Sox2. Medical search. Frequent questions

Elevated expression of SOX2 and FGFR1 in correlation with poor prognosis in patients with small cell lung cancer. (dbs-india.com)

The difference in brain size between humans and apes, for instance, has been linked to mutations in the gene Asb11, which is an upstream activator of SOX2 in the developing neural system. (wikipedia.org)
The SOX2 gene provides instructions for making a protein that plays a critical role in the formation of many different tissues and organs during embryonic development. (medlineplus.gov)
At least 33 mutations in the SOX2 gene have been found to cause SOX2 anophthalmia syndrome. (medlineplus.gov)
Some of these mutations prevent the gene from making any SOX2 protein, while others result in the production of an abnormally short, nonfunctional version of the protein. (medlineplus.gov)
SOX2 anophthalmia syndrome: 12 new cases demonstrating broader phenotype and high frequency of large gene deletions. (medlineplus.gov)
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. (thermofisher.com)
The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. (thermofisher.com)
The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). (thermofisher.com)
Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia. (thermofisher.com)
The SOX2 gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors. (dbs-india.com)
SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer. (dbs-india.com)
Pre-made h OCT4 expression Adenovirus, expressing human stem cell factor, SOX2 gene under suCMV promoter . (gentarget.com)
Although the SOX2 gene mutation could lead to severe phenotypes, it played an important role in eyeball development, which suggested that this gene was probably a candidate for ametropia.we selected SOX2 gene, screened three tag SNPs for sequencing analysis, trying to find out high myopia-related loci to explore the association between SOX2 gene and high myopia. (growkudos.com)
In Chinese population, rs4575941 in SOX2 gene was likely to play some roles in the genetic susceptibility to high myopia, the rs4575941 allele G might be a risk gene for high myopia. (growkudos.com)
The sex-determining region Y-box 2 ( SOX2 ) gene, located on chromosome 3q26.3-q27, belongs to the SOX family [ 6 ]. (biomedcentral.com)
We identified frequent mutations involving a 40kb distal repressor region for the key stem cell differentiation gene SOX2. (ox.ac.uk)
Here, by analysing Sox2 conditional knockout mouse embryos and chick embryos deprived of Sox2 in the olfactory epithelium using CRISPR-Cas9, we show that Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 and for subsequent differentiation of the neuronal lineage. (unimib.it)
2 Sox2 and 52 of its gene targets were also included. (tamhsc.edu)

The following product was used in this experiment: Sox2 Recombinant Rabbit Monoclonal Antibody (OR-4F2), TrueRAB™ from Thermo Fisher Scientific, catalog # TA591001. (thermofisher.com)

Varying levels of Sox2 affect embryonic stem cells' fate of differentiation. (wikipedia.org)
Sox2 inhibits differentiation into the mesendoderm germ layer and promotes differentiation into neural ectoderm germ layer. (wikipedia.org)
Npm1/Sox2 complexes are sustained when differentiation is induced along the ectodermal lineage, emphasizing an important functional role for Sox2 in ectodermal differentiation. (wikipedia.org)
However, Sox2 is downregulated during progenitors' final cell cycle during differentiation when they become post mitotic. (wikipedia.org)
In lung development, Sox2 controls the branching morphogenesis of the bronchial tree and differentiation of the epithelium of airways. (wikipedia.org)
SOX2 is expressed in multipotent neuronal stem cells, and may aid to identify cells that are capable of self-renewal and multipotent differentiation (1-3). (dbs-india.com)
Using this system, it was possible to identify tumor suppressor p27 as a repressor of Sox2 during differentiation. (oncotarget.com)
In addition, our results support that Sox2 and Prox1 should not be the main blockers for terminal differentiation of HCs newly regenerated from postnatal cochlear SCs that still maintain Sox2 and Prox1 expression. (bath.ac.uk)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
Methods Pathways governing airway mucus cell differentiation include SRY (sex determining region Y)-box 2 (SOX2), Notch, forkhead box A3(FOXA3)/SAM pointed domain containing ETS transcription factor (SPDEF), epidermal growth factor (EGF) and the EGF-related neuregulins NRG1α and NRG1β. (bmj.com)
Results In IPF, the bronchiolised and enlarged distal airspaces stained for SOX2 are consistent with epithelial differentiation characteristic of conducting airway epithelium. (bmj.com)

NPM1, a transcriptional regulator involved in cell proliferation, individually forms complexes with Sox2, Oct4 and Nanog in embryonic stem cells. (wikipedia.org)
Sox2 binds to DNA cooperatively with Oct4 at non-palindromic sequences to activate transcription of key pluripotency factors. (wikipedia.org)
Surprisingly, regulation of Oct4-Sox2 enhancers can occur without Sox2, likely due to expression of other Sox proteins. (wikipedia.org)
However, a group of researchers concluded that the primary role of Sox2 in embryonic stem cells is controlling Oct4 expression, and they both perpetuate their own expression when expressed concurrently. (wikipedia.org)
In an experiment involving mouse embryonic stem cells, it was discovered that Sox2 in conjunction with Oct4, c-Myc and Klf4 were sufficient for producing induced pluripotent stem cells. (wikipedia.org)
Loss of pluripotency is regulated by hypermethylation of some Sox2 and Oct4 binding sites in male germ cells and post-transcriptional suppression of Sox2 by miR134. (wikipedia.org)
Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. (dbs-india.com)
Expression of sox2 and oct4 and their clinical significance in human non-small-cell lung cancer. (dbs-india.com)
To reveal the effect of enzyme digestion into cell clumps on protein levels of octamer-binding protein 4 (OCT4) and sex determining region Y-box 2 (SOX2) in the human embryonic stem cells (hESCs) and its possible molecular mechanism. (shsmu.edu.cn)
① Western blotting was conducted to detect the protein levels of OCT4 and SOX2 in the hESCs treated by enzyme digestion into cell clumps [Dispase or collagenase type Ⅳ (COL4)], enzyme digestion into single cells (Accutase or trypsin), or mechanical scraping dissociation. (shsmu.edu.cn)
② Ethylene glycol tetraacetic acid (EGTA) was used to destruct hESC-hESC interaction, and protein levels of OCT4 and SOX2 in the hESCs treated with EGTA alone or combined with COL4 were detected by Western blotting. (shsmu.edu.cn)
④ hESCs were pre-treated with proteasome inhibitor (bortezomib) and lysosome inhibitor (chloroquine), respectively, followed by Western blotting and immunofluorescence staining to measure their effects on COL4-induced down regulation of OCT4 and SOX2. (shsmu.edu.cn)
① COL4 or Dispase treatment led to protein levels decrease of OCT4 and SOX2, while Accutase, trypsin and mechanical dissociation did not elicit such effect. (shsmu.edu.cn)
② EGTA rescued OCT4 and SOX2 protein levels decrease indcued by COL4 treatment. (shsmu.edu.cn)
③Quantitative mass spectrometry and functional enrichment analysis suggested that microtubule, actin filament (F-actin) and lysosome-associated proteins might be related to OCT4 and SOX2 protein levels decline in the suspended clumps of hESCs upon COL4 treatment. (shsmu.edu.cn)
④Chloroquine, instead of bortezomib, could block COL4-induced protein levels decrease of OCT4 and SOX2. (shsmu.edu.cn)
Upon hESC detachment in cell clumps induced by enzyme treatment, the protein levels of SOX2 and OCT4 decline, which may be related to Rac1/cofilin/F-actin signaling pathway and lysosome. (shsmu.edu.cn)
Effect of enzyme digestion into cell clumps on protein levels of OCT4 and SOX2 in human embryonic stem cells[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(4): 413-420. (shsmu.edu.cn)
With the exception of Myc (which was only present in a subset of benign, borderline, and malignant tumors), Oct4, Nanog, Sox2, and Klf4 were detectable at variable levels across both normal and diseased tissues. (medscape.com)
Semi-quantitative evaluation of our immunohistochemical staining revealed that protein expression of Oct4, Nanog, Myc, and Sox2, but not Klf4, was significantly increased in benign, borderline, and malignant vascular tumors relative to non-diseased vascular tissue controls. (medscape.com)

The SOX2 protein is especially important for the development of the eyes. (medlineplus.gov)
On the basis of this action, the SOX2 protein is called a transcription factor. (medlineplus.gov)
A few mutations change single protein building blocks (amino acids) in the SOX2 protein. (medlineplus.gov)
Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. (thermofisher.com)
⑤ Western blotting analysis was conducted to test the effect of COL4 treatment on cofilin as well as Rac1 inhibitors (EHT1864 and EHop-016) treatment on the protein level of SOX2 in the hESCs. (shsmu.edu.cn)
⑤The treatment of COL4 or Rac1 inhibitors could downregulate protein levels of cofilin and SOX2. (shsmu.edu.cn)
Here we show that PARP-1, a nucleosome-binding protein, cooperates with intrinsic properties of the pioneer TF Sox2 to facilitate its binding to intractable genomic loci in embryonic stem cells. (elsevierpure.com)

Oct-4, Sox2 and Nanog positively regulate transcription of all pluripotency circuitry proteins in the LIF pathway. (wikipedia.org)

The utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders. (ox.ac.uk)
(G-L) Sagittal optical section of whole-mount immunofluorescence with anti-Sox2 antibodies (red) before amputation (G,H) and at 4 dpa (I,J) rostral and (K,L) caudal regions. (biomedcentral.com)

Thus signals controlling Sox2 expression in the presumptive neuronal compartment, like Notch signaling, control what size the neuronal compartment finally reaches. (wikipedia.org)

Premalignant SOX2 overexpression in the fallopian tubes of ovarian cancer patients: Discovery and validation studies. (ox.ac.uk)

Importantly, we show that SOX2 overexpression in FTE is nearly ubiquitous in patients with HGSOCs (n=100), and common in BRCA1-BRCA2 mutation carriers (n=71) who underwent prophylactic salpingo-oophorectomy. (ox.ac.uk)
We propose that the finding of SOX2 overexpression in FTE could be exploited to develop biomarkers for detecting disease at a premalignant stage, which would reduce mortality from this devastating disease. (ox.ac.uk)

In neurogenesis, Sox2 is expressed throughout developing cells in the neural tube as well as in proliferating central nervous system progenitors. (wikipedia.org)
Paternal UBE3A also partially colocalizes with a marker of neural progenitors, SOX2, implying that relaxed or incomplete imprinting of paternal Ube3a reflects an overall immature molecular phenotype. (nature.com)

Deficiency of Sox2 in mice has been shown to result in neural malformities and eventually fetal death, further underlining Sox2's vital role in embryonic development. (wikipedia.org)

Differences in brain size between the species thus relate to the capacity of different species to maintain SOX2 expression in the developing neural systems. (wikipedia.org)
To our knowledge, this is the first time that human iPS cells have been generated from somatic cells without exogenous Sox2 expression. (ca.gov)
Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-low). (cam.ac.uk)
A ) The expression of SOX2-OT was tested by qPCR in the tumor tissues of the mice. (aging-us.com)
Increased SOX2 expression in less differentiated breast carcinomas and their lymph node metastases. (dbs-india.com)
SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancer. (dbs-india.com)
Predictive value of Sox2 expression in transurethral resection specimens in patients with T1 bladder cancer. (dbs-india.com)
In this work we studied the relative contribution of the retinoblastoma family members to the regulation of Sox2 expression. (oncotarget.com)
We also identified binding of pRb and p130 to an enhancer with crucial regulatory activity on Sox2 expression. (oncotarget.com)
View cart "h SOX2 expression Adenovirus, in vivo ready" has been added to your cart. (gentarget.com)
Among these patients with SCNEC, SOX2, P16 INK4A and HR-HPV RISH expression and SOX2/HR-HPV RISH co-expression were detected in 68(77.3%), 76(86.4%), 73(83.0%), and 48(54.5%), respectively. (biomedcentral.com)
Alternatively, univariate analysis revealed that SOX2 and HR-HPV RISH expression, either separately or in combination, predicted the poor prognosis of SCNEC patients. (biomedcentral.com)
Overall, the results of the present study suggest that the co-expression of SOX2 with HR-HPV RISH in SCNEC may represent a specific subgroup exhibiting remarkably poorer prognostic outcomes compared with the expression of any one marker alone. (biomedcentral.com)
The small infiltrating cancer nests surrounding CIN 3 margins or the CIN 3-like SCC with deep invasion generally display a decreased SOX2 level locally, and this indicates reduced SOX2 expression during invasive growth [ 13 ]. (biomedcentral.com)
However, its expression, clinical significance and the association between SOX2 and HPV status in SCNEC have not been evaluated. (biomedcentral.com)
We report that Sox2 is expressed in all dermal papillae at E16.5,but from E18.5 onwards expression is confined to a subset of dermal papillae. (biologists.com)
Our results also suggest that Sox2 activity promotes the neurogenic domain in the nasal epithelium by restricting Bmp4 expression. (unimib.it)
Conclusion Expression of SOX2 and MUC5B and lack of SPDEF in atypically differentiated cells of bronchiolised distal airspaces are consistent with abnormal programming of airway epithelial cells in IPF. (bmj.com)
Embryonic ethanol exposure alters expression of sox2 and other early transcripts in zebrafish, producing gastrulation defects. (tamhsc.edu)

SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells. (wikipedia.org)
Sox2 holds great promise in research involving induced pluripotency, an emerging and very promising field of regenerative medicine. (wikipedia.org)
LIF (Leukemia inhibitory factor) signaling, which maintains pluripotency in mouse embryonic stem cells, activates Sox2 downstream of the JAK-STAT signaling pathway and subsequent activation of Klf4 (a member of the family of Kruppel-like factors). (wikipedia.org)
The loss of Sox2 has also been shown to affect naïve pluripotency, with Sox2-depleted mouse embryonic cells becoming able to differentiate into extraembryonic trophoblast. (wikipedia.org)
Induced pluripotency is possible using adult neural stem cells, which express higher levels of Sox2 and c-Myc than embryonic stem cells. (wikipedia.org)
Sox2 modulation increases naïve pluripotency plasticity. (cam.ac.uk)
The transcription factor Sox2 is necessary to maintain pluripotency of embryonic stem cells, and to regulate neural development. (unimib.it)

In postnatal skin, Sox2 is only expressed in the dermal papillae of guard/awl/auchene follicles, whereas CD133 is expressed both in guard/awl/auchene and in zigzag dermal papillae. (biologists.com)
Using transgenic mice that express GFP under the control of the Sox2 promoter, we isolated Sox2 + (GFP + ) CD133 + cells and compared them with Sox2 - (GFP - ) CD133 + dermal papilla cells. (biologists.com)

Blockade or knockdown of CDK1 resulted in reduced phosphorylation, nuclear localization, and transcriptional activity of Sox2," the article indicated. (genengnews.com)

Identification of novel mutations and sequence variants in the SOX2 and CHX10 genes in patients with anophthalmia/microphthalmia. (medlineplus.gov)

We aimed to establish if SOX2 antibodies could be used to identify SCLC and other tumours found in a range of paraneoplastic disorders and controls. (ox.ac.uk)
SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC. (ox.ac.uk)

A few studies have reported that SOX2 is overexpressed in cervical squamous cell carcinoma (SCC), and plays an important role in the progression from squamous dysplasia to SCC. (biomedcentral.com)

Detailed results appeared in the journal Cancer Research , in an article titled, " CDK1 interacts with Sox2 and promotes tumor initiation in human melanoma . (genengnews.com)
Exosomal SOX2-OT promotes tumor growth of ovarian cancer in vivo . (aging-us.com)
Sox2 acts antagonistically and promotes neural development. (researcher-app.com)

Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CDX2 predict patient outcome. (dbs-india.com)

Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. (wikipedia.org)
2 It is hypothesized that transcription factors that regulate stem/progenitor cell development such as Sox2 are key components in the pathogenesis of FASD. (tamhsc.edu)
PARP-1-dependent Sox2-binding sites reside in euchromatic regions of the genome with relatively high nucleosome occupancy and low co-occupancy by other transcription factors. (elsevierpure.com)

B) Magnification of the inset indicated in (A). (C) Reverse transcription polymerase chain reaction (RT-PCR) analysis of sox2 and Xenopus brachyury ( Xbra ) mRNA levels at the tip of the regenerating tail indicating that sox2 is upregulated after tail amputation. (biomedcentral.com)

The role Sox2 plays for the development of the olfactory epithelium and neurogenesis within has, however, not been determined. (unimib.it)

Moving forward, Dr. Fujita's group hopes to further define the mechanism of Sox2 regulation via CDK1 in hopes of finding essential links that might be targets for new drugs aimed, eventually, at stopping the action of Sox2. (genengnews.com)

2 Synthetic Sox2 mRNA was injected into some of the ethanol exposed embryos, and gastrulation delays were measured. (tamhsc.edu)

Moreover, chromatin immunoprecipitation data show that Sox2 directly binds to the Hes5 promoter in both the PNS and CNS. (unimib.it)

The conditional pioneer activity observed with Sox2 at a subset of binding sites may be a key feature of other pioneer TFs operating at intractable genomic loci. (elsevierpure.com)

Sox2 has a critical role in maintenance of embryonic and neural stem cells. (wikipedia.org)
Sox2 is a transcription factor that helps embryonic and neural stem cells keep their stem-ness. (genengnews.com)
SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. (dbs-india.com)

2 Synthetic Sox2 treatment rescued ethanol exposed embryos from gastrulation delays. (tamhsc.edu)

Knockout of Sox2 in CDK1-overexpressing cells reduced CDK1-driven tumor-initiating capacity substantially. (genengnews.com)

Conclusions: Our results suggest that the developmental program of cochlear differentiating HCs is refractory to Notch reactivation and that Notch is an upstream regulator of Sox2 and Prox1 in cochlear development. (bath.ac.uk)

The present work aimed to assess the feasibility of SOX2 and HPV statuses as predictive indicators of SCNEC prognosis. (biomedcentral.com)

Ultimately, the CU scientists conducted a proteomic analysis that revealed an interaction between CDK1 and the pluripotent stem cell transcription factor Sox2. (genengnews.com)
SOX2 mediates carbon nanotube -induced fibrogenesis and fibroblast stem cell acquisition. (cdc.gov)

Strikingly, upon the removal of self-renewing cues Sox2-low nPSCs differentiate into both embryonic and extraembryonic cell fates in vitro and in vivo. (cam.ac.uk)
A - F ) The impact of exosomal SOX2-OT on tumor growth of ovarian cancer cells in vivo was analyzed by nude mice tumorigenicity assay (n = 5). (aging-us.com)

This led to the demonstration that defects in the repression of Sox2 can contribute to tumor development. (oncotarget.com)

Under normal conditions, Sox2 is critical for maintaining self-renewal and appropriate proportion of basal cells in adult tracheal epithelium. (wikipedia.org)

We can show Sox2 is very important for tumorigenesis, but it's difficult to have a Sox2 inhibitor," says Mayumi Fujita, M.D., Ph.D., an investigator at the CU Cancer Center and senior author of the current study, which found that CDK1 directly interacts with Sox2 to keep cancer cells "stemmy. (genengnews.com)

The associations of SOX2 and/or high-risk (HR)-HPV RNA in situ hybridization (RISH) levels with clinicopathological characteristics and prognostic outcomes for 88 neuroendocrine carcinoma (NEC) cases were analyzed. (biomedcentral.com)
(D-F) In situ hybridization using an antisense probe against sox2 during tail regeneration of stage 49 tadpoles at (D) 3, and (E,F) 7 days post amputation (dpa), sox2 was detected on the spinal cord and (D, inset) neural ampulla. (biomedcentral.com)

Sox2-low nPSCs do not show impaired neuroectoderm specification and differentiate efficiently in vitro into all embryonic germ lineages. (cam.ac.uk)

The Sox2-deficient olfactory epithelium displays diminished cell cycle progression and proliferation, a dramatic increase in apoptosis and finally olfactory pit atrophy. (unimib.it)
F) Transversal section of the regenerating tail at 7 dpa at the level indicated in (E), arrow indicates sox2 staining in the ependymal epithelium. (biomedcentral.com)

Conversely, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and was shown to be an independent positive prognostic marker (11-14). (dbs-india.com)

Cells expressing Sox2 are capable of both producing cells identical to themselves and differentiated neural cell types, two necessary hallmarks of stem cells. (wikipedia.org)
Importantly, this signature of MHC Class 1, CDK1, and Sox2 was common across melanoma, colon, and pancreatic cancers, implying that cancer stem cells across cancer types may share common features. (genengnews.com)
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOX2 (RC200757, Right lane) cDNA for 48 hrs and lysed. (thermofisher.com)
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. (ca.gov)
The SKOV-3 cells were treated with control shRNA or SOX2-OT shRNA exosome. (aging-us.com)
We have thus demonstrated a previously unrecognised heterogeneity in dermal papilla cells and shown that Sox2-positive cells specify particular hair follicle types. (biologists.com)
Mucus cells lining abnormal airways from patients with IPF expressed MUC5B and SOX2 but lacked SAM pointed domain containing ETS transcription factor (SPDEF) and forkhead box A3(FOXA3). (bmj.com)
2 Adult hippocampal samples with prolonged alcohol exposure showed significant decreases in Sox2 + neural stem/progenitor cells. (tamhsc.edu)
3 Mice with IUGR showed abnormal memory with reduced hippocampal volumes and fewer Sox2 + cells. (tamhsc.edu)

SOX2 has been shown to be a negative prognostic factor and associated with aggressive phenotypes in breast, head and neck, gastric, colorectal and bladder cancers (4-10). (dbs-india.com)
In small cell lung cancers, SOX2 was also correlated with a poor prognosis. (dbs-india.com)

Synthetic peptide within Human Sox2 aa 150-200. (thermofisher.com)
2 Hippocampal tissue from human adult donors with severe alcohol abuse was stained for Sox2 and other markers to determine the cell types present after prolonged alcohol exposure. (tamhsc.edu)

RBP-J loxp/loxp mice, we demonstrated that ectopic NICD in differentiating HCs caused reactivation of Sox2 and Prox1 in an RBP-J-dependent manner. (bath.ac.uk)

High SOX2 levels predict better outcome in non-small cell lung carcinomas. (dbs-india.com)

Anatomy43

Organisms7

Diseases15

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Psychiatry and Psychology1

Phenomena and Processes42

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Elevated expression of SOX21

Gene18

Antibody1

Differentiation11

Oct420

Protein7

Nanog1

Anti-SOX2 antibodies2

Controlling Sox2 expression1

Premalignant SOX21

Overexpression2

Progenitors2

Embryonic development1

Expression19

Pluripotency7

CD1332

Transcriptional1

Genes1

Antibodies2

Squamous cell carc1

Promotes3

Immunohistochemical1

Transcription factors3

Brachyury1

Neurogenesis1

Regulation1

MRNA1

Chromatin1

Subset1

Neural stem3

Embryos1

Knockout1

Upstream1

Predictive1

Stem-cell2

Vivo2

Tumor development1

Self-renewal1

Inhibitor1

Situ hybridization2

Differentiate1

Epithelium2

Marker1

Cells9

Cancers2

HUMAN2

Mice1

Lung1