• J-2156 binds with nanomolar affinity to the human somatostatin receptor subtype 4 and is over 400-fold subtype-selective against the other somatostatin receptors. (aspetjournals.org)
  • Somatostatin receptors are widely expressed in many tissues. (aspetjournals.org)
  • Further research on peptide agonists that have some binding affinity for all five somatostatin receptors. (targetedonc.com)
  • However, they often express high levels of somatostatin receptors (SSTRs). (diva-portal.org)
  • Reubi JC, Maurer R, von Werder K (1987) Somatostatin receptors in human endocrine tumors. (springer.com)
  • This cross-talk is specific to G q and G i /G o , and is not limited to the AVP and somatostatin receptors. (biochemj.org)
  • 2) PCR-cloning of somatostatin receptors genomic clones for somatostatin receptor typel (SSTR1) and somatostatin receptor type2 (SSTR2) were obtained by PCR-cloning. (nii.ac.jp)
  • 3) Expression of somatostatin receptors High level of expression of SSTR1 was found in stomach ad small intestine. (nii.ac.jp)
  • 4) Point mutation of somatostatin receptors SSCP and TGGE analysis detected various mutated band in tissues of thyroid adenoma, adenomatous goiter, thyroid papillary carcinoma and ACTH producing cell line. (nii.ac.jp)
  • While this octapeptide exhibited high affinity (IC 50 = 2.80 nM) for an apparently single population of binding sites (n H = 0.89 ± 0.1) and exceptional selectivity for mu opioid receptos with an IC 51 (DPDPE)/IC 50 (naloxone) ratio of 4,829, it also displayed very low affinity for somatostatin receptors (IC 50 = 22,700 nM). (elsevier.com)
  • While this octapeptide exhibited high affinity (IC50 = 2.80 nM) for an apparently single population of binding sites (nH = 0.89 ± 0.1) and exceptional selectivity for mu opioid receptos with an IC51(DPDPE)/IC50 (naloxone) ratio of 4,829, it also displayed very low affinity for somatostatin receptors (IC50 = 22,700 nM). (elsevier.com)
  • The OCT-induced alterations in GHRH may explain previously reported changes in sleep whereas angiotensin may mediate OCT-induced drinking, vasopressin secretion and rises in blood pressure via sst2 somatostatin receptors. (elsevier.com)
  • Somatostatin peptides such as somatostatin 28 or 14 are known for their high binding affinity to G-coupled peptide receptors, which are often over-expressed on tumor cells. (nsti.org)
  • Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. (mybiosource.com)
  • Somatostatin binding in human gastrointestinal tissues: effect of cations and somatostatin analogues. (bmj.com)
  • This study characterises the somatostatin binding site in human gastrointestinal cancer and mucosa in terms of cationic specificity and relative affinity for three somatostatin analogues. (bmj.com)
  • Displacement studies were then performed with somatostatin-14 and somatostatin analogues RC-160, somatuline, and octreotide. (bmj.com)
  • An immunohistochemical study assessing factors predicting pasireotide responsiveness in somatotroph pituitary adenomas resistant to somatostatin analogues. (springer.com)
  • Lanreotide belongs to the class of medications called somatostatin analogues . (medbroadcast.com)
  • Vasoactive drugs can be divided into two categories: terlipressin (Glypressin), and somatostatin and its analogues, especially octreotide. (kuleuven.be)
  • Lanreotide and octreotide are somatostatin analogues i.e. drugs that copy or mimic the action of somatostatin. (netpatientnetwork.ie)
  • Sometimes interferon is given on its own, but quite often it is given as a combination therapy with somatostatin analogues. (netpatientnetwork.ie)
  • Somatostatin produced by the hypothalamus acts as a neurohormone that inhibits the secretion of other hormones, especially growth hormone and thyrotropin. (dictionary.com)
  • Ho LT, Lam HC, Wang JT, Tang KT, Perng JC, Liu YF, Chen RL (1986) Establishment of a radioimmunoassay of somatostatin in human plasma and in rat hypothalamus. (springer.com)
  • Patel Y, Reichlin S 1978 Somatostatin in hypothalamus, extra-hypothalamic brain and peripheral tissues of the rat. (springer.com)
  • We here report the partial characterization of immunoreactive somatostatin released from rat nervous system in vitro (hypothalamus, spinal cord and hypothalamic, cortical, thalamic and striatal synaptosomes). (portlandpress.com)
  • In addition, immunoreactive material released from hypothalamus, spinal cord and hypothalamic and cortical synaptosomes inhibited somatotropin (growth hormone, 'STH', 'GH') release from perifused anterior pituitary in a dose-related manner, indicating biological similarity to synthetic somatostatin. (portlandpress.com)
  • In contrast, peptides SRIF-14 and SRIF-28 (1-11) derived from somatostatin (SRIF, somatotropin release inhibiting factor) were significantly upregulated by imipramine in the hypothalamus. (diva-portal.org)
  • Krueger, J. M. / The somatostatin analog, octreotide, causes accumulation of growth hormone-releasing hormone and depletion of angiotensin in the rat hypothalamus . (elsevier.com)
  • Combined retrograde tracing and fluorescence in immunohistochemistry revealed somatostatin-immunoreactive neurons doubly labelled following injections of Fluorogold in the basal hypothalamus. (edu.au)
  • Somatostatin is secreted by the delta cells of the islet of Langerhans in the pancreas as well as by the hypothalamus and intestine. (fishersci.se)
  • The distribution of somatostatin immunoreactivity was determined throughout the hypothalamus of the sheep and comparisons were made with the known distribution of somatostatin immunoreactivity in the rat. (edu.au)
  • Octreotide (OCT) is a somatostatin analogue (SSA) available in a long-acting formulation, conventionally administered every 28 days at the maximum dose of 30 mg. (clinicaltrials.gov)
  • This study plans to demonstrate the safety and efficacy of [68Ga]-DOTA-tyr3-Octreotide ([68Ga]-DOTATOC) as an accurate imaging technique for diagnosis, staging, and monitoring of response to treatment in patients with Somatostatin receptor expressing tumors who undergo imaging with a clinical indication. (clinicaltrials.gov)
  • The last significant study Caplin summarized was the PROMID study of somatostatin analog, octreotide LAR in patients with well-differentiated, metastatic midgut NETs. (targetedonc.com)
  • The somatostatin analogue octreotide was used to induce fasting motility. (diva-portal.org)
  • Neural crest cells are the embryonic progenitors of several adult cell types, including some neurons that contain the neuroactive peptide somatostatin. (jneurosci.org)
  • Dynamic properties of the somatostatin type 2A receptor were therefore examined in resting conditions and after agonist activation in living hippocampal neurons. (jneurosci.org)
  • In this study, we first examined the mobility of the somatostatin (SRIF) type 2A (sst 2A ) receptor at the plasma membrane of cultured hippocampal neurons by fluorescence recovery after photobleaching (FRAP). (jneurosci.org)
  • Oertel W, Graybiel A, Mugnaini E, Elde R, Schmechel D 1983 Coexistence of glutamic acid decarboxylase and somatostatin immunoreactivity in neurons of the feline nucleus reticularis thalami. (springer.com)
  • Hokfelt T, Elde R, Johansson 0, Luft R, Nilsson G, Arimura A 1976 Immunohistochemical evidence for separate populations of somatostatin containing and substance-P containing primary afferent neurons in the rat. (springer.com)
  • Hokfelt T, Elfin L, Elde R, Schultzberg M, Goldstein M, Luft R 1977 Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons. (springer.com)
  • Costa M, Patel Y, Furness JB, Arimura A 1977 Evidence that some intrinsic neurons of the intestine contain somatostatin. (springer.com)
  • Finley J, Grossman G, Dimeo P, Petrusz P 1978 Somatostatin containing neurons in the rat brain. (springer.com)
  • Delfs J, Robbins R, Connolly JL, Dichter M, Reichlin S 1980 Somatostatin production by rat cerebral neurons in dissociated cell cultures. (springer.com)
  • Combined immunohistochemical labelling for neurons containing growth hormone (GH) releasing factor (GRF) or somatostatin and single labelling immunohistochemistry combined with Fluorogold retrograde transport labelling were used to examine whether somatostatin or GRF neurons might be reciprocally innervated. (edu.au)
  • Occasional somatostatin-immunoreactive neurons in the periventricular preoptic area were found to be closely approached by GRF-immunoreactive fibres, providing possible evidence of scant innervation of somatostatin neurons by GRF cells. (edu.au)
  • In contrast, many GRF-immunoreactive neurons in the arcuate nucleus appeared to have somatostatin-immunoreactive fibres closely applied to their perikarya suggesting that GRF neurons might be innervated by somatostatin cells. (edu.au)
  • The innervation of GRF neurons by somatostatin fibres may be derived from local somatostatin neurons. (edu.au)
  • Somatostatin can be used to identify medium size aspiny neurons in the striatum, cortex, and hippocampus. (fishersci.se)
  • These results show that FK960 reverses G protein-dependent inhibition of Ca 2+ currents by somatostatin in hippocampal neurons. (aspetjournals.org)
  • abstract = "The influence of somatostatin on discrete stages of collagenous-matrix-induced endochondral bone formation has been investigated. (elsevier.com)
  • Somatostatin secreted by the pancreas acts as a hormone that inhibits the secretion of the other pancreatic hormones, insulin and glucagon, and reduces the activity of the digestive system. (dictionary.com)
  • Benoit R, Bohlen P, Brazeau P, Ling N, Guillemin R (1980) Isolation and characterization of rat pancreatic somatostatin. (springer.com)
  • High Chromograinin, vip, pancreatic polypeptides & somatostatin. (healthtap.com)
  • Known or suspected somatostatin receptor positive NETs (e.g. carcinoid, pancreatic neuroendocrine tumors, and pheochromocytoma). (clinicaltrials.gov)
  • The goal of this study is to assess the safety and efficacy of the combination of everolimus and the intravenous radiolabeled Lu-177 DOTATATE Therapy (a somatostatin analogue) as a first line therapy in unresectable well to moderately differentiated metastatic neuroendocrine tumors of all gastrointestinal, lung and pancreatic origins. (clinicaltrials.gov)
  • The original phase III CLARINET study, published in the New England Journal of Medicine in 2014, was the first randomized placebo-controlled trial investigating PFS with a somatostatin analog in a population that included patients with pancreatic NETs and with grade G2 tumors. (targetedonc.com)
  • Expression of somatostatin is present in hyperplasia of the pancreatic islets as well as islet cell tumors such as somatostatinomas. (fishersci.se)
  • Somatostatin, gastrointestinal peptides, and the carcinoid syndrome. (bmj.com)
  • Somatostatin-28 [1-12]-like peptides. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Somatostatin-28 [1-12]-like peptides. (elsevier.com)
  • This study investigated the effects of neuroactive steroids, which have been reported to modulate GABA-ergic transmission, on the secretion of somatostatin (SRIH) and also dopamine (DA) from primary rat hypothalamic cell cultures, where the release of both substances is regulated by a GABA A receptor-mediated inhibitory tone. (wiley.com)
  • Epelbaum J, Willoughby J, Brazeau P, Martin J 1977 Effects of brain lesions and hypothalamic deafferentation on somatostatin distribution in the rat brain. (springer.com)
  • Brownstein MJ, Arimura A, Fernandez-Durango R, Schally AV, Kizer JS 1977 The effect of hypothalamic deafferentation on somatostatin-like activity in the rat brain. (springer.com)
  • Somatostatin (SRIF) is a tetradecapeptide originally isolated as a hypothalamic hypophysiotropic growth hormone (GH)-inhibiting factor. (nii.ac.jp)
  • Publications] N.Miki: 'Age- and sex-related changes in hypothalamic rat grwoth hormone-releasing factor (GRF) and somatostatin (SRIF) secretion in vitro. (nii.ac.jp)
  • Publications] M.Ono: 'Postnatal development of somatostatin (SRIF) inhibition of hypothalamic growth hormone-releasing factor(GRF) secrition in rats:An in vitro stuey with cysteamine. (nii.ac.jp)
  • SST: Somatostatin inhibits the release of somatotropin. (mybiosource.com)
  • Somatostatin also inhibits the release of numerous secondary hormones, such as insulin and glucagon. (fishersci.se)
  • The changes in both the thermoregulatory responses and brain somatostatin (SS) levels produced by ambient temperature ( T a ) changes were assessed in rats after they had been equilibrated to each of the T a for a period of about 90 min. (springer.com)
  • Petrusz P, Sar M, Grossman G, Kizer JS 1977 Synaptic terminals with somatostatin-like immunoreactivity in the rat brain. (springer.com)
  • We describe the characterization of somatostatin-like immunoreactivity (SRIF-LI) found by radioimmunoassay (RIA) to be present in normal human serum. (diabetesjournals.org)
  • SRA880, an antagonist of the somatostatin-1 autoreceptor (sst1) which positively modulates release of endogenous SRIF, was found to synergize with imipramine in causing antidepressant-like effects in the tail suspension test. (diva-portal.org)
  • Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or somatotrophin release-inhibiting factor (SRIF), is a peptide hormone with two active forms (14 and 28 amino acids) produced by alternative cleavage of a single preproprotein. (fishersci.se)
  • Of the emerging new systemic modalities are Everolimus and radiolabelled somatostatin analogue. (clinicaltrials.gov)
  • TT-232 is a somatostatin analogue containing a five-residue ring structure. (kuleuven.be)
  • Brown MR, Ling N, Rivier J (1981a) Somatostatin-28, somatostatin-14 and somatostatin analogs: effects of thermoregulation. (springer.com)
  • The future of somatostatin analogs for neuroendocrine tumors (NETs) includes potential advances on several fronts, according to a presentation at the NANETS' 2015 Neuroendocrine Tumor Symposium. (targetedonc.com)
  • One advance involves higher doses of somatostatin analogs, for example, a stronger formulation of lanreotide, which is in a phase II trial with optimal dosing not yet determined. (targetedonc.com)
  • That study illustrates the growing sentiment that higher doses of several somatostatin analogs will likely work better without increasing dangerous toxicities, said Martyn Caplin, BSc, DM, FRCP, a professor, consultant gastroenterologist, and neuroendocrine tumor physician at the Royal Free Hospital, London. (targetedonc.com)
  • The efficacy of somatostatin analogs and their limited side effects will increasingly move these agents into standard, first-line therapy for many NETs, Wouter de Herder, MD, PhD, told Targeted Oncology in an interview. (targetedonc.com)
  • Gallstones are no longer a significant issue with somatostatin analogs, according to de Herder, who moderated a symposium session on the future of somatostatin analog therapy. (targetedonc.com)
  • Since administering somatostatin analogs can be complex, de Herder added that he looks forward to having more liquid dosing to make injections easier and eventually lead to self-dosing. (targetedonc.com)
  • The general message of these studies is that somatostatin analogs are often well-tolerated, effective treatments for grades 1 and 2 NETs. (targetedonc.com)
  • Somatostatin is thus a potent inhibitor of carcinoid flushing, but no evidence has been found for the gut hormones measured to be mediators of flushing. (bmj.com)
  • Somatostatin is a hormone produced by the body that controls many processes in the body by blocking the action of other hormones. (medbroadcast.com)
  • Spherical clusters of cells throughout the pancreas, called the islets of Langerhans, produce and secrete the peptide hormones insulin (produced by beta cells) and glucagon (produced by alpha cells), which regulate blood glucose levels, as well as the hormone somatostatin, which inhibits the secretion of both insulin and glucagon. (wikipremed.com)
  • AequoScreen® Double Transfected Cell Lines: Somatostatin, sst3 subtype. (perkinelmer.com)
  • AequoScreen® Double Transfected Cell Lines: Somatostatin, sst4 subtype. (perkinelmer.com)
  • We conclude that the endogenous ligands somatostatin-14 and somatostatin-28 do not define maximal agonism on the human somatostatin receptor subtype 4 and that J-2156 represents a so-called superagonist. (aspetjournals.org)
  • These data suggest a distinct somatostatin receptor subtype in gastrointestinal tissues. (bmj.com)
  • It seems to us most likely that the well-known suppression of the secretion of growth hormone and glucagon, both insulin antagonists, is responsible for the antidiabetic action of somatostatin. (diabetesjournals.org)
  • The types of molecules which stimulate IRS release, the electrophysiologic effects of somatostatin, and the recognition of abnormal IRS levels in human CNS diseases were all used to formulate a working model of the role of the somatostatinergic cell in ongoing cerebral cortical function. (springer.com)
  • Pretreatment with pertussis toxin, which inactivates G i /G o , abolished the effects of somatostatin. (biochemj.org)
  • Brownstein M, Arimura A, Sato H, Schally AV, Kizer JS 1975 The regional distribution of somatostatin in the rat brain. (springer.com)
  • Bennett-Clarke C, Romagnano M, Joseph S 1980 Distribution of somatostatin in the rat brain telencephalon and diencephalon. (springer.com)
  • Somatostatin is an inhibiting hormone that is also known as growth hormone inhibiting hormone or somatotropin release inhibiting factor or hormone. (healthtap.com)
  • 1. Three weeks after partial enterectomy in the rabbit there was an increased somatostatin concentration and a decreased number of somatostatin-binding sites (without changes in the corresponding affinity values) in the cytosol of the residual intestinal tissue, except in the terminal ileum and the colon. (portlandpress.com)
  • Lamberts SWJ, Bakker WH, Reubi JC (1990) Somatostatin-receptor imaging in the localization of endocrine tumors. (springer.com)
  • Publications] Fujinaka Y: 'Expression of somatostatin receptor genes in endocrine tumors' Folia Endocrinol Japon. (nii.ac.jp)
  • Multimodality imaging of somatostatin receptor-positive tumors with nuclear and bioluminescence imaging. (envigo.com)
  • 1) Solubilization of somatostatin receptor Somatostatin receptor was solubilized from pig pituitary and human placental membrane fractions using 10 mM CHAPS.The solubilized receptor cross-linked with isotope labelled ligand using 1 mM DSS showed multiple band on SDS-PAGE and was eluted from Sephacryl-S300 column at the void volume, indicating high molecular complex formation. (nii.ac.jp)
  • The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. (mybiosource.com)
  • Cohn ML (1975) Cyclic AMP, thyrotropin-releasing hormone, and somatostatin: key factors in the regulation of the duration of narcosis. (springer.com)
  • In a cyclic AMP assay, J-2156, somatostatin-28, and somatostatin-14 all act as full agonists. (aspetjournals.org)
  • However, this outcome is most likely due to the presence of a receptor reserve in the cyclic AMP assay since there is a large gain of apparent potency in the cyclic AMP assay and the gain is larger for J-2156 than for somatostatin. (aspetjournals.org)
  • The somatostatin (SS) gene is transcriptionally regulated via the cyclic AMP (cAMP) response element (CRE), located in the proximal promoter (-41 to -48 bp). (biochemj.org)
  • Twice daily local injections of the hormone during cartilage formation also resulted in an inhibition, but this was shown to be due to impaired cell proliferation rather than to a direct effect of somatostatin on differentiation. (elsevier.com)
  • Concurrent injections of insulin and somatostatin obliterated the inhibitory effect of the latter on cell proliferation. (elsevier.com)
  • Somatostatin, a hormone that signals via G i /G o , usually inhibits increases in intracellular calcium concentration ([Ca 2+ ] i ) and insulin release from β-cells. (biochemj.org)
  • Intracellular application of the protein kinase inhibitor H-7 did not alter somatostatin-induced inhibition and had no significant effect on blockade by FK960. (aspetjournals.org)
  • A unique subset of interneurons which are rich in immunoreactive somatostatin (IRS) exists in the cerebral cortex. (springer.com)
  • Comparison was made with the somatostatin binding site in rat cerebral cortex. (bmj.com)
  • Davies P, Katzman R, Terry RD . Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa . (alzforum.org)
  • Takagi H, Somogyi P, Somogyi J, Smith A 1983 Fine structural studies on a type of somatostatin-immunoreactive neuron and its synaptic connections in the rat neostriatum. (springer.com)
  • Forssman WG, Burnweit C, Shehab T, Triepol J 1979 Somatostatin immunoreactive cell bodies and fibers in the medulla oblongata and spinalis. (springer.com)
  • Characterization of immunoreactive somatostatin released from rat nervous system in vitro. (portlandpress.com)
  • Numerous somatostatin-immunoreactive perikarya were observed in the periventricular arcuate region in colchicine-pretreated animals. (edu.au)
  • Somatostatin immunoreactive fibres were concentrated in the dorsal VMH and arcuate nucleus as well as in the median eminence. (edu.au)
  • The respiratory responses to bilateral microinjections (30-50nl) of 5mM somatostatin (SOM) or 10mM cyclosomatostatin (c-SOM, a SOM antagonist) into the Bötzinger complex (BötC), the pre-Bötzinger complex (preBötC) and the rostral inspiratory portion of the ventral respiratory group (iVRG) were investigated in urethane-chloralose anesthetized, vagotomized, paralysed and artificially ventilated rabbits. (biomedsearch.com)
  • This drug selectively increases somatostatin release from hippocampal slices and augments long-term potentiation (LTP) in the CA3 area of the hippocampus. (aspetjournals.org)
  • Together, these mechanisms may be involved in the selective effects of FK960 on somatostatin release, excitatory transmission, and synaptic plasticity in the hippocampus. (aspetjournals.org)
  • Somatostatin has a variety of functions, such as regulating the endocrine system and affecting neurotransmission and cell proliferation. (fishersci.se)
  • Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. (mybiosource.com)
  • Epelbaum J, Brazeau P, Tsang D, Brawer J, Martin JB (1977) Subcellular distribution of radioimmunoassayable somatostatin in rat brain. (springer.com)
  • Kobayashi RM, Brown M, Vale W 1977 Regional distribution of neurotensin and somatostatin in rat brain. (springer.com)
  • Keyley CF, Miller RP, Berman MC, Schally AV (1981) Depolarization and ionophore-induced release of octacosa somatostatin from stalk median eminence synaptosomes. (springer.com)
  • Arimura A, Fishback J 1981 Somatostatin: regulation of secretion. (springer.com)
  • One significant study was the open-label extension (OLE) of CLARINET, which studied the somatostatin analog, lanreotide 120 mg. (targetedonc.com)
  • Sz vettanilag nem lehet egy rtelm en elk l n teni a benignus s a malignus pancreas B-sejtes daganatokat, m j-metastasis jelenl te egy rtelm en malignitas mellett sz l. (vitalitas.hu)
  • Immunohistochemistry (IHC) (Anti-Somatostatin antibody IHC of human pancreas. (mybiosource.com)
  • Increasing concentrations of somatostatin-14 cause a concentration-dependent rightward shift of the dose-response curves for J-2156, without affecting its maximal response. (aspetjournals.org)
  • 2. Five weeks after surgery both the somatostatin concentration and the number of somatostatin-binding sites returned towards control values. (portlandpress.com)
  • The dose-response relationship on calcium current enhancement was bell-shaped with a maximum effect at 0.1 μM FK960, the same concentration as that for increasing on somatostatin release and CA3-LTP. (aspetjournals.org)
  • The monoclonal antibody ICDCLS recognizes human, mouse, and rat Somatostatin. (fishersci.se)
  • In a sixth patient with severe prolonged carcinoid flushing, subcutaneous Des AA1, 2, 4, 5, 12D Trp8 somatostatin markedly reduced the incidence and severity of flushing for two days. (bmj.com)
  • Local injection of somatostatin, i.e., without any measurable systemic effect, resulted in a 75% reduction of cell proliferation as measured by [ 3 H]thymidine incorporation and ornithine decarboxylase activities. (elsevier.com)
  • Local injection of somatostatin, i.e., without any measurable systemic effect, resulted in a 75{\%} reduction of cell proliferation as measured by [3H]thymidine incorporation and ornithine decarboxylase activities. (elsevier.com)
  • 3. These results suggest that an increase in bowel somatostatin content could lead to down-regulation of somatostatin-binding sites in the intestinal mucosa. (portlandpress.com)
  • Somatostatin can locally regulate the proliferation and differentiation of chondroprogenitor and osteoprogenitor cells in vivo and may directly contribute to the regulation of bone growth by its ability to counteract the stimulatory effect of insulin. (elsevier.com)
  • Immunogen Description: Somatostatin conjugated to Thyroglobulin. (mybiosource.com)
  • Immunogen: SST / Somatostatin antibody was raised against somatostatin conjugated to Thyroglobulin. (mybiosource.com)
  • When tetradecapeptide somatostatin was infused on another day no patient flushed at any time, even when 16 microgram of either noradrenaline or pentagastrin were administered. (bmj.com)
  • Hökfelt TS, Efendic S, Johansson RL, Arimura A (1974) Immunohistochemical localization of somatostatin (growth hormone release inhibiting factor) in the guinea pig. (springer.com)
  • We have found that in the presence of arginine vasopressin (AVP), which signals via G q , somatostatin increased [Ca 2+ ] i , leading to insulin release in HIT-T15 cells. (biochemj.org)
  • Somatostatin alone failed to increase [Ca 2+ ] i and insulin release. (biochemj.org)
  • Our findings suggest that somatostatin signals through G i /G o , and involves phospholipase C and Ca 2+ release from the endoplasmic reticulum. (biochemj.org)
  • The increase in [Ca 2+ ] i by somatostatin leads to insulin release. (biochemj.org)
  • However, the molecular mechanism responsible for the ability of FK960 to enhance somatostatin release is not fully understood. (aspetjournals.org)
  • U-73122, an inhibitor of phospholipase C, antagonized the somatostatin-induced increase in [Ca 2+ ] i . (biochemj.org)
  • Competitive displacement assays were performed on plasma membranes from human gastric and colonic tissues using radiolabelled somatostatin-14 as ligand. (bmj.com)