• Analysis of the proteins that activate and repress different enhancers is combined with genetic studies to accurately position these factors within complex signalling networks. (ox.ac.uk)
  • SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). (wikipedia.org)
  • It is encoded by a gene on the Y chromosome and contains a specific HMG-BOX DOMAIN that is found within members of the SOX family of transcription factors. (nih.gov)
  • A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. (bvsalud.org)
  • Enhancers are densely clustered groups of transcription factor binding motifs and are the principal regulators of spatio-temporal patterns of gene transcription. (ox.ac.uk)
  • This complex process is regulated by the interplay of transcription factors with a chromatin environment, both of which provide the epigenetic information maintaining cell-type specific gene expression patterns. (amegroups.org)
  • Cell-to-cell signalling is induced by specific ligands such as growth factors which activate their cognate receptor molecules. (amegroups.org)
  • Environmental and genetic risk factors both have a role in SAH. (biomedcentral.com)
  • All in all, our knowledge of risk factors for both the development and rupture of intracranial aneurysms remains rather meager, and hopes are high that genetic research will further increase our understanding of such risk factors. (biomedcentral.com)
  • SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. (ox.ac.uk)
  • A transcription factor that plays an essential role in the development of the TESTES . (nih.gov)
  • Therefore, prevention seems an attractive option to reduce the burden of SAH, and knowledge on risk factors is essential for the development of preventive measures. (biomedcentral.com)
  • We also highlight recent studies identifying the cis -regulatory elements such as enhancers at the global level and explain how their developmental activity is regulated by the cooperation of cell-type specific and ubiquitous transcription factors with extrinsic signals. (amegroups.org)
  • This graph shows the total number of publications written about "SOXC Transcription Factors" by people in this website by year, and whether "SOXC Transcription Factors" was a major or minor topic of these publications. (umassmed.edu)
  • Genetic disruption of SoxF binding sites established a clear requirement for members of this group of transcription factors (SOX7, SOX17 and SOX18) to drive the activity of these enhancers in vivo Endogenous deletion of the notch1b enhancer led to a significant loss of arterial connections to the dorsal aorta in Notch pathway-deficient zebrafish. (ox.ac.uk)
  • SRY-box containing gene 17 (Sox17) is a member of the high mobility group (HMG) transcription factor superfamily, which plays critical roles in the regulation of development and stem/precursor cell function, at least partly through repression of Wnt pathway activity. (nih.gov)
  • Overexpression of SOX17 in HCT116 CRC cells inhibits colony growth and beta-catenin/T-cell factor-dependent transcription. (nih.gov)
  • Initial embryonic determination of artery or vein identity is regulated by genetic factors that work in concert to specify the endothelial cell׳s (EC) fate, giving rise to two structurally unique components of the circulatory loop. (nih.gov)
  • This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological). (nih.gov)
  • These findings position SoxF transcription factors directly upstream of Notch receptor expression during the acquisition of arterial identity in vertebrates. (ox.ac.uk)
  • SOXC Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)
  • SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. (ox.ac.uk)
  • This graph shows the total number of publications written about "SOXC Transcription Factors" by people in this website by year, and whether "SOXC Transcription Factors" was a major or minor topic of these publications. (umassmed.edu)