequence, a specific effect of melanoma cell spreading on laminin. (ac.be)