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  • tissues
  • In the adult Xenopus, XI characterizes the ganglioside pattern of the central nervous system while is absent in all the other tested tissues. (biomedsearch.com)
  • The N-glycolyl GM3 ganglioside (NeuGcGM3) expression in cutaneous melanoma and breast ductal carcinoma using 14F7 Mab, as well as its limited presence in normal adult human tissues was previously reported by our group [ 10 ]. (hindawi.com)
  • Here, we employed matrix-assisted laser desorption/ionization-MS imaging (MALDI-MSI) approaches to visualize lipid species directly in seed tissues of upland cotton ( Gossypium hirsutum ). (plantcell.org)
  • We conclude that comprehensive lipidomics images generated by MALDI-MSI report accurate, relative amounts of lipid species in plant tissues and reveal previously unseen differences in spatial distributions providing for a new level of understanding in cellular biochemistry. (plantcell.org)
  • Gangliosides are a group of sialylglycosphingolipids, widely distributed in body tissues, mainly as components of plasma membranes. (biomedcentral.com)
  • Gangliosides are a group of sialic acid glycosphingolipids, which are complex bio-active lipids, widely distributed in body tissues mainly as components of plasma membranes. (biomedcentral.com)
  • neuronal
  • The immunohistochemical staining of human and rat brains with specific monoclonal antibodies to the gangliosides showed that they are expressed in region-or neuronal cell type-specific manner. (nii.ac.jp)
  • The implications of these findings in vivo and in vitro are discussed in the search for a general physicochemical model of ganglioside function in neuronal membranes. (go.jp)
  • targets
  • Remarkably, the vast majority of these strategies have focused on protein antigens and recently mAbs recognizing cell surface gangliosides have recently proven to be effective for cancer therapeutic targets [ 1 ]. (hindawi.com)
  • Biol
  • Publications] 横山三紀: 'Identification of gangliosides as inhibitors of ADP-ribosyltrans ferases of pertussis foxin and exoenzyme C_3' J.Biol.Chem.270. (nii.ac.jp)
  • Publications] Furuya, S: 'Ganglioside GD1a in cerebellar Purkinje cells' J.Biol.Chem.269. (nii.ac.jp)
  • Melanoma
  • The evaluation of 14F7 Mab (anti-N-glycolyl GM3 ganglioside) immunorecognition in normal skin, cutaneous malignant melanoma (CMM), and in lymph node metastases (LNM) has been previously reported. (hindawi.com)
  • moiety
  • Acquotti D, Sonnino S, Masserini M, Casella L, Fronza G, Tettamanti G (1986) A new chemical procedure for the preparation of gangliosides carrying fluorescent or paramagnetic probes on the lipid moiety. (springer.com)
  • neuron
  • Publications] 入江史敏: 'Distribution of cholinergic neuron,specific gangliosides (GT1aα and GQ1bα) in the rat central nervous system' Brain Res.665. (nii.ac.jp)
  • differences
  • Almost 200 gangliosides species have been described, showing differences in the number, the order, and the linkage of the glycosyl and sialyl residues [ 4 ]. (hindawi.com)
  • In this aspect, the main goal of the current paper was to be investigated the differences in GM3 ganglioside levels in lysates of in vitro -incubated normal and malignant cells. (imedpub.com)
  • behavior
  • Further evidence for involvement of gangliosides in nervous system function is indicated by the behavior of the neurotoxin of Clostridium tetani . (springer.com)
  • accumulation
  • Furthermore, it has long been recognized that certain lipidoses that affect the nervous system, such as Tay Sachs disease, are characterized by ganglioside accumulation within cells of the brain. (springer.com)
  • preparative
  • Gazzotti G, Sonnino S, Ghidoni R, Kirschner G, Tettamanti G (1984a) Analytical and preparative high-performance liquid chromatography of gangliosides. (springer.com)
  • Pathway
  • Remarkably, the diversity of gangliosides is generated by only a few glycosyltransferases and sialyltransferases that act within a combinatorial biosynthetic pathway [ 9 ]. (hindawi.com)
  • The discovery of these ganglioside species provides essential links for a new possible biosynthetic pathway leading to the major tetrasialoganglioside, G Q1c , of the fish brain. (springer.com)
  • therapeutic
  • Our results show that GM3 ganglioside is a negative regulator of insulin signaling, making it a potential therapeutic target in type 2 diabetes. (pnas.org)
  • analyses
  • Further analyses by comparative 2D-TLC with adult fish and chick embryo brains indicate the pentasialilated ganglioside GP1c as the possible structure of XI. (biomedsearch.com)
  • Specific
  • Ghidoni R, Sonnino S, Masserini M, Orlando P, Tettamanti G (1981) Specific tritium labeling of gangliosides at the 3-position of sphingosines. (springer.com)
  • The current study was directed to determine the values of both GM3 ganglioside and specific anti-GM3 antibodies in in vitro -incubated normal cells, malignant cell and mixed cultures of co-cultivated cells from both types as well. (imedpub.com)
  • The levels of ganglioside GM3 and of specific antibodies to it were assessed by enzyme-linked immuno-sorbent assay (ELISA) technique. (imedpub.com)
  • diseases
  • Ghidoni R, Tettamanti G, Zambotti V (1977) Labelling of natural substrates for the radiochemical assay of enzymes involved in the lipid storage diseases: a general procedure for tritiation of gangliosides. (springer.com)
  • cells
  • Furthermore, GM3 ganglioside depressed insulin-mediated signaling in cultured cells ( 6 , 8 ). (pnas.org)
  • Beyond the undesirable effects of gangliosides in cancer cells, a substantial number of cancer immunotherapies have been developed in recent years that have used gangliosides as the main target. (frontiersin.org)
  • 24 The B subunit (CTB) is multifunctional, binding simultaneously to both the galactose and sialic acid moieties of the ganglioside, GM1, expressed on the surface of intestinal cells. (rsc.org)
  • According to other references a protective function of the increased values of this ganglioside in malignant cells has been proposed. (imedpub.com)