The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. (wikipedia.org)
Regulatory proteins, namely the Transcription Factors (TFs), bind in a sequence-specific manner to TFBSs to activate or suppress gene transcription (gene expression). (biomedcentral.com)
It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
CST uses peptide libraries as immunogens to produce antibodies reactive against short linear phosphorylated motifs present in many different proteins. (cellsignal.com)
The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
Briefly, we have defined a range of peptide motifs, each motif being present in 5-100 different proteins. (lu.se)
In this manner, 100 antibodies, binding 100 different motifs commonly distributed among different proteins, would potentially target a protein cluster of 10(4) individual molecules, i.e. around 50% of the nonredundant human proteome. (lu.se)
Notably, these motif-specific antibodies would be directly applicable to any proteome in a specie independent manner and not biased towards abundant proteins or certain protein classes. (lu.se)
Peptide3
Furthermore, our understanding of peptide targeting mechanisms towards specific pathogens and their membranes remains limited, hindering further advancements in this field. (timeshighereducation.com)
This ERC funded project aims to identify peptide sequence motifs that are responsible for targeting pathogens, while maintaining minimal toxicity towards human cells. (timeshighereducation.com)
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. (bvsalud.org)
Protein6
Scientists of the European Research Institute for the Biology of Ageing discovered that the protein Mms1 interacts with G-rich motifs in the genome that can form stable DNA structures in regulation of DNA replication and genome integrity. (umcg.nl)
Beverly, MA-October 22, 2002 Business Wire - Cell Signaling Technology (CST) announced today the issuance of its U.S. Patent No. 6,441,140, directed to the production of a novel class of motif-specific, context-independent antibodies, highly useful for the identification of subclasses of protein kinase substrates. (cellsignal.com)
This novel method is broadly applicable to any protein kinase for which a substrate consensus motif has been identified and can also be used to produce antibodies highly reactive against acetylation, methylation and proteolytic cleavage containing motifs. (cellsignal.com)
Their μ homology domains (μHDs) interact with the C-terminal region of an endocytic scaffold protein, Eps15, containing fifteen Asp-Pro-Phe (DPF) motifs. (rcsb.org)
We hypothesized that CCAAT/enhancer-binding protein α (C/EBPα), one of the most studied lineage-specific transcription factors in hematopoiesis, might influence the expression of NKG2D-Ls. (bvsalud.org)
The H5N1 Inventory is an inclusive compilation of amino acid changes and/or motifs identified within each viral protein that affect one or more biological properties, provided in broad categories. (cdc.gov)
Mutations2
These mutations in the helix-encoding region in the hair-specific keratins hHb1 and hHb6 may represent different novel heterozygous point mutations of the same codon in exon 7 of the hHb6 gene. (medscape.com)
The H5N1 Inventory should be used by those conducting surveillance in humans and animals as well as research on influenza H5N1 viruses as a reference for the identification of specific mutations in naturally occurring H5N1 viruses that may signal adaptation to mammalian species or alter susceptibility to existing antivirals. (cdc.gov)
Genes7
I was wondering what is the efficient method to determine if each GO term or identified motifs has a biological meaning or not or if there is any way to filter out the genes/motifs for only specific cell types such as PBMCs, how to prioritize genes? (stackexchange.com)
I know random matches might even surpass the biologically relevant matches but right now I am not sure how to narrow down the motifs/genes? (stackexchange.com)
After peak calling and annotation for each marks, I have more than 2000 genes for each mark and more than 500 motifs called by Homer. (stackexchange.com)
For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
In other words, expression of specific genes might have relevance to pathogenesis of diseases. (intechopen.com)
researchers are working to determine which specific genes are involved and how they relate to these features. (medlineplus.gov)
More importantly, chromatin immunoprecipitation (ChIP) coupled with high-throughput sequencing captured C/EBPα motif signatures at the enhancer regions of the ULBP 2/5/6 genes. (bvsalud.org)
Sequences4
Cytosine rich DNA sequences can fold into a structure called an i-motif. (news-medical.net)
The structure of i-motif was found using NMR, where it was found that the length of cytosine sequences ranged from 3 to 12 bases, and it may also have thymine residues in between the cytosine sequences. (news-medical.net)
We further used cleavage under target and release using nuclease (CUT&RUN) to identify the exact motif sequences on the genome where complexes containing YT bind in the normal and fibrotic lung epithelial. (lu.se)
We further identified putative TFs that are known to bind the motif sequences identified. (lu.se)
Structures6
This motifs can form G-quadruplex (G4) structures in vitro. (umcg.nl)
The methodology used is what Wikander refers to as 'etymological poetics': the study of poetic and mythological structures as transmitted through specific lexical material. (worldcat.org)
But under specific conditions, the DNA may fold into hairpin or Z DNA structures where the DNA has a left-handed twist with a zigzag sugar phosphate backbone. (news-medical.net)
Studies have investigated the relative presence of tetraplex structures (i-motifs and G-quadraplex) and Watson-Crick duplexes. (news-medical.net)
We present the crystal structures of the SGIP1 μHD in complex with peptides containing two DPF motifs. (rcsb.org)
The two DPF motifs, which adopt three-dimensional structures stabilized by sequence-specific intramotif and intermotif interactions, are extensively recognized by the μHD and are both required for binding. (rcsb.org)
Similarity2
Users can easily specify the difference amongst expected motif kinds via similarity test. (biomedcentral.com)
Return the similarity score based on pearson correlation for the given motif against self. (biopython.org)
Promoter2
With the applications of an electrophoresis mobility shift assay and a chromatin immunoprecipitation assay, we could successfully identify a specific ER-α binding element in the apoM promoter region. (lu.se)
TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. (fishersci.com)
Bind1
The DNA binding domain(s) of a TF can recognize and bind to a collections of similar TFBSs, from which a conserved pattern called motif can be obtained. (biomedcentral.com)
Lend1
Christianity itself contains an array of tropes and motifs that lend themselves to such interpretations. (lu.se)
Histone2
For chip-seq data, I had analyzed the samples until motif discovery using both cluster profiler and Homer for each histone mark. (stackexchange.com)
Finally, we identified that histone demethylase lysine-specific demethylase 1 (LSD1) inhibition can restore the expression of ULBPs via induction of CEBPA expression in AML cells, which may represent a novel therapeutic strategy for CEBPA-mutated AML. (bvsalud.org)
Deletion1
1p36 deletion syndrome is caused by a deletion of genetic material from a specific region in the short (p) arm of chromosome 1. (medlineplus.gov)
Patterns2
The first chapter, Motifs, is divided into five sections that cover everything from the simplest crosses and spirals to geometric shapes, pictures, lacy patterns and bold, beautiful flowers. (rylandpeters.com)
afghan folklore' and 'japanese folklore' draw their motifs from stories, characters and specific allegorical elements, using tribal and sociological references and patterns to convey heritage and belief systems. (designboom.com)
Stability2
Such stability of binding motifs is even more exhibited in DNase accessible regions. (biomedcentral.com)
The number of C-C base pairs also determines the stability of the i-motifs. (news-medical.net)
Aims1
This joint project "Ganzheitliche und Multikriterielle Optimierung zur Ausbauplanung für Nachhaltige Fernwärmesysteme" (MOTIF) aims at investigating innovative mathematical methods for the expansion planning of sustainable district heating networks as well as putting these methods to the test based on real-world scenarios. (zib.de)
Embryo1
The expression analysis of both gene family members reflect their preferential seed-specific expression, especially during the mature embryo development stage. (nature.com)
Examples1
By clicking on any of the links below, you will be taken to specific definitions and examples. (labyrinthsociety.org)
Methods2
In this section, motif discovery is introduced, followed by the summarization of existing methods, and methods beyond the scope of this paper. (biomedcentral.com)
Based on this phenomenon, de novo motif discovery using computational methods have been proposed to identify and predict TFBSs and their corresponding motifs. (biomedcentral.com)
Bases1
The presence of six or less C bases lead to intermolecular folding of i-motifs, whereas longer than six C residues promote the formation of intramolecular folding of i-motifs. (news-medical.net)
Minimal1
Minimal possible score for this motif. (biopython.org)
Biological4
de novo motif discovery serves as a promising way to predict and better understand TFBSs for biological verifications. (biomedcentral.com)
Additionally, multiple, possibly overlapping, candidate motifs are desired and necessary for biological verification in practice. (biomedcentral.com)
It serves as an attractive alternative for providing pre-screening and prediction of unknown TFBS motifs to the expensive and laborious biological experiments such as DNA footprinting [ 1 ] and gel electrophoresis [ 2 ]. (biomedcentral.com)
The biological sample is digested, exposed to these immobilized antibodies, whereby motif-containing peptides are specifically captured, enriched and subsequently detected and identified using MS. (lu.se)
Roles1
Thus, consecutive and singly scattered DPF motifs play distinct roles in μHD binding. (rcsb.org)
Reveal2
Further analysis of transcription factors with conserved binding motifs can reveal cell regulatory pathways crucial for the survivability of various human cancers. (biomedcentral.com)
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. (nih.gov)
Binding2
Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs. (alzforum.org)
Here we present analysis of transcription factor binding motifs co-localized with non-coding variants. (biomedcentral.com)
Found2
It was found that Mms1 specifically interacts with particular G-rich motifs. (umcg.nl)
A) in the HTM motif (exon-7) of the KRTHB6 gene was found in all the affected members, leading to E413K change in this basic keratin. (medscape.com)
Human2
Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
Genetic epidemiology of glioblastoma multiforme: confirmatory and new findings from analyses of human leukocyte antigen alleles and motifs. (cdc.gov)
Aesthetics1
Design used to display the visualization with specific aesthetics, including borders and styles, among other elements. (wordpress.org)
Expression1
Upon depletion of RBPJ using CRISPR/Cas9, we observed specific upregulation of Notch target gene expression. (mdpi.com)
Analyses1
Further analyses restricted to female GBM cases and controls revealed a second association with a specific HLA-B sequence motif corresponding to Bw4-80Ile (odds ratio = 2.71, p = 0.02). (cdc.gov)
Chair2
With the Motif Armchair we wanted to create a chair that is harmonious and beautiful from all angles. (skandium.com)
When potential clients visit your office, you can make an impression with the Serta Commercial Motif High-Back Executive Chair. (officedepot.com)
Share1
These mini-motif tops share the sweetness of the season with everyone around you -- whether you're at the hair salon, soccer field, or fall festival. (qvc.com)
Delicate1
The delicate milgrain contour of the vine motif provides a vintage and romantic look to the band. (jamesallen.com)
Type1
Melody also advises on the type of yarn to use, the tension and the size of the motif, and gives tips on how to achieve the best result. (rylandpeters.com)
Show1
With sketches and photos showing how the motif can be used, either on its own, with several together or partnered with other motifs, 201 Crochet Motifs will show you that the crocheting possibilities are endless. (rylandpeters.com)
Matrix3
Return the Position-Specific Scoring Matrix. (biopython.org)
The Position-Specific Scoring Matrix (PSSM) contains the log-odds scores computed from the probability matrix and the background probabilities. (biopython.org)
Class for the support of Position Specific Scoring Matrix calculations. (biopython.org)
Range3
Real TFBSs of a motif may vary in their widths and their conservation degrees within a certain range. (biomedcentral.com)
We propose a new generalized model to tackle the motif widths by considering and evaluating a width range of interest simultaneously, which should better address the width uncertainty. (biomedcentral.com)
This gene is conserved and Y-specific among a wide range of mammals, and encodes a testis-specific transcript. (nih.gov)