Specific phospholipid transfer proteins. Medical search. Frequent questions

This is mostly attributed to its capacity to transfer lipid components (TGs, cholesterol esters and phospholipids) to the endoplasmic reticulum lumen, where these lipoproteins are assembled. (current-pharmaceutical-design.com)
Lipid transport proteins at membrane contacts, where organelles are closely apposed, are critical in redistributing lipids from the endoplasmic reticulum (ER), where they are made, to other cellular membranes. (rupress.org)
The nucleus stores chromatin (DNA plus proteins) in a gel-like substance called the nucleoplasm.The nucleolus is a condensed region of chromatin where ribosome synthesis occurs.The boundary of the nucleus is called the nuclear envelope.It consists of two phospholipid bilayers: an outer membrane and an inner membrane.The nuclear membrane is continuous with the endoplasmic reticulum.Nuclear pores allow substances to enter and exit the nucleus. (coursehero.com)
The endoplasmic reticulum modifies proteins and synthesizes lipids, while the golgi apparatus is where the sorting, tagging, packaging, and distribution of lipids and proteins takes place. (coursehero.com)
The N -terminal transmembrane domain of ACBP1 and ACBP2 targets each protein to the endoplasmic reticulum (ER) and the plasma membrane while ACBP3 is targeted extracellularly. (aocs.org)
Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)

Phosphatidylcholine transfer protein (PCTP), also known as StAR-related lipid transfer domain protein 2 (STARD2), is a specific intracellular phospholipid binding protein that can transfer phosphatidylcholine between different membranes in the cytosol. (wikipedia.org)
PCTP transfers phosphatidylcholine molecules between membranes in vitro. (wikipedia.org)
Non-specific lipid-transfer proteins (nsLTPs) are involved in the movement of phospholipids, glycolipids, fatty acids, and steroids between membranes. (rcsb.org)
Phosphatidylinositol transfer proteins (PITPs) can bind specifically and transfer a single phosphatidylinositol (PI) molecule between phospholipid membranes in an ATP-independent manner in vitro. (embl.de)
Both the inner and outer membranes of the nuclear envelope are phospholipid bilayers. (coursehero.com)
Lipopolysaccharide-binding protein mediates CD14-independent intercalation of lipopolysaccharide into phospholipid membranes. (shengsci.com)
[22] A mitochondrion contains outer and inner membranes composed of phospholipid bilayers and proteins . (wikipedia.org)
The diversity of lipid species in biological membranes testifies to the multiple roles of these molecules as structural units, precursors to second messengers, as scaffolding units that impose spatial and temporal regulation on assembly of proteins, and as regulators of the catalytic activities of proteins. (tamu.edu)
Mounting evidence suggests that the genetic disorders/mutation and diseases change not only the protein expression patterns but also membranes themselves. (lu.se)
Native membrane derived polymer-supported lipid bilayers (nSLBs) are poised to bridge the gap between live cell experiments and traditional model membrane architectures that by offering a combination of accessibility by surface sensitive analytical instrumentation and a composition which more closely resembles cellular membranes by displaying a diversity of endogenous membrane proteins, lipids, and carbohydrates. (lu.se)

PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
Among these, CARD18 (caspase recruitment domain-containing protein 18), PKD2 (polycystin 2), and PSG2 (pregnancy-specific glycoprotein 2) were upregulated, whereas HGF (hepatic growth factor), PLTP (phospholipid transfer protein), IGF2R (insulin growth factor 2 receptor), and SWP70 (switch-associated protein 70) were downregulated. (bvsalud.org)
0.0001), phospholipid transfer protein (PLTP) at -0.26 (p=0.0005), uromodulin (UMOD) at -0.14 (p=0.002), fetuin-B (FETUB) at -0.31 (p=0.002), and ficolin-2 (FCN2) at -0.46 (p=0.005). (bmj.com)

Furthermore, in the caprate complex, the ligand binds to the protein cavity in two orientations with equal occupancy. (rcsb.org)
The structural plasticity of the ligand binding cavity and the predominant involvement of non-specific van der Waals interactions with the hydrophobic tail of the ligands provide a structural explanation for the non-specificity of maize nsLTP. (rcsb.org)
The CRAL-TRIO domain is found in GTPase-activating proteins (GAPs), guanine nucleotide exchange factors (GEFs) and a family of hydrophobic ligand binding proteins, including the yeast SEC14 protein and mammalian retinaldehyde- and alpha-tocopherol-binding proteins. (embl.de)
The physiological role of FABP's within the cell remains unclear but a targeting role for the protein would provide an attractive mechanism for ligand (fatty acid) transfer to membrane sites for further metabolism and requires an interaction between the FABP and the membrane. (soton.ac.uk)
The ligand release that was observed with anionic vesicles was sensitive to the ionic strength of the assay conditions and the anionic charge density of the phospholipid at the interface, indicating that non-specific electrostatic interactions play an important role in the process. (soton.ac.uk)
The most likely explanation for ligand release is that interaction of LFABF with an anionic membrane interface induces a rapid conformational change, reducing the affinity of DAUDA for the protein. (soton.ac.uk)
The nature of this interaction involves both electrostatic and non-polar interactions as maximal release of LFABP from phospholipid vesicles with recovery of ligand binding cannot be achieved with high salt and requires the presence of a non-anionic detergent. (soton.ac.uk)
At the molecular level, we show that SLPI is a ligand for the phospholipid scramblase 1 (PLSCR1) and PLSCR4, membrane proteins that are involved in the regulation of the movements of phospholipids between the inner and outer leaflets of the plasma membrane. (hal.science)

MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Regulated fusion of secretory granules with the plasma membrane in secretory cells requires ATP, Ca2+ and cytosolic as well as membrane proteins. (nih.gov)
ATX generates LPA from plasma membrane phospholipids and from circulating lysophosphatidylcholine (LPC) bound to albumin [ 23 ]. (hindawi.com)

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. (nih.gov)
Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl.de)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Liver fatty acid binding protein (LFABP) belongs to a family of small (14kDa) intracellular lipid-binding proteins, which have a characteristic β-barrel structure. (soton.ac.uk)
Intracellular phosphate is an integral component of phospholipids and phosphoproteins (organic phosphate). (gpnotebook.com)

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
In plants cells, lipid-transfer proteins (LTPs) and acyl-CoA-binding proteins (ACBPs) have been identified as candidates for lipid transfer within the cell [reviewed in 1,2]. (aocs.org)

and the golgi apparatus is where the sorting of lipids and proteins takes place. (coursehero.com)
For the metabolic syndrome in which multiple mild abnormalities in lipids, waist size (abdominal circumference), blood pressure, and blood sugar increase the risk of CHD, the designated HDL cholesterol levels that contribute to the syndrome are sex-specific. (medscape.com)
Plasma lipoproteins are macromolecular complexes of lipids and proteins that are classified by density and electrophoretic mobility. (medscape.com)
The nonpolar lipids (ie, cholesterol ester, triglycerides [TGs]) reside in a core surrounded by more polar components (eg, free cholesterol, phospholipids, proteins). (medscape.com)
The antiphospholipid (aPL) autoantibodies bind moieties on negatively charged PLs or moieties formed by the interaction of negatively charged PLs with other lipids, PLs, or proteins. (medscape.com)
Due to the lack of detergent solubilization and reconstitution steps, the nSLBs created using this approach contain essentially all of the native lipids, as well as the membrane-associated proteins and carbohydrates from the donor membrane. (lu.se)

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). (embl.de)
PEP3 was recently identified as phosphatidylinositol transfer protein (PtdInsTP), and here we report that PEP1 consists of the type I phosphatidylinositol-4-phosphate 5-kinase (PtdInsP5K). (nih.gov)
Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects. (tamu.edu)
Yeast phosphatidylinositol transfer protein (Sec14p) function is essential for production of Golgi-derived secretory vesicles, and this requirement is bypassed by mutations in at least seven genes. (tamu.edu)

In preliminary studies it was shown that LFABP released the fluorescent fatty acid 11(5-dimethylaminonapthalenesulphonylamino) undecanoic acid (DAUDA) in the presence of anionic phospholipid vesicles under conditions that indicated a direct interaction between the LFABP and the anionic phospholipid interface. (soton.ac.uk)
Here, the authors demonstrate that two ER membrane proteins, RTN3 and RTN4, are hijacked by SARS-CoV-2 to help promote the formation of virally induced double-membrane vesicles that are critical for efficient viral genome replication. (silverchair.com)

This is one of many tasks regulated by lipid transport proteins such as PCTP. (anl.gov)
Their interaction was strong, selective, and new: PPARdelta was known to interact with lipid transport proteins but not phosphatidylcholine transport proteins. (anl.gov)
They can act as transport proteins, regulator proteins, or activator proteins. (rush.edu)

Protein kinase C phosphorylation promotes localization of PCTP to the mitochondrion where it may activate Them2. (wikipedia.org)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)

The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)

The crystal structure of yeast PITP Sec14p reveals a large hydrophobic pocket to accommodate the acyl chains of phospholipid molecules. (embl.de)
Despite the wide range of proposed biomarkers for Parkinson's disease (PD), there are no specific molecules or signals able to early and uniquely identify the pathology onset, progression and stratification. (frontiersin.org)
Enzymatic hydrolysis of membrane phospholipids by phospholipases produces these lipid second messengers, as well as soluble second messengers such as inositol 1,4,5-trisphosphate, and also other molecules such as choline (Cho) that are released to the extracellular medium. (jneurosci.org)
One of those molecules, phosphatidylcholine transfer protein (PCTP), suppresses the activity of the other, PPARdelta, a gene regulator critical in burning fat and energy metabolism, under conditions of overnutrition. (anl.gov)
This allows carbon-based molecules to form chains, rings, and branched structures, creating the kind of complex molecules that can carry out the information and energy storage and transfer functions that make like possible. (learn-biology.com)
Swaisgood proposed the principle of physical isolation of nascent folding polypeptide chains and has shown that even proteins that cannot be refolded in solution to give biologically active structure can be refolded to the native state if the folding molecules are physically isolated by immobilization. (ncsu.edu)

However, the mechanisms by which phospholipases switch from physiological second-messenger production to phospholipid degradation remain unclear. (jneurosci.org)
At the physiological concentrations found in saliva, SLPI has a specific antiviral activity against HIV-1 that is related to the perturbation of the virus entry process at a stage posterior to the interaction of the viral surface glycoprotein with the CD4 receptor. (hal.science)
Herein, we report specific physiological circumstances under which an unanticipated requirement for PLD activity in yeast vegetative Golgi secretory function is revealed. (tamu.edu)
Nevertheless, it is involved in a wide range of activities, from phospholipid synthesis to a number of physiological responses as a lipid mediator [ 3 ]. (hindawi.com)
The three-dimensional structure of proteins exhibits marginal stability even under physiological conditions. (ncsu.edu)
Hence, any substantial structural perturbation due to salt, pH, alcohol, or heat treatment leads to irreversible changes in protein structure, even if a simulated physiological environment is restored. (ncsu.edu)

Overactivation of NMDA receptors is believed to induce neuronal death by increasing phospholipid hydrolysis and subsequent degradation. (jneurosci.org)
Excessive Ca 2 + entry through glutamate receptors activates a large array of potential neurotoxic mechanisms, which include activation of enzymes such as phospholipases, calpains and other proteases, protein kinases, nitric oxide synthetase, endonucleases, as well as reactive oxygen species (for review, see Sattler and Tymianski, 2000 ). (jneurosci.org)
LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. (hindawi.com)
LPA activates at least six G-coupled protein receptors (LPA 1-6 ) stimulating different signaling pathways through heterotrimeric G proteins such as G i/0 , G 12/13 , G q/11 , and G s . (hindawi.com)
here, discrete export signals on the cargo are recognized and captured by specific receptors that are concentrated at sites of vesicle budding. (biologists.com)
This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
Transport by partitioning is distinct from both bulk flow and receptor-mediated transport, because differently from bulk flow, cargo can be concentrated in transport carriers, yet the concentrating process does not depend on specific cargo receptors ( Fig. 1 and Box 1 ). (biologists.com)

A plausible role of phospholipid scramblase 3 (PLSCR3) in Pb2+ and Hg2+ induced apoptosis was investigated with human embryonic kidney (HEK 293) cells. (bvsalud.org)

1997. Fibrillogenesis of Alzheimer beta-Amyloid Peptides Studied by Fluorescence Energy Transfer. (utoronto.ca)
1996. Membrane Disruption byAlzhemier beta-Amyloid Peptides Mediated Through Specific Binding to either Phospholipids or Gangliosides: Implications for Neurotoxicity. (utoronto.ca)
Helix Capping Propensities in Peptides Parallel Those Found in Proteins. (utoronto.ca)
In vivo infusion of each of the anti-b2GPI antibodies into BALB/c mice followed by administration of the corresponding specific peptides prevents the peptide-treated mice from developing experimental APS. (medscape.com)

The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). (nih.gov)
Liver-specific MTP inhibitors reduce secretion of very low density lipoproteins (VLDL) mostly containing apoB100, while the intestine-specific ones reduce secretion of chylomicrons containing apoB48. (current-pharmaceutical-design.com)
Main lipid and protein components of high-density lipoproteins. (encyclopedia.pub)

The nucleus houses the cell's DNA and directs the synthesis of proteins and ribosomes. (coursehero.com)
Therefore, the nucleus houses the cell's DNA and directs the synthesis of proteins and ribosomes, the cellular organelles responsible for protein synthesis. (coursehero.com)
On the basis of these results, we hypothesized that excitotoxicity results from inhibition of synthesis rather than from increased degradation of phospholipids. (jneurosci.org)
We now investigated the effect of NMDA receptor overactivation on synthesis and degradation of major membrane phospholipids in the early stages of the excitotoxic process. (jneurosci.org)
These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)
The effect of dexamethasone on mRNA and protein synthesis of lipocortins (LCT) 1, 2 and 5 has been investigated in U-937 cells. (shengsci.com)

In humans, phosphatidylcholine transfer protein is encoded by the PCTP gene. (wikipedia.org)

Phosphorus is found in the sugar-phosphate backbone of nucleic acids, in phospholipids, and in the energy transfer molecule ATP. (learn-biology.com)

In order to gain a better understanding of the structural basis of the non-specific binding of hydrophobic ligands by nsLTPs and to investigate the plasticity of the fatty acid binding cavity in nsLTPs, seven high-resolution (between 1.3 A and 1.9 A) crystal structures have been determined. (rcsb.org)
The main pathway is the cleavage of membrane phospholipids into lysophospholipids by the removal of a fatty acid chain by phospholipase A (PLA1 or PLA2). (hindawi.com)
FLAVOR CHARACTERISTICS OF FORAGE-FED AND GRAIN-FED BEEF AS INFLUENCED BY PHOSPHOLIPID AND FATTY-ACID COMPOSITIONAL DIFFERENCES. (ncsu.edu)
ABSTRACT Neutral lipid (NL) and phospholipid (PL) fractions and their corresponding fatty acid (FA) profiles from the L. dorsi of Angus‐Hereford heifers (n=27) were compared as a function of forage grazing (FG) and time in the feedlot after grazing (DIF) on pasture. (ncsu.edu)

Crystal structure of the membrane fusion protein CusB from Escherichia coli. (harvard.edu)

Proteins and proteomics, 2018. (ucla.edu)

Given that recombinant Arabidopsis ACBPs show preferences for different acyl-CoA esters and phospholipids in in vitro binding assays, it was hypothesized that members in the Arabidopsis ACBP family have nonoverlapping functions in the plant cell. (aocs.org)

Such protein-mediated transfer is especially important for maintaining organelles disconnected from secretory pathways, like mitochondria. (rupress.org)

Pre-β HDL is converted by lipidation with free cholesterol (FC) and phospholipids (PL) via ABCA-1 and ABCG-1 and cholesterol esterification via lecithin:cholesterol acyltranferase (LCAT) to spherical HDL3. (encyclopedia.pub)

ABSTRACT The kinetic compensation effect in the heat denaturation of whey proteins was demonstrated using two different kinetic compensation relationships, i.e. (ncsu.edu)

The stoichiometric relationship between anionic phospholipid and LFABP suggests that the LFABP coats the surface of the phosphilipid vesicle. (soton.ac.uk)
The results of these studies suggested that α-helix II, in particular, residue K31 of LFABP are involved in interactions with the anionic phospholipid interface. (soton.ac.uk)

ATP-dependent steps in Ca(2+)-activated secretion from PC12 cells require three cytosolic PEP proteins (priming in exocytosis proteins, PEP1-3), the identity of which will provide insights into the required ATP-using reactions. (nih.gov)
The three other ACBPs (ACBP4, ACBP5 and ACBP6) are cytosolic proteins. (aocs.org)

Such stark differences in phenotype led the scientists to make a liver-specific PCTP knockout. (anl.gov)

In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. (nih.gov)

Lysine residues in the α-helical region of adipocyte and heart FABP had previously been identified as important for interactions between these proteins and the phospholipid interface. (soton.ac.uk)
Finally, the researchers focused on the specific protein interactions driving the different phenotypes. (anl.gov)
ACBP1 and ACBP2 each possess a C-terminal domain of ankyrin repeats, which facilitates protein-protein interactions. (aocs.org)
The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)

It is generally assumed that enzymatic hydrolysis of phospholipids leads to phospholipid degradation and membrane damage. (jneurosci.org)
This new approach has been shown to preserve mobility and enzymatic activity of transmembrane proteins in the resulting nSLB. (lu.se)

Sequence-specific binding property of Arabidopsis thaliana telomeric DNA binding protein 1 (AtTBP1). (shengsci.com)
We have identified an Arabidopsis thaliana cDNA, designated as AtTBP1, encoding a protein with a predicted size of 70.6 kDa that specifically binds to the plant telomeric repeat sequence TTTAGGG. (shengsci.com)
While LTPs are small proteins (~9 kDa), ACBPs in the model plant Arabidopsis range in size from 10 to 73 kDa. (aocs.org)
Some Arabidopsis ACBPs have also been observed to bind phospholipids in filter binding assays, e.g. recombinant ACBP6 binds phosphatidylcholine (PC). (aocs.org)
The six Arabidopsis ACBPs are subcellularly located in various compartments based on experimental results using a variety of techniques including fluorescent protein tagging in confocal microscopy, immunoelectron microscopy and western blot analysis of subcellular fractions from wild-type plants as well as from transgenic plants expressing fluorescent-tagged ACBPs. (aocs.org)

This subfamily consists of PCTP, StarD7, StarD10 and collagen type IV alpha-3-binding protein or StarD11, all of which bind phosphatidylcholine except for StarD11 which prefers ceramide. (wikipedia.org)

The protein is expressed at high levels in tissues engaged in high metabolism, notably including the liver and macrophages. (wikipedia.org)
Re-expression of PLIN5 S155A in the liver of Plin5 liver-specific null mice reduced lipolysis compared with wild-type PLIN5 re-expression, but was not associated with other changes in hepatic lipid metabolism. (uci.edu)
The proteins, termed apolipoproteins, play an important role in lipoprotein metabolism. (medscape.com)
Proteins that bind to and are involved in the metabolism of phosphate ions. (uams.edu)

Moreover, inhibition of Ca(2+)-activated secretion by PtdIns(4,5)P2-specific antibodies and phospholipase C implies that 5-phosphorylated inositides play a novel, necessary role in the regulated secretory pathway. (nih.gov)
Inhibition and enhancement of odorant-induced cAMP accumulation in rat olfactory cilia by antibodies directed against G alpha S/olf- and G alpha i-protein subunits. (shengsci.com)

Evidence from multiple sources is building towards a concept where Sec14-like PITPs are specific components of lipid metabolic nanoreactors and, in this capacity, help impose a functional specification of lipid signaling pools. (tamu.edu)

Phospholipid transfer protein: its impact on lipoprotein homeostasis and atherosclerosis. (nih.gov)
Mitochondrial Triglyceride (TG) transfer protein (MTP) is a key enzyme for apoB-containing lipoprotein assembly and secretion. (current-pharmaceutical-design.com)

The protein folding code can also be used to identify the biochemical consequences of mutations that cause disease. (utoronto.ca)

The Rho family of GTP-binding proteins has been implicated in the regulation of various cellular functions including actin cytoskeleton-dependent morphological change. (embl.de)

However, the detailed structural basis of the non-specific binding of hydrophobic ligands by nsLTPs is still poorly understood. (rcsb.org)

The highly diverse and complex three-dimensional (3D) structures of proteins are integral to their equally diverse and complex functions. (utoronto.ca)

For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)

This graph shows the total number of publications written about "Membrane Fusion Proteins" by people in Harvard Catalyst Profiles by year, and whether "Membrane Fusion Proteins" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Membrane Fusion Proteins" by people in Profiles. (harvard.edu)
Below are the most recent publications written about "Discs Large Homolog 1 Protein" by people in Profiles. (umassmed.edu)
This graph shows the total number of publications written about "Phosphate-Binding Proteins" by people in UAMS Profiles by year, and whether "Phosphate-Binding Proteins" was a major or minor topic of these publications. (uams.edu)
Below are the most recent publications written about "Phosphate-Binding Proteins" by people in Profiles over the past ten years. (uams.edu)
Below are the most recent publications written about "Calcium-Binding Proteins" by people in Profiles. (rush.edu)

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development. (cas.cz)

It's not a smoking gun-they would require very sophisticated mass spectrometry or kinetics to look at the transfer of phospholipid from one protein to another-but the researchers were able to support their hypothesis that the interaction between PCTP and PPARdelta is repressive, and when PCTP is unable to bind phosphatidylcholines, it is unable to interact with and repress PPARdelta. (anl.gov)

Sec14p-like domains in NF1 and Dbl-like proteins indicate lipid regulation of Ras and Rho signaling. (embl.de)

To investigate this difference, we used shotgun proteomics to identify 49 HDL-associated proteins in a uremia-specific pattern. (lww.com)

While many studies have been focused on the membrane structure, the dynamics of such systems are crucial for the function of the membrane including membrane bound proteins. (lu.se)

The guanine nucleotide exchange factor (GEF) Dbl targets Rho family proteins thereby stimulating their GDP/GTP exchange, and thus is believed to be involved in receptor-mediated regulation of the proteins. (embl.de)

A constitutive expression of both mRNAs and proteins was detected in undifferentiated U-937 cells. (shengsci.com)
ACBP mRNAs are expressed in all plant organs with some mRNAs more highly expressed than others in specific organs, e.g. (aocs.org)

A crucial step in the process was directly linking phospholipids to the suppression of PPARdelta. (anl.gov)

Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments. (nih.gov)

Calcium-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Proteins to which calcium ions are bound. (rush.edu)

Proteins enriched in HDL from patients with ESRD (ESRD-HDL) included surfactant protein B (SP-B), apolipoprotein C-II, serum amyloid A (SAA), and α-1-microglobulin/bikunin precursor. (lww.com)
Vitamin K serves as a cofactor in the carboxylation of certain glutamic acid residues on precursor coagulation proteins. (medscape.com)

Membrane Fusion Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Discs Large Homolog 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
Phosphate-Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)

This soluble protein is 214 amino acids long. (wikipedia.org)
An amino-terminal portion conserved among a subset of Dbl family proteins is sufficient for the binding of Gbetagamma. (embl.de)
The mechanism by which a particular protein folds into its 3D structure is encoded in its amino acid sequence. (utoronto.ca)
a]Nitrogen is found in amino acids, the monomers of proteins, and in the nitrogenous bases that make up nucleotides (the monomers of nucleic acids). (learn-biology.com)
Amino acids are building blocks of proteins. (medlineplus.gov)

Anatomy2

Organisms3

Diseases1

Chemicals and Drugs40

Phenomena and Processes5

Technology, Industry, Agriculture1

Information Science2

Endoplasmic reticulum7

Membranes10

PLTP3

Ligand8

Plasma membrane3

Intracellular5

Lipid transfer2

Lipids6

Phosphatidylinositol transfe4

Vesicles2

Transport proteins3

Phosphorylation2

Adaptor Proteins1

Molecules6

Physiological6

Receptors8

Scramblase1

Peptides4

Lipoproteins3

Synthesis6

Phosphatidylcholine transfer protein1

Molecule1

Fatty acid4

Membrane fusion1

20181

Vitro1

Mitochondria1

Free cholesterol1

Abstract1

Anionic2

Cytosolic2

Phenotype1

Cholesterol1

Interactions4

Enzymatic2

Arabidopsis5

Consists1

Metabolism4

Inhibition2

Metabolic1

Lipoprotein2

Biochemical1

Implicated in the regulation1

Structural1

Integral1

Transmembrane1

Profiles6

Degradation1

Bind1

Sec14p1

Proteomics1

Dynamics1

Regulation1

MRNAs2

Suppression1

Compartments1

Calcium2

Precursor2

MeSH3

Amino5