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  • Sox2
  • We reported recently that a pituitary-specific transcription factor PROP1 is present in SOX2-positive cells and disappears at the early stage of the transition from progenitor cell to committed cell during the embryonic development of the rat pituitary. (biomedsearch.com)
  • Using electroporation in the wild-type embryonic OE in vitro as well as Fgf8, Sox2 and Ascl1 mutant mice in vivo, we found that Sox2 dose and Meis1 - independent of Pbx co-factors - regulate Ascl1 expression and the transition from lateral to medial precursor state. (biologists.org)
  • To investigate whether this technology could be applied to endangered species, where the limited availability of gametes makes production and research on embryonic stem cells difficult, we attempted generation of induced pluripotent stem (iPS) cells from snow leopard (Panthera uncia) fibroblasts by retroviral transfection with Moloney-based retroviral vectors (pMXs) encoding four factors (OCT4, SOX2, KLF4 and cMYC). (nih.gov)
  • The vertebrate transcription factor Sox2 is well known for its role in maintaining pluripotency of stem cells, but little is known on the mechanism of its function in the terminal differentiation of postmitotic neurons. (embopress.org)
  • bHLH
  • We show that the ability of bHLH factors to regulate the development of distinct neuronal subtypes in the Xenopus retina depends upon the timing of their function. (jove.com)
  • In addition, we find that the timing of bHLH function can be regulated posttranslationally, so that bHLH factors with overlapping expression can function independently. (jove.com)
  • protein
  • The activity of the basal transcription apparatus (BTA) is positively affected by the proteins bound at sites TGTGT and CCAAT and negatively by the protein bound at site TACGG (orange lines). (els.net)
  • Using quantitative mass spectrometry, we analyzed the (phospho)proteome of human embryonic stem cells (hESCs) during differentiation induced by bone morphogenetic protein (BMP) and removal of hESC growth factors. (nih.gov)
  • A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. (harvard.edu)
  • neural
  • The transcription of the foxD3 gene in the neural crest of chickens (shaded blue area of schematised chick embryo, anterior to the right) is controlled by two regulatory modules, NC1 and NC2. (els.net)
  • Both receive the transcription factors Msx and Pax7, which are expressed throughout the entire neural crest (red bar below), as activating inputs. (els.net)
  • Transcriptional
  • SOX9 transcriptional targets identified in this data could be used as predictive factors of heart valve disease, or as targets for new therapeutic strategies for disease and congenital defects. (ubc.ca)
  • expression
  • Together with the activity of Boz, Nodal factor signalling activates expression of chordin ( chd ) and goosecoid ( gsc ) ( Schier and Talbot, 2005 ). (biologists.org)
  • In the processes of pituitary organogenesis, these endocrine cells are terminally differentiated under control of numerous signalling factors and transcription factors whose expression and function are coordinated under spatial-temporal regulation. (biomedsearch.com)
  • Regulation of gene expression occurs primarily at the level of transcription. (els.net)
  • These uncertainties could be overcome if each transgenic factor were replaced with a small molecule that either directly activated its expression from the somatic genome or in some way compensated for its activity. (nih.gov)
  • Analysis of tissue-specific SOX9-DNA binding regions with gene expression profiles from Sox9 mutant heart valves indicates that SOX9 directly regulates a collection of transcription factors known to be important for heart development. (ubc.ca)
  • role
  • The transcription factor SOX9 has an essential role in heart valve and cartilage formation and its loss leads to major congenital abnormalities in the embryo. (ubc.ca)