• A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1/hnRNP D". Arch. (wikipedia.org)
  • These events regulate the inclusion of repetitive GY-SLiMs within nearly all members of the heterogeneous nuclear ribonucleoprotein (hnRNP) A and D families of RNA binding proteins. (cam.ac.uk)
  • There were no polypeptides in the isolated antigen which corresponded in MW to the core proteins of heterogeneous nuclear ribonucleoprotein (hnRNP) particles described by other investigators. (eurekamag.com)
  • 2012). The main families of these SFs are the Ser/Arg-rich (SR) proteins and heterogeneous nuclear ribonucleoprotein particle (hnRNP) proteins. (biomedigs.org)
  • CONCLUSION: Peptide p155-175 encompasses a disease-specific immunodominant epitope of hnRNP-A2. (cnrs.fr)
  • OBJECTIVES: Autoantibody formation and T cell reactivity against the heterogeneous nuclear ribonucleoprotein A2 (hnRNP-A2) has been observed in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). (cnrs.fr)
  • Heterogeneous nuclear ribonucleoprotein L (hnRNP L) interacted with this ESS, and downregulation of hnRNP L expression induced an increase in the caspase-9a/9b ratio. (elsevierpure.com)
  • Although expression of hnRNP L lowered the caspase-9a/9b ratio in NSCLC cells, expression of hnRNP L produced the opposite effect in non-transformed cells, suggesting a post-translational modification specific for NSCLC cells. (elsevierpure.com)
  • This study therefore identifies a cancer-specific mechanism of hnRNP L phosphorylation and subsequent lowering of the caspase-9a/9b ratio, which is required for the tumorigenic capacity of NSCLC cells. (elsevierpure.com)
  • The heterogeneous nuclear ribonucleoprotein (hnRNP) C proteins, among the most abundant pre-mRNA-binding proteins in the eukaryotic nucleus, have a single RNP motif RNA-binding domain. (korea.ac.kr)
  • Grgurević, Lovorka (2019) Tumor tissue hnRNP M and HSP 90α as potential predictors of disease-specific mortality in patients with early-stage cutaneous head and neck melanoma: a proteomics-based study . (irb.hr)
  • infection of human epidermoid carcinoma no. 2 cells with herpes simplex virus type 1 (hsv-1) leads to a reorganization of antigens associated with both the small and heterogeneous nuclear ribonucleoprotein complexes (snrnp and hnrnp). (liverpool.ac.uk)
  • the hnrnp core protein antigens remain associated with the host chromatin, which appears to collapse into internal aggregates and along the nuclear envelope. (liverpool.ac.uk)
  • Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an alternative splicing factor that is mainly nuclear, although it shuttles rapidly between nuclear and cytoplasmic compartments. (pasteur.fr)
  • This treatment results in serine-specific phosphorylation within a C-terminal peptide, dubbed the "F-peptide," which is adjacent to the M9 motif that mediates bidirectional transport of hnRNP A1. (pasteur.fr)
  • Our findings suggest that the phosphorylation of F-peptide by cell-signaling pathways regulates the rate of hnRNP A1 nuclear import. (pasteur.fr)
  • 2, 4] Protein sequencing of highly purified RA33 revealed that it is indistinguishable from heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2B1). (medscape.com)
  • Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a protein that in humans is encoded by the HNRNPD gene. (wikipedia.org)
  • The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. (wikipedia.org)
  • TDP-43 is a highly conserved, ubiquitously expressed, multifunctional nucleic acid-binding protein composed of two RNA recognition motifs (RRM), nuclear localization (NLS) and export signals (NES), and a carboxy-terminal glycine rich region. (nature.com)
  • The stargazin-related protein γ7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including Cav2. (google.cl)
  • The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). (nih.gov)
  • It consists of five small nuclear ribonucleoprotein particles (snRNPs) and over 200 additional proteins (Wahl et al. (biomedigs.org)
  • These proteins bind specific sequences in the pre-mRNA called intronic or exonic splicing enhancer or LY404039 suppressor sequences. (biomedigs.org)
  • Conversely, overexpression of a catalytically inactive mutant, Clk/STY(K190R), causes retention of hypophosphorylated SR proteins in nuclear speckles. (rupress.org)
  • RRMs are found in a variety of RNA binding proteins, including heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs). (embl.de)
  • To display all proteins with a RRM domain in a specific node, click on it. (embl.de)
  • Unreported homologies in the RRM-enriched database to the metazoan SR family of splicing factors are described for an Arg-rich human nuclear protein and two yeast proteins (S. pombe mei2 and S. cerevisiae Npl3). (embl.de)
  • Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation. (embl.de)
  • Its M9 domain acts as both a nuclear localization and nuclear export signal. (antibodies-online.com)
  • an investigation of their specific localization in human brain and their influence on CaV2. (google.cl)
  • Both immunofluorescence and transmission electron microscopy analyses of cells overexpressing Clk/STY indicate that IGC components are completely redistributed to a diffuse nuclear localization, leaving no residual structure. (rupress.org)
  • On the other hand, AUF1 downregulation with specific siRNA inhibited EMT and reduced the stemness features in breast cancer cells. (nature.com)
  • Chromatin target of Prmt1 (Chtop) is a vertebrate-specific chromatin-bound protein that plays an important role in transcriptional regulation. (embl.de)
  • Post-transcriptional regulation of human genes by TE-derived sequences has been observed in specific contexts, but has yet to be systematically and comprehensively investigated. (biomedcentral.com)
  • A fraction of the bound antigen, comprising less than 0.15% of the total nuclear protein, was isolated in antigenically active form. (eurekamag.com)
  • hsv specific antibody production was detected in culture supernatants of pbmc from hsv seropositive healthy individuals by stimulating with optimal concentrations of hsv antigen without mitogens. (liverpool.ac.uk)
  • One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family. (genetex.com)
  • Mixed connective tissue disease is an uncommon, specifically defined syndrome characterized by clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen. (msdmanuals.com)
  • an enzyme linked immunosorbent assay (elisa) system to study specific anti-herpes simplex virus (hsv) antibody production in vitro by human peripheral blood mononuclear cells (pbmc) has been developed. (liverpool.ac.uk)
  • PCBP1 plays a role in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. (prospecbio.com)
  • 2] Anti-RA 33 antibody has been described as a highly specific antinuclear antibody for RA. (medscape.com)
  • Demonstration of a new antinuclear antibody (anti-RA33) that is highly specific for rheumatoid arthritis. (medscape.com)
  • The feasibility of using human autoimmune antibodies to isolate and characterize specific nuclear ribonucleoprotein (nRNP) complexes was investigated. (eurekamag.com)
  • Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
  • the system is designed to identify and type hsv from direct lesion smears (ds) and from cell culture smears (cs) infected with a swab from the patient's lesion by means of an indirect fluorescence assay (ifa) using hsv type-common and hsv-2 type-specific monoclonal antibodies. (liverpool.ac.uk)
  • Diagnosis is by the combination of clinical features, antibodies to ribonucleoprotein, and absence of antibodies specific for other autoimmune diseases. (msdmanuals.com)
  • However, relatively little is known about the role of specific amino acids of the RBD in the binding to RNA. (korea.ac.kr)
  • Tumor-specific variations in splicing may generate new epitopes that can serve as a starting point for immune therapy or targeted delivery, as well as for the development of new diagnostic or prognostic tools [ 6 ]. (biomedcentral.com)
  • Splicing of the NS segment, which encodes the host shutoff protein non-structural protein 1 (NS1), generates the nuclear export protein (NEP/NS2) that is involved in viral RNP export from the host nucleus [ 8 ]. (biomedcentral.com)
  • 5FMC is a nuclear complex that can only be recruited by Chtop when the latter is arginine-methylated by Prmt1. (embl.de)
  • Each segment is wrapped by a nucleoprotein (NP) into a viral ribonucleoprotein (RNP) complex along with a viral RNA polymerase complex comprising polymerase basic 1 (PB1) polymerase, cap‐binding PB2 subunit, and polymerase acidic (PA) endonuclease. (biomedcentral.com)
  • Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. (medscape.com)
  • Arsenic exposure of human HaCaT keratinocytes induced nuclear accumulation of PRMT1 and PRMT4, histone H4R3 and H3R17 methylation proximal to the ARE, but not to the non-ARE regions of ferritin genes. (embl.de)
  • The discrepancy in M2-dependence emphasizes the importance of M2 in human influenza A virus pathogenicity, which leads to subtype-specific evolution. (biomedcentral.com)
  • limiting dilution analysis of specific in vitro anti-herpes simplex virus antibody production by human lymphocytes. (liverpool.ac.uk)
  • specific phosphorylation of 5-ethyl-2'-deoxyuridine by herpes simplex virus-infected cells and incorporation into viral dna. (liverpool.ac.uk)
  • and unpublished results), making it possible to better address the biological function of these nuclear domains. (rupress.org)
  • This remark is certainly a stunning point in favor of a significant Refametinib contribution to growth development control by FSP-specific Testosterone levels cells in vivo , producing those peptides extremely interesting applicants for the advancement of targeted vaccination strategies. (immune-source.com)
  • Further, alignment coverage peaks on specific positions of the TE consensus sequences, illuminating a diversity of TE-specific RBP binding motifs. (biomedcentral.com)
  • Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
  • It is also thought have a primary role in the formation of specific myometrial protein species in parturition. (antibodies-online.com)
  • This requires that the RNA have a specific secondary and tertiary structure, bringing the two exons close together while looping out the intron. (pressbooks.pub)
  • PCBP1 and PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promotes poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. (prospecbio.com)
  • Specific mutations involving the FUS gene are involved in several types of cancer. (medlineplus.gov)
  • For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)
  • They play major roles in the tissue- and stage-specific expression of protein isoforms as well as in the maintenance of protein homeostasis. (encyclopedia.pub)
  • Other splicing-specific microarrays have been developed to cover most alternative splicing events. (biomedcentral.com)
  • Medical charts were retrospectively reviewed to determine time elapsed since diagnosis to disease-specific death or censoring. (irb.hr)
  • trifluorothymidine: potential non-invasive diagnosis of herpes simplex infection using 19f nuclear magnetic resonance in a murine hepatitis model. (liverpool.ac.uk)
  • A maximum of 2.9% of the nuclear RNA and 0.7% of the protein bound to anti-nRNP but not to control IgG columns. (eurekamag.com)
  • 0.64 mg/ml (Please refer to the vial label for the specific concentration. (genetex.com)
  • You can use + and - symbols to force inclusion or exclusion of specific words. (pasteur.fr)
  • In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. (nih.gov)