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  • RUNX2
  • Through the analysis of the ER cistrome in tamoxifen-resistant breast cancer cells, we have uncovered a role for an RUNX2-ER complex that stimulates the transcription of a set of genes, including most notably the stem cell factor SOX9, that promote proliferation and a metastatic phenotype. (icr.ac.uk)
  • citation needed] Testing of this pathway has indicated that the Wnt/β-Catenin increases β-Catenin levels before the activation of the Runx2 and Osx transcription factors which seems to suggest that early β-Catenin levels can be a sign of whether an early mesenchymal progenitor cell will progress to a chondrocyte or to an osteoblast. (wikipedia.org)
  • Runx2 (which may also be known as Cbfa1), and Osx (a zinc finger containing transcription factor) are necessary for osteochondroprogenitor cells to differentiate into the osteoblast cell lineage. (wikipedia.org)
  • proliferation
  • Context-independent SOX9 binding suggests that SOX9 may play a role in regulating proliferation-associated genes across many tissues. (ubc.ca)
  • Activation of the pathway at the cerebellar ventricular zone led to a reduction in the number of cells expressing the glial lineage markers Sox9 and GFAP and the interneuron marker Pax2, but had no consistent effect on either proliferation or apoptosis. (biomedsearch.com)
  • Pax7 is a transcription factor that plays a role in myogenesis through regulation of muscle precursor cells proliferation. (wikipedia.org)
  • tissues
  • Comparisons of SOX9DNA-binding regions among tissues revealed both context-dependent and context-independent SOX9 interacting regions. (ubc.ca)
  • During development, slincR was expressed in tissues with sox9 essential functions, including the jaw/snout region, otic vesicle, eye, and brain. (aspetjournals.org)
  • lineage
  • Genetic lineage tracing experiments have been performed by various research groups to show that the cell clusters originating from the developing foregut express a transcription factor called PDX1 (Pancreatic and duodenal homeobox 1). (wikipedia.org)
  • Sox9 blocked osteochondroprogenitor cells were found to express osteoblast marker genes, reprogramming the cells into the osteoblastic lineage. (wikipedia.org)
  • development
  • Understanding the role of SOX9 in acquired diseases: lessons from development. (axonmedchem.com)
  • During tumor development, tumor cells acquire super-enhancers at key oncogenes, which drive higher levels of transcription of these genes than in healthy cells. (wikipedia.org)
  • There is evidence from work on suppression of male development that DAX1 can interfere with function of SF1, and in turn transcription of SRY by recruiting corepressors. (wikipedia.org)
  • SF-1 is a critical regulator of reproduction, regulating the transcription of key genes involved in sexual development and reproduction, most notably StAR and P450SCC. (wikipedia.org)
  • regulators
  • Large or multi-component transcription regulators with a range of mechanistic properties, including locus control regions, clustered open regulatory elements, and transcription initiation platforms, were observed shortly thereafter. (wikipedia.org)
  • cells
  • This transcription factor has been shown to give rise to the multipotent stem cell lineages contributing to the endocrine, exocrine and ductal cells of the pancreas. (wikipedia.org)
  • The transcription factor Sox9 can be found in multiple sites in the body (pancreas, central nervous system, intestines) and it is also found in all chondrocyte progenitor cells, suggesting that they are important in chondrogenesis. (wikipedia.org)