AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth CareGeographicals
Species SpecificityCoronavirusCoronavirus InfectionsCoronavirus 229E, HumanCoronaviridaeCoronavirus OC43, HumanCoronavirus, FelineCoronaviridae InfectionsCoronavirus, BovineMolecular Sequence DataSARS VirusMurine hepatitis virusSensitivity and SpecificityChiropteraCoronavirus NL63, HumanTransmissible gastroenteritis virusSpike Glycoprotein, CoronavirusAmino Acid SequenceSubstrate SpecificityBase SequenceCoronavirus, CanineInfectious bronchitis virusPhylogenyViverridaeFeline Infectious PeritonitisLactosylceramidesCell LineSevere Acute Respiratory SyndromeCoronavirus, RatGenome, ViralCross ReactionsSequence Homology, Amino AcidCatsNidoviralesCattleAntibody SpecificityVirus ReplicationCoronavirus, TurkeyHost SpecificitySequence AlignmentProtein BindingSequence Analysis, DNARNA, ViralNucleocapsid ProteinsViral ProteinsReceptors, SomatotropinBinding SitesModels, MolecularAntibodies, MonoclonalCricetinaeRespiratory Tract InfectionsEpitopesEnteritis, Transmissible, of TurkeysViral Envelope ProteinsRabbitsAntigens, CD13SwineCloning, MolecularAcetylesteraseProtein Structure, TertiaryHaplorhiniMutationCercopithecus aethiopsDogsPolymerase Chain ReactionEvolution, MolecularG(M3) GangliosideRecombinant ProteinsRNA ReplicaseOpen Reading FramesKineticsReceptors, VirusEnzyme-Linked Immunosorbent AssaySequence Homology, Nucleic AcidDNA PrimersViral Nonstructural ProteinsSialyltransferasesBird DiseasesEscherichia coliMembrane GlycoproteinsBacterial ProteinsTranscription, GeneticProtein ConformationArterivirusCells, CulturedRecombinant Fusion ProteinsGastroenteritis, Transmissible, of SwineStructure-Activity RelationshipGlycoproteinsFertilizationVirusesVirologyDNA, ComplementaryVirus DiseasesAntibodies, ViralSperm-Ovum InteractionsReceptors, InterferonMutagenesis, Site-DirectedElectrophoresis, Polyacrylamide GelDisease Reservoirs
InfectionPneumoniaDiseaseMERS-COV2019-nCoVInfluenzaVirusesAntiviralAntibodiesWuhanSevereACE2InfectProteinPangolinsPorcineSensitivityReplicationEntericGenomeFelineNucleocapsidELISAGastroenteritisSpikesPathogensReservoirsPositive-sense RNAHumanRecombinantVirusSARSSpikeEnvelopeTherapeuticCharacteristicsIntermediateTransmissionHostRole
Infection12
  • Feline enteric coronavirus is responsible for an infection of the mature gastrointestinal epithelial cells (see also enterocytes, brush border, microvilli, villi). (wikipedia.org)
  • The arteriviruses are highly species specific, but share many biological and molecular properties, including virion morphology, a unique set of structural proteins, genome organization and replication strategy, and the ability to establish prolonged or true persistent infection in their natural hosts. (bionity.com)
  • However, the epidemiology and pathogenesis of the infection caused by each virus is distinct, as are the diseases they cause. (bionity.com)
  • SARS rarely manifests as a subclinical infection, and at present, wild animal species are the only important natural reservoirs of the virus. (cdc.gov)
  • Previous research has shown that infection with coronaviruses activates an innate immune response upon sensing of viral RNA by interferon-induced with helicase C domain 1 (IFIH1), also known as MDA5. (frontiersin.org)
  • While the amyloid aggregation of peptide Aß has long been implicated in neurodegeneration in AD, primarily through the production of toxic polymorphic aggregates and reactive oxygen species, viral infection has a less explicit role in the etiology of the brain disease. (bvsalud.org)
  • Our study implicated SARS-CoV-2 viral infection as a potential contributor to AD pathogenesis, a little explored area in our quest for understanding and overcoming Long Covid. (bvsalud.org)
  • These findings provide evidence that Nsp5-dependent cleavage of TRMT1 and perturbation of tRNA modification patterns contribute to the cellular pathogenesis of SARS-CoV-2 infection. (elifesciences.org)
  • 2021) Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Infection on Pregnancy Outcomes: A Population-based Study. (vircell.com)
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection relies on its spike protein binding to angiotensin-converting enzyme 2 (ACE2) on host cells to initiate cellular entry. (bvsalud.org)
  • This specificity is critical for the virus to establish a systemic infection and cause COVID-19 disease. (bvsalud.org)
  • This research includes molecular surveillance of Taiwanese strains, mechanistic study of host-restriction of influenza virus infection, pathogenesis study and development of anti-flu agents. (cgu.edu.tw)
Pneumonia4
  • In early January, the aetiological agent of the pneumonia cases was found to be a coronavirus 3 , subsequently named SARS-CoV-2 by an International Committee on Taxonomy of Viruses (ICTV) Study Group 4 and also named hCoV-19 by Wu et al. (nature.com)
  • Since the end of 2019, a new type of coronavirus pneumonia (COVID-19) caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout the world. (medsci.org)
  • The precise pathogenesis from pneumonia to COVID-19 ARDS (CARDS) is unclear. (peertechzpublications.com)
  • All 3 species can cause pneumonia in humans. (medscape.com)
Disease21
  • It has two different forms: feline enteric coronavirus (FECV) that infects the intestines and feline infectious peritonitis virus (FIPV) that causes the disease feline infectious peritonitis (FIP). (wikipedia.org)
  • However, to date, BoPyV-1 has not been causally associated with pathology or disease in any animal species, including humans. (cdc.gov)
  • In depth knowledge of the molecular basis of the viral cycle is needed to control viral pathogenesis and disease spreading. (bionity.com)
  • Since severe acute respiratory syndrome (SARS) and the corona virus (SARS-CoV) that causes it have emerged and spread, considerable progress has been made in understanding the biology, pathogenesis, and epidemiologic features of both the virus and the disease. (cdc.gov)
  • Pangolins have been identified, besides bats, as a possible source of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of coronavirus disease 2019 (COVID-19) ( 10 - 14 ). (frontiersin.org)
  • Topics covered include virus epidemiology, disease pathogenesis, existing and prospective immunoprophylaxis against the viruses. (apoptosisblog.com)
  • Naturally Occurring Animal Coronaviruses as Models for Studying Highly Pathogenic Human Coronaviral Disease. (nih.gov)
  • In late 2019 SARS-CoV-2 emerged as a highly infectious coronavirus that causes respiratory disease in humans, termed COVID-19. (nature.com)
  • The best way to prevent and control the spread of coronaviruses is to be well informed about the disease and how the virus spreads. (stemcelldaily.com)
  • Coronavirus disease 2019 (COVID-19) emerged in late 2019 by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and posed a global public health emergency. (ajmb.org)
  • A collaborative resource to develop a host-pathogens mechanism based disease map for the pathogenesis of COVID-19. (isar-icar.com)
  • Coronavirus disease-2019 (COVID-19), caused by the respiratory virus severe acute respiratory syndrome coronavirus (SARS-CoV-2), has resulted in a global pandemic with over 16 million cases and 300,000 deaths in the U.S. alone. (medrxiv.org)
  • Since the outbreak of coronavirus disease 2019 (COVID-19) associated with the novel SARS-CoV-2, infections have spread worldwide. (aaqr.org)
  • The epidemic progression during the first wave of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its associated disease COVID-19 in northern Italy had its most dramatic impact in certain hotspots across the Po-Valley, stretching from north-western provinces such as Piedmont, Lombardy all the way to towards the north-east affecting even Emilia Romagna and Veneto. (aaqr.org)
  • Preclinical studies confirm the functional effects of M1295-mediated neutralization of human IL-13 in human cell based in vitro assays using mechanistically relevant endpoints associated with the pathogenesis of asthma, atopic dermatitis, and eosinophil-mediated disease (US8399630). (absoluteantibody.com)
  • It is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils. (qedbio.com)
  • E. E. Tyzzer at Harvard University provided the solid foundation upon which our present knowledge of coccidiosis, and the species of Eimeria involved in the disease, is based. (bioone.org)
  • It produces the aforementioned disease due to coronavirus 2019 (COVID-19), and has led to a declaration of a world public health emergency by the World Health Organisation. (analesdepediatria.org)
  • The mode of transmission is different among the 3 species ( C pneumoniae, C psittaci, C trachomatis), but all can cause systemic disease by hematogenous spread. (medscape.com)
  • The official name of the illness is COVID-19 (a shortening of COronaVIrus Disease-2019) 15 and it is caused by the "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2) 16,22,46 . (radiopaedia.org)
  • The coronavirus disease 2019 (COVID-19) pandemic escalated this fragmentation. (bvsalud.org)
MERS-COV1
2019-nCoV2
Influenza4
  • RNA was tested for influenza A, B, and D,4-6 coronavirus,7 and enterovirus8 using Superscript III One-step RT-PCR with Platinum Taq Polymerase. (datexis.com)
  • She then integrated the Viroscience Department for her post-doctoral studies, which have focused on the pathogenesis, virulence and transmissibility of influenza A viruses, with special emphasis on genetic and phenotypic viral factors involved in the emergence of new pandemics. (erasmusmc.nl)
  • The research of her team focusses on the understanding of highly pathogenic avian influenza viruses (HPAIV) emergence, their pathogenesis and the development of new vaccination strategies to cope with antigenic diversity in the context of pandemic preparedness. (erasmusmc.nl)
  • Porcine innate and adaptative immune responses to influenza and coronavirus infections. (nih.gov)
Viruses7
  • Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? (mdpi.com)
  • There are outstanding evolutionary questions on the recent emergence of human coronavirus SARS-CoV-2 including the role of reservoir species, the role of recombination and its time of divergence from animal viruses. (nature.com)
  • SARS-CoV-2 itself is not a recombinant of any sarbecoviruses detected to date, and its receptor-binding motif, important for specificity to human ACE2 receptors, appears to be an ancestral trait shared with bat viruses and not one acquired recently via recombination. (nature.com)
  • Across a large region of the virus genome, corresponding approximately to ORF1b, it did not cluster with any of the known bat coronaviruses indicating that recombination probably played a role in the evolutionary history of these viruses 5 , 7 . (nature.com)
  • Like all plus-strand RNA viruses, the SARS-CoV-2 replication process within cells requires de novo production of viral RNA species, including single-strand (ss)RNA and double-strand (ds)RNA that can be sensed by cytosolic pattern recognition receptors (PRRs) subsequently activating antiviral pathways 7 . (nature.com)
  • The RNase T2 family consists of evolutionarily conserved endonucleases that express in many different species, including animals, plants, protozoans, bacteria, and viruses. (frontiersin.org)
  • Coronaviruses are a group of related RNA viruses that cause diseases in mammals and birds. (stemcelldaily.com)
Antiviral1
Antibodies3
  • S glycoprotein, also konwn as spike protein, densely decorates the viral surface and is a key player in pathogenesis, it is the main target of neutralizing antibodies and the focus of intense interest for vaccine design. (creative-biolabs.com)
  • In conclusion, the CRNT for COVID-19 is a convenient assay system that can be performed in a BSL-2 laboratory with high specificity and sensitivity for evaluating the occurrence of neutralizing antibodies against SARS-CoV-2. (biomedcentral.com)
  • Specificity These antibodies specifically recognize human serum alpha-1-antichymotrypsin. (qedbio.com)
Wuhan2
Severe2
  • A total of 1,068 asymptomatic close contacts of patients with severe acute respiratory (SARS) from the 2003 epidemic in Hong Kong were serologically tested, and 2 (0.19%) were positive for SARS coronavirus immunoglobulin G antibody. (cdc.gov)
  • The transmission of pathogens from other vertebrate animals to humans is of particular concern because the resulting diseases, known as zoonoses, have caused major epidemics in the past and continue to pose enormous threats to the human population, as exemplified by the recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak ( 1 , 2 ). (frontiersin.org)
ACE22
  • The receptor of SARS-CoV-2, i.e., angiotensin I converting enzyme 2 (ACE2) is conserved in pangolins ( 18 ) and coronaviruses isolated from pangolins have a receptor binding domain in their spike protein that is uniquely similar to that of SARS-CoV-2 ( 10 , 19 ). (frontiersin.org)
  • The spike protein (S) of SARS-CoV-2 is able to bind to the human angiotensin-converting enzyme 2 (ACE2) receptor with a much higher affinity compared to other coronaviruses. (bvsalud.org)
Infect3
  • Each genus includes different species of coronaviruses that infect different hosts. (stemcelldaily.com)
  • 6 Compared with known coronaviruses that can infect humans, the SARS-CoV-2 structure has certain differences, so it is defined as the seventh coronavirus. (medsci.org)
  • This genomic diversity enables coronaviruses to evolve and periodically infect the respiratory tract of human hosts. (peertechzpublications.com)
Protein5
  • FCoV type II is a recombinant virus type I with spike genes (S protein) replacement from FCoV by the canine coronavirus (CCoV) spikes. (wikipedia.org)
  • CoV N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. (bionity.com)
  • Therapeutic peptides are a major class of pharmaceutical drugs owing to their target-binding specificity as well as their versatility in inhibiting aberrant protein-protein interactions associated with human pathologies. (bvsalud.org)
  • Here we first identified the amyloidogenic potential of 1058HGVVFLHVTYV1068, a short fragment of the spike protein of SARS-CoV-2 coronavirus. (bvsalud.org)
  • FK506-Binding Protein like (FKBPL) Has an Important Role in Heart Failure with Preserved Ejection Fraction Pathogenesis with Potential Diagnostic Utility. (lenus.ie)
Pangolins3
  • Pangolins were recently identified as carriers and intermediate hosts of coronaviruses. (frontiersin.org)
  • Here, we performed a comparative genomics study of RNA sensor genes in three species of pangolins. (frontiersin.org)
  • Eight species of pangolins form the mammalian order Pholidota which is most closely related to Carnivora (cat-like and dog-like carnivorans). (frontiersin.org)
Porcine2
Sensitivity1
  • The specificity of these assays is fairly high, but problems are present such as relatively low sensitivity except for ELISA and a high rate of false positives. (biomedcentral.com)
Replication2
  • Coronavirus (CoV) genome replication takes place in the cytoplasm in a membrane-protected microenvironment, and starts with the translation of the genome to produce the viral replicase. (bionity.com)
  • Nsp3 and Nsp5 are essential for viral replication and represent well-characterized drug targets among coronaviruses. (elifesciences.org)
Enteric1
Genome1
Feline4
Nucleocapsid1
ELISA1
  • 2018) Valoración de un nuevo ensayo quimioluminiscente en comparación con ELISA en la detección de IgG contra el virus de la hepatitis E. Revista de la Sociedad Andaluza de Microbiología y Parasitología Clínica. (vircell.com)
Gastroenteritis1
Spikes2
  • Coronaviruses are named for the spikes that protrude from their surfaces, resembling a crown or the sun`s corona. (stemcelldaily.com)
  • 9 Coronavirus is characterized by spikes sticking out from the surface, which in part have the same characteristics as SARS-CoV, and other four Human coronaviruses HCoV-NL63 (human coronavirus NL63), HCoV-229E (human coronavirus 229E), HCoV-OC43 (human coronavirus OC43), and HCoV-HKU1 (human coronavirus HKU1), which only cause mild respiratory diseases. (medsci.org)
Pathogens1
  • In a broader sense, viral and bacterial pathogens are among the strongest drivers of evolutionary change and the genomes of vertebrate species have been shaped, to a large extent, by adaptations to pathogens. (frontiersin.org)
Reservoirs1
  • Species that tolerate infections can carry a high burden of infectious agents, and therefore may be important reservoirs for transmissions to other species. (frontiersin.org)
Positive-sense RNA1
  • The SARS-CoV-2 is a β -coronavirus, which is an enveloped non-segmented positive-sense RNA virus 2. (apiculture-wallonie.be)
Human2
  • Altogether, these lesions resemble the 'cytopathic-inflammatory pathology pattern' proposed in the pathogenesis of Human polyomavirus-1-associated nephropathy in immunocompromised people and kidney allograft recipients. (cdc.gov)
  • Ghoran SH, El-Shazly M, Sekeroglu N, Kijjoa A (2021) Natural products from medicinal plants with anti-human coronavirus activities. (vegetosindia.org)
Recombinant3
  • The study of MCF pathogenesis has been impeded by an inability to produce recombinant virus, mainly due to the fact that AlHV-1 becomes attenuated during passage in culture. (microbiologyresearch.org)
  • The availability of the AlHV-1 BAC is an important advance for the study of MCF that will allow the identification of viral genes involved in MCF pathogenesis, as well as the production of attenuated recombinant candidate vaccines. (microbiologyresearch.org)
  • Manufactured using AbAb's Recombinant Platform with variable regions (i.e. specificity) from the synthetic construct M1295. (absoluteantibody.com)
Virus3
  • Nsp15 is conserved across coronavirus family members [6], to the point where it has been proposed as a universal genetic marker to distinguish nidoviruses [7] from all other RNA virus families. (insidecorona.net)
  • This new SARS-CoV-2 virus could share characteristics and an immune response similar to those described for other coronavirus. (analesdepediatria.org)
  • Este nuevo virus SARS-CoV-2 podría compartir características y respuesta inmune a las descritas para otros coronavirus. (analesdepediatria.org)
SARS2
  • A cross-coronavirus investigation from the same group has extended this observation by finding that TRMT1 interacts with a catalytic-inactive version of Nsp5 encoded by SARS-CoV-1, which is 98.7% similar to SARS-CoV-2 ( Gordon et al , 2020a ). (elifesciences.org)
  • A narrative review was made of the current evidence about immunity against coronavirus and its applicability to SARS-CoV-2. (analesdepediatria.org)
Spike1
  • They are enveloped by a lipid bilayer derived from the host cell membrane, and have spike (S) glycoproteins protruding from the surface, giving them a crown-like appearance (hence the name coronavirus). (stemcelldaily.com)
Envelope1
  • The 3D structure of the coronavirus, obtained by cryo-electron tomography, reveals that it is spherical and has an envelope. (medsci.org)
Therapeutic1
Characteristics1
  • Despite these efforts, however, a fundamental understanding of the chemistry, characteristics and function of peptido-nanocomposites is lacking, and a systematic analysis of such strategy for combating a range of amyloid pathogeneses is missing. (bvsalud.org)
Intermediate1
  • Risk Assessment of the Possible Intermediate Host Role of Pigs for Coronaviruses with a Deep Learning Predictor. (nih.gov)
Transmission1
  • Alcelaphine herpesvirus 1 (AlHV-1), carried asymptomatically by wildebeest, causes malignant catarrhal fever (MCF) following cross-species transmission to a variety of susceptible species of the order Artiodactyla. (microbiologyresearch.org)
Host1
  • Her team is developing innovative culture methods for avian primary epithelial and endothelial cells to study the understanding of the host species-specificity of HPAIVs genesis. (erasmusmc.nl)
Role3
  • Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)
  • could play a key role in the pathogenesis of respiratory tract infections. (bvsalud.org)
  • Thus, in this study, we investigated-for the first time-FKBPL's role in the pathogenesis and as a biomarker of HFpEF. (lenus.ie)