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  • Sox9
  • The transcription factor SOX9 has an essential role in heart valve and cartilage formation and its loss leads to major congenital abnormalities in the embryo. (ubc.ca)
  • Analysis of tissue-specific SOX9-DNA binding regions with gene expression profiles from Sox9 mutant heart valves indicates that SOX9 directly regulates a collection of transcription factors known to be important for heart development. (ubc.ca)
  • SOX9 transcriptional targets identified in this data could be used as predictive factors of heart valve disease, or as targets for new therapeutic strategies for disease and congenital defects. (ubc.ca)
  • roles
  • Pubmed ID: 11854453 Receptors for bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGFbeta) superfamily, are persistently expressed during cardiac development, yet mice lacking type II or type IA BMP receptors die at gastrulation and cannot be used to assess potential later roles in creation of the heart. (jove.com)
  • Olig2
  • In Aim 2, we will determine whether the newly identified compounds that increase Olig2 transcription activate the Sonic hedgehog-Gli pathway or the mitogen-activated protein kinase pathway and test compounds that affect different pathways for their ability to promote remyelination in EAE. (grantome.com)
  • pluripotency
  • Therefore, reprogramming protocols involving the expression of oncogenic pluripotency factors might cause tumorigenesis by disrupting the epigenetic marks for the correct gene expression circuitry. (springer.com)
  • novel
  • Upon exposure to blue light, they observed the formation of a novel, synthetic loop together with nascent transcription of Zfp462 , suggesting that their system is indeed efficient in editing the 3D genome. (biologists.com)
  • However
  • However, when actin is depleted prematurely from the lateral sides, the tissue does not increase its height, suggesting that actin is necessary but not sufficient for triggering cell elongation and that additional factors contribute to tissue shape change. (biologists.com)