Sorting protein. Medical search. Frequent questions

Violin plots show distribution of expression levels for Vacuolar protein sorting-associated protein 16 homolog (SMED30016921) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of Vacuolar protein sorting-associated protein 16 homolog (SMED30016921) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
Violin plots show distribution of expression levels for Vacuolar protein sorting-associated protein 16 homolog (SMED30016921) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
Description: A competitive for quantitative measurement of Mouse Vacuolar protein sorting associated protein 29(VPS29) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (bioanalitica.it)
Description: A competitive ELISA for quantitative measurement of Mouse Vacuolar protein sorting associated protein 53 homolog(VPS53) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (bioanalitica.it)
VPS13 , vacuolar protein sorting-associated protein. (cdc.gov)

Protein Sorting Signals" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Protein Sorting Signals" by people in this website by year, and whether "Protein Sorting Signals" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Protein Sorting Signals" by people in Profiles. (umassmed.edu)

Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments. (umassmed.edu)
Sorting of proteins to specific compartments within mitochondria. (manchester.ac.uk)
After internalization, MT1-MMP is sorted in endosomal compartments, and a fraction is recycled back to the plasma membrane. (nature.com)

By curating TA proteins with experimentally determined localizations and assessing hypotheses for recognition, we bioinformatically and experimentally verify that a hydrophobic face is the most accurate singular metric for separating ER and mitochondria-destined yeast TA proteins. (caltech.edu)

The aim of this unit is to examine the molecular mechanisms of protein sorting in eukaryotes, and will review recent data demonstrating that some of these processes are fundamental to all living cells. (manchester.ac.uk)

Structural and biochemical insights into lipid transport by VPS13 proteins. (nih.gov)

A protein-sorting transpeptidase is an enzyme, such as the sortase SrtA of Staphylococcus aureus, that cleaves one or more target proteins produced by the same cell, as part of a specialized pathway of protein targeting. (wikipedia.org)

However, a growing number of additional protein sorting systems has been described in prokaryotes, involving sorting enzymes that lack any homology to sortase and that appear to have arisen separately by convergent evolution. (wikipedia.org)
Although the sortases are the best described members of the protein-sorting transpeptidases, work on the analogous enzymes archaeosortase, rhombosortase, and the PorU enzyme of type IX secretion systems (T9SS) has been accumulating. (wikipedia.org)
With the support of the Marie Skłodowska-Curie Actions programme, the EPPIMAL project will take a closer look at key enzymes (protein catalysts) in important metabolic pathways of existing land plants. (europa.eu)
Iron functions as a component of proteins and enzymes. (cdc.gov)

The water-to-land transition was likely accompanied by the emergence and/or expansion of protein families that supported novel plant metabolic pathways. (europa.eu)
However, little is known about the proteins in these pathways and their interactions in complex protein networks. (europa.eu)
Characterising protein-protein interaction networks will shed light on the evolution of plant metabolic pathways and potentially reveal overlooked proteins. (europa.eu)
While these three plant metabolic pathways are almost fully elucidated, little is known about (i) the organization of involved proteins in interacting networks and (ii) the evolutionary relevance of protein-protein interaction (PPI) networks for the emergence and function of metabolic pathways. (europa.eu)
The project shall disclose the conservation or expansion of PPI networks in the course of land plant evolution and potentially identify overlooked protein involved in investigated metabolic pathways. (europa.eu)
Altogether, EPPIMAL will bring original information on the evolution of protein networks shaping three iconic land plant metabolic pathways that supported plant adaptation to land. (europa.eu)

Mitochondrial proteins are degraded by autophagy in aged cells. (elifesciences.org)
Loss of vacuole function triggers mitochondrial protein degradation. (elifesciences.org)
Mitochondrial protein degradation is not triggered by loss of mitochondrial membrane potential or oxidative stress. (elifesciences.org)

Additionally, sorting and subsequent exposure of sperm to either seminal plasma or seminal plasma proteins did not influence mRNA expression in bovine IVP embryos. (uzh.ch)
Myo4p, She2p, and She3p are hypothesized to form a heterotrimeric protein complex that directly transports ASH1 mRNA to daughter cells. (elsevierpure.com)

The course aims at demonstrating the workflow from sample purification to determining the atomic structure of a soluble or membrane protein. (epfl.ch)

Penn State scientists have discovered a new mechanism by which bacteria can select between different rare earth elements, using the ability of a bacterial protein to bind to another unit of itself, or "dimerize," when it is bound to certain rare earths, but prefer to remain a single unit, or "monomer," when bound to others. (machprinciple.com)
However, the protein was less good at discriminating between the individual rare earths. (todayheadline.co)

Derived from experimental measurements of a few TA proteins, there has been little examination of the TMD features that determine localization. (caltech.edu)
As a result, the localization of many TA proteins are misclassified by the simple heuristic of overall hydrophobicity. (caltech.edu)
We studied the effect of membrane geometry on the localization of membrane-bound proteins. (ku.dk)
She2p is an RNA-binding protein that directly interacts with ASH1 cis-acting localization elements and associates with She3p. (elsevierpure.com)
To define the localization of WDFY2 in the endocytic pathway, we transiently transfected hTERT-RPE1 cells with green flourescent protein (GFP)-WDFY2 and performed structured illumination microscopy (SIM) together with APPL1 and EEA1 visualized with antibodies (Fig. 1a ). (nature.com)

2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
Brassinolide-controlled adjustments in PIN2 sorting and intracellular distribution governs formation of a lateral PIN2 gradient in gravistimulated roots, coinciding with adjustments in auxin signaling and directional root growth. (cas.cz)

This compartmental organisation demands that newly synthesised proteins are accurately and efficiently targeted to their appropriate sub-cellular locations. (manchester.ac.uk)
The correct targeting and insertion of tail-anchored (TA) integral membrane proteins is critical for cellular homeostasis. (caltech.edu)
Quantitative comparative experiments between the two most abundant cellular membrane geometries, spherical and cylindrical, revealed that geometry regulates the spatial segregation of proteins. (ku.dk)
Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)

The protein encoded by this gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. (nih.gov)
RNA-seq was performed in blood Ly6C high and Ly6C low MC sorted by flow cytometry from control and HHcy cystathionine β-synthase gene-deficient ( Cbs -/- ) mice. (frontiersin.org)

Crosstalk between brassinolide signaling and endocytic PIN2 sorting, thus, appears essential for determining the rate of gravity-induced root curvature via attenuation of differential cell elongation. (cas.cz)
Sorting of endocytic cargos occurs at specialized tubular domains of early endosomes. (nature.com)
Here, we have studied the function of WDFY2, a cytosolic protein that has been described to reside on endocytic vesicles close to the plasma membrane 6 . (nature.com)

The goal of the present study was to assess the effect of seminal plasma and seminal plasma proteins as a supplement to sorted sperm on subsequent embryonic development, as a beneficial effect of these substances has been reported. (uzh.ch)

How MMPs are sorted in endosomes is largely unknown. (nature.com)

Mandon EC, Trueman SF, Gilmore R. Protein translocation across the rough endoplasmic reticulum. (umassmed.edu)
Trueman SF, Mandon EC, Gilmore R. Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity. (umassmed.edu)
Jiang Y, Cheng Z, Mandon EC, Gilmore R. An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation. (umassmed.edu)
Protein translocation into and across the ER membrane. (manchester.ac.uk)

The most enriched proteins released were the nucleosomal histones, which have previously been identified as damage-associated molecular pattern proteins (DAMPs) that can initiate sterile inflammatory responses. (nature.com)
It is likely that sorting of MMPs occurs by similar mechanisms, however, the molecular factors that regulate this process are largely unknown. (nature.com)

Structure, function and organization of lipids and proteins in biological membranes. (biomembranes.nl)
Biogenesis of membranes and the transport and sorting of lipids and proteins. (biomembranes.nl)

Variation in hormone transport, which depends on a delicate interplay between PIN2 sorting to and from polar plasma membrane domains, determines root growth. (cas.cz)

TA proteins are defined by a hydrophobic transmembrane domain (TMD) at their C-terminus and are targeted to either the ER or mitochondria. (caltech.edu)
Orthologous to human LAPTM4B (lysosomal protein transmembrane 4 beta). (nih.gov)

We show that WDFY2 regulates exocytosis of MT1-MMP by controlling endosomal sorting of the v-SNARE VAMP3. (nature.com)

Quinoa is an amazing source of protein and is a popular superfood across the globe. (indiatimes.com)
Protein content: 85 grams of cooked quinoa has 8 grams. (indiatimes.com)

We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)

A protein-rich diet speeds up your metabolism, keeps you fuller for a longer time and helps to build muscle mass. (indiatimes.com)
Protein is an essential nutrient that maintains muscle mass, metabolism, gives you energy, fuels oxygen in your blood, and maintains your immune system. (a1supplements.com)

Proteins are derived from various sources such as whey, eggs, plants, casein, and animals such as chicken or meat. (a1supplements.com)

We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)
Protein levels of TLR2 were determined using Western blots and fluorescence activated cell sorting (FACS) on cells exposed to 0, 50, and 100 mM alcohol. (cdc.gov)

Use of synthetic signal sequences to explore the protein export machinery. (umassmed.edu)

Protein content: 1 large egg has 6 grams of protein. (indiatimes.com)
Protein content: 136 grams of skinless chicken breast contains 26 grams of protein. (indiatimes.com)
Protein content: 155 grams of cooked edamame beans contains 17 grams of protein. (indiatimes.com)
Protein content: 28 grams of pumpkin seeds contains 5grams of protein. (indiatimes.com)
Almost two-thirds of the iron in the body (approximately 2.5 grams of iron) is found in hemoglobin, the protein in red blood cells that carries oxygen to tissues. (cdc.gov)

Certainly, protein intake is helpful after an intense workout session but it is not necessary to take protein powder or supplements for it at all. (indiatimes.com)

You might have seen bodybuilders and athletes guzzling protein shakes post-workout session and would have even considered to try it once. (indiatimes.com)
Having a handful of pumpkin seeds post-workout is an easy way to increases your protein intake. (indiatimes.com)

This makes it essential to have sorting and grading systems that are accurate, fast, and robust. (tomra.com)

Our results show that neither the bulk sorting procedure nor the addition of seminal plasma or seminal plasma proteins, respectively, affected cleavage and development rates when sperm from a specific bull was used. (uzh.ch)

Here, we show that the endosomal protein WDFY2 controls the recycling of MT1-MMP. (nature.com)

Chicken breast is another great source of protein. (indiatimes.com)

SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
Cryo-electron microscopy structural analysis of proteins. (epfl.ch)

Black beans are packed with protein and fiber, which are necessary when trying to shed kilos. (indiatimes.com)

Weight loss story: "I lost 16 kilos by eating a protein-rich brea. (indiatimes.com)

Our technology offers high efficiency, precision, and speed - working faster than other sorting technologies and wasting fewer resources in the process. (tomra.com)

There will be a formative ePBL exercise, complementary to the lecture material to further consolidate the course's experimental/problem-driven approach to the topic of protein sorting. (manchester.ac.uk)

There are plenty of protein-rich foods that you can include in your diet for a similar result. (indiatimes.com)

Arabidopsis PIN2 protein directs transport of the phytohormone auxin from the root tip into the root elongation zone. (cas.cz)

Food sorting machines and integrated post-harvest solutions play a vital role in ensuring food safety and product quality. (tomra.com)
A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins. (nih.gov)

Vacuolar protein6

Signals3

Compartments3

Yeast1

Eukaryotes1

VPS131

Target proteins1

Enzymes4

Pathways6

Mitochondrial3

MRNA2

Membrane protein1

Rare earths2

Localization5

Intracellular2

Cellular4

Gene2

Endocytic3

Substances1

Endosomes1

Translocation4

Molecular2

Membranes2

Plasma membrane1

Transmembrane2

Regulates1

Quinoa2

Occurs2

Metabolism2

Whey1

Cell2

Sequences1

Grams5

Powder1

Workout2

Essential1

Specific1

Show1

Chicken1

Structural2

Fiber1

Kilos1

Efficiency1

Experimental1

Diet1

Transport1

Role2