Specific or somatic stem cells. Medical search. Frequent questions

Gene therapy has been utilized successfully to repair or inactivate mutations in animal models of monogenic human diseases 19 as well as human in vitro cells 12 . (nature.com)
It is evident that some stem cell clones acquire somatic mutations that endow them with a self-renewal advantage, leading to their expansion and tissue-takeover in old age. (irbbarcelona.org)
Mutations in a gene expressed in smooth muscle cells account for about 14% of cases of hereditary thoracic aortic aneurysm. (hum-molgen.org)
As people age, they can acquire somatic mutations that lead to clonal expansion within their population of regenerating hematopoietic stem cells, which in turn can lead to hematological cancer and coronary heart disease. (genomeweb.com)
Overall, we observe that germline genetic variation shapes hematopoietic stem cell function, leading to CHIP through mechanisms that are specific to clonal hematopoiesis as well as shared mechanisms that lead to somatic mutations across tissues," co-senior authors Sekar Kathiresan and Pradeep Natarajan, both of the Broad, and their colleagues wrote in their paper. (genomeweb.com)
This variant predisposes individuals to developing CHIP driven by a number of somatic mutations, suggesting the variant doesn't specifically predispose individuals to TET2-specific CHIP. (genomeweb.com)
The true incidence of somatic mutations in MDS/MPN overlap syndromes remains uncertain, since these syndromes were previously under-diagnosed. (medscape.com)
PNH is caused by somatic mutations in PIGA (which encodes phosphatidylinositol N-acetylglucosaminyltransferase subunit A) in one or more HSC clones. (medscape.com)
Clinical manifestations of PNH occur when a HSC clone carrying somatic PIGA mutations acquires a growth advantage and differentiates, generating mature blood cells that are deficient of GPI-anchored proteins. (medscape.com)
DNMT3A gene mutations that cause DNMT3A overgrowth syndrome are found in all of the body's cells and lead to a decrease in normal enzyme function. (medlineplus.gov)
they are typically found in a small percentage of cells and the mutations are not inherited. (medlineplus.gov)
Somatic DNMT3A gene mutations are also found relatively frequently in another form of blood cancer called T-cell acute lymphoblastic leukemia. (medlineplus.gov)
As in cytogenetically normal acute myeloid leukemia (described above), the mutations disrupt the normal pattern of methylation in cells, which blocks differentiation. (medlineplus.gov)

citation needed] Since iPSCs can be derived directly from adult tissues, they not only bypass the need for embryos, but can be made in a patient-matched manner, which means that each individual could have their own pluripotent stem cell line. (wikipedia.org)
Similarly, the transplantation of other tissue-specific stem cells, such as stem cells isolated from epithelial and neural tissues, can treat mouse disease models and human patients in which epithelial and neural cells are damaged. (articlecity.com)
Blastocytes obtained through nuclear transfers would be used to generate the embryonic stem cells that could be differentiated to specific tissues or organs for transfer to the nuclear donor. (spiked-online.com)
Alternatively, NPCs can be isolated from fresh nervous tissues using cell sorting with NPC markers (PMID: 11121071). (sanbio.nl)
In this study, we compared hematopoietic differentiation capacity of 35 human iPSC lines derived from four different tissues and four embryonic stem cell lines. (nih.gov)
Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
endoderm, mesoderm and ectoderm, from which all somatic tissues in an organism can be traced. (edu.au)
Development of new or improved laboratory/experimental techniques, instruments, or supporting software that measure the location and dynamics of molecules in situ, and organelles, cells, or tissues on the nanometer and micrometer length scales. (nih.gov)
Cloning of human cells is a technology that holds the potential to cure many diseases and provide a source of exactly matched transplant tissues and organs. (news-medical.net)
In Estonia, the legislation covering aspects of tissues and cells being used as starting materials in a medicinal product is based on the Tissues and Cells Directive (2004/23/EC) on setting standards of quality and safety for the donation, procurement, testing, processing, preservation, storage and distribution of human tissues and cells as in other European Union countries . (eurostemcell.org)
It has been transposed in Estonian law mainly by the Procurement, Handling and Transplantation of Cells, Tissues and Organs Act and the regulation on Criteria for the selection of cell, tissue, and organ donors, list of precluding circumstances for the donation of cells, tissues, or organs, list of mandatory laboratory studies established for a donor, and the conditions and procedure for carrying out these studies . (eurostemcell.org)
the use of cells, tissues and organs in scientific research if used for purposes other than medical use on human beings. (eurostemcell.org)
Its sister company Progenitor Labs uses CombiCult to produce 'synthetic' adult progenitor cells for drug screening, for discovery of small molecules that regenerate specific tissues, potentially restoring organ function in disease and ageing. (technologynetworks.com)
POT1 mutation carriers had a range of benign and malignant neoplasms involving epithelial, mesenchymal, and neuronal tissues in addition to B- and T-cell lymphoma and myeloid cancers. (cdc.gov)
The key functions of adult stem cells are to maintain and repair the specific tissues where they reside (e.g. skin or blood). (bvsalud.org)

dubious - discuss] In his Nobel seminar, Yamanaka cited the earlier seminal work of Harold Weintraub on the role of myoblast determination protein 1 (MyoD) in reprogramming cell fate to a muscle lineage as an important precursor to the discovery of iPSCs. (wikipedia.org)
iPSCs are typically derived by introducing products of specific sets of pluripotency-associated genes, or "reprogramming factors", into a given cell type. (wikipedia.org)
It is also clear that pro-mitotic factors such as C-MYC/L-MYC or repression of cell cycle checkpoints, such as p53, are conduits to creating a compliant cellular state for iPSC reprogramming. (wikipedia.org)
Upon introduction of reprogramming factors, cells begin to form colonies that resemble pluripotent stem cells, which can be isolated based on their morphology, conditions that select for their growth, or through expression of surface markers or reporter genes. (wikipedia.org)
The molecule also plays a crucial role in the reprogramming of body cells into pluripotent stem cells. (sciencedaily.com)
In this reprogramming technique, somatic cells are converted into induced pluripotent stem cells (iPSCs). (sciencedaily.com)
E-Cadherin is necessary for maintaining pluripotent stem cells and also for inducing the pluripotent state in the reprogramming of somatic cells," Dr. Besser said. (sciencedaily.com)
Induced pluripotent stem cells, which harness the power of genetic reprogramming - basically, the altering of a cell's DNA - to change the course of cellular development. (articlecity.com)
NPCs can additionally be obtained by direct reprogramming of somatic cells from different cell lineage (PMID: 22445518). (sanbio.nl)
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is an epigenetic phenomenon. (hud.ac.uk)
A method of reprogramming rhesus macaque adult fibroblasts into embryonic stem cells using somatic cell nuclear transfer is presented. (hum-molgen.org)
Induced pluripotent stem cells, another types of pluripotent stem cells derived from any tissue by reprogramming and are the homologous source of stem cells. (benthamscience.com)
Plaintiffs allege that Fate is the 21 22 23 24 25 26 27 28 1 Induced pluripotent stem cells ("iPSCs") "are pluripotent stem cells generated from somatic cells by reprogramming. (justia.com)
43.) "Four specific genes-cMYC, OCT3/4, SOX2 and KLF4-encoding transcription factors play a role in converting or reprogramming somatic cells into pluripotent stem cells. (justia.com)
No. 184, Counterclaims ¶ 43 ("iPSCs are generated in culture from somatic cells through the introduction of reprogramming factors that transform a somatic cell into a pluripotent state. (justia.com)
2 The '369 Patent is entitled "Compositions for reprogramming somatic cells" and 3 was issued on December 6, 2011. (justia.com)
The '856 Patent is entitled 4 "Methods for reprogramming somatic cells" and was issued on January 13, 2015. (justia.com)
7 The '536 Patent is entitled "Methods for making somatic cells more susceptible to 8 reprogramming" and was issued on January 27, 2015. (justia.com)
We also begin to produce and characterize a new type of human stem cells, namely induced pluripotent cells that are obtained by converting somatic cells into stem cell through reprogramming. (ca.gov)
Induced pluripotent stem (iPS) cells can be generated by somatic cell reprogramming following the exogenous expression of specific transcription factors (Oct-3/4, KLF4, SOX2, and c-Myc). (rndsystems.com)
Our portfolio includes human Mesenchymal stem cells, iPS cell lines, disease-specific iPS cell lines, growth and differentiation media, custom iPS reprogramming, and drug screening assay services. (cedarlanelabs.com)
This was the first successful reprogramming of human somatic cells into embryonic stem cells using a cloning technique, SCNT. (news-medical.net)
Reprogramming of differentiated cells can be efficiently induced in oocytes. (selectbiosciences.com)
Human pluripotent stem cells can be derived from somatic cells by forced expression of defined factors, and more recently by nuclear-transfer into human oocytes, revitalizing a debate on whether one reprogramming approach might be advantageous over the other. (nih.gov)
Cellular reprogramming is a new and rapidly emerging field in which somatic cells can be turned into pluripotent stem cells or other somatic cell types simply by the expression of specific combinations of genes. (lu.se)
article{4b5db5d0-c1b6-463c-9ca2-f61b01429744, abstract = {{Cellular reprogramming is a new and rapidly emerging field in which somatic cells can be turned into pluripotent stem cells or other somatic cell types simply by the expression of specific combinations of genes. (lu.se)
Olariu V, Manesso E, commitment and Peterson C. 2017 A deterministic method for estimating free energy genetic network reprogramming paths landscapes with applications to cell commitment and reprogramming paths. (lu.se)
those of cell reprogramming, thereby avoiding exhaustive trial- energy landscape, deterministic models, and-error simulations with rate equations for different stem cell commitment, reprogramming parameter sets. (lu.se)
We explore the method on three circuits for haematopoiesis and embryonic stem cell development for commitment and reprogramming scenarios and illustrate how the method can be used to determine sequential steps for onsets of external factors, essential for efficient reprogramming. (lu.se)
AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation. (ox.ac.uk)
BACKGROUND: The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming. (ox.ac.uk)
In AF10 knock-out cells, re-expression wild-type AF10, but not a DOT1L binding-impaired mutant, rescues overall H3K79 methylation and reduces reprogramming efficiency. (ox.ac.uk)
Transcriptomic analyses during reprogramming show that AF10 suppression results in downregulation of fibroblast-specific genes and accelerates the activation of pluripotency-associated genes. (ox.ac.uk)
CONCLUSIONS: Our findings establish AF10 as a novel barrier to reprogramming by regulating H3K79 methylation and thereby sheds light on the mechanism by which cell identity is maintained in somatic cells. (ox.ac.uk)
Reprogramming of somatic (e.g., skin or blood) cells is an emerging technology which gives the possibility to develop any cell type avoiding the ethical concerns with the use of human embryonic stem (ES) cells. (lu.se)
We are currently generating neurons by iPS and iN cell technology aiming to produce cortical neurons and after intracerebral transplantation or direct in vivo reprogramming of non-neuonal cells restore damaged neuronal network. (lu.se)
Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

While the iPSC technology has not yet advanced to a stage where therapeutic transplants have been deemed safe, iPSCs are readily being used in personalized drug discovery efforts and understanding the patient-specific basis of disease. (wikipedia.org)
One of the next preclinical steps, according to the authors, is to evaluate, in the lab, differentiated patient-specific human embryonic stem cell lines for immune-system tolerance, therapeutic efficacy and safety. (scienceblog.com)
A renewable, tissue culture source of human cells capable of differentiating into a wide variety of cell types would have broad applications in basic research and therapeutic techniques. (spiked-online.com)
Kuldip S. Sidhu , " Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside ", Bentham Science Publishers (2012). (benthamscience.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
Since hepatic stem cells (HepSCs) possess self-renewal and bipotency with the capacity to differentiate into both hepatocytes and cholangiocytes, they have therapeutic potential for treating liver disease. (figshare.com)
Summary of Research Progress: Our research aims to identify the optimal culture conditions and the best hESC lines for the derivation of nerve lineage cells in therapeutic cell transplantation. (ca.gov)
Although ES cells may be ideal in terms of their pluripotency, from a therapeutic point of view, their great disadvantage is that they are not patient derived. (edu.au)
The therapeutic potential of cloned human cells has been demonstrated by another study using human oocytes to reprogram adult cells of a type 1 diabetic. (news-medical.net)
Although attempts have not yet been made to create a therapeutic transplant from embryonic stem cells, the methods have been developed to allow the creation of functional, mature cells using human cell cloning technology. (news-medical.net)
Novel culture and cryopreservation systems for human pluripotent stem cells and neural stem cells will be presented and their advantages and applicability in the production of high quality advanced therapeutic products or functional screening tools for preclinical research discussed. (selectbiosciences.com)
The opportunities and challenges of development of stem cell-based therapeutic interventions for joint surface repair for the treatment and prevention of osteoarthritis will be discussed. (selectbiosciences.com)
This presentation will describe the current status of strategies to generate induced pluripotent stem (iPS) cells from mouse and human somatic cells for patient-specific disease modeling and cell therapeutic applications. (selectbiosciences.com)
SCNT, or therapeutic cloning, is one method used to produce a source of individually-tailored stem cells. (medicalxpress.com)
The use of mouse feeder layers and animal serum are particularly problematic in the culturing of stem cells for possible therapeutic applications. (ddw-online.com)
The present invention also provides methods of using the differentiated cells of the present invention for therapeutic purposes. (justia.com)
In particular, the induction of stem cells to differentiate into muscle cells (myocytes) is useful for muscle transplantation and therapeutic purposes, as well as providing potential human disease models in culture (e.g. for testing pharmaceuticals). (justia.com)
The induction of cardiomyocyte differentiation in stem cells is especially useful in developing therapeutic methods and products for heart disease and abnormal heart conditions. (justia.com)
By linking together basic and clinical research, we aim to clarify cellular mechanisms of regeneration following damage to the brain and develop new therapeutic strategies to restore function in this organ (primarily in stroke and Parkinson's disease) by transplantation of stem cells or reprogrammed cells and optimization of endogenous repair mechanisms. (lu.se)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

For example, the stem cells can differentiate into cells that display characteristics of skin and retina cells, muscle cell bundles, bone matrix cells and cells of the gastrointestinal and respiratory lining. (scienceblog.com)
Researchers have discovered what enables embryonic stem cells to differentiate into diverse cell types and thus to be pluripotent. (sciencedaily.com)
Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have discovered what enables embryonic stem cells to differentiate into diverse cell types and thus to be pluripotent. (sciencedaily.com)
They are able to differentiate into any cell of an organism and have the ability of self-renewal. (articlecity.com)
Embryonic stem cells are derived from early embryos and have the ability to differentiate into any cell type. (spiked-online.com)
Neural progenitors are precursor cells able to further differentiate into various neuronal and glial cells. (sanbio.nl)
Stem cells are undifferentiated cells that have the potential to differentiate into many cell types. (neurosciencenews.com)
These cell types are capable of unlimited, undifferentiated proliferation in vitro and still maintain the capacity to differentiate into a wide variety of somatic cells. (rndsystems.com)
Progenitor cells are similar to embryonic stem cells in their capacity to differentiate into various cell types. (ddw-online.com)
However, progenitor cells can only differentiate into a limited number of cell types. (ddw-online.com)
Generally, when a stem cell culture is induced to differentiate, the differentiated population is analysed for particular cell types by expression of genes, markers or phenotypic analysis. (justia.com)
It uses CombiCult, its proprietary bead-based combinatorial screening platform, to differentiate induced pluripotent stem cells, embryonic and adult stem cells into a variety of somatic lineages for use by biotechnology and pharmaceutical companies. (technologynetworks.com)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)

Figure 3) or PSA-NCAM are markers frequently used for intermediate progenitor cells and early immature neurons (PMID: 29625071). (sanbio.nl)
Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Huang et al. (stemcell.com)
Activation of OCT4 enhances ex vivo expansion of human cord blood hematopoietic stem and progenitor cells by regulating HOXB4 expression. (stemcell.com)
Progenitor cells can be far easier to handle in culture than ES cells. (ddw-online.com)
For example, neural progenitor cells derived from a human ES cell line are easily propagated and require less handling than human ES cells. (ddw-online.com)
Most type II PNH cells (total lack of GPI-linked protein) are due to a frame shift mutation occurring in the early hematopoietic progenitor cells, resulting in same mutation in all blood cell lines. (medscape.com)
Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)

This new technique may help researchers avoid the controversies that come with the use of human embryos to produce human embryonic stem cells for research purposes. (sciencedaily.com)
Stem cells exist both in embryos and adult cells. (articlecity.com)
Embryonic stem cells, which must be extracted from embryos three to five days old (known as blastocysts, which contain only about 150 cells at this point of development). (articlecity.com)
Embryonic stem (ES) cells are pluripotent stem cells derived from the inner cell mass of pre-implantation embryos. (rndsystems.com)
In humans, a major roadblock in achieving successful SCNT leading to embryonic stem cells has been the fact that human SCNT embryos fail to progress beyond the eight-cell stage. (news-medical.net)
They derived several human embryonic stem cell lines from these cloned embryos whose DNA was an exact match to the adult cell that donated the DNA. (news-medical.net)
One aspect to this project will be to source oocytes, or immature egg cells to generate SCNT embryos from which embryonic stem cells are harvested. (medicalxpress.com)
The eggs will then be used by scientists from Newcastle and Durham Universities to create embryos from which they will attempt to derive stem cells . (progress.org.uk)
After becoming chief pathologist at the University of Wisconsin-Madison Wisconsin Regional Primate Center in 1995, James A. Thomson began his pioneering work in deriving embryonic stem cells from isolated embryos. (asu.edu)

Pluripotent stem cells hold promise in the field of regenerative medicine. (wikipedia.org)
Oct. 10, 2023 Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine. (sciencedaily.com)
Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)
Cells from the blood samples are reprogrammed into clinical-grade human induced pluripotent stem cells, which can be distributed to recipients for regenerative medicine. (wjgnet.com)
Stem cell-based regenerative medicine shows much promise. (selectbiosciences.com)
The remarkable potential of stem cells to generate several hundred differentiated cell types is driving their use for regenerative medicine and for supporting the traditional drug discovery and development process (Figure 1). (ddw-online.com)
Cell therapy and regenerative medicine is a focus of SBC's open innovation activities, and these two new tenants are expected to play a major role in the incubator's growing network in this area. (technologynetworks.com)

They hypothesized that genes important to embryonic stem cell (ESC) function might be able to induce an embryonic state in adult cells. (wikipedia.org)
Unlike SCNT, iPS cells are derived from adult cells, such as skin, which are reprogrammed to behave like embryonic stem cells. (medicalxpress.com)

Patient-matched embryonic stem cell lines can now be derived using somatic cell nuclear transfer (SCNT). (wikipedia.org)
This method is called "somatic cell nuclear transfer" or SCNT. (scienceblog.com)
One cloning technology that has been developed for mammalian and human cells is somatic cell nuclear transfer (SCNT). (news-medical.net)
SCNT is a method of cloning mammalian cells that can be used to create personalized embryonic stem cells from an adult animal or human. (news-medical.net)
But SCNT can also be used to clone human cells for transplant or other therapies. (news-medical.net)
In 2013, scientists reported a successful SCNT procedure by modifying the protocol for specific human oocyte biology. (news-medical.net)
Another successful attempt at human SCNT was made using cells from two adult males. (news-medical.net)
Scientists from the Monash Institute of Medical Research (MIMR) and colleagues from New South Wales will compare two different methods of creating patient-specific stem cells: somatic cell nuclear transfer (SCNT) and induced pluripotent stem cells (iPS). (medicalxpress.com)
Once our team produces the iPS cells, we will compare the properties of iPS versus cells developed through SCNT. (medicalxpress.com)
Australia is already a global leader in overall stem cell research and this new and clear regulatory framework gives us an opportunity to extend our leadership into SCNT which could transform how we treat diabetes, heart diseases and Parkinson's," Mr Jennings said. (medicalxpress.com)
체세포 핵 치환 (Somatic-cell nuclear transfer, SCNT)은 난자 의 핵 을 제거한 후에, 체세포 의 핵을 이식하여 복제 를 하는 기술을 말한다. (wikipedia.org)

Direct conversion from fibroblasts to generate hepatocyte like-cells (iHeps) bypassing the pluripotent state has been described in previous reports as an attractive method acquiring hepatocytes for cell-based therapy. (figshare.com)

The bladder and urethra are innervated by 3 sets of peripheral nerves arising from the autonomic nervous system (ANS) and somatic nervous system. (medscape.com)

Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. (wikipedia.org)
Unlike the first generation of iPSCs, these second generation iPSCs produced viable chimeric mice and contributed to the mouse germline, thereby achieving the 'gold standard' for pluripotent stem cells. (wikipedia.org)
Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
Infection of iPSCs with lentiviral inserts is a highly efficient process since stem cells grow quickly, remain undifferentiated in specific cell culture conditions and can establish fully infected clones within 2-3 passages. (nature.com)
NPCs can be differentiated from embryonic stem cells (ESCs) but also from induced pluripotent stem cells (iPSCs) (PMID: 11731782). (sanbio.nl)
The variation among induced pluripotent stem cells (iPSCs) in their differentiation capacity to specific lineages is frequently attributed to somatic memory. (nih.gov)
These data demonstrated that variations in the hematopoietic differentiation capacity of iPSCs are not attributable to somatic memories of their origins. (nih.gov)
8 Specifically, Plaintiffs allege that Defendants, individually and acting in concert, make, 9 use, sell, offer for sale, and/or import induced pluripotent stem cells ("iPSCs") that infringe 10 one or more claims of the asserted patents.1 (Id. (justia.com)
212 ("iPSCs used by Defendants to make at least the iPSC-derived 13 natural kill (NK) cell platforms are made by a process that comprises at least each step of 14 claim 1 of the '856 Patent. (justia.com)
Similar to iPSCs NT-ESCs displayed clone- and gene-specific aberrations in DNA methylation and allele-specific expression of imprinted genes, similarly to iPSCs. (nih.gov)
In somatic cells and induced pluripotent stem cells (iPSCs) higher order H3K79 methylation is dependent on AF10 expression. (ox.ac.uk)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)

The fibroblasts were engineered so that any cells reactivating the ESC-specific gene, Fbx15, could be isolated using antibiotic selection. (wikipedia.org)
Dr. Daniel Besser, Prof. Walter Birchmeier and Torben Redmer from the MDC, a member of the Helmholtz Association, used mouse embryonic fibroblasts (MEFs) in their stem cell experiments. (sciencedaily.com)
Normal tissue cells called fibroblasts can help to form a path for invading carcinoma cells, and may thereby promote tumour metastasis. (hum-molgen.org)
Mouse embryonic fibroblasts may be used to maintain and expand pluripotent stem cells in an undifferentiated state. (rndsystems.com)
Dermal fibroblasts were taken from a 35-year old male and a 75-year-old male and used to create embryonic stem cells. (news-medical.net)

The iPSC technology was pioneered by Shinya Yamanaka and Kazutoshi Takahashi in Kyoto, Japan, who together showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors could convert somatic cells into pluripotent stem cells. (wikipedia.org)
Found within Wharton's jelly - which is easily harvested from what would otherwise be post-natal medical waste - are several distinct stem cell genes. (articlecity.com)
Alternatively, transgenesis and gene targeting techniques can be used to introduce the patient's genes into the stem cell line. (spiked-online.com)
We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
In other words, expression of specific genes might have relevance to pathogenesis of diseases. (intechopen.com)
This is because Drosophila genes controlling fundamental cellular functions, such as cell growth and death, are quite identical to those found in human cells. (ataxia.org)
I created a plot comparing the TSS coverage (normalised to RPM) of stem-cell specific genes and found that MEFs had much higher coverage. (biostars.org)
During differentiation the expression of stem cell specific genes and markers are often lost and cells acquire gene expression profiles of somatic cells or their precursors. (justia.com)
Methods of inducing differentiation in stem cells and muscle cells produced therefrom may be used for the study of cellular and molecular biology of tissue development, for the discovery of genes and proteins such as differentiation factors that play a role in tissue development and regeneration. (justia.com)
Decreased DNA methylation likely disrupts the normal regulation of important developmental genes, although how these change cause the specific features of DNMT3A overgrowth syndrome is unknown. (medlineplus.gov)

The process of differentiation in stem cells involves selective development of immature cells to committed and fully mature cells of various lineages. (justia.com)

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell (HSC) disease. (medscape.com)
Allogeneic hematopoietic stem cell transplantation is curative but it requires a histocompatible donor and is associated with significant morbidity and mortality, so it is reserved for severe cases of PNH with aplastic anemia or transformation to leukemia. (medscape.com)
Paroxysmal nocturnal hemoglobinuria (PNH) was previously classified as purely an acquired hemolytic anemia due to a hematopoietic stem cell mutation defect. (medscape.com)

Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
It has been suggested that iPSC retain some tissue-specific memory whereas little is known about interindividual epigenetic variation. (hud.ac.uk)
Induced pluripotent stem cells (iPSC), generated by introduction of a few defined factors in a somatic cell, provide an ideal patient-specific source for disease modeling, drug discovery and cellular therapies. (stanford.edu)
162 ("Defendants' 11 use of their 'iPSC-derived cell therapy manufacturing platform' infringe[] at least claim 1 12 of the '369 Patent. (justia.com)
Here we compared the genetic and epigenetic stability of human nuclear-transfer embryonic stem cell (NT-ESC) lines and isogenic induced pluripotent stem cell (iPSC) lines, derived from the same somatic cell cultures of fetal, neonatal and adult origin. (nih.gov)

Inclusion of fetal bovine serum in stem cell media further contributes to an illdefined culture system. (ddw-online.com)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
Células madre de un tejido específico (también denominadas células madre somáticas) que aparecen durante el desarrollo fetal y permanecen en el cuerpo durante toda la vida. (bvsalud.org)
Tissue-specific stem cells (also known as Somatic Stem Cells) that appear during fetal development and remain in the body throughout life. (bvsalud.org)

Scientists have isolated the first human embryonic stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various ages, suffering from disease or spinal cord injury. (scienceblog.com)
Each of the 11 new human embryonic stem cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient into a donated egg, or "oocyte," whose nucleus had been removed. (scienceblog.com)
Bisulfite converted genomic DNA lysates from induced pluripotent stem cell and embryonic stem cell lines were hybridized to Illumina HumanMethylation450 BeadChip. (nih.gov)
Professor Tuch's team will also use their proficiencies in characterising human embryonic stem cell lines and bioinformatics. (medicalxpress.com)

Stem cells are defined by their capacity for self-renewal and multilineage differentiation, making them uniquely situated to treat a broad spectrum of human diseases. (articlecity.com)
Neural stem cells (NSCs) are undifferentiated neural cells with the capacity for long-term self-renewal and for differentiation into all types of neuronal and glial cells. (sanbio.nl)
Oct-4 (POU5F1) is a transcription factor that is critically involved in the self-renewal of pluripotent stem cells, and its expression is commonly used as a marker for pluripotency. (stemcell.com)
They further traced that locus to a likely causal variant that affects a TET2 enhancer to lead to an increase in the self-renewal of hematopoietic stem cells. (genomeweb.com)
In a series of assays, they found that individuals with this variant had decreased TET2 expression and that the reduction of TET2 activity was linked to increased self-renewal and proliferation of hematopoietic stem cells. (genomeweb.com)
We are interested in understanding the role of the extracellular matrix in regulating stem cell self-renewal and differentiation, and how this regulation goes awry in cancer. (stanford.edu)
Cancer stem cells are a selective clonal subset of tumour cells that have avoided various cell regulatory mechanisms, including terminal differentiation, and yet have retained the self-renewal properties and proliferative potential of adult stem cells. (who.int)

Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. (wikipedia.org)
With the addition of four proteins, adult human skin cells can be transformed into neurons over a month-long period. (stanforddaily.com)
The method may make it easier to produce patient- or disease-specific neurons for study. (stanforddaily.com)
The researchers showed they could convert human embryonic stem cells to neurons by infecting them with a virus that expressed the same proteins used in the study. (stanforddaily.com)
This treatment, nicknamed "BAM" after an acronym of the three proteins, converted the embryonic stem cells into functional neurons within six days. (stanforddaily.com)
it triggered the skin cells' transformation into functional neurons within about four to five weeks. (stanforddaily.com)
The cells expressed electrical activity characteristic of neurons and even integrated and interacted with mouse neurons on a laboratory dish. (stanforddaily.com)
While they found that approximately 20 percent of mouse skin cells transform directly into functional neurons, under current culture conditions only about two to four percent of human skin cells do the same. (stanforddaily.com)
Neural stem cells are generally accepted to produce three different cell types: neurons, astrocytes and oligodendrocytes. (neurosciencenews.com)
Drosha degrades the messenger RNA for NFIB in the adult hippocampal stem cells and prevents the expression of this transcription factor which is necessary for the differentiation of oligodendrocytes and thus blocks their development and therefore biases differentiation towards neurons. (neurosciencenews.com)
Magenta: the hippocampal stem cells generate newborn neurons. (neurosciencenews.com)
Adult neural stem cells (NSCs) are defined by their inherent capacity to self-renew and give rise to neurons, astrocytes, and oligodendrocytes. (neurosciencenews.com)
The resulting cells are nonproliferating and present an alternative to induced pluripotent stem cells for obtaining patient- and disease-specific neurons to be used for disease modeling and for development of cell therapy. (lu.se)
We are transplanting different types of neuroblasts generated either from human skin cell-derived induced pluripotent stem (iPS) cells or via direct conversion of skin cells to neurons (iN cells) (Fig.1). (lu.se)
Due to mechanisms that are still insufficiently understood, the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta leads to resting tremor, bradykinesia, and gait- and balance deficits. (lu.se)
Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)
The peripheral nervous system consists of more than 100 billion nerve cells (neurons) that run throughout the body like strings, making connections with the brain, other parts of the body, and often with each other. (msdmanuals.com)

Before patient-specific stem cells can potentially be used in the clinic, a variety of issues must be addressed, the researchers emphasized. (scienceblog.com)
In addition, researchers must develop methods to efficiently direct the differentiation of embryonic stem cells to specific stable cell types. (scienceblog.com)
The Korean researchers who performed this stem cell research improved upon their protocols that yielded the first embryonic stem cell line from a cloned human blastocyst. (scienceblog.com)
From the 185 donated oocytes, endowed with the genetic material from a different person (or in one case, the same person), the researchers report development of 31 hollow balls of cells called "human nuclear-transfer blastocysts. (scienceblog.com)
The researchers generated these stem cell lines ten times more efficiently than in their 2004 Science study, using improved laboratory methods. (scienceblog.com)
In a second step the researchers investigated what happens when somatic cells that normally neither have E-cadherin nor are pluripotent are reprogrammed into a pluripotent stem cell state. (sciencedaily.com)
The MDC researchers found that in contrast to the original cells, the new pluripotent cells derived from mouse connective tissue contained E-cadherin. (sciencedaily.com)
Next, the MDC researchers want to find out to what extent E-cadherin also regulates human embryonic stem cells. (sciencedaily.com)
Since the initial discovery of the self-renewing properties of stem cells in the early 1960s - pioneered by a small team of researchers at the Ontario Cancer Institute [3] - the understanding of the power and diversity of stem cells has increased rapidly. (articlecity.com)
The researchers found that BAM treatment to skin cells from fetuses and newborns didn't have the same effect as it did on the stem cells. (stanforddaily.com)
This conference will provide an interdisciplinary forum for researchers interested in aging, somatic mosaicism, epigenetics, plasticity, stem cells and immunity. (irbbarcelona.org)
Researchers have identified the cells responsible for rapid delivery of blood-borne antigens to specialized sites in the spleen. (hum-molgen.org)
Now, researchers have found abnormal immune cells may play a role. (hum-molgen.org)
Researchers from the Department of Biomedicine at the University of Basel have now found that the fate of adult hippocampal stem cells is not only controlled by their local niche, but also by a cell-intrinsic mechanism. (neurosciencenews.com)
Researchers are investigating several approaches, such as enzymatic treatments of RBCs, the generation of RBCs from human induced pluripotent stem cells, and the development of artificial oxygen carriers, all with the goal of advancing universal blood. (cap.org)
As the researchers reported on Wednesday in Nature , they identified three germline genetic loci associated with CHIP, including one in the TET2 gene that appears to be specific to individuals of African ancestry. (genomeweb.com)
The researchers used a somatic variant caller to identify individuals from the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine (TOPMed) program cohort with CHIP. (genomeweb.com)
The variant near TET2, the researchers noted, was specific to individuals with African ancestry, and had not previously been linked to disease, possibly due to the underrepresentation of individuals of African ancestry in genetic association studies. (genomeweb.com)
The researchers homed in on a set of about two dozen likely causal variants, which they hypothesized affects a TET2 enhancer in hematopoietic stem cells. (genomeweb.com)
This, the researchers wrote, shows that "at this locus, both germline noncoding and somatic coding variation converge to affect TET2 and influence the development of CHIP. (genomeweb.com)
Researchers speculate that the altered gene activity prevents hematopoietic stem cells from differentiating normally, which leads to the overproduction of abnormal, immature white blood cells characteristic of acute myeloid leukemia. (medlineplus.gov)

Identifying the right cocktail of media conditions, supplements and growth factors that successfully drive stem cells toward a desired lineage on a reproducible basis is a time-consuming, iterative exercise. (ddw-online.com)
Whilst differentiation of some lineage specific stem cells can be induced with a degree of certainty, a differentiation outcome of a population of pluripotent stem cells is less predictable. (justia.com)
or movements in a free energy landscape such that lineage choices are paths between stable cell states. (lu.se)
Recently, we distinguished myeloid and lymphoid CH which are selectively associated with risk of lineage-specific blood cancers. (lu.se)

For example, because hematopoietic stem cells can reconstitute the entire blood system, bone marrow transplantation has long been used in the clinic to treat various diseases. (articlecity.com)
Finally, cell transplantation in a mouse stroke model will be used to study the mechanisms and efficacy of different types of hESC-derived neural cells in neural repair. (ca.gov)
Finally, we also made excellent progress on the procedure of cell transplantation. (ca.gov)
We have found a suitable substrate that can be used to enhance neuronal survival after cell transplantation and we expect to publish a research paper in this new method of cell transplantation. (ca.gov)
The induction of a specific differentiated cell type can be useful for transplantation or drug screening and drug discovery in vitro. (justia.com)
In addition, using iPS and iN cell technology patient-specific cells can be generated for transplantation, avoiding the need for immunosuppression and risk for rejection. (lu.se)
Our laboratory for the first time combines transplantation of stem cells, stimulation of endogenous neurogenesis and modulation of inflammatory responses in order to develop clinically effective cell replacement therapies for human neurodegenerative diseases. (lu.se)

In their new paper, Science author Woo Suk Hwang from Seoul National University in Seoul, Korea and colleagues replaced the nuclei from donated oocytes with nuclei from skin cells from male and female patients, ranging in age from 2 to 56, who had spinal cord injuries, juvenile diabetes and the genetic disease "congenital hypogamma-globulinemia. (scienceblog.com)
Banking of multiple cell lines with varying genetic spectrum that can be matched to patients is one possibility. (spiked-online.com)
Here, the stem cell line is created using the genetic properties of the prospective recipient via somatic cell nuclear transfer. (spiked-online.com)
The common denominator in the disease, a biochemical defect, appears to be a genetic mutation leading to the inability to synthesize the glycosyl-phosphatidylinositol (GPI) anchor that binds these proteins to cell membranes. (medscape.com)
5. Most countries in the African Region have no specific regulations and policies governing genetic manipulations for assisted conception, treatment and research. (who.int)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
This paper gives an Islamic perspective on some of these advances, including abortion, in vitro fertilization, genetic engineering, cloning and stem cell research. (who.int)
Clonal hematopoiesis (CH) is a pre-leukemic condition defined by somatic genetic alterations associated with blood cancer in healthy individuals. (lu.se)

A subset of NSCs is present in the developed nervous system and acts as a reservoir of cells for cell replacement and nervous tissue regeneration (PMID: 20110496). (sanbio.nl)
NPCs are distinct from differentiated cells of the nervous system at the molecular level. (sanbio.nl)
The central nervous system is composed of the brain, brain stem, and the spinal cord. (medscape.com)
Each large axon is surrounded by oligodendrocytes in the brain and spinal cord and by Schwann cells in the peripheral nervous system. (msdmanuals.com)

He expressed hope that one day the cells could be used for human therapies. (stanforddaily.com)
3 Today, serologic and molecular techniques, along with laboratory information systems and electronic health records, contribute to precise blood product management and personalized transfusion therapies, particularly benefiting complex patients with sickle cell disease, thalassemia, and other diseases requiring chronic transfusion support. (cap.org)
This full potentiality makes them particularly suitable for developing cell replacement therapies or establishing cellular model systems. (edu.au)
These cells have been sought after as potential therapies for diseases ranging from heart disease to Parkinson's to cancer. (news-medical.net)
The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)

Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)
However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific transcriptional programs remain unknown. (ox.ac.uk)

We have reprogrammed mesenchymal stromal cells from human bone marrow (iP-MSC) and compared their DNA methylation profiles with initial MSC and embryonic stem cells (ESCs) using high-density DNA methylation arrays covering more than 450,000 CpG sites. (hud.ac.uk)
What is more, by deriving NT-ESCs from patient cells, the problem of immune rejection may be avoided. (benthamscience.com)

Unmapped bibliographic data: ST - Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles [Field not mapped to EPrints] C2 - PMC3538313 [Field not mapped to EPrints] AD - Institute for Neurophysiology, Medical Center, University of Cologne, Cologne, Germany. (hud.ac.uk)
We will further characterize molecular changes during directed cell differentiation and identify the cells that exhibit a pattern of DNA modification, namely DNA methylation, similar to primary neural cells in human brain. (ca.gov)
We also test the pattern of DNA methylation in different lines of human stem cells. (ca.gov)
By engineering stem cells carrying different levels of methylation, we aim to find the optimal levels of DNA methylation for efficient nerve cell differentiation. (ca.gov)
Both cell types shared similar genome-wide gene expression and DNA methylation profiles. (nih.gov)
Shoemaker R, Deng J , Wang W, Zhang K . (2010) Allele-specific methylation is prevalent and is contributed by CpG-SNPs in the human genome. (openwetware.org)
In early blood cells, called hematopoietic stem cells, the methylation patterns established by DNA methyltransferase 3 alpha promote maturation (differentiation) into different blood cell types. (medlineplus.gov)

These unlimited supplies of autologous cells could be used to generate transplants without the risk of immune rejection. (wikipedia.org)
Finally an outline of disease-specific pluripotent stem cells is reviewed within the context of their capacity to generate the cell type of interest. (edu.au)
We are working to generate red blood cells in vitro from pluripotent stem cells, however the extremely large cell numbers involved pose unique challenges to culture technology and scale-up. (selectbiosciences.com)

It is likely that human stem cells will have similar properties. (spiked-online.com)
In the past year, we have made progress in guiding several lines of human stem cells into nerve cells. (ca.gov)
In Estonia, there is no specific law on research on human stem cells. (eurostemcell.org)
Estonian law covers research on pluripotent stem cells derived from somatic cells only if the human stem cells are used in scientific research with the final purpose of medical use on human beings. (eurostemcell.org)
Thus, the Estonian rules covering research on human stem cells are covered by the Estonian legislation covering human stem cells used for medical uses. (eurostemcell.org)

Every cell type has its own unique needs when grown in vitro and stem cells are no exception. (ddw-online.com)
The need to control differentiation of embryonic stem cells in vitro presents another set of challenges. (ddw-online.com)

Generation of reprogrammed somatic cells, known as induced pluripotent stem (iPS) cells, was initially performed by ectopic expression of four transcription factors, however, now this process is becoming more streamlined by improved methods. (edu.au)

We will give specific focus to methodological and quantitative advances from the fields of genomics and single-cell biology, which have led to a revolution in the way we are understanding aging and tumor evolution. (irbbarcelona.org)
From the basic biology perspective, these findings have revealed that cell fates are inherently plastic and are dynamically regulated. (stanford.edu)
More recently, advances in medical biology have shown that the genomic state of a somatic cell can be altered or 'reprogrammed' to become pluripotent. (edu.au)
CET specializes in stem cell research, tissue engineering and cancer biology. (cedarlanelabs.com)
Dr Paul Verma, Program Leader of MIMR's Stem Cell Biology Program and the Chief Investigator of the Victorian project team, will create the iPS cells for this project. (medicalxpress.com)

Scientists anticipate that in the future stem cell lines will provide a virtually unending supply of pancreatic cells for diabetic patients, neuronal cells for patients with neural disorders such as Parkinson's or Alzheimer's disease, and a host of heart cells that may treat a variety of cardiac problems. (spiked-online.com)
Direct neuronal conversion of resident glial cells is advantageous since they are ubiquitously distributed brain cells able to self-renew and replenish their number, making them ideal candidates for endogenous repair. (lu.se)

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

They are 3-dimensional, complex, multicellular structures that can be derived from patient specific human induced pluripotent stem cells (hiPSCs). (nature.com)
This approach is particularly useful for obtaining patient-specific NPCs used as established disease models (PMID: 28105055). (sanbio.nl)
Therefore, directly converting iHepSCs from somatic cells may facilitate the development of patient-specific cell-based therapy for chronic liver damage. (figshare.com)
This is a significant leap forward for obtaining patient-specific pluripotent stem cells that can then be differentiated to the cell type of interest. (edu.au)
We manufacture specialized media and cell lines, and provide contractual research services with normal and patient-specific stem cells. (cedarlanelabs.com)

Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)

Gene expression must be appropriately maintained to regulate development, differentiation, and proliferation of cells. (intechopen.com)
The limited proliferation of iHeps, however, has hampered it uses in cell-based therapy. (figshare.com)
Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. (wjgnet.com)

Abstract for "Multipotency of Adult Hippocampal NSCs In Vivo Is Restricted by Drosha/NFIB" by Chiara Rolando, Andrea Erni, Alice Grison, Robert Beattie, Anna Engler, Paul J. Gokhale, Marta Milo, Thomas Wegleiter, Sebastian Jessberger, and Verdon Taylor in Cell Stem Cell . (neurosciencenews.com)
Abstract title:Stem cells from the mammalian blastocyst-How similar are mouse and human? (csh-asia.org)

The role and effect of 5hmC on 5mC turnover and hence DNA demethylation, on gene expression per se and stem cell fate and differentiation is a topic of vigorous interest. (stanford.edu)

The work also moves scientists one step closer to the goal of transplanting healthy cells into humans to replace cells damaged by diseases such as Parkinson's and diabetes. (scienceblog.com)
Understanding the molecular relationships is essential for using human somatic cells to develop stem cell therapy for diseases such as heart attack, Alzheimer's or Parkinson's disease or diabetes," Dr. Besser said. (sciencedaily.com)
Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
In the adult brain, the hippocampus is responsible for specific forms of memory - a brain region that is also affected in diseases such as dementia, depression and epilepsy. (neurosciencenews.com)
Clinically, these findings have uncovered the possibility of unprecedented sources for patient-autologous cells with far reaching implications in a variety of diseases. (stanford.edu)

In addition, after transcription, a wide array of RNA-binding proteins interacts with cis -acting elements located mainly in the 3' untranslated region, determining the fate of mRNAs in eukaryotic cells. (frontiersin.org)

Subsequently, we searched for CpG sites with donor-specific variation. (hud.ac.uk)
By transferring adult cell DNA into an embryonic stem cell, it is possible to create a line of immortal embryonic cells that are able to develop into any type of adult cell, genetically identical to the donor. (news-medical.net)
Those were spindle removal, donor cell fusion, and cytoplast activation. (news-medical.net)
The mitochondrial DNA of the stem cells, however, matched the donor egg's mitochondrial DNA. (news-medical.net)
The adult cell nuclei were transferred into metaphase-II stage human oocytes, producing a karyotypically normal diploid embryonic stem cell line from each of the adult male donor cells. (news-medical.net)
The resulting cells were pluripotent and could be differentiated into insulin-producing beta cells to restore the function of the pancreas in the donor. (news-medical.net)

Retrieved on December 04, 2023 from https://www.news-medical.net/life-sciences/Cloning-Human-Cells.aspx. (news-medical.net)

This presentation describes the current state of the stem cells marketplace as it relates to their utilization for pharmaceutical screening as well as their development for cellular therapy. (selectbiosciences.com)
Details are provided about the quantitative market opportunity for various stem cell classes as well as the current state of the clinical trials space wherein stem cell-based therapeutics are being evaluated for therapy in various disease classes. (selectbiosciences.com)
Since germ therapy is too late for everyone alive, we have to correct the genotype of a significant number of our somatic cells or replace them by new ones. (senescence.info)
Until recently, no specific therapy was available. (medscape.com)
Dr Martino Picardo, CEO of Stevenage Bioscience Catalyst, said 'SBC recognizes the patient benefits inherent in cell therapy, and is working to develop a network to catalyze innovation in this area. (technologynetworks.com)
The overall aim of this thesis has been to assess the potential of autologous grafting in cell replacement therapy for PD. (lu.se)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)
PNH results in the death of approximately 50% of affected individuals due to thrombotic complications and, until recently, had no specific therapy. (medscape.com)

May 20, 2020 In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. (sciencedaily.com)
In his original report, Thompson demonstrated that human embryonic stem cells could be coaxed into developing gut-like structures, bone, cartilage and muscle (1). (spiked-online.com)
A gene that allows mice to accept human bone marrow cells more efficiently is presented online. (hum-molgen.org)
for the procurement of bone marrow and peripheral blood stem cells, the blood sample for carrying out laboratory studies has to be collected within 30 days before the procurement ( § 8 (4) of the regulation ). (eurostemcell.org)

Shinya Yamanaka was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent. (wikipedia.org)
Induced pluripotent stem cells were first generated by Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University, Japan, in 2006. (wikipedia.org)

For decades scientists have been trying to reproduce cell culture environment for the closest mimicry of the natural cellular "embedding" within a living organism. (selectbiosciences.com)

Anatomy51

Organisms16

Diseases10

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes43

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science2

Named Groups1

Health Care1

Mutations13

Tissues16

Reprogramming38

Therapeutic20

Differentiate13

Progenitor cells7

Embryos9

Regenerative medicine8

Adult cells2

SCNT11

Pluripotent state1

Autonomic nervou1

IPSCs13

Fibroblasts5

Genes11

Lineages1

Hematopoietic stem3

IPSC5

Fetal4

Embryonic stem cell4

Self-renewal7

Neurons19

Researchers21

Lineage4

Transplantation7

Genetic8

Nervous system4

Therapies5

Mechanisms2

ESCs2

Methylation7

Generate3

Human stem cells5

Vitro2

Known as induced1

Biology5

Neuronal2

Hematopoiesis1

Patient-specific5

Convert1

Proliferation3

Abstract2

Gene expression1

Diseases6

Transcription1

Donor6

20231

Therapy8

Bone4

Yamanaka2

Organism1