ReductaseDehydrogenaseSynthaseNADPHEscherichiaProteinsCharacterizationHoloInterproscanSubstratesMethylAcceptorFatty acid biosyntCarnitineAminoOxidationIntermediateProstheticReactionDeficiencyGeneElongationNeonatalMeasurementCarbon chainReceptorsGenesHydrogenPeptidaseTissueSubstrateEssentialSignalResiduesNamesResistanceCommonProfilesCellStudiesPropertiesSupport for a specific
Reductase8
- Other names in common use include acyl-ACP dehydrogenase, reductase, enoyl-[acyl carrier protein] (reduced nicotinamide, adenine dinucleotide phosphate), NADPH 2-enoyl Co A reductase, enoyl acyl-carrier-protein reductase, enoyl-ACP reductase, and enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific). (wikipedia.org)
- Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
- This graph shows the total number of publications written about "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" by people in this website by year, and whether "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" was a major or minor topic of these publications. (umassmed.edu)
- Below are the most recent publications written about "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" by people in Profiles. (umassmed.edu)
- 3-Oxo-acyl-acyl carrier protein (ACP) reductase (FabG) plays a key role in the bacterial fatty acid synthesis II system in pathogenic microorganisms, which has been recognized as a potential drug target. (dundee.ac.uk)
- Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
- to get instant updates about '3-Oxoacyl-(Acyl-Carrier-Protein) Reductase' on your MyPage . (rediff.com)
- Other names in common use include beta-ketoacyl-(ACP) reductase , beta-ketoacyl acyl carrier protein (ACP) reductase , beta-ketoacyl reductase , beta-ketoacyl thioester reductase , beta-ketoacyl-ACP reductase , beta-ketoacyl-acyl carrier protein reductase , 3-ketoacyl acyl carrier protein reductase , NADPH-specific 3-oxoacyl-reductase , and 3-oxoacyl-reductase . (rediff.com)
Dehydrogenase9
- It has also been linked to an inherited enzyme deficiency called long chain acyl-CoA dehydrogenase (LCHAD) in the baby. (britishlivertrust.org.uk)
- Short-chain acyl-coenzyme A dehydrogenase deficiency. (harvard.edu)
- Coordinated and reversible reduction of enzymes involved in terminal oxidative metabolism in skeletal muscle mitochondria from a riboflavin-responsive, multiple acyl-CoA dehydrogenase deficiency patient. (harvard.edu)
- Anesthetic considerations for a patient with compound heterozygous medium-chain Acyl-CoA dehydrogenase deficiency. (harvard.edu)
- Neonatal screening for medium--chain acyl-CoA dehydrogenase deficiency. (harvard.edu)
- Compound heterozygosity in four asymptomatic siblings with medium-chain acyl-CoA dehydrogenase deficiency. (harvard.edu)
- Short-chain acyl-CoA dehydrogenase deficiency: a cause of ophthalmoplegia and multicore myopathy. (harvard.edu)
- OBJECTIVES: Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is an autosomal recessive disorder of the fatty acid oxidative metabolism. (bvsalud.org)
- Outcomes in pediatric studies of medium-chain acyl-coA dehydrogenase (MCAD) deficiency and phenylketonuria (PKU): a review. (cdc.gov)
Synthase2
- SCO0127 putative multi-domain beta keto-acyl synthase 112932:119654 forward MW:235996 0009. (kitasato-u.ac.jp)
- SCO0126 putative multi-domain beta keto-acyl synthase 106637:112885 forward MW:214716 0012. (kitasato-u.ac.jp)
NADPH1
- Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. (systemsbiology.net)
Escherichia2
- protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
- protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
Proteins6
- Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. (rsc.org)
- Selectivity for the holo over apo -form of acyl carrier proteins is demonstrated indicating that only the phosphopantetheine - thiol is modified. (rsc.org)
- Transport proteins that carry specific substances in the blood or across cell membranes. (reference.md)
- ASOB2 has been identified as apolipoprotein D (apoD), a known member of the lipocalin family of carrier proteins. (medscape.com)
- The yeast metal resistance proteins, which are 850-900 amino acyl residues in length, also exhibit two or three putative TMSs. (tcdb.org)
- The CorA proteins of E. coli and S. typhimurium are each 316 amino acyl residues in length. (tcdb.org)
Characterization1
- Advances in understanding the molecular and biochemical basis include cloning and characterization of most genes that encode specific enzymes required for sphingolipid metabolism. (medscape.com)
Holo2
- Catalyzes the formation of 2-(5''-triphosphoribosyl)-3'- dephosphocoenzyme-A, the precursor of the prosthetic group of the holo- acyl carrier protein (gamma chain) of citrate lyase, from ATP and dephospho-CoA. (string-db.org)
- Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein. (string-db.org)
Interproscan1
- PTS system sorbose-specific iic component [Interproscan]. (ntu.edu.sg)
Substrates1
- [ 1 , 2 ] Lipid substrates share a common structure, including a ceramide backbone (2- N -acyl-sphingosine), in which various sphingolipids are derived by substitution of hexoses, phosphorylcholine, or one or more sialic acid residues on terminal hydroxyl groups of the ceramide molecule. (medscape.com)
Methyl1
- Some of the functional groups transferred by coenzymes are hydride ions, hydrogen atoms, methyl groups, and acyl groups. (pediaa.com)
Acceptor2
- This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. (wikipedia.org)
- Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (genebiosystems.com)
Fatty acid biosynt2
- An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein] in the fatty acid biosynthesis pathway. (umassmed.edu)
- FabG catalyzes reduction of a 3-oxo-acyl-ACP intermediate during the elongation cycle of fatty acid biosynthesis. (dundee.ac.uk)
Carnitine3
- Acylcarnitines are formed in the mitochondria by esterification between carnitine and acyl-CoAs. (bvsalud.org)
- The diagram (top left corner) shows long chain fatty acids going through the plasma membrane converted to acyl CoA within the mitochondrion (between the mitochondrial double membranes) where it combines with carnitine (catalyzed by CPT I) to produce acylcarnitine, which can cross the inner mitochondrial membrane (IMM). (mcatquestionoftheday.com)
- Acylcarnitine's "job" seems over as it is converted back to carnitine and acyl CoA which, as fatty acids are known to do, undergoes beta-oxidation. (mcatquestionoftheday.com)
Amino4
- Furthermore, hDASPO interacts with the primate-specific protein pLG72 (a well-known negative chaperone of D-amino acid oxidase, the enzyme deputed to D-serine degradation in the human brain), yielding a ~114 kDa complex, with a micromolar dissociation constant, promoting the flavoenzyme inactivation. (bvsalud.org)
- Most members of the MIT family are between 300 and 400 amino acyl residues in length and possess two (or three) putative transmembrane α-helical spanners (TMSs). (tcdb.org)
- Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
- The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. (lookformedical.com)
Oxidation2
- Measurement of tissue acyl-CoAs using flow-injection tandem mass spectrometry: acyl-CoA profiles in short-chain fatty acid oxidation defects. (harvard.edu)
- Specific acylcarnitines accumulate as a result of various organic acidurias and fatty acid oxidation disorders, and, thus, acylcarnitines profiles are used for the diagnosis of these disorders. (bvsalud.org)
Intermediate1
- While facilitating the enzymatic action, coenzymes serve as intermediate carriers of electrons, specific atoms or functional groups between biochemical reactions. (pediaa.com)
Prosthetic1
- Small molecules capable of acylating this prosthetic group will provide a simple and reversible means of introducing novel functionality onto carrier protein domains. (rsc.org)
Reaction3
- The main function of an enzyme is to catalyze a specific biochemical reaction inside the cell at body temperature and pH. (pediaa.com)
- Their ability to catalyze a specific biochemical reaction is one of the characteristic features of an enzyme. (pediaa.com)
- An enzyme refers to a substance produced by living organisms to act as a biological catalyst to bring about a specific biochemical reaction while a coenzyme refers to a non-protein compound necessary for the functioning of an enzyme. (pediaa.com)
Deficiency1
- In each disorder, a deficiency of a lysosomal hydrolase is inherited, which leads to lysosomal accumulation of the enzyme's specific sphingolipid substrate. (medscape.com)
Gene2
- Samples were screened by using a quantitative real-time PCR that targeted a portion of the Bartonella 16S-23S intergenic spacer region ( 10 ) and a specific B. quintana gene, fabF3 , encoding 3-oxoacyl-(acyl-carrier-protein) ( 9 ). (cdc.gov)
- Often men and women do not know they are a carrier of this changed (mutated) gene, as their bodies are able to continue to metabolise fatty acids normally. (britishlivertrust.org.uk)
Elongation1
- Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids. (genebiosystems.com)
Neonatal1
- 1995 with screening for phenylke- specific neonatal screening form and Rad). (who.int)
Measurement1
- Research has led to development of diagnostic assays for identification of affected individuals, which usually rely on measurement of specific enzymatic activity in isolated leukocytes or cultured fibroblasts. (medscape.com)
Carbon chain1
- It has a preference for acyl derivatives with carbon chain length from 4 to 16. (umassmed.edu)
Receptors2
- here, discrete export signals on the cargo are recognized and captured by specific receptors that are concentrated at sites of vesicle budding. (biologists.com)
- Transport by partitioning is distinct from both bulk flow and receptor-mediated transport, because differently from bulk flow, cargo can be concentrated in transport carriers, yet the concentrating process does not depend on specific cargo receptors ( Fig. 1 and Box 1 ). (biologists.com)
Genes3
- CMS can be suppressed by specific nuclear genes called restorers of fertility ( Rf s). (frontiersin.org)
- CMS can be suppressed by specific nuclear genes called restorers of fertility ( Rf ), which restore partial to normal pollen production to plants carrying a corresponding CMS-inducing cytoplasm. (frontiersin.org)
- Member of the two-component regulatory system DpiA/DpiB, which is essential for expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. (string-db.org)
Hydrogen1
- Inhibitor binding relies primarily on hydrophobic interactions, but specific hydrogen bonds are also observed. (dundee.ac.uk)
Peptidase1
- Evidence suggests precolibactins are converted to genotoxic colibactins by colibactin peptidase (ClbP)-mediated cleavage of an N-acyl-d-Asn side chain, and all isolation efforts have employed ?clbP strains to facilitate accumulation of precolibactins. (omicsdi.org)
Tissue1
- In general, storage of any particular substrate in a specific tissue is dependent on the normal distribution of the compound in the body. (medscape.com)
Substrate1
- Cannot accept L- tyrosine as substrate and propionyl-CoA, succinyl-CoA or (S)- methylmalonyl-CoA as acyl donors. (string-db.org)
Essential3
- Making a specific diagnosis in an affected individual is essential in order to provide accurate genetic counseling. (medscape.com)
- Because glycosphingolipids are essential components of all cell membranes, inability to degrade these substances and their subsequent accumulation results in physiologic and morphologic alterations of specific tissues and organs that lead to characteristic clinical manifestations. (medscape.com)
- In our scientific activity at the Division of Physical Chemistry 1 we find it essential to establish long-term goals and policies that are based on an unbiased analysis of the specific situation, rather than an uncritical following of the current trends. (lu.se)
Signal1
- c-d) Tensor tomographic reconstruction of the myelin-specific signal results in a tensor representing the myelinated axon orientation distribution per voxel (d) and quantitative 3D myelin maps (c). (stanford.edu)
Residues1
- Site-specific mutagenesis studies of three conserved residues in TMS 3 suggest that they contribute to the Mg 2+ transport pathway. (tcdb.org)
Names1
- CusabioAlternative Name(s): N(4)- cytosine-specific methyltransferase BglIIGene Names: bglIIMResearch Areas: OthersOrganism: Bacillus subtilis (strain 168)AA. (joplink.net)
Resistance1
- Our study provides a molecular-level view of the first reported cyclopropane hydrolase and support for a specific mechanistic role of this enzyme in colibactin resistance. (omicsdi.org)
Common1
- The most common of these are E-3M2H and (RS)-3-hydroxy-3-methlyhexanoic acid (HMHA), which are released through the action of a specific zinc-dependent N -alpha-acyl-glutamine aminoacylase (N-AGA) from Corynebacterium species. (medscape.com)
Profiles2
- This graph shows the total number of publications written about "Acyl-CoA Dehydrogenases" by people in Harvard Catalyst Profiles by year, and whether "Acyl-CoA Dehydrogenases" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Acyl-CoA Dehydrogenases" by people in Profiles. (harvard.edu)
Cell1
- However, clinical trials evaluating administration of iNKT cell-specific agonist α-galactosylceramide (α-GalCer) have failed to achieve obvious tumor regression. (bvsalud.org)
Studies1
- These studies have resulted in identifying specific disease-causing mutations and have led to improved clinical and laboratory diagnosis, prenatal diagnosis, and carrier identification. (medscape.com)
Properties1
- Vegetable oils have their specific physicochemical properties due to which they are playing vital role in human nutritional diet for health benefits. (scielo.br)
Support for a specific1
- Find support for a specific problem in the support section of our website. (mdpi.com)