Abnormalities, MultipleChromosome AberrationsCongenital AbnormalitiesChromosome DisordersKaryotypingEye AbnormalitiesMagnetic Resonance ImagingBrainPhenotypeMutationPregnancyCardiovascular AbnormalitiesTime FactorsCraniofacial AbnormalitiesSyndromeSkin AbnormalitiesMolecular Sequence DataUrogenital AbnormalitiesInfant, NewbornTrisomyIn Situ Hybridization, FluorescenceMusculoskeletal AbnormalitiesTooth AbnormalitiesRetrospective StudiesSensitivity and SpecificityDisease Models, AnimalCase-Control StudiesAneuploidyElectrocardiographyImage Processing, Computer-AssistedTranslocation, GeneticBase SequenceProspective StudiesRisk FactorsReproducibility of ResultsMice, KnockoutTomography, X-Ray ComputedMice, Inbred C57BLElectroencephalographySex Chromosome AberrationsSchizophreniaAbnormalities, Drug-InducedFetal DiseasesPedigreeCarbonMice, TransgenicFollow-Up StudiesBrain DiseasesCytogenetic AnalysisAnalysis of VarianceNitrogenPolymerase Chain ReactionChromosome DeletionReference ValuesHeart Defects, CongenitalUltrasonography, PrenatalCells, CulturedMice, Mutant StrainsPrognosisPrenatal DiagnosisChromosome BandingCytogeneticsEchocardiographyHeterozygotePredictive Value of TestsNervous System MalformationsHomozygoteImmunohistochemistryPrevalenceRNA, MessengerSequence Analysis, DNAAge FactorsGene DeletionBrain MappingBiopsyIntellectual DisabilityGenotypeCulture MediaTreatment OutcomeCerebral CortexAmino Acid SequenceModels, BiologicalChromosomes, Human, Pair 13Cohort StudiesHeartGlucoseDown SyndromeLiverUnited StatesGestational AgeAgenesis of Corpus CallosumHeart DiseasesBiological MarkersAtrophyPhylogenyDigestive System AbnormalitiesSeverity of Illness IndexAcute DiseaseMosaicismDiffusion Magnetic Resonance Imaging