Specific hla a3 antigen. Medical search. Frequent questions

The expression of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 in fresh cancer tissues from 113 patients with non-small cell lung cancer were analyzed by RT-PCR. (bmj.com)

In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
A cohort of HLA-A2+ NSCLC donors demonstrated that the number of epitope specific CD8+ T cells increased in NSCLC than healthy controls when measured with tetramer derived from the candidate MAGE-A3 epitopes, especially epitope Mp4 (MAGE-A3: 160-169, LVFGIELMEV). (thno.org)
HIV-1-specific CD8+ T-cell responses broadened significantly during subsequent exposure to the virus, ultimately targeting 27 distinct CTL epitopes, including 15 different CTL epitopes restricted by a single HLA class I allele (HLA-A3). (ox.ac.uk)
In addition, they demonstrate that HIV-1-specific CD8+ T-cell responses can ultimately target a previously unexpected and unprecedented number of epitopes in a single infected individual, even though these are not detectable during the initial exposure to virus. (ox.ac.uk)
Importantly, we show for three different epitopes that MCC specific T cells are capable of killing target cells expressing Large T antigen, including HLA-matched MCC cell lines, indicating that these T cells could provide functional activity upon in vivo transfer, and thus be employed in adoptive T cell therapy for MCC. (biomedcentral.com)
T cell epitopes from Large T antigen of MCPyV display a large sequence variation with other polyomaviruses, but are highly conserved among different strains of MCPyV. (biomedcentral.com)
Targeting these epitopes are therefore likely to lead to specific recognition of the tumor cells bearing the Large T integration - that is essential for growth and survival of the tumor cells. (biomedcentral.com)
These data confirm the presence of tumor-specific TCR within the cancer tissue and suggest the existence of shared epitopes among different patients that might be used as targets for tumor immunotherapy. (oncotarget.com)
Specific CTL were found at high frequency in 5 of 21 CML patients, suggesting that these epitopes are, to some extent, immunogenic in vivo during the course of the disease. (pasteur.fr)

In 2006 administration of normal circulating lymphocytes transduced with a retrovirus encoding a T-cell receptor (TCR) that recognized the MART-1 melanoma-melanocyte antigen, mediated tumor regression. (wikipedia.org)
In 2010 administration of lymphocytes genetically engineered to express a chimeric antibody receptor (CAR) against B cell antigen CD19 was shown to mediate regression of an advanced B cell lymphoma. (wikipedia.org)
In 2016, CD19-specific chimeric antigen receptor (CAR)-modified T cells were used to treat patients with relapsed and refractory CD19+ B cell malignancies, including B cell acute lymphoblastic leukemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells. (wikipedia.org)
a1) T cells can also interact with, and be activated by, DCs presenting via MHC/HLA a specific antigen matching the T-cell receptor, and accompanied by co-stimulatory (CD80/CD86 DCs, and CD28 T cells) and adhesive molecules (ICAM-1/LFA-3 DCs, and LFA-1/CD2 T cells). (weizmann.ac.il)
Given its relevance to Kite Pharma, the NCI's data on an engineered T-cell receptor against Mage-A3 was a keenly awaited AACR presentation, but when it went live on Sunday researchers could boast of no new responses versus what had been presented last November. (evaluate.com)
First, the major histocompatibility complex (MHC) and T-cell receptor (TCR) contact residues were identified by analysis of single site substituted analogue peptides for HLA-DR4 binding and cognate T cell recognition using both T hybridomas and polyclonal T cells from peptide-immunized HLA-DR4 transgenic mice. (biomedcentral.com)
We demonstrate that targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to CD40 (αCD40.RBD) induces significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model. (nature.com)

This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
We have mapped the T cell recognition of MCPyV by use of a novel technology platform for T-cell enrichment and combinatorial encoding of histocompatibility antigen (HLA) class I multimers. (biomedcentral.com)
CeD is triggered by gluten consumption in genetically susceptible individuals carrying certain major histocompatibility complex (MHC) class II human leukocyte antigen (HLA) variants ( 5 , 6 ). (frontiersin.org)
Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
Unlike CAR-T constructs, which target cell-surface proteins, TCRs require an intracellular antigen to be presented on a cell's major histocompatibility complex (MHC). (evaluate.com)
The human leukocyte antigen (HLA) system is a major histocompatibility complex (MHC) protein in humans. (biomedcentral.com)
AIH usually develops in individuals with a genetic background mainly consisting of some risk alleles of the major histocompatibility complex (HLA). (wjgnet.com)

We show that the monocyte:macrophage balance is disrupted in colon inflammation to favour recruitment of CD14 + HLA-DR Int cells in humans, and Ly6C Hi monocytes in mice. (frontiersin.org)

Antigen CD19 appears only on B cells, which go awry in lymphoma and leukemia. (wikipedia.org)

Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors. (lookformedical.com)
Advances in understanding the role of dendritic cells (DCs) as the major antigen (Ag)-presenting cell type of the immune system combined with the recent development of methods for the ex vivo expansion of human DCs have opened the possibility for the transfer of tumor Ags to DCs with a view toward tumor immunotherapy. (lookformedical.com)

We investigated the T cell recognition of both the oncogenic proteins, Large and Small T antigen and the capsid protein VP1 that is profoundly expressed also in the non-symptomatic MCPyV infected healthy individuals. (biomedcentral.com)
Our discovery is focused on several target classes including shared tumour antigens, cancer driver mutations and viral proteins. (anocca.com)
however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)

The additional non\specific protein\binding sites within the ELISA plates were clogged with 300 l 2% MPBS per well for 1 hr at space temp. (fsu93.org)
HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes. (thermofisher.com)
We also found that high MAGE-A3 mRNA and protein expression is associated with worse overall survival in UPS/MFS. (moleculardepot.com)
Furthermore, our results show no human leukocyte antigen (HLA) expression loss and relatively high lymphocyte infiltration by lymphocyte specific protein tyrosine kinase (LCK) marker expression. (moleculardepot.com)

KIR3DL2 has shown peptide-specific binding to some HLA-A antigens, including A3 and A11 (4, 7, 8). (rndsystems.com)
This peptide has a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. (peptides.de)
This product is a MHC pentamer of peptide composed MAGE-A3 derived peptide of KVAEELVHFL sequence covering 112-120 and A*02:01 molecule. (peptides.de)
c) The gel filtration chromatography of refolded peptide human being leucocyte antigen (pHLA) (MAGE\A3) and biotinylation effectiveness analysis of purified pHLA (MAGE\A3). (fsu93.org)
This peptide, as well as those binding to HLA-A3, -A11, and -B8 molecules (previously identified by others), elicits primary CTL responses in vitro from PBLs of both healthy donors and CML patients. (pasteur.fr)
We sought to identify an altered peptide ligand (APL) based on the endogenously expressed synovial auto-epitope of human cartilage glycoprotein-39 (HC gp-39) for modulation of cognate, HLA-DR4-restricted T cells. (biomedcentral.com)
Kosor Krnic E , Gagro A , Drazenovic V , Kuzman I , Jeren T , Cecuk-Jelicic E , Enumeration of haemagglutinin-specific CD8+ T cells after influenza vaccination using MHC class I peptide tetramers. (cdc.gov)

Several environmental, genetic, and immune factors create a "perfect storm" for the development of coeliac disease: the antigen gluten, the strong association of coeliac disease with HLA, the deamidation of gluten peptides by the enzyme transglutaminase 2 (TG2) generating peptides that bind strongly to the predisposing HLA-DQ2 or HLA-DQ8 molecules, and the ensuing unrestrained T cell response. (frontiersin.org)
In this review, we will discuss how tissue destruction in the context of coeliac disease results from the complex interactions between gluten, HLA molecules, TG2, and multiple innate and adaptive immune components. (frontiersin.org)
However, while up to 40% of the general population in Western countries express one of the predisposing HLA molecules, the global prevalence of CeD is just 1% ( 8 ). (frontiersin.org)
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
In fact, we identified a junctional nonapeptide (SSKALQRPV) which binds to HLA-A2.1 molecules. (pasteur.fr)
Rocha N, Neefjes J. MHC class II molecules on the move for successful antigen presentation. (pitt.edu)
Although the nature of the antigens responsible for RA pathogenesis is unknown, there is evidence that the disease-associated HLA-DR (B1*0401, 0404, 0405 and 0101) molecules are involved in disease pathogenesis [ 2 ]. (biomedcentral.com)

HER2 is a commonly expressed tumor-associated antigen in breast (BrCa) and, therefore, an attractive target for immunotherapy. (biomedcentral.com)
The MCPyV oncoproteins represent highly attractive targets for immunotherapy of MCC, being both foreign to the host and specific for the infection. (biomedcentral.com)
Numerous T cell responses were detected against MCPyV in both healthy donors and MCC patients, with a striking observation that T cell responses against Large and Small T antigens were found exclusively in MCC patients, suggesting that these oncoproteins are only presented to the immune system in the tumor-bearing host and represent highly specific targets for cancer immunotherapy of MCC. (biomedcentral.com)
Immunotherapy approaches targeting MAGE-A3 in other cancers have shown mixed results in the clinic, however, use of cancer testis antigens such as MAGE-A3 may have therapeutic value in the treatment of soft tissue sarcomas. (moleculardepot.com)
Based on these results, we propose targeting MAGE-A3 in UPS/MFS by immunotherapy techniques. (moleculardepot.com)
These peptides could be useful for the development of specific immunotherapy in CML patients. (pasteur.fr)
Cancer testis (CT) antigens as targets for immunotherapy in cancer patients have been heavily investigated. (bmj.com)

The expression of HLA-A2 was detected by flow cytometry. (bmj.com)
These surface markers were used to establishe routine monitoring of tumor-specific T-cell subsets by multicolor flow cytometry. (dc-research.eu)

Importantly, T cells artificially expressing the MAGE-A3-Mp4 specific TCRs exhibited strong MAGE-A3+ tumor cell recognition and killing effect. (thno.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
Moreover, T cells were preferentially activated by EGFRIs in individuals carrying HLA-C*15:02. (bvsalud.org)
The case series revealed that EGFRI-induced EPDS may be mediated by drug-specific T cells. (bvsalud.org)
The humanized MAGE\A3 TCR (SRm1g13t)\transfected T\cells showed enhanced cytotoxicity. (fsu93.org)
T cell immunity is at the center of the disease contributing to the inflammatory process through the loss of tolerance to gluten and the differentiation of HLA-DQ2 or HLA-DQ8-restricted anti-gluten inflammatory CD4 + T cells secreting pro-inflammatory cytokines and to the killing of intestinal epithelial cells by cytotoxic intraepithelial CD8 + lymphocytes. (frontiersin.org)
We discovered that the damaged blood vessels release specific bits of cells: small membrane vesicles that put the immune system on alert. (genengnews.com)
HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
Melanoma-associated antigen 3 (MAGE-A3) expression is generally restricted to the placenta and germline cells of the testis, but it may also be expressed in sarcoma and other cancers and is associated with poor prognosis. (moleculardepot.com)
Such CTL recognize HLA-matched, BCR-ABL-positive leukemic cells, implying efficient natural processing and presentation of these junctional peptides. (pasteur.fr)
a4) Activated T-cells form intercellular contacts with each other and cluster through ICAM-1-LFA-1 binding. (weizmann.ac.il)
Scientifically the anti-Mage-A3 asset is intriguing because, as stressed at AACR, it involves the isolation of CD4+, or helper, T cells for transfection and reinfusion into the patients. (evaluate.com)
The logic of isolating a specific population or subpopulation of cells is to enhance their expansion and persistence, but its therapeutic value is basically unknown. (evaluate.com)
Another reason for defining the cell composition is that a previous study targeting Mage-A3 with isolated CD8+ T cells, transfected with an MHC class I-restricted TCR, had failed, Dr Lu told EP Vantage . (evaluate.com)
Previous studies have shown the accumulation of human CD14 Hi or CD14 + HLA-DR Int cells in the GI tract lamina propria (LP) during inflammation ( 2 , 6 , 11 - 14 ). (frontiersin.org)
Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. (nature.com)
The impacts of proinflammatory cytokines and antigen presentation by pleural mesothelial cells (PMCs) on Th22-cell differentiation were explored. (atsjournals.org)
In particular, PMCs were able to function as antigen-presenting cells to stimulate CD4 + T-cell proliferation and Th22-cell differentiation. (atsjournals.org)
Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
Naive CD4 + T cells can develop into various helper T (Th) subsets with different cytokine profiles and play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology. (atsjournals.org)
The group therefore set out truncating the FGF-5 gene and determining if these truncations, when expressed in human (HLA)-A3-expressing COS-7 cells, could be recognized by C2 CTLs. (biomedcentral.com)

Next-generation-based human leucocyte antigen (HLA) typing showed all patients carried HLA-C*15:02, and modelling studies showed that afatinib and erlotinib bound well within the E/F binding pockets of HLA-C*15:02. (bvsalud.org)
Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection. (ox.ac.uk)
Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses generated during acute infection play a critical role in the initial control of viremia. (ox.ac.uk)
Figure B. PE conjugated Mouse anti Human CD11c ( MCA2087PE ) and Amethyst Orange conjugated Mouse anti Human HLA DP DQ DR ( MCA477AMO ). (bio-rad-antibodies.com)
Human leucocyte antigens serve as a unique identifier for each person. (genengnews.com)
Tumor Associated Antigens-TAA), su specifični antigeni koje prepoznaju citotoksični T limfociti u okviru glavnog sustava gena tkivne snošljivosti (Major Human Leukocyte Antigens-HLA) tipa I. Najznačajniji među njima su antigeni koji čine tzv. (unizg.hr)
The serum level of soluble Human Leukocyte Antigen-antigen-D Related (HLA)-(DR) (sHLA-DR) may appear as a useful parameter to monitor maternal immune response during pregnancy. (pitt.edu)
HLA-G in human reproduction: aspects of genetics, function and pregnancy complications. (pitt.edu)
To compare single nucleotide polymorphisms (SNPs) in the 3′-untranslated region (3′UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia pregnancies. (biomedcentral.com)
De nombreuses études scientifiques sérieuses et récentes montrent le rôle important -mais non exclusif bien entendu- joué par l'odeur corporelle lors du choix du partenaire dans la constitution des couples, avec une attirance spontanée entre les deux partenaires qui semble bien être liée à leur complémentarité au niveau de leurs gènes du groupe HLA (Human Leucocyte Antigen) aussi appelé CMH (complexe majeur d'histocompatibilité). (geobiotech.fr)

These studies demonstrate a consistent pattern in the development of epitope-specific responses restricted by a single HLA allele during acute HIV-1 infection, as well as persistence of the initial pattern of immunodominance during subsequent STI. (ox.ac.uk)

We analyzed MAGE-A3 expression of sarcoma subtypes available in the Cancer Genome Atlas and Cancer Cell Line Encyclopedia and show that undifferentiated pleomorphic sarcoma/myxofibrosarcoma (UPS/MFS) expresses this potential target gene. (moleculardepot.com)
Arthritis susceptibility genes were sought by analysis of differential gene expression between pristane-induced arthritis (PIA)-susceptible DA rats and PIA-resistant E3 rats. (biomedcentral.com)
In the present study, inguinal lymph nodes from the PIA-susceptible DA rat and from the PIA-resistant E3 strain were analyzed for differential gene expression using Affymetrix technology (Affymetrix, Inc., Santa Clara, CA, USA). (biomedcentral.com)

Statistical and machine-learning based analyses demonstrated that the MAGE-A3-Mp4 epitope-specific CD8+ T cell clones were mostly in effector and proliferating state. (thno.org)
Cross-reactivity risk analysis of the candidates TCRs showed high binding stability to MAGE-A3-Mp4 epitope and low risk of cross-reaction. (thno.org)
We have investigated HER2-derived peptides as vaccines mixed with GM-CSF to include GP2 (a HLA-A2 and HLA-A3 restricted, CD8+ eliciting epitope) and AE37 (a HLA unrestricted, MHC class II, CD4+ eliciting epitope). (biomedcentral.com)
The hybridomas all respond to the HC gp-39(263-275) epitope when bound to HLA-DR4(B1*0401) but differ in their fine specificities. (biomedcentral.com)
We] wanted to proceed to find the specific nine or ten amino acids of FGF-5 that was the recognized epitope," Yang told us. (biomedcentral.com)

Le rôle naturel du Système HLA est primordial dans l'équilibre fragile des défenses immunitaires de l'organisme contre les agents considérés comme extérieurs (infections parasitaires, bactériennes et virales, allergies, cancers, greffes, maladies auto-immunes). (geobiotech.fr)

In naïve DA rats IgE, the bone marrow stromal cell antigen 1 ( Bst1 ) and the MHC class II β-chain ( MhcII ) were expressed at a higher level, and the immunoglobulin kappa chain ( Igκ ) was expressed at a lower level. (biomedcentral.com)

Adoptive cell therapy using engineered T-cell receptors (TCRs) targeting cancer-testis antigens, such as Melanoma-associated antigen 3 (MAGE-A3), is a potential approach for the treatment of NSCLC. (thno.org)
This work identified candidate TCRs potentially suitable for TCR-T design targeting HLA-A2 restricted MAGE-A3 tumor antigen. (thno.org)
All other TCR projects have so far used MHC class I-restricted TCRs, and have focused on the HLA-A2 type - the most common for this class. (evaluate.com)
Anocca has established a pipeline of TCRs against multiple antigen classes, including targets that are shared amongst tumours, against specific genetic mutations that drive cancer, and against viruses that cause cancer. (anocca.com)

The same few peptides were consistently targeted in an additional 17 persons expressing HLA-A3 and/or -B7 during acute infection. (ox.ac.uk)
In addition, CeD patients produce highly disease-specific antibodies against deamidated gluten peptides and the enzyme tissue transglutaminase 2 (TG2) ( 2 - 4 ). (frontiersin.org)

When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize any non-specific polymer interactions. (thermofisher.com)
The presence or absence of EBV viral capsid antigen (VCA) IgG, VCA IgM and EBV nuclear antigen (EBNA) IgG antibodies was recorded. (who.int)

The HLA\A*0201 and and IBs were denatured in 6 m guanidine\HCl with 15 mm dithiothreitol at 37 for 30 min. (fsu93.org)

CT antigens might be prognostic markers and factors related to the progress of NSCLC, and also be served as the immunotherapeutic targets of NSCLC, especially in multi-antigen vaccine preparations and tumor antigen specific lymphocytes infusion. (bmj.com)

With the Mage-A3 project the NCI transfected patients with an MHC class II-restricted TCR matched with the HLA-DP0401 haplotype, which is present in 60% of the Caucasian population. (evaluate.com)

However, systematic analysis of T cell immune responses to MAGE-A3 antigen and corresponding antigen-specific TCR is still lacking. (thno.org)

D'avril 2000 à septembre 2003, tous les patients hémodialysés adressés au service d'hémodialyse d'un hôpital de Babol ont reçu 4 µg de vaccin intramusculaire à 0, 1 et 6 mois. (who.int)

In these studies, we tailor extracellular nanopatterns that can provide specific stimulation of cytokines, and reduce the rate of cell death. (weizmann.ac.il)

This work is conducted on a library of HLA genes that address a majority of the world-wide population. (anocca.com)

Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
CD8 + CTL clones recognizing minor H antigens were isolated from five patients studied. (aacrjournals.org)
Most of the RCC patients presented "patient-specific" TCR sequences, and those clonotypes were present at higher frequency in tumor lesions suggesting a specific extravasation from the blood. (oncotarget.com)
90-95% of CeD patients carry the HLA-DQ2.5 variant (DQA1*05:01, DQB1*02:01) that confers the highest risk of developing CeD while the remaining patients carry HLA-DQ2.2 (DQA1*02:01, DQB1*02:02) or HLA-DQ8 (DQA1*03, DQB1*03:02) ( 5 , 7 ). (frontiersin.org)
Objective: The aim was to compare HLA-G serum levels in patients with or without preeclampsia. (pitt.edu)
These TCR assets pipelines address a range of HLA restrictions, expanding the reach of TCR-modified T-cell (TCR-T) therapies to many more patients. (anocca.com)
Haemodialysis patients who were and are unable to eliminate the virus positive for hepatitis B virus surface antigen because of their impaired immune systems. (who.int)

We aim to evaluate the expression of CT antigens in non-small cell lung cancer and the correlation with the clinical characteristics. (bmj.com)
49.6% non-small cell lung cancer samples were HLA-A2 positive. (bmj.com)
CT antigens were frequently expressed in non-small cell lung cancer. (bmj.com)
Anocca deploys antigen technologies to discover and validate new cancer antigens, down to the level of individual mutations in specific individual tumours. (anocca.com)

Des mesures de protection contre cet type d'iinfection devraient être mises en place. (who.int)

HLA-G quantification was performed in peripheral blood samples through the Enzyme-linked Immunosorbent Assay (ELISA) method. (pitt.edu)

We investigated the T cell recognition of 398 in silico predicted HLA-ligands from Large T, Small T and VP1 and identified T-cell responses restricted to HLA-A1, A2, A3, A11 and B7. (biomedcentral.com)

The junctional region of the BCR-ABLb3a2 molecule represents a potential leukemia-specific antigen which could be recognized by cytotoxic T lymphocytes (CTL). (pasteur.fr)

It also binds the abnormally folded HLA-B27 homodimer found in spondylarthritides, but not the normal heterodimer of HLA-B27 with beta 2‑microglobulin (9, 10). (rndsystems.com)

The following product was used in this experiment: HLA-DR Monoclonal Antibody (LN3), Super Bright™ 436, eBioscience™ from Thermo Fisher Scientific, catalog # 62-9956-42, RRID AB_2744822. (thermofisher.com)
After HBV vaccination, specific antibody is were considered as seroprotective. (who.int)

In this study, HIV-1-specific CD8+ T-cell responses in 18 acutely infected individuals expressing HLA-A3 and/or -B7 were characterized. (ox.ac.uk)
The amino acids Ala268, Ser269, Glu271 and Thr272 constituted the major TCR contact residues, as substitution at these positions did not affect HLA-DR4(B1*0401) binding but abrogated T cell responses. (biomedcentral.com)

Genomic deoxyribonucleic acid was extracted from placenta tissue and the 3′UTR region of HLA-G was amplified via polymerase chain reaction. (biomedcentral.com)

In fact, the HLA locus which is the main inherited genetic susceptibility factor for CeD, only accounts for ~ 40% of the genetic variance of the disease. (frontiersin.org)

L'EBV est une infection courante à Bahreïn. (who.int)

MAGE-A3 is a Clinically Relevant Target in Undifferentiated Pleomorphic Sarcoma/Myxofibrosarcoma. (moleculardepot.com)
Based on the recent success of anti-programmed death-1 (PD-1) therapy in undifferentiated pleomorphic sarcoma, we hypothesize that MAGE-A3-based immunotherapies may also provide benefits in this sarcoma type. (moleculardepot.com)

The sexual intercourse frequency is a major factor to develop preeclampsia and the serum HLA-G levels measured previous to the child delivery or cesarean are not different between women with or without preeclampsia. (pitt.edu)
Recently, associations between preeclampsia and SNPs in the 3′ untranslated region (3′UTR) of HLA-G have been observed [ 13 ]. (biomedcentral.com)
Therefore, the aim of the present study was to compare SNPs in the 3′UTR of the HLA-G between pregnancies complicated with spontaneous preterm births and those with preeclampsia in gestational age matched placentas. (biomedcentral.com)

melanoma-associated antigens" (MAGE) i antigen NY-ESO-1. (unizg.hr)

This finding suggests that these HLA variants contribute to, but are not sufficient for, the development of the disease and that additional genetic and environmental factors are needed to mount a pathogenic immune response against gluten ( 9 ). (frontiersin.org)
Working closely with other collaborators active in this field, we aim to identify specific genetic variants that cause this predisposition and to investigate the kinds of biological processes that they take part in. (brookes.ac.uk)

Cette particularité que l'on rencontre également chez d'autres mammifères semble bien avoir pour origine naturelle l'intérêt sélectif pour la descendance d'avoir hérité d'un patrimoine adéquatement diversifié à ce niveau. (geobiotech.fr)
Une hypothèse intéressante sur le mécanisme de cette relation existant chez un individu donné entre d'une part ses préférences en matières d'odeurs et d'autre part son identité HLA se base l'observation d'une concentration importante de gènes de récepteurs olfactifs jouxtant directement ceux du système HLA, ce qui favorisera leur transmettre en bloc d'une génération à la suivante avec une plus grande probabilité. (geobiotech.fr)

The latter suggests the ongoing of an antigen-driven response [ 1 ]. (biomedcentral.com)

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