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  • regulatory
  • The mechanochemical activity of p97 is linked to substrate proteins by an array of 13 UBX (ubiquitin regulatory X) domain adapters that bind the N-terminal domain of p97 ( 17 ), as well as the non-UBX domain adaptors Ufd1 and Npl4 ( 18 ). (pnas.org)
  • inhibits
  • DBeQ also potently inhibits cancer cell growth and is more rapid than a proteasome inhibitor at mobilizing the executioner caspases-3 and -7. (pnas.org)
  • They went on to show that TPh A inhibits interaction between pirin and its binding partner, Bcl3, and that it also inhibits the migration of melanoma cells by reducing expression of the tumor mobility protein SNAI2. (riken.jp)
  • Adenylate
  • The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. (abcam.com)
  • cellular
  • Since protein synthesis occurs in the cytosol, translocation of proteins across biological membranes is essential for cellular function. (springer.com)
  • The broad range of cellular functions for p97 is thought to derive from its ability to unfold proteins or disassemble protein complexes, but the detailed mechanism of how p97 works and is linked to specific cellular processes remains largely unknown. (pnas.org)
  • SUMO, a small ubiquitin-like modifier protein, is conjugated to a large number of cellular target proteins. (atlasgeneticsoncology.org)
  • Characterizing the functions of proteins in the cell, whose role in mediating complex metabolic and signaling networks is central to cellular biochemistry, is essential for developing new medicines and treatments. (riken.jp)
  • Small-molecule inhibitors have proven an effective tool for doing this, binding to target proteins and disrupting their normal function in order to reveal their network of cellular interactions. (riken.jp)
  • reactive
  • Although the mechanisms underlying cardiac remodeling are multifactorial, a significant body of evidence points to the crucial roles of increased reactive oxygen species. (springer.com)
  • This article reviews recent advances in delineating the different sources of production for reactive oxygen species (namely mitochondria, xanthine oxidase, uncoupled nitric oxide synthases, and NADPH oxidases) that may be involved in cardiac remodeling and the aspects of the remodeling process that they affect. (springer.com)
  • The intranasal exposure of acrolein induced the expression of GADD34, developing the pulmonary damage with inflammation and increase of reactive oxygen species (ROS). (hindawi.com)
  • showed that acrolein produced reactive oxygen species (ROS) in mast cells [ 7 ]. (hindawi.com)
  • Beyond that, acrolein can cause oxidative stress and generate reactive oxygen species (ROS) [ 8 ]. (hindawi.com)
  • The carbine species are so reactive that they react with every type of small molecule. (riken.jp)
  • interact
  • Whereas all UBX proteins interact with p97, only those containing a ubiquitin-associated domain associate with ubiquitin conjugates ( 19 ). (pnas.org)
  • PIAS3 do, however, not only operate as SUMO-E3, since its coregulator effects are often independent of its RING-finger like domain but dependent on its capability to interact with sumoylated proteins via its conserved SIM (SUMO-interacting motif) or SAP (scaffold attachment factor-A/B/acinus/PIAS) domain (figure 2). (atlasgeneticsoncology.org)
  • The immobilized small molecules retain their ability to interact with their binding proteins. (riken.jp)
  • Broad
  • Broad inhibition of translocation is also an interesting target for the development of new anticancer drugs because cancer cells heavily depend on efficient protein translocation into the endoplasmic reticulum to support their fast growth. (springer.com)
  • kinase
  • Protein kinase inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF 3 -fenylamino)-1Н-pyrrol-2,5-dione (MI-1) (Figure 1 ) has been synthesized at Chemistry Department of Taras Shevchenko National University of Kyiv. (hindawi.com)
  • localization
  • Sumoylation is a dynamic process with highly diverse outcomes, ranging from changes in subcellular localization, signal transduction, transcriptional regulation to altered activity and stability of the modified protein. (atlasgeneticsoncology.org)
  • Phosphorylation
  • Acrolein-induced phosphorylation of eIF2 α in GADD34-knockout epithelial cells by shRNA protected cell death by reducing misfolded protein-caused oxidative stress. (hindawi.com)
  • cells
  • Growth arrest and DNA damage-inducible protein (GADD34/Ppp1r15a) was originally isolated from UV-inducible transcripts in Chinese hamster ovary (CHO) cells [ 15 ]. (hindawi.com)
  • residues
  • Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. (uniprot.org)
  • Domain
  • Ankyrin-repeat domain protein]-L-histidine + 2-oxoglutarate + O 2 = [ankyrin-repeat domain protein]-(3S)-3-hydroxy-L-histidine + succinate + CO 2 . (uniprot.org)