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DengueDengue VirusSevere DengueDengue VaccinesAedesInsect VectorsAntibodies, ViralCulicidaeThailandNicaraguaAntibody-Dependent EnhancementViral Nonstructural ProteinsDisease OutbreaksVietnamFlavivirusMosquito ControlSerotypingImmunoglobulin MPuerto RicoDisease VectorsTravelBrazilEnzyme-Linked Immunosorbent AssayRNA, ViralAmericasViral Envelope ProteinsSri LankaCubaRainAntigens, ViralPolynesiaSingaporeEncyclopedias as TopicHypotensionFeverCentral African RepublicMadagascarParisTranslational Medical Research
FeverHemorrhagicInfectionMosquitoesVaccineAedesOutbreaksTreatment for dengueMosquito-borneSerotypeDENVEndemicTreat dengue2023Contracted dengue virusInfectionsAntibodiesTypes of dengueOutbreakZikaShockInfected with dengue virusVectorsChikungunyaInfectious DiseasesReported dengue casesLive attenuated dengueVaccinesTropical and subtropicalClinicalRisk for dengueSpread of denguePeople with dengueDistribution of dengueSerotypes and genotypesDiseaseHospitalizationPreventionImmuneAnti-dengueIllnessDiseasesELISACasesVirus antibody
Fever120
Hemorrhagic2
  • Subsequent infections by other serotypes also increase the risk of developing severe, or hemorrhagic, dengue. (pasteur.fr)
  • Six people have died, including three infected with the severe hemorrhagic variant, which accounts for a fraction of dengue cases. (nbcnews.com)
Infection54
  • We show here that the interactions between DV E protein, the sole mannosylated glycoprotein present on DV particles, and the C-type lectin dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) are essential for DV infection of DCs. (unboundmedicine.com)
  • Anyone who lives in or travels to an area with risk of dengue is at risk for infection. (cdc.gov)
  • In 2019, the U.S. Food and Drug Administration approved Dengvaxia for use in children 9-16 years old with laboratory evidence of a previous dengue infection and living in areas where dengue is common. (cdc.gov)
  • Children 9-16 years old with laboratory-confirmed previous dengue infection and living in areas where dengue occurs frequently. (cdc.gov)
  • Your child must test positive for a previous dengue infection before being vaccinated. (cdc.gov)
  • Therefore, to reduce the risk of vaccinating children who have never had dengue, a blood test can check for a previous dengue infection. (cdc.gov)
  • Dose 1 can be given after confirming that your child had a prior dengue infection. (cdc.gov)
  • The durably protective antibody response to DENV after primary infection is serotype specific. (bvsalud.org)
  • Following infection with one serotype, subsequent infection with a different serotype increases a person's risk of severe dengue and death. (paho.org)
  • The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. (mdpi.com)
  • Scientists from the Institut Pasteur in Paris and the Institut Pasteur in Cambodia, in collaboration with teams from the CNRS and Inria, have demonstrated that asymptomatic dengue infection in children is associated with activation of the immune system via control mechanisms, resulting in the elimination of viral infection without excessive immune activation. (pasteur.fr)
  • This paper, published in the scientific journal Science Translational Medicine on August 30, 2017, represents an important step in improving understanding of the role played by immunity in dengue viral infection. (pasteur.fr)
  • There are currently no specific treatments for infection by the dengue virus. (pasteur.fr)
  • To identify the internal mechanisms used to control dengue virus infection in asymptomatic patients, scientists from the Institut Pasteur in Paris, the Institut Pasteur in Cambodia, the CNRS and Inria examined the composition of blood serum, immune cells and the gene expression profile in asymptomatic Cambodian children infected with the dengue virus and compared them to those of patients presenting with clinical signs. (pasteur.fr)
  • There is no specific treatment for dengue infection. (cdc.gov)
  • The risk of dengue infection for the international traveler appears to be small, unless an epidemic is currently in progress. (cdc.gov)
  • In Asia, children under the age of 15 years who are experiencing a second dengue infection appear to have the highest risk of developing DHF. (cdc.gov)
  • Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. (hindawi.com)
  • Knowledge about the pathogenesis of dengue infection is limited, but both viral and immune host factors appear to be associated with severe illness [ 26 ]. (hindawi.com)
  • Infection with one results in immunity to that specific virus but not to the other 3. (nih.gov)
  • If an infection is suspected, you will get a blood test to check for the dengue virus. (medlineplus.gov)
  • Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. (org.in)
  • These results indicate that dengue virus-specific CD4+ CD8- CTL are generated in short-term bulk cultures as well as in long-term-cultured cell lines, and support the concept that CD4+ CTL may be generated in vivo during infection. (umassmed.edu)
  • High-resolution analysis of intrahost genetic diversity in dengue virus serotype 1 infection identifies mixed infections. (broadinstitute.org)
  • Index cluster study of dengue virus infection in Nicaragua. (broadinstitute.org)
  • Investigators in UVM's Vaccine Testing Center and Center for Translational Global Infectious Disease Research (TGIR) have uncovered details of the human immune response to infection with dengue - a close "cousin" of the Zika virus - which 40 percent of the global population is at risk for contracting. (uvm.edu)
  • Study findings, reported recently in the Lancet 's open-access journal EBioMedicine , illustrate new critical information that could provide much-needed help to evaluating dengue vaccine formulations and assist with advancing safe and efficacious candidate vaccines to help combat the most important mosquito-borne viral infection in our time. (uvm.edu)
  • One of the challenges of dengue infection is that it can be caused by one of four versions - or serotypes - of the virus, which are numbered dengue 1 to 4. (uvm.edu)
  • Infection by one serotype typically results in long-term protection specific to that serotype. (uvm.edu)
  • In this study, co-led by Huy Tu, a fifth-year Ph.D. candidate in the Cellular and Molecular Biomedical Sciences program, the group defined the evolution of the antibody response in dengue infection in a controlled human model where subjects were treated with a weakened version of the virus. (uvm.edu)
  • Talking to media, he said that dengue is a viral infection transmitted by mosquitoes. (com.pk)
  • Dengue, a viral infection that transmits through mosquito bites, has long plagued tropical and sub-tropical regions. (globalissues.org)
  • This study describes the susceptibility to dengue virus infection of a monocytic cell line at different states of differentiation. (microbiologyresearch.org)
  • Infection enhancement of dengue type 2 virus in the human U-937 monocyte line by antibodies to Flavivirus cross-reactive determinants. (microbiologyresearch.org)
  • Dengue (DEN) is a result of infection by one or multiple types of four dengue viruses known as Dengue virus (DENV) 1-4. (lww.com)
  • For prevention of disease through vaccines that are administered to the patient before dengue infection, we should use those that are effective against the smooth surface virus. (journalforclinicalstudies.com)
  • Following an infection with one DENV serotype, the antibodies induced are type-specific and also cross-reactive with other DENV sero-types (Wilder-Smith et al. (cdc.gov)
  • The World Health Organization recommends that the vaccine only be given to persons with confirmed prior dengue virus infection. (cdc.gov)
  • In May 2019, Dengvaxia® was approved by the U.S. Food and Drug Administration (FDA) in the United States for use in children 9-16 years old living in an area with endemic dengue with laboratory confirmed prior dengue virus infection. (cdc.gov)
  • Should 3-doses of Dengvaxia ® be administered routinely to persons 9-16 years of age with laboratory-confirmed previous dengue infection and living in endemic areas to prevent virologically confirmed dengue, hospitalizations and severe dengue? (cdc.gov)
  • Malaria and dengue are endemic in similar tropical regions, and therefore, may result in the possibility of co-infection. (who.int)
  • The Tufts team set out to develop and test a Simoa-based dengue test hoping that the digital platform might be able to more sensitively detect anti-dengue antibodies, opening up the possibility of detecting the disease earlier after infection. (genomeweb.com)
  • Overall, the results suggest that Simoa may be able to detect dengue infection at a much earlier stage of infection as compared to ELISAs, the authors wrote. (genomeweb.com)
  • To determine what specific chemical compound changes with flavivirus infection, the scientists isolated chemicals that were released into the air by infected and uninfected mice. (smithsonianmag.com)
  • Global levels of dengue infection are more than three times higher than previous estimates from the World Health Organization, according to new research just published in the journal Nature . (planetsave.com)
  • Until now, little was known about the current distribution of the risk of dengue virus infection and its public health burden around the world. (planetsave.com)
  • Jimmy Whitworth, Head of International Activities at the Wellcome Trust, said: "Over time, this comprehensive map of global disease burden will also help to demonstrate which control measures are making the biggest difference in reducing the number of people suffering from dengue infection. (planetsave.com)
  • Dengue and Zika virus infection has been found to up against a human and mosquito immune defense mechanism and highjack specific host proteins for virus replication. (medindia.net)
  • The Panbio Dengue Duo IgM Capture & IgG Capture ELISA offers an improvement over the HAI assay as an aid for the serological diagnosis of dengue infections between primary and secondary infection using a single dilution of serum, rather than a series of dilutions required for HAI assays. (proteincrystallography.org)
  • 1997). Commercial Assays for the Serological Diagnosis of Dengue Infection. (proteincrystallography.org)
  • Cuzzubbo, A., et al (1998) Detection of Specific Antibodies in Saliva during Dengue Infection. (proteincrystallography.org)
  • Sang, C., et al (1998) Evaluation of a Commercial Capture Enzyme-Linked Immunosorbent Assay for Detection of Immunoglobulin M and G Antibodies Produced during Dengue Infection. (proteincrystallography.org)
  • Titers in acute and convalescent phase serum samples can reliably establish dengue virus infection and may indicate the specific dengue virus type involved. (msdmanuals.com)
  • Dengue virus infection has emerged as marker in clinical practice ( 11 ). (who.int)
Mosquitoes21
  • Dengue is spread by several species of female mosquitoes of the Aedes genus, principally Aedes aegypti. (wikipedia.org)
  • Dengue is a disease spread by mosquitoes through bites. (cdc.gov)
  • Dengue is a viral disease transmitted to humans by mosquitoes of the Aedes genus. (pasteur.fr)
  • It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . (hindawi.com)
  • The dengue virus is spread through the bite of infected Aedes mosquitoes. (bigislandvideonews.com)
  • Dengue and chikungunya fevers are viral illnesses transmitted by day-biting mosquitoes in many tropical areas. (emoryhealthcare.org)
  • A team led by Omar Akbari's lab at UC San Diego has engineered the first mosquitoes that repel the four known types of Dengue virus. (isaaa.org)
  • An international team of scientists led by Associate Professor Omar Akbari's Lab at the University of California San Diego (UC San Diego) has engineered mosquitoes that stop the transmission of the Dengue virus. (isaaa.org)
  • The development marks the first engineered approach in mosquitoes that targets the four known types of Dengue, improving upon previous designs that addressed single strains. (isaaa.org)
  • The research team then designed the antibody "cargo" to be synthetically expressed in female Aedes aegypti mosquitoes, which spread the Dengue virus. (isaaa.org)
  • Aedes aegypti mosquitoes are one of primary vectors for dengue. (globalissues.org)
  • Specific actions involve vector control strategies for larvae and adult mosquitoes and source reduction, especially of water storage practices, and include covering, draining and cleaning household water storage containers on a weekly basis, using insecticide-treated nets and indoor space spraying (fogging). (globalissues.org)
  • Supportive government initiatives to promote awareness dengue-carry mosquitoes, technological advancements in healthcare, rising prevalence of dengue globally, and rapid rise in population are some key factors boosting demand for dengue testing kits. (reportsanddata.com)
  • Dengue viruses (DENV) transmitted by Aedes aegypti mosquitoes present a growing public health challenge (Shepard et al. (cdc.gov)
  • The second thing I tell people is that dengue caused outbreaks here in the United States in the 1800s and beginning of the 1900s - and we still have the right mosquitoes to spread disease in the southeastern United States. (cdc.gov)
  • In the first part of their multi-step study, Cheng's team tested whether two species of mosquitoes, Aedes aegypti and Aedes albopictus , were more attracted to Zika or dengue infected mice than to uninfected mice. (smithsonianmag.com)
  • To test whether humans become more attractive to mosquitoes when they get infected, Cheng's team recruited both dengue patients and uninfected participants. (smithsonianmag.com)
  • As with the mice, the mosquitoes showed the strongest attraction to odors from humans that were infected with dengue. (smithsonianmag.com)
  • There are currently no licensed vaccines or specific treatments for dengue, and substantial efforts to control the mosquitoes that transmit the disease have not stopped its rapid emergence and global spread. (planetsave.com)
  • Results of the three-year study, published in the New England Journal of Medicine this week, found that infecting dengue-carrying mosquitoes with a harmless bacteria called Wolbachia led to a 77 percent drop in human cases. (aljazeera.com)
  • Wolbachia suppresses the ability of the virus to replicate in dengue-carrying Aedes aegypti mosquitoes and cause infections when they bite humans. (aljazeera.com)
Vaccine22
  • Two types of dengue vaccine have been approved and are commercially available. (wikipedia.org)
  • Ask your child's healthcare provider about the safe and effective dengue vaccine. (cdc.gov)
  • The vaccine is safe and effective among children who have had dengue before. (cdc.gov)
  • In children who have not already had dengue before, the dengue vaccine increases the risk of severe illness and hospitalization if the child gets dengue after vaccination. (cdc.gov)
  • The findings of this original study open up new avenues of research for the development of a vaccine against the dengue virus that will offer more comprehensive protective immunity against the four serotypes of the dengue virus and also prevent the spread of this disease, which represents a considerable global threat. (pasteur.fr)
  • No vaccine is available for dengue, but travelers can protect themselves by using anti-mosquito measures to avoid being bitten. (cdc.gov)
  • To date, there is no effective vaccine or specific antiviral therapy for dengue. (hindawi.com)
  • Just one dose of a low-cost vaccine proved safe and stimulated a strong immune response against the dengue virus in most participants in an early-stage clinical trial. (nih.gov)
  • The ideal vaccine, therefore, would be tetravalent - meaning it protects against all 4 dengue viruses. (nih.gov)
  • In previous work, a research team led by Dr. Anna Durbin of Johns Hopkins University tested vaccine candidates against each dengue virus. (nih.gov)
  • Peripheral blood mononuclear cells (PBMC)3 from a donor who had been immunized with an experimental live attenuated dengue 1 vaccine 8 months earlier were used. (umassmed.edu)
  • In 2019, the Food and Drug Administration (FDA) approved a vaccine for children ages 9-16 years who have had dengue in the past and live in areas where dengue is common. (medicalnewstoday.com)
  • In May 2019 , the FDA approved the first dengue vaccine. (medicalnewstoday.com)
  • Concomitant with the anticipated release of these vaccines, vaccine allocation strategies for dengue-endemic countries in Southeast Asia and Latin America are currently under development. (oregonstate.edu)
  • More specifically, we showed that, during the first years following introduction of a dengue vaccine, it is optimal to target children for dengue mass vaccination in Thailand, whereas young adults should be targeted in Brazil. (oregonstate.edu)
  • This could give rise to new approaches in vaccine development and treatment for dengue disease. (journalforclinicalstudies.com)
  • Our study gives a new direction to vaccine development and treatment for dengue disease. (journalforclinicalstudies.com)
  • There is no approved vaccine to prevent it, and no specific treatment. (thenationalnews.com)
  • A vaccine to prevent dengue (CYD-TDV, Dengvaxia®) is licensed and available in 20 countries for people ages 9-45 years old. (cdc.gov)
  • The US Advisory Committee on Immunization Practices (ACIP) Dengue Vaccine Work Group reviewed Dengvaxia ® safety and efficacy data in a systematic literature review in 2018. (cdc.gov)
  • There is no vaccine or antiviral medicine for this disease, so those who have dengue-like symptoms should see a physician. (cdc.gov)
  • Without a vaccine or specific treatment options, it's crucial that we understand where best to direct the limited resources available for preventing this resurgent disease. (planetsave.com)
Aedes6
  • In the Americas, Aedes aegypti is the mosquito vector that is the main source of dengue transmission. (paho.org)
  • Dengue is transmitted by the bite of infective Aedes mosquitos which are found primarily in urban areas. (cdc.gov)
  • Dengue is a viral disease transmitted by urban Aedes mosquitos. (cdc.gov)
  • Vertical transmission in Aedes aegypti and Aedes albopictus is considered a maintenance mechanism for dengue virus (DENV) during unfavorable conditions and may be implicated in dengue outbreaks. (nature.com)
  • Dengue virus is transmitted through bite of female mosquitos of the Aedes aegypti species that dwell in tropical and subtropical regions. (reportsanddata.com)
  • The Aedes mosquito - potentially together with flaviviruses like dengue and Zika - is found in most tropical and subtropical countries, and South-East Asia is no exception. (medindia.net)
Outbreaks7
  • Dengue outbreaks are occurring in many countries of the world in the Americas, Africa, the Middle East, Asia, and the Pacific Islands. (cdc.gov)
  • This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. (hindawi.com)
  • A phylogenetic analysis using full-length viral genomes of South American dengue serotype 3 in consecutive Venezuelan outbreaks reveals a novel NS5 mutation. (broadinstitute.org)
  • There generally is no specific treatment for the disease, but vaccines are available Other countries, such as Cyprus and Bolivia, also have seen outbreaks this year. (texomashomepage.com)
  • Clinical symptoms activity with multiple and large outbreaks occurring resemble dengue, and while chikungunya is a generally yearly. (who.int)
  • In the Western Pacific Region in 2014 alone, milder disease, debilitating sequelae such as persistent there were outbreaks involving 1513 dengue cases arthralgia have been reported in 36-64% of cases. (who.int)
  • There is currently no specific treatment for dengue, and vector control and vaccination are the only effective methods to prevent future outbreaks. (who.int)
Treatment for dengue2
  • Treatment for dengue involves managing the symptoms. (medicalnewstoday.com)
  • While there is currently no specific treatment for dengue, early detection and appropriate healthcare for case management can significantly reduce mortality. (globalissues.org)
Mosquito-borne5
  • Dengue is the most important reemerging mosquito-borne viral disease worldwide. (hindawi.com)
  • Both `malaria' and `dengue' are known to be rapidly spreading mosquito-borne diseases and of high importance in terms of both mortality and morbidity, posing a worldwide public health problem due to ease in globalised travel. (who.int)
  • Cheng writes in an email that his team's findings could "inform real-world public health strategies for controlling mosquito-borne flaviviral viral diseases such as dengue and Zika. (smithsonianmag.com)
  • While previous studies had found evidence of increased mosquito attraction in humans infected with mosquito-borne diseases, this study is one of the first to clearly identify a specific chemical as the reason for this attraction. (smithsonianmag.com)
  • Dengue is the most rapidly spreading mosquito-borne disease in the world with more than 50 million cases globally every year, including about eight million in Indonesia. (aljazeera.com)
Serotype7
  • Identification of Dengue Virus Serotype 3 Specific Antigenic Sites Targeted by Neutralizing Human Antibodies. (bvsalud.org)
  • However, there is an incomplete understanding of the antigenic determinants for DENV type-specific (TS) antibodies , especially for DENV serotype 3, which has only one well-studied, strongly neutralizing human monoclonal antibody (mAb). (bvsalud.org)
  • Dynamics of dengue disease severity determined by the interplay between viral genetics and serotype-specific immunity. (broadinstitute.org)
  • Genetic diversity and lineage dynamic of dengue virus serotype 1 (DENV-1) in Cambodia. (broadinstitute.org)
  • Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia. (broadinstitute.org)
  • 6) The outbreak of dengue in Sudan was observed since 1984 in Portsudan caused by serotype 1, 2, and recently in Kassala 2010, Portsudan 2014 and Alfashir 2014. (who.int)
  • Global dengue incidence has increased in autochthonous outbreak in over 70 years 4,5 and DENV- recent decades, though the actual numbers of serotype 3 was found to be circulating in the Pacific after dengue cases are masked by underreporting. (who.int)
DENV13
  • The rational design of dengue virus (DENV) vaccines requires a detailed understanding of the molecular basis for antibody-mediated immunity . (bvsalud.org)
  • The four dengue serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) circulate throughout the Americas, and in some countries simultaneously. (paho.org)
  • In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the 'vascular-leak' syndrome seen in severe dengue in humans. (mdpi.com)
  • Dengue is an arthropod-borne disease caused by the Dengue virus (DENV) [ 1 ]. (hindawi.com)
  • Nevertheless, the involved DENV type and the host genetic makeup may explain some differences in clinical manifestations observed, since genetic polymorphisms appear to provide protection or predispose to more severe forms of dengue [ 27 ]. (hindawi.com)
  • Dengue Virus (DENV) belongs to the genus flavivirus in the Flaviviridae family. (lww.com)
  • serological testing such as Non-structural Protein 1 (NS 1) ELISA, DENV specific IgM antibody captures ELISA are used. (lww.com)
  • Dengue virus (DENV) infects about 400 million people annually around the world, with a high prevalence in tropical and sub-tropical regions. (journalforclinicalstudies.com)
  • There are 4 dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4), all of which circulate globally, with most endemic coun-tries reporting circulation of all 4 serotypes in recent years. (cdc.gov)
  • Dendritic cells (DC), present in the skin, are the first target cells of dengue virus (DENV). (unboundmedicine.com)
  • Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) is present on DC and recognizes N-glycosylation sites on the E-glycoprotein of DENV. (unboundmedicine.com)
  • Module A contained serum samples spiked with cultured dengue virus (DENV) or chikungunya virus (CHIKV) for the detection of nucleic acid and DENV non-structural protein 1 (NS1) antigen. (who.int)
  • External quality assessment of dengue and chikungunya diagnostics, 2015 co-circulation with DENV. (who.int)
Endemic3
  • Endemic dengue associated with the co-circulation of multiple viral lineages and localized density-dependent transmission. (broadinstitute.org)
  • Sudan is endemic for malaria, whereas dengue has established itself in an epidemic transmission cycle. (who.int)
  • RT-PCR tests are available for early dengue diagnosis, but serological methods are more cost effective and easily available making them attractive, especially in dengue endemic countries. (genomeweb.com)
Treat dengue2
  • There is no specific medicine to treat dengue. (cdc.gov)
  • Infected people are overwhelming hospitals across the country, but some doctors and nurses are not sufficiently experienced, or trained, in how to treat dengue cases, experts say. (texomashomepage.com)
20231
  • A man attends to his wife who is being treated for dengue at Mugda Medical College and Hospital in Dhaka, Bangladesh, Thursday, Aug. 10, 2023. (texomashomepage.com)
Contracted dengue virus1
  • The man reported not having traveled outside the country in the last year, suggesting that he contracted dengue virus locally. (cdc.gov)
Infections8
  • Dengue is considered the most serious re-emergent viral disease transmitted by arthropods, with approximately 390 million infections worldwide each year, 7% of which occur in Brazil 1 , 2 . (nature.com)
  • Age, co-morbidities, host genetics, and virus strain are risk factors for severe dengue with heterotypic secondary infections being the most prominent factor associated with severe dengue (Wilder-Smith et al. (cdc.gov)
  • Concurrent infections of malaria and dengue are when both the diseases occur simultaneously in an individual. (who.int)
  • Since there are similarities in the clinical characteristics between these two infections, diagnosis of malaria and dengue co-infections might be either misdiagnosed or misinterpreted as mono-infections. (who.int)
  • The team estimate that there are 390 million dengue infections across the globe each year, of which 96 million reach any level of clinical or subclinical severity. (planetsave.com)
  • Porter, K., et al (1999) Evaluation of a Commercially Available Immunoglobulin M Capture Enzyme-Linked Immunosorbent Assay Kit for Diagnosing Acute Dengue Infections. (proteincrystallography.org)
  • The trial involved releasing Wolbachia into the mosquito population across specific parts of Yogyakarta to measure how it affected the incidence of infections among three to 45-year-olds. (aljazeera.com)
  • DHAKA,Bangladesh (AP) - Bangladesh is struggling to deal with higher casualties and infections from dengue this year, with officials warning that the death toll this month could break records. (texomashomepage.com)
Antibodies6
  • Your body needs time to make specific antibodies to fight dengue. (medlineplus.gov)
  • Over a six-month period, Diehl and his colleagues tracked the immune response and measured its different aspects, from the levels of certain immune blood cells to the levels of antibodies they produce and how these antibodies can recognize different dengue serotypes. (uvm.edu)
  • In the study, published this week online as an accepted manuscript in the Journal of Clinical Microbiology , the Tufts group described their development of a Simoa-based assay to detect type 2 anti-dengue IgG and IgM and compared its sensitivity to two commercially available ELISA kits for the two antibodies. (genomeweb.com)
  • According to the group, currently used ELISAs for anti-dengue antibody detection suffer from a lack of sensitivity in the first few days of illness, when antibodies against the disease may be present at too low a concentration to be detected. (genomeweb.com)
  • Their group's indirect Simoa method relies on inactivated dengue virus type 2 antigen-coated magnetic beads for the capture of dengue-specific antibodies, the authors wrote. (genomeweb.com)
  • The Panbio Dengue Duo IgM Capture & IgG Capture ELISA is for the qualitative detection of IgM and IgG antibodies to dengue virus in serum. (proteincrystallography.org)
Types of dengue1
Outbreak3
  • We report an outbreak of dengue in Darfur, western Sudan, during September 2014-April 2015. (cdc.gov)
  • Health Minister Graciela Ocana said Wednesday that a dengue outbreak in the country has worsened to an epidemic, as nearly 8,000 people are officially reported to be infected with the disease. (nbcnews.com)
  • So the big question is whether this case represents a persistence of last year's outbreak or a new introduction of dengue from an outside traveler. (cdc.gov)
Zika5
  • These viruses, chikungunya and zika , are common in the same places as the dengue virus, and they cause similar symptoms. (medlineplus.gov)
  • These side chambers had air piped in from nearby containers of mice, which were either uninfected or infected with Zika or dengue. (smithsonianmag.com)
  • Twenty chemical compounds differed between the mice infected with Zika or dengue compared to the uninfected mice. (smithsonianmag.com)
  • Acetophenone was emitted into the air more by mice that were infected with Zika or dengue compared to uninfected mice. (smithsonianmag.com)
  • En Paraguay los virus dengue, fiebre amarilla y Zika fueron detectados en infecciones humanas, pero los estudios de flavivirus en mosquitos son aún escasos. (bvsalud.org)
Shock4
  • The illness can evolve to severe dengue, characterized by shock, respiratory distress, severe bleeding, and/or serious organ impairment. (paho.org)
  • The disease can evolve into severe dengue, characterized by shock, shortness of breath, severe bleeding and / or complications in the organs. (paho.org)
  • Severe dengue can cause internal bleeding and shock , which can be life-threatening. (medlineplus.gov)
  • Circulatory collapse and multiorgan failure, called dengue shock syndrome, may develop rapidly 2 to 6 days after onset. (msdmanuals.com)
Infected with dengue virus3
Vectors1
  • These vectors also transmit dengue and chikungunya virus and are found throughout much of the Americas, including parts of the United States. (cdc.gov)
Chikungunya3
  • While dengue has been long present in the tropics worldwide, chikungunya has been emerging and rapidly spreading in recent years, including to the Caribbean and Latin America. (emoryhealthcare.org)
  • To conduct an external quality assessment (EQA) of dengue and chikungunya diagnostics among national-level public health laboratories in the Asia Pacific region following the first round of EQA for dengue diagnostics in 2013. (who.int)
  • Accurate laboratory testing is a critical component of dengue and chikungunya surveillance and control. (who.int)
Infectious Diseases1
  • d WHO Collaborating Centre for Arbovirus Reference and Research (Dengue/Severe Dengue), Tropical Infectious Diseases Research and Education Centre, Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. (who.int)
Reported dengue cases1
  • According to the World Health Organization (WHO), the number of reported dengue cases is steadily rising. (reportsanddata.com)
Live attenuated dengue1
  • The majority of those were excluded as describing different live attenuated dengue vaccines or not including primary trial data. (cdc.gov)
Vaccines4
  • Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines. (mdpi.com)
  • Country- and age-specific optimal allocation of dengue vaccines. (oregonstate.edu)
  • Several dengue vaccines are under development, and some are expected to become available imminently. (oregonstate.edu)
  • Researchers from Duke-NUS Medical School (DukeNUS), in collaboration with the Agency for Science, Technology and Research (A*STAR)'s Bioinformatics Institute (BII), and the University of Texas Medical Branch (UTMB), USA, have discovered that the dengue virus changes its shape through mutations in Envelope (E) protein to evade vaccines and therapeutics. (journalforclinicalstudies.com)
Tropical and subtropical1
  • Although dengue was initially found only in the world's tropical and subtropical climates, it has now reached Europe. (pasteur.fr)
Clinical8
  • Presenters will also review dengue clinical classification, diagnosis, and general treatment guidelines based on World Health Organization and Centers for Disease Control and Prevention recommendations. (cdc.gov)
  • Recognize the three phases (febrile, critical, convalescent) and the three severity levels of symptomatic dengue (dengue, dengue with warning signs, severe dengue) based on a patient's clinical and laboratory findings. (cdc.gov)
  • Despite 50 years of research, the pathophysiological mechanisms that lead some patients to develop a severe clinical form of dengue have not yet been clearly elucidated. (pasteur.fr)
  • The case-fatality ratio for severe dengue is 10% or higher when untreated but can be reduced to less than 1% with good clinical management. (cdc.gov)
  • Kassala witnessed increasing of dengue cases during the last three years according to the clinical services records. (who.int)
  • 11) Clinical manifestations include symptoms that are non specific and cannot be distinguished reliably from other febrile illnesses or other malarias, in addition to misdiagnosis for both malaria and dengue detections may also lead to ambiguity in term of the disease burden in this area. (who.int)
  • Professor Jeremy Farrar, Director of the Wellcome Trust Vietnam Research Programme and Oxford University Clinical Research Unit Hospital for Tropical Diseases in Vietnam, explains that the map and estimates produced by Hay's group set the benchmark for the disease: "This is the first systematic robust estimate of the extent of dengue. (planetsave.com)
  • Patients with World Health Organization-defined clinical criteria plus thrombocytopenia ( ≤ 100,000/mcL [≤ 100 x 10 9 /L]) or hemoconcentration (Hct increased by ≥ 20%) are presumed to have the disease (see the Centers for Disease Control and Prevention's Dengue Virus: Clinical Guidance ). (msdmanuals.com)
Risk for dengue1
Spread of dengue3
  • Rising focus on community involvement to control spread of dengue is one of the factors driving market growth going ahead. (reportsanddata.com)
  • Authorities can fumigate areas identified as breeding grounds, but the best way to prevent the spread of dengue to humans is to avoid stagnant water, or areas where pools of water collect from after the rains. (thenationalnews.com)
  • Professor Farrar states: "This really does represent a crucial period in the global spread of dengue. (planetsave.com)
People with dengue1
Distribution of dengue2
  • Dr Samir Bhatt, who led the modelling for the study, says: "Our aim was to take all of the evidence that is currently available on the distribution of dengue worldwide and combine it with the latest in mapping and mathematical modelling to produce the most refined risk maps and burden estimates. (planetsave.com)
  • It brings map with distribution of dengue. (bvs.br)
Serotypes and genotypes1
  • The blots were dried and stored at 4°C and 28°C and tested for presence of dengue RNA, serotypes and genotypes after 7 days of incubation. (lww.com)
Disease8
  • Treatment of acute dengue is supportive and includes giving fluid either by mouth or intravenously for mild or moderate disease. (wikipedia.org)
  • PAHO/WHO provides advice and technical support for dengue prevention and control based on a regional strategy adopted by PAHO / WHO member States in 2016, called the " Strategy for arboviral disease prevention and control " (CD55.R6). (paho.org)
  • Dengue, also known as "tropical flu", is continuing to spread rapidly across the world and is now considered as a re-emerging disease. (pasteur.fr)
  • These actions can be identified through comprehensive tools such as all-hazards National Action Plans for Health Security (NAPHS), disease-specific plans, contingency plans, and other sources. (who.int)
  • Some people who get sick with dengue will develop severe dengue disease. (medlineplus.gov)
  • Dengue (DEN) is a neglected tropical viral disease. (lww.com)
  • The authors suggest that the hidden African dengue burden could be a result of the disease being masked by symptomatically similar illnesses, under-reporting and highly variable treatment-seeking behaviour. (planetsave.com)
  • Incidence of dengue has increased many fold in the past 50 years and has expanded to areas that were previously free from the disease. (who.int)
Hospitalization2
Prevention5
  • Dengue prevention and control must be intersectoral and involve the family and the community. (paho.org)
  • The Health Ministry has launched a national campaign to educate people on dengue prevention, including wearing insect repellant and covering exposed body parts with thick clothing. (nbcnews.com)
  • No specific treatment is available and measures to stop spreading the virus depend on prevention and control. (isaaa.org)
  • Controlling mosquito populations is an effective prevention against dengue. (globalissues.org)
  • If we work together and everybody shows awareness and acts responsibly, our collective effort will make dengue prevention possible," he said. (texomashomepage.com)
Immune5
  • Current data suggest that the strain of dengue virus, and the age, immune status, and genetic background of the human host are important risk factors for developing DHF. (cdc.gov)
  • They will become immune to the specific virus that caused it, though they will not be immune to the other three viruses. (medicalnewstoday.com)
  • People who have weaker immune system are at higher risk to be infected multiple times by a virulent variant (of dengue)," he said. (texomashomepage.com)
  • dengue virus-antibody immune complexes trigger release of vasoactive mediators by macrophages. (msdmanuals.com)
  • Most commonly, clinically relevant viral encephalitis affects children, young adults, or elderly patients, but the spectrum of involvement depends on the specific viral agent, host immune status, and genetic and environmental factors. (medscape.com)
Anti-dengue2
  • In contrast, the IgG Simoa was able to detect anti-dengue IgG at 1:10,000,000 dilution, making it 1,000 times more sensitive than the EuroImmun IgG ELISA kit. (genomeweb.com)
  • Similarly, the IgM Simoa was able to detect anti-dengue IgM at 10,000 times higher dilution than the EuroImmun IgM ELISA kit. (genomeweb.com)
Illness5
  • The state is still unable to officially connect the confirmed dengue case count to the viral videos produced by Charles Trippy and Allie Wesenberg, who published a day by day account of their visit to Hawaii Island, and Wesenberg's subsequent illness, on their YouTube channel CTFxC . (bigislandvideonews.com)
  • Dengue virus-specific PCR testing of 50 samples from nonmalaria febrile illness case-patients confirmed 35 dengue cases. (cdc.gov)
  • For some patients, dengue is a life-threatening illness. (org.in)
  • Health complication due to severe dengue has caused serious illness and deaths in various Latin America and Asia regions. (reportsanddata.com)
  • Combined with the dengue virus RNA amplification test, it can provide a diagnosis within the first 1 to 7 days of illness. (msdmanuals.com)
Diseases6
  • Many vector-borne diseases pose a specific threat to children's health. (who.int)
  • And with them, the many diseases that they carry, such as malaria and dengue. (planetsave.com)
  • Even when they do get sick, the symptoms can easily be confused with other diseases such as the flu or dengue. (medindia.net)
  • ABSTRACT Dengue is one of the most important arthropod-borne viral diseases. (who.int)
  • Dengue virus is transmitted to was approved by the Ethics Committee borne viral diseases worldwide ( 1 ). (who.int)
  • They can cause diseases in humans and animals, they also include specific insect viruses that only infect and replicate in insects, not in vertebrates. (bvsalud.org)
ELISA5
  • Based on product type, the dengue testing market is segmented into ELISA-Based Test, RT-PCR-Based Tests, Dengue lgG/lgM Rapid Test , and Others. (reportsanddata.com)
  • In their study, the Tufts team first measured the Simoa assay's sensitivity, as well as those of two ELISA kits for dengue detection, using serial dilutions of dengue type 2-positive plasma. (genomeweb.com)
  • This data has been extracted from the Dengue IgM Capture and Dengue IgG Capture ELISA Instructions for Use. (proteincrystallography.org)
  • 2015 we analysed the serum samples of 140 patients with a suspicion of dengue, using ELISA and multiplex polymerase chain reaction. (who.int)
  • Les échantillons de sérum de 140 patients susceptibles d'avoir contracté le virus de la dengue ont été analysés entre mai et octobre 2015 à l'aide du test ELISA et de l'amplification en chaîne par polymérase multiplexe. (who.int)
Cases8
  • Dengue incidence has increased in the Americas over the past four decades, from 1.5 million cumulative cases in the 1980s to 16,2 million in the decade 2010-2019. (paho.org)
  • The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. (hindawi.com)
  • Dr. Park says the health department plans to create a specific page on the DOH website to serve as a repository for the latest information, including updated numbers of confirmed cases. (bigislandvideonews.com)
  • WHO assessed the dengue risk at the national level as "High", primarily due to the escalating case numbers, high case fatality rate, and the extensive geographical distribution of cases. (globalissues.org)
  • Most cases are reported in October, just after the monsoon rains when the weather starts cooling, but reports of patients with dengue have been coming in from the southern states since last month. (thenationalnews.com)
  • And yet, despite at least 100 travelers diagnosed with dengue each year in the United States and frequent epidemics right across the US border with Mexico, we have seen only a handful of local cases in Texas. (cdc.gov)
  • Previous trials involving Wolbachia - commonly found in fruit flies and other insects - also showed positive results in reducing dengue cases, researchers said. (aljazeera.com)
  • In the first 10 days of August, more than 23,000 people were diagnosed with dengue, compared to 43,854 cases during all of July. (texomashomepage.com)
Virus antibody2