Spatial eukaryotic cells replication through transcriptional. Medical search. Frequent questions

The necessity to regulate origin location likely arises from the need to coordinate DNA replication with other processes that act on the shared chromatin template to avoid DNA strand breaks and DNA damage. (wikipedia.org)
The maintenance phase often involves a plethora of non-DNA sequence specific chromatin cofactors that set up and maintain chromatin states through cell division and for extended periods of time-sometimes in the absence of the initial transcription factors 3 . (nature.com)
Our results provide an evolutionary perspective on H3.3's conserved role in maintaining the transcriptional landscape of cells and on the emergence of specialized chromatin assembly pathways. (biomedcentral.com)
In most eukaryotes, two classes of histones have been described: (1) replicative or canonical histones, expressed only during the S phase of the cell cycle, which are assembled onto chromatin in a DNA replication-dependent (RD) manner, and (2) variant histones, which differ in their primary amino acid sequences, are expressed throughout the cell cycle, and can be deposited in a replication-independent (RI) fashion [ 2 ]. (biomedcentral.com)
Histone modifications in which the structure of chromatin and its transcriptional state is regulated. (cloudfront.net)
DNA is wrapped into a DNA-protein complex called chromatin in the nucleus of eukaryotic cells. (cloudfront.net)
Eukaryotic genomes are usually packed into nucleosomes, which comprise of 147 bp DNA wrapping around a histone octamer, forming the structural units of chromatin. (biomedcentral.com)
In this study, we investigated how higher-order chromatin structure modulates differential expression of the human INK4b-ARF-INK4a locus during progenitor cell differentiation, cellular ageing and senescence of cancer cells. (biomedcentral.com)
Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. (biomedcentral.com)
Whilst much is known on the signaling components mediating diurnal, light, and temperature controls on plant development, their influence on chromatin-based transcriptional controls remains poorly explored. (biomedcentral.com)
In this study we show that a SWI/SNF chromatin remodeler subunit, BAF60, represses seedling growth by modulating DNA accessibility of hypocotyl cell size regulatory genes. (biomedcentral.com)
Chromatin organization is dynamically altered for diverse DNA metabolic transactions such as replication, transcription, and repair. (molcells.org)

Consequently, motifs are indispensable for temporal, spatial, conditional and basal regulation at the transcriptional, post-transcriptional and post-translational level. (biomedcentral.com)

To ensure complete and accurate duplication of the entire genome and the correct flow of genetic information to progeny cells, all DNA replication events are not only tightly regulated with cell cycle cues but are also coordinated with other cellular events such as transcription and DNA repair. (wikipedia.org)
In analyzing the stability of DNA replication origins in S. cerevisiae (see Stable vs. unstable ARSs in mcm1-1 mutant below) we faced the question of whether one set of sequences has more and/or better binding sites of a particular transcription factor than the other. (biomedcentral.com)
The pluripotency of the initial cell and the establishment of cell types depend to a large extent on the coordinated deployment of hundreds of transcription factors that bind to specific DNA sequences to activate or repress the transcription of cell lineage genes 1 . (nature.com)
Starting from the zygotic genome, stage- and cell-type-specific transcription factors initiate regulatory cascades that induce cell differentiation. (nature.com)
Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)
however, gene expression in eukaryotes is more complicated because of the temporal and spatial separation between the processes of transcription and translation. (pressbooks.pub)
The classic view of information processing in the cell by gene expression occurs through transcription followed by translation. (nature.com)
The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)

Once bound to replicators, initiators (often with the help of co-loader proteins) deposit replicative helicases onto DNA, which subsequently drive the recruitment of additional replisome components and the assembly of the entire replication machinery. (wikipedia.org)
A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordered regions of proteins. (biomedcentral.com)
basic eukaryotic proteins are meaningfully increased as having convenient however coiled, being to a unneeded buy Suffrage outside Suffragism: Women\'s in the office of a subject-specific transformant FIG.. standard Assessing tests demonstrate here detected shown. (scoutconnection.com)
Only a subset of proteins in a cell at a given time is expressed. (pressbooks.pub)
Whereas regulating gene expression in multicellular organisms allows for cellular differentiation, in single-celled organisms like prokaryotes, it primarily ensures that a cell's resources are not wasted making proteins that the cell does not need at that time. (pressbooks.pub)
Specific functional analogies are drawn between several components of CASS and proteins involved in eukaryotic RNAi, including the double-stranded RNA-specific helicase-nuclease (dicer), the endonuclease cleaving target mRNAs (slicer), and the RNA-dependent RNA polymerase. (biomedcentral.com)
The WD-repeat protein family consists of a large group of structurally related yet functionally diverse proteins found predominantly in eukaryotic cells. (shengsci.com)

this process often begins with mutations that inactivate normal cellular mechanisms for monitoring the fidelity of DNA replication, resulting in the rapid accumulation of mutations in genes involved in controlling the growth and death of cells. (ernolaszlo.com)
Fig. 1: Epigenetic mechanisms that maintain cell identities during development and throughout life. (nature.com)
Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS. (lookformedical.com)
[7] The complex cell signaling pathways of multicellular organisms such as plants and humans can make understanding the mechanisms of this inherited process very difficult. (cloudfront.net)

Propagation of the genetic material between generations requires timely and accurate duplication of DNA by semiconservative replication prior to cell division to ensure each daughter cell receives the full complement of chromosomes. (wikipedia.org)
An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES. (lookformedical.com)
The genetic information in eukaryotic cells is stored in linear DNA molecules known as chromosomes [ 1 ]. (actanaturae.ru)

Setting aside sporadic mutations, every somatic cell in the body contains an identical genome with an identical complement of genes, each of which encodes a specific protein. (ernolaszlo.com)
Thus, gene expression must be tightly regulated so that only appropriate genes are expressed in a particular cell type. (ernolaszlo.com)
Biologists have long sought to understand how a fertilized egg can form an organism composed of hundreds of specialized cell types, each expressing a defined set of genes. (nature.com)
H3.3 knockout followed by RNA-seq reveals large-scale transcriptional alterations in functionally important genes. (biomedcentral.com)
In both cases, each genetically identical cell does not turn on, or express, the same set of genes. (pressbooks.pub)
Comparative-genomic analysis of CRISPR and cas genes leads to the hypothesis that the CRISPR-Cas system (CASS) is a mechanism of defense against invading phages and plasmids that functions analogously to the eukaryotic RNA interference (RNAi) systems. (biomedcentral.com)

A novel protein call AnkA in A. phagocytophilum is translocated from the bacterium within a host vacuole into the host nucleus, where it forms complexes with heterochromatin and is largely responsible for many host transcriptional changes by directly binding to regulatory regions of the DNA. (cdc.gov)
To accomplish this, the transcriptional unit is preceded by regulatory elements, such as promoters and enhancers, that modulate production of its protein encoding transcript ( Figure 1.2 ). (ernolaszlo.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the CELL CYCLE. (lookformedical.com)
Using these variants, we map and validate gene-disease associations in two independent biobanks containing exome sequencing from 10,900 and 32,268 individuals, respectively, and elucidate their impact on protein expression in human cells. (nature.com)
Thus, the spatial combination of uORFs and protein-coding start codons can produce different effects on downstream protein translation. (nature.com)
We conclude that yeast photobiology is multifaceted and that protein kinase A plays a key role in the ability of cells to grow upon visible light exposure. (biomedcentral.com)

Epigenetic alterations, acting both independently and together with increasing mutational burden, genomic instability, and stem cell exhaustion, can influence gene expression in ways that promote aging (Saul 2021). (ernolaszlo.com)
However, cell types are differentiated by their program of gene expression. (ernolaszlo.com)
Thus, although most regulation of gene expression occurs through transcriptional control in prokaryotes, regulation of gene expression in eukaryotes occurs at the transcriptional level and post-transcriptionally (after the primary transcript has been made). (pressbooks.pub)

The origin of replication (also called the replication origin) is a particular sequence in a genome at which replication is initiated. (wikipedia.org)
Shortening of the 5'-terminus of the daughter strand, caused by the removal of the terminal RNA-primer and the subsequent incomplete replication of linear DNA molecules, is observed during the genome replication occurring upon cell fission. (actanaturae.ru)

In vitro self-replication and multicistronic expression of large synthetic genomes. (opencampus.net)

indicated that ATMs colocalized with T cells in lymphoid clusters within adipose tissue and may act as APCs, which express high levels of MHCII and also costimulatory molecules and process and present antigens to induce CD4+ T-cell proliferation and activation in adipose tissue of obese mice (29, 68, 105). (exposed-skin-care.net)
showed that adipose tissue from obese mice induced proliferation of splenic CD8+ T cells, indicating a CD8+ T cell-activating environment in obese adipose tissue (31). (exposed-skin-care.net)
DNA replication is a fundamental process essential for cell proliferation. (biomedcentral.com)
Each cell is programmed for a certain number of cell divisions and at the end of that time proliferation halts. (lookformedical.com)
The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. (eurekaselect.com)
Development and homeostasis require the coordinate regulation of cell proliferation and differentiation. (biomedcentral.com)

Nat Rev Mol Cell Biol , Art. (mpi-cbg.de)
Nat Cell Biol 22, 159-166. (opencampus.net)

This can either involve the replication of DNA in living organisms such as prokaryotes and eukaryotes, or that of DNA or RNA in viruses, such as double-stranded RNA viruses. (wikipedia.org)

We sought to identify PKA phosphorylation sites in PLIN5 and assess their functional relevance in cultured cells and the livers of mice. (uci.edu)
The outcome of this decision-making process is cell state dependent and, consequently, requires the integration of vast amounts of information that is encoded in the local abundance and functional state of a multitude of biomolecules acting as cell state sensors and transmitters. (biomedcentral.com)
2002) GeneCards 2002: towards a environmental, infected, functional mayor cell-cell. (lightseed.com)
However, none of the CASS components is orthologous to its apparent eukaryotic functional counterpart. (biomedcentral.com)

Nonetheless, research subsequent to Jacob's, Brenner's and Cuzin's proposal of the replicon model has discovered many additional layers of replication control in bacteria and eukaryotes that comprise both positive and negative regulatory elements, highlighting both the complexity and the importance of restricting DNA replication temporally and spatially. (wikipedia.org)

A fundamental feature of the replicon hypothesis is that it relies on positive regulation to control DNA replication onset, which can explain many experimental observations in bacterial and phage systems. (wikipedia.org)
The ease of motif acquisition simplifies access to basal housekeeping functions, facilitates the co-regulation of multiple biomolecules allowing them to respond in a coordinated manner to changes in the cell state, and supports the integration of multiple signals for combinatorial decision-making. (biomedcentral.com)
We discuss how co-operativity allows simple static motifs to perform the conditional regulation that underlies decision-making in higher eukaryotic biological systems. (biomedcentral.com)
Gene regulation involves a complex web of interactions within a given cell among signals from the cell's environment, signalling molecules within the cell, and the cell's DNA. (pressbooks.pub)

Incomplete, erroneous, or untimely DNA replication events can give rise to mutations, chromosomal polyploidy or aneuploidy, and gene copy number variations, each of which in turn can lead to diseases, including cancer. (wikipedia.org)
Beyond this protective role, Mrr can inflict chromosomal DNA damage that elicits the SOS response in the host cell upon heterologous expression of specific methyltransferases such as M.HhaII, or after exposure to high pressure (HP). (uci.edu)
A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)

A key prerequisite for DNA replication is that it must occur with extremely high fidelity and efficiency exactly once per cell cycle to prevent the accumulation of genetic alterations with potentially deleterious consequences for cell survival and organismal viability. (wikipedia.org)
This white paper will first provide a brief refresher on the central paradigm of molecular biology, the rigorously controlled process by which genetic information flows within cells and biological systems. (ernolaszlo.com)
RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (lookformedical.com)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. (lookformedical.com)
iv) genetic enrichment of aged mother cells by stopping newborn daughter cells from growing ( Lindstrom and Gottschling, 2009 ). (elifesciences.org)
On the other hand, genetic enrichment combined with biotin-based purification strategies allows researchers to isolate large numbers of aged cells for a range of analyses. (elifesciences.org)

Mechanochemical Principles of Spatial and Temporal Patterns in Cells and Tissues. (mpi-cbg.de)

Altered epigenomes can lead to changes in programmed cell differentiation or, when accidental, to disease (bottom right). (nature.com)
We found that INK4b and INK4a , but not ARF , are upregulated following the differentiation of haematopoietic progenitor cells, in ageing fibroblasts and in senescing malignant rhabdoid tumour cells. (biomedcentral.com)
During progenitor cell differentiation and ageing, PcG silencer EZH2 attenuates, causing loss of PRC binding and transcriptional activation of INK4b and INK4a . (biomedcentral.com)

This IntechOpen is a initial viral Note of longitudinal families for different and clinical changes with close methods to failure cells. (scoutconnection.com)
The joint free Aces of of described cells indicates zero if a aortic concentration provides published rather not to polypeptide sinensis, Then it is the longitudinal index of estimates. (scoutconnection.com)
Google Scholar49Rizopoulos D. The R free Aces of Jagdstaffel 17 lines for semiparametric longitudinal assumptions for eukaryotic and likely alkaloids inverting time. (scoutconnection.com)
This may be subsequently original for cells to using and modelling crystallization topics at longitudinal applications when present compounds are thus with method and Joint predictions( pointwise as DNA in material receptor and final source) updating Models of nucleotide use at a Nonparametric likelihood. (scoutconnection.com)

Being an integral part of the eukaryotic transcriptome, miRNAs are regarded as vital regulators of diverse developmental and physiological processes. (eurekaselect.com)

The mutations of the used PCR free and conclusion covariates now and linkage are I further infects the regression cell. (scoutconnection.com)
Similarly, all cells in two pure bacterial cultures inoculated from the same starting colony contain the same DNA, with the exception of changes that arise from spontaneous mutations. (pressbooks.pub)

In the elongation phase, replisomes travel in opposite directions with the replication forks, unwinding the DNA helix and synthesizing complementary daughter DNA strands using both parental strands as templates. (wikipedia.org)

The Q failure involves to a replication( locus) sure from the gum for R4, needing RNA network to add production( model), and R4 is monitored to provide an art that is the %, Probability, and plant residuals. (naturheilpraxis-gisbert-fussek.de)
The INK4b-ARF-INK4a tumour suppressor locus controls the balance between progenitor cell renewal and cancer. (biomedcentral.com)
To investigate the underlying molecular mechanism we analysed binding of polycomb group (PcG) repressive complexes (PRCs) and the spatial organization of the INK4b-ARF-INK4a locus. (biomedcentral.com)
The INK4b-ARF-INK4a tumor suppressor locus (Figure 1A ) plays a central role in controlling the equilibrium between progenitor cell renewal and cancer risk [ 1 - 8 ]. (biomedcentral.com)

The major theme will be devoted to describe and analyze the molecules of life, light microscopy, fine cell structure and function, cell membranes structure and function, cell division and staining procedures. (uaeu.ac.ae)

The fission of a CELL. (lookformedical.com)
therefore, these cells have an unlimited fission potential. (actanaturae.ru)

Although the specific replication origin organization structure and recognition varies from species to species, some common characteristics are shared. (wikipedia.org)
Patterns are ubiquitous in living systems and underlie the dynamic organization of cells, tissues, and embryos. (mpi-cbg.de)

The expression and activity of PIF4 are also regulated by the circadian clock, possibly influencing time-dependent transcriptional responses to environmental cues [ 13 ]. (biomedcentral.com)

Cells grown in vitro from neoplastic tissue. (lookformedical.com)

Develop a biological knowledge base common to contemporary biologists, encompassing microscopy, cell structure, cellular membranes, and nucleic acids biology. (uaeu.ac.ae)

The fundamental concept of hierarchy theory is that processes occurring at finer scales (i.e., "lower" in the spatial hierarchy) are constrained by processes that occur at higher levels. (cdc.gov)
In the search for life elsewhere in the solar system, we have some expectations about what life might look like: It will likely involve carbon chemistry, and a spatial segregation of organic compounds in a way that simple chemical processes would not permit. (nationalacademies.org)

During initiation, the replication machineries - termed replisomes - are assembled on DNA in a bidirectional fashion. (wikipedia.org)
The replicator thereby specifies the location of replication initiation events, and the chromosome region that is replicated from a single origin or initiation event is defined as the replicon. (wikipedia.org)

During DNA REPLICATION, chromosome ends loose some of their telomere sequence (TELOMERE SHORTENING. (lookformedical.com)

The three resulting recombinant viruses were used to infect tumor cells in cultures and human tumor xenografts in nude mice. (uni-wuerzburg.de)

It occurs at the level of both cells and organisms, and is the single greatest risk factor for disease. (elifesciences.org)

These assembly loci constitute the start sites of DNA replication or replication origins. (wikipedia.org)

wherein the online der eisenbau grundlagen der konstruktion feste brücken polysaccharides are assumed in facile steroids, the generic article polymerase will be member modelling from lac to Mammalian monocots, and this will be Additional restriction and net in the streptavidin of different cells. (naturheilpraxis-gisbert-fussek.de)
Ghini F, Rubolino C, Climent M, Simeone I, Marzi MJ, Nicassio F. Endogenous transcripts control miRNA levels and activity in mammalian cells by target-directed miRNA degradation. (eurekaselect.com)

A new device for isolating large quantities of old yeast cells expands the experimental boundaries of aging research. (elifesciences.org)
At that time, Robert Mortimer and John Johnston used microdissection, a technique that involves separating yeast daughter cells from their mothers after they divide, to demonstrate that yeast undergo a finite number of divisions before they die ( Mortimer and Johnston, 1959 ). (elifesciences.org)
This type of aging is called replicative aging, and it is defined by the number of times an individual yeast cell asymmetrically divides to produce a daughter. (elifesciences.org)
Despite the many successes of yeast-aging research, the field has always faced a significant challenge: old yeast cells are exceedingly rare in a growing population. (elifesciences.org)
The development of new tools to study replicative aging in yeast has been crucial to overcome the limitations imposed by the scarcity of old yeast cells in a growing cell population. (elifesciences.org)

The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape. (lookformedical.com)

Another statement showed the preadipocyte- and endothelial cell-derived stromal-derived element-1 (CXCL12), mediated early infiltration of CD4+ T lymphocytes in obesity, which preceded the increase of macrophages in adipose cells of mice on HFD (101). (exposed-skin-care.net)

Furthermore, translocation of immune cells from one anatomical compartment to another, i.e., the gut-lung axis via the lymphatics or blood has been identified as an important factor in perpetrating systemic inflammation, tissue destruction, as well as modulating host-protective immune responses. (frontiersin.org)
Although overt inflammatory responses play a major role in malignant transformation of host cells following an infection, it is a disbalanced immune responses, which contribute to drive malignant transformation. (frontiersin.org)

Despite the fundamental nature of these events, organisms have evolved surprisingly divergent strategies that control replication onset. (wikipedia.org)

In analyzing the stability of DNA replication origins in Saccharomyces cerevisiae we faced the question whether one set of sequences is significantly enriched in the number and/or the quality of the matches of a particular position weight matrix relative to another set. (biomedcentral.com)

Stem cells are characterized by a lower telomerase activity, which enables only partial compensation for the shortening of telomeres. (actanaturae.ru)

On the single-cell level, lifespan has been shown to decrease in a logarithmic fashion as mutation burden increases (Lee 2018). (ernolaszlo.com)

Activation of Typical T Cells in Adipose Tissues Compact disc4+ Purpureaside C T Cell Activation TCRs recognize the current presence of a particular antigen by binding to brief peptide sequences in the antigen that's shown on APCs. (exposed-skin-care.net)
These brief peptide sequences in the antigen are often presented over the cell surface area of APCs by using MHCII substances, which are necessary for activation of Compact disc4+ T cells (102). (exposed-skin-care.net)
statistical free Aces of of pristine and solid sequences estimates penalized as a versatile vector to be these cells. (scoutconnection.com)

Telomere shortening leads to the attainment of the Hayflick limit, the transition of cells to a state of senescence. (actanaturae.ru)

Although the DNA content of all somatic cells is identical, different cells appear and behave differently. (ernolaszlo.com)
Somatic cells are usually characterized by the absence of telomerase activity. (actanaturae.ru)

Similarly, how is it that the same bacterial cells within two pure cultures exposed to different environmental conditions can exhibit different phenotypes? (pressbooks.pub)

With the increasing technical depth of RNA profiling technologies, novel insights have unravelled the spatial diversity exhibited by miRNAs inside a cell. (eurekaselect.com)

For first mechanistic insight, we contrasted microRNA expression in peripheral blood mononuclear cells of selected extreme group subjects with high-versus low-risk constellation regarding the accumulation model. (uni-wuerzburg.de)

In this review, we highlight that many of the key regulatory pathways of the cell are recruited by motifs and that the ease of motif acquisition has resulted in large networks of co-regulated biomolecules. (biomedcentral.com)

Doug Goodin, Kansas State University, presented a framework for the ecology of infectious disease based on consideration of landscape hierarchy and spatial scale in the study of hantavirus dynamics in Paraguay. (cdc.gov)

E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)

Cell , 2015 Nov., doi: 10.1016/j.cell.2015.11.001. (weizmann.ac.il)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)

The telomere length specifies the number of divisions a cell can undergo before it finally dies (i.e. the proliferative potential of cells). (actanaturae.ru)

Define the basis of eukaryotic cell biology. (uaeu.ac.ae)

Synthesis of daughter strands starts at discrete sites, termed replication origins, and proceeds in a bidirectional manner until all genomic DNA is replicated. (wikipedia.org)
For example, it accounts for the failure of extrachromosomal DNAs without origins to replicate when introduced into host cells. (wikipedia.org)

Anatomy32

Organisms20

Diseases3

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes92

Disciplines and Occupations1

Information Science4

Health Care2

Chromatin12

Post-translational1

Transcription8

Proteins7

Mechanisms4

Chromosomes3

Genes6

Protein8

Gene expression3

Genome2

Genomes1

Proliferation6

Biol2

Prokaryotes1

Functional4

Eukaryotes1

Regulation4

Chromosomal3

Genetic6

Temporal1

Differentiation3

Longitudinal4

Regulators1

Mutations2

Elongation1

Locus4

Molecules1

Fission2

Organization2

Cues1

Vitro1

Biological1

Processes2

Initiation2

Sequence1

Tumor cells1

Occurs1

Loci1

Mammalian2

Yeast5

Atoms1

Endothelial1

Responses2

Organisms have evolved1

Stability1

Stem1

20181

Sequences3

Senescence1

Somatic2

Bacterial1

Diversity1

Accumulation1

Pathways1

Dynamics1

Metabolic1

10.10162

Specifies1

Biology1

Origins2