It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. (wikipedia.org)
However, it is unknown whether this synapse is fully assembled and leads to T-cell activation by enabling interaction between the T-cell receptor (TCR) and human leukocyte antigen class II (HLA-II). (ashpublications.org)
Adhesion molecule pairs, such as CD2-CD58 and CD11a-CD54, induce a transient adhesion of T cells to APCs, after which the T-cell receptor (TCR) scans the cell surface for antigens presented in the context of human leukocyte antigen (HLA) molecules. (ashpublications.org)
Tisagenlecleucel is a chimeric antigen receptor T-cell (CAR-T) treatment-a type of therapy in which patients' own T cells are harvested, reprogrammed to target a protein called CD19 that is expressed on the surface of cancer cells, and returned to the patient to fight ALL and lymphoma. (aacr.org)
The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. (childrensmercy.org)
CD2 antigen has been characterised as the receptor for sheep erythrocytes. (angiogenesis-blog.com)
It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. (wikipedia.org)
CD2 interacts with lymphocyte function-associated antigen (LFA-3/CD58) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. (ptglab.com)
Korinek V, Stefanova I, Angelisova P, Hilgert I, Horejsi V: The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. (exbio.cz)
Receptors5
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
[4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
Lymphocyte functio2
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Lymphocyte Function Associated Antigen 3 (LFA3) in serum, plasma, cell lysatesand other biological fluids. (envite.org)
Description: A sandwich ELISA kit for detection of Lymphocyte Function Associated Antigen 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (envite.org)
CD98 Light Chains1
It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. (wakehealth.edu)
Ligand1
The major ligand for CD2 is CD58 (also known as LFA-3). (biolegend.com)
APCs3
The lymphatic vessels and secondary lymphoid organs (SLOs) are arranged in a manner that optimizes interactions among antigens, APCs, and innate and adaptive effector cells. (jci.org)
5-7 These molecules are important components of the immunological synapse (IS), which enables antigen-dependent communication between T cells and antigen-presenting cells (APCs). (ashpublications.org)
[ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)
Molecules3
Upon antigen recognition, F-actin polymerization enables stabilization of the mature IS with a central region that contains the TCR-HLA molecules and interacting adhesion molecules in the periphery. (ashpublications.org)
We are currently investing this problem by studying the organisation of key molecules, such as CD45, TCR, CD4 and pMHC, on the surface of T cells and antigen presenting cells during the early stages of an immune response. (lu.se)
T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikidoc.org)
CD473
Antigens, CD47" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Antigens, CD47" by people in this website by year, and whether "Antigens, CD47" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)
Dendritic cells4
Dendritic cells (DCs) can take up an array of different antigens, including microorganisms which they can process and present more effectively than any other antigen presenting cell. (biomedcentral.com)
In particular, the role of Dendritic cells (DCs) in the initiation of specific T cell immunity to M. tuberculosis has not been clearly elucidated. (biomedcentral.com)
Effective induction of antigen-specific T-cell responses requires interaction between the dendritic cells and T lymphocytes to prime the latter cells for expansion and subsequent immune responses. (medscape.com)
The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. (wakehealth.edu)
Adhesion1
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion . (wikidoc.org)
CD451
This approach was recently used by me and collaborators to study how exclusion of the long phosphatase CD45 from SLB/T-cell contacts can initiate T-cell signalling without any antigens, 1,2 and how the model membrane itself can induce signaling. (lu.se)
Rosette1
Intriguingly, the level of CD58 expression correlated with the extent of rosette formation, and CD58 knockout or CD2 blockade reduced both rosette formation and T-cell activation. (ashpublications.org)
Modulate1
We further examined the power of peptide 6 to modulate antigen-specific immune system response inside a human being RA-relevant pet model through the use of CIA-susceptible HLA-class II transgenic mice. (bio-biz-navi.com)
Proteins1
(A) A schematic illustration showing specific binding between the proteins CD2 on a T cell with fluorescently-labelled CD58 in an SLB. (lu.se)
SURFACE3
TCRs can recognize fragments of antigen attached to MHC on the surface of an APC. (medscape.com)
Mouse monoclonal to CD2.This recognizes a 50KDa lymphocyte surface antigen which is expressed on all peripheral blood T lymphocytes,the majority of lymphocytes and malignant cells of T cell origin, including T ALL cells. (angiogenesis-blog.com)
Lower level of BAFF transcripts (or a higher level of soluble BAFF) show a higher risk of producing donor-specific antibodies in the investigated patients. (wikidoc.org)
Donor-specific antibodies bind with high affinity to the vascular endothelium of graft and activate complement . (wikidoc.org)
Cells15
CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. (wikipedia.org)
LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes. (jci.org)
Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
Hodgkin tumor cells extensively interact with rosetting CD4 + T cells by immunological synapse formation involving HLA class II and CD58. (ashpublications.org)
In conclusion, T-cell rosetting in HL is established by formation of the IS, and activation of rosetting T cells critically depends on the interaction of both TCR-HLA-II and CD2-CD58. (ashpublications.org)
DCs comprise a family of antigen presenting cells that act like 'conductors' of the immune response in their capacity to orchestrate signals derived from the different parts of the immune system [ 2 ]. (biomedcentral.com)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
An important step is the triggering of T cells to start an immune response, which takes place when a T cell contacts an antigen presenting cell. (lu.se)
(B) White light image showing the contour of two binding T cells (top image), and a fluorescence microscopy images showing accumulation of CD58 underneath the T cells (bright areas in the lower image). (lu.se)
Decreasing the dose of the virus increased IFNγ production by TP cells, suggesting that higher antigen loads led to the generation of TP cells with repressed effector functions. (acir.org)
In another group of Eppendorf pipes Caco-2 cells had been added with 50 μL of FITC-labeled anti-CD58 100 μL of peptide 6 at different concentrations was added and incubated for 30 min at 4 °C. Following the incubation the Birinapant (TL32711) cells had been Birinapant (TL32711) spun down at 720 × g at space temp for 10 min and resuspended in 4-5 mL of PBS. (bio-biz-navi.com)
The adverse control was Caco-2 cells without FITC-anti-CD58. (bio-biz-navi.com)
Caco-2 cells concurrently treated using the peptide at different concentrations and with FITC-labeled anti-CD58 had Birinapant (TL32711) been analyzed using movement cytometry. (bio-biz-navi.com)
Committed stem cells can mature to become antigen-processing cells, with some possessing phagocytic capabilities. (medscape.com)
Immunological2
00:14.1 Today, I'm going to talk to you about 00:16.1 the immunological synapse, 00:17.2 Part 1 - antigen recognition. (ibiology.org)
Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. (wikidoc.org)
A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. (wakehealth.edu)
Distinct1
The TCR complex and CD4 each bind to distinct regions of the antigen-presenting MHCII molecule - α1/β1 and β2, respectively. (wikidoc.org)
Bind1
MYC/MAX heterodimers bind to specific DNA elements, designated as E-boxes, located in the promoter regions of target genes mediating either activation or repression of transcription. (ashpublications.org)
Activation1
and this enhances antigen-specific T-cell activation. (bvsalud.org)
Interaction1
The extension of our findings to primary HL tissue by immunohistochemistry and proximity ligation assays showed interaction of CD2 with CD58 and of TCR-associated CD4 with HLA-II. (ashpublications.org)
Expression1
Hammarstrom S. The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. (wikidoc.org)
Higher1
this was found to be the direct result of higher viral loads, and thus higher antigen burden in the chronic infection model. (acir.org)
Conditions1
The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms. (wikipedia.org)
University1
This is the first paper to show an approach that identifies markers of relapse that are very specific, allowing clinicians to add additional therapy prior to relapse that will prevent it," said Michael Pulsipher, MD, lead author of the study and a professor of pediatrics and the division chief of Pediatric Hematology and Oncology at Intermountain Primary Children's Hospital and the Huntsman Cancer Institute of the University of Utah. (aacr.org)