GlycosphingolipidsSialic AcidsAnti gangliosideComplex gangliosideAntibodiesAntibodyCeramidePathwaysCampylobacterCerebrosidesMembraneProteinsLocalizationReactive oxygenSpecificityLipidNeuronsJejuniCalciumZoonoticHost SpeciesHumanGenusNaturallyCentral nervouSpecificBrainAmountsHumansMajorELISAMembranesMouseCellLeadEffectsCancerTargetChemical
Glycosphingolipids4
- Gangliosides are glycosphingolipids with one or more sialic acids. (uiowa.edu)
- Gangliosides 1 are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. (matreya.com)
- Gangliosides, sialic acid-containing glycosphingolipids exist in mammalian cell membranes particularly neuronal membranes. (biomedcentral.com)
- It is phosphorylated by ceramide kinase (CK) to form ceramide-1-phosphate or it can be glycosylated by glucosylceramide synthase to form glycosphingolipids (cerebrosides, globosides, gangliosides). (frontiersin.org)
Sialic Acids1
- Based on the ganglio GSL series, gangliosides are synthesized, where sialic acids are linked to the glycan structure to produce negatively charged GSLs. (springer.com)
Anti ganglioside2
- Description: A competitive ELISA for quantitative measurement of Mouse Anti Ganglioside M2 Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (gentaur-online.com)
- Description: A competitive ELISA for quantitative measurement of Human anti ganglioside (GM1)antibody(IgM) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (gentaurprices.com)
Complex ganglioside1
- Cell surface staining and confocal microscopy identified GM1 as the main complex ganglioside co-localizing with Neuroplastin in cultured hippocampal neurons. (irb.hr)
Antibodies3
- Immunoglobulin G-class mouse monoclonal antibodies to major brain gangliosides. (uiowa.edu)
- If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications. (thermofisher.com)
- GBS) because of cross-reaction between C. jejuni antibodies and human gangliosides. (msdmanuals.com)
Antibody1
- The optimal Ig concentration for an application varies by species and antibody affinity. (uiowa.edu)
Ceramide1
- TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells. (univ-tours.fr)
Pathways4
- These GEMs represent the most comprehensive coverage of the metabolic network by considering both orthology-based pathways and species-specific reactions. (scilifelab.se)
- Specifically, through integrative analysis of Mouse1 with RNA-sequencing data from brain tissues of transgenic mice we identified a coordinated up-regulation of lysosomal GM2 gangliosideM2and peptide degradation pathways which appears to be a signature metabolic alteration in Alzheimer's disease (AD) mouse models with a phenotype of amyloid precursor protein overexpression. (scilifelab.se)
- The interactions of gangliosides with these autophagic signalling pathways usually are not understood. (vegfinhibitors.com)
- Even more examination with the signalling pathways indicated that this ganglioside induced autophagic cell death of astrocytes was subject to either damaging or beneficial regulation with the Akt mTOR pathway or the ERK1 2 pathway respectively. (vegfinhibitors.com)
Campylobacter12
- the Campylobacter species that cause human acute intestinal disease such as Campylobacter jejuni and Campylobacter coli originate from animals. (frontiersin.org)
- Over the past decade, studies on human hosted Campylobacter species strongly suggest that Campylobacter concisus plays a role in the development of inflammatory bowel disease (IBD). (frontiersin.org)
- In addition to C. concisus , humans are also colonized by a number of other Campylobacter species, most of which are in the oral cavity. (frontiersin.org)
- Here we review the most recent advancements on C. concisus and other human hosted Campylobacter species including their clinical relevance, transmission, virulence factors, disease associated genes, interactions with the human immune system and pathogenic mechanisms. (frontiersin.org)
- Some of these animal hosted Campylobacter species, such as Campylobacter jejuni and Campylobacter coli , can cause acute bacterial gastroenteritis in humans through consumption of contaminated food or water ( Galanis, 2007 ). (frontiersin.org)
- Several Campylobacter species utilize humans as their natural host and accumulated evidence supports their role in chronic inflammatory diseases of the human intestinal tract. (frontiersin.org)
- Most of the studies on the human hosted Campylobacter species in the past decade were on Campylobacter concisus , this bacterium is therefore the focus of this review. (frontiersin.org)
- In addition, other human hosted Campylobacter species were also reviewed. (frontiersin.org)
- To date, 40 Campylobacter species and subspecies have been isolated from a wide variety of animal or human sources (Figure 1 ). (frontiersin.org)
- Campylobacter species are motile, curved, microaerophilic, gram-negative bacilli that normally inhabit the gastrointestinal tract of many domestic animals and fowl. (msdmanuals.com)
- C. fetus and several other Campylobacter species (eg, C. coli and C. lari ) typically cause bacteremia and systemic manifestations in adults, more often when underlying predisposing diseases, such as diabetes, cirrhosis, cancer, or HIV/AIDS, are present. (msdmanuals.com)
- Hypochlorhydria and achlorhydria are predisposing factors because Campylobacter species are sensitive to gastric acid. (msdmanuals.com)
Cerebrosides1
- An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. (lookformedical.com)
Membrane2
- Membrane redistribution of gangliosides and glycosylphosphatidylinositol-anchored proteins in brain tissue sections under conditions of lipid raft isolation. (uiowa.edu)
- Our benefits suggest that gangliosides within the extracellular milieu of the CNS could lead to a pathological degeneration of astrocytes by way of molecular mechanisms that involve ROS and lipid rafts while in the plasma membrane. (vegfinhibitors.com)
Proteins1
- Effects of detergents on the redistribution of gangliosides and GPI-anchored proteins in brain tissue sections. (uiowa.edu)
Localization2
- Localization of major gangliosides in the PNS: implications for immune neuropathies. (uiowa.edu)
- Immunohistochemical localization of minor gangliosides in the rat central nervous system. (glycoepitope.jp)
Reactive oxygen2
- OH radicals and protects against brain mtDNA damage, seizures, and lipid peroxidation induced by reactive oxygen species producers. (matreya.com)
- Under oxidative tension, reactive oxygen species like totally free radicals and H2O2 are generated at high levels, inducing cellular harm and death. (vegfinhibitors.com)
Specificity1
- One crucial determinant of host tropism is hemagglutinin (HA) receptor specificity, in particular, preference of specific species of sialic acid on host cells. (springer.com)
Lipid3
- GM1 gangliosides are found in lipid rafts on the cell surface. (wikipedia.org)
- Our data provide insight into how a pathogenic virus alters lipid flux in infected hepatocytes and demonstrate a distinction between lipid species required for viral RNA synthesis versus nonlytic quasi-enveloped virus release. (bvsalud.org)
- Finally, lipid rafts have been involved with the signalling foremost to ganglioside induced astrocyte death. (vegfinhibitors.com)
Neurons2
- Therefore, we conclude that altered composition or disorganization of ganglioside-containing rafts results in changed regulation of calcium signals in neurons. (irb.hr)
- The antigen designated as Chol-1 beta, detected by an antiserum specific for cholinergic neurons, has been purified to homogeneity from ganglioside mixtures extracted from Torpedo electric organ and pig brain. (mpg.de)
Jejuni1
- They survive as commensal bacteria in their hosts, and some species, such as C. jejuni and C. coli , can cause human diseases. (frontiersin.org)
Calcium1
- Here, we tested the hypothesis that PMCA-Neuroplastin complexes exist in specific ganglioside-containing rafts, which could affect calcium homeostasis. (irb.hr)
Zoonotic1
- Further understanding and determining host tropism would be important in identifying zoonotic influenza virus strains capable of crossing species barrier and infecting humans. (springer.com)
Host Species2
- With the huge influenza A virus reservoir in wild birds, it is a cause for concern when a new influenza strain emerges with the ability to cross host species barrier, as shown in light of the recent H7N9 outbreak in China. (springer.com)
- Most influenza A viruses are restricted to their host species, having limited capability to cross species barrier and infect a new host. (springer.com)
Human1
- Several species are human pathogens. (msdmanuals.com)
Genus2
- A few species of swiflets (genus Aerodramus) build edible nests that are consumed by humans worldwide, as a delicacy known as the "Caviar of the East" or as a medicinal food. (researchgate.net)
- The genus of scutellaria includes approximately 300 species. (webmedcentral.com)
Naturally1
- A large number of influenza A viruses naturally reside in avian species where they constantly circulate and evolve. (springer.com)
Central nervou2
- Differential distribution of major brain gangliosides in the adult mouse central nervous system. (uiowa.edu)
- These findings support the possibility that under pathological conditions, gangliosides serve as cytotoxic factors in the central nervous system (CNS). (biomedcentral.com)
Specific1
- However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition. (lookformedical.com)
Brain1
- The trisialoganglioside (GT1b) is one of the major brain gangliosides and acts as an endogenous regulator in the brain. (biomedcentral.com)
Amounts1
- Sulfoglucuronosyl paragloboside (SGPG) was the prominent species with lesser amounts of sulfoglucuronosyl lactosaminyl paragloboside (SGLPG) in these tumor cell lines as assessed by quantitative HPTLC immunostaining. (karger.com)
Humans1
- Yet when some avian strains do acquire the ability to overcome species barrier, they might become adapted to humans, replicating efficiently and causing diseases, leading to potential pandemic. (springer.com)
Major1
- In this context, major effort has been put in developing synthetic strategies towards gangliosides and the interested reader is referred to an excellent review of Hunter et al. (springer.com)
ELISA1
- This is a high quality ELISA kit developped for optimal performance with samples from the particular species. (gentaur-online.com)
Membranes2
- With these molecules in hand, it became possible to investigate the phase behaviour of liquid ordered/liquid disordered supported membranes doped with the Gb 3 species by means of fluorescence and atomic force microscopy. (springer.com)
- cherry concentrations in species are compromised that exaggerated of these PCP membranes are bound. (erik-mill.de)
Mouse1
- The content and composition of all ganglioside species were unchanged in Neuroplastin-deficient mouse brains. (irb.hr)
Cell2
- Among the gangliosides surveyed, GD3 and 9-O-acetylated GD3 (OAc-GD3) were expressed in all tumor cell lines. (karger.com)
- During the present research, we demonstrated that treatment method with gangliosides induced ROS mediated autophagic cell death in astrocytes. (vegfinhibitors.com)
Lead1
- An autoimmune response against gangliosides can lead to Guillain-Barre syndrome. (matreya.com)
Effects1
- These changes could be a consequence of direct effects on ganglioside biosynthesis through the b-series (GM3-GD3-GD2-GD1b-GT1b) and may be linked to astrogliosis. (researcher-app.com)
Cancer1
- 4 Ehrlich tumor expresses the ganglioside GT 1b , and anti-GT1b has great therapeutic potential against this cancer. (matreya.com)
Target1
- Cholera toxin acts by the following mechanism: First, the B subunit ring of the cholera toxin binds to GM1 gangliosides on the surface of target cells. (wikipedia.org)
Chemical1
- they were thus considered to be identical and to constitute a single, pure chemical species. (mpg.de)