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Otx Transcription FactorsTranscription FactorsTranscription, GeneticSOX9 Transcription FactorDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceTrans-ActivatorsHomeodomain ProteinsGene Expression Regulation, DevelopmentalTranscriptional ActivationBinding SitesBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerNuclear ProteinsProtein BindingSOXB1 Transcription FactorsRepressor ProteinsTranscription Factor AP-1High Mobility Group ProteinsCell LineSignal TransductionForkhead Transcription FactorsAmino Acid SequenceCell DifferentiationDNAMutationSOXC Transcription FactorsSOX Transcription FactorsSOXD Transcription FactorsSOXE Transcription FactorsBasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2Kruppel-Like Transcription FactorsTransfectionChromatin ImmunoprecipitationCell NucleusGenes, ReporterSOXF Transcription FactorsTranscription Factors, TFIICells, CulturedGATA4 Transcription FactorHeLa CellsEnhancer Elements, GeneticReverse Transcriptase Polymerase Chain ReactionPaired Box Transcription FactorsYY1 Transcription FactorSTAT3 Transcription FactorTranscription Factor TFIIDActivating Transcription Factor 3NFATC Transcription FactorsElectrophoretic Mobility Shift AssayTranscription Initiation SiteGene Expression ProfilingSp3 Transcription FactorNF-kappa BZinc FingersMicrophthalmia-Associated Transcription FactorActivating Transcription Factor 2Regulatory Sequences, Nucleic AcidTranscription Factor TFIIBCloning, MolecularRecombinant Fusion ProteinsGene ExpressionE2F1 Transcription FactorIn Situ HybridizationRNA Polymerase IIBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPlasmidsMEF2 Transcription FactorsHMGB ProteinsGATA3 Transcription FactorLuciferasesTCF Transcription FactorsGATA Transcription FactorsGATA1 Transcription FactorCell Line, TumorGATA2 Transcription FactorProtein Structure, TertiaryGene Expression Regulation, FungalMice, TransgenicOligonucleotide Array Sequence AnalysisSTAT1 Transcription FactorActivating Transcription FactorsSequence Homology, Amino AcidMice, KnockoutPhenotypeNerve Tissue ProteinsPhosphorylationTranscription Factor RelAModels, BiologicalChromatinE2F Transcription FactorsHelix-Loop-Helix MotifsSaccharomyces cerevisiaeBlotting, WesternGATA6 Transcription Factor
OTX2Genes
OTX25
  • SOX2 and OTX2 are the two most commonly mutated genes in monogenic MAC. (nih.gov)
  • Here, a comprehensive mutational analysis of the CHX10, GDF6, RAX, SOX2 and OTX2 genes was performed in 50 MAC subjects. (nih.gov)
  • Eight mutations (16% prevalence) were recognised, including four GDF6 mutations (one novel), two novel RAX mutations, one novel OTX2 mutation and one SOX2 mutation. (nih.gov)
  • Otx2, which is an encoded protein that plays the role of a transcription factor, has also been shown to be involved in the regional patterning of the midbrain and forebrain. (wikipedia.org)
  • A "knockin" mouse line was generated where Crx (Otx family homeoprotein) was replaced by Otx2 and vice versa to examine the functional substitutability. (wikipedia.org)
Genes1
  • By using a combination of in situ hybridization screening, overexpression of mRNA, recombinant ligand treatments, and morpholino-based loss-of-function studies, we identified a cohort of transcription factors and signaling molecules expressed in the ventral ectoderm , dorsal ectoderm , and interposed neurogenic ("ciliary band") region in response to the known key signaling molecules Nodal and BMP2/4 and defined the epistatic relationships between the most important genes. (echinobase.org)