Somatic stem cells. Medical search. Frequent questions

Stem cells reside in niches that provide signals to maintain self-renewal, and differentiation is viewed as a passive process that depends on loss of access to these signals. (ucl.ac.uk)
Here, we demonstrate that the differentiation of somatic cyst stem cells (CySCs) in the Drosophila testis is actively promoted by PI3K/Tor signaling, as CySCs lacking PI3K/Tor activity cannot differentiate properly. (ucl.ac.uk)
We find that an insulin peptide produced by somatic cells immediately outside of the stem cell niche acts locally to promote somatic differentiation through Insulin-like receptor (InR) activation. (ucl.ac.uk)
Thus, we show that somatic cell differentiation is controlled by PI3K/Tor signaling downstream of InR and that the local production of positive and negative InR signals regulates the differentiation niche. (ucl.ac.uk)
These results support a model in which leaving the stem cell niche and initiating differentiation are actively induced by signaling. (ucl.ac.uk)
It has been reported that Sirtuin 6 (Sirt6), a member of the sirtuin family of NAD + -dependent protein deacetylases, is involved in embryonic stem cell differentiation. (biomedcentral.com)
OP9 feeder cell co-culture system was used to measure the hematopoietic differentiation from mouse ES and iPS cells. (biomedcentral.com)
Furthermore, we showed that Sirt6-null iPS-like cell line has intrinsically a differentiation defect even though the establishment of normal self-renewal. (biomedcentral.com)
To further understand the epigenetic regulators for specific lineage differentiation from iPS cell would have great significance for potential regeneration therapy and human disease modeling [ 8 ]. (biomedcentral.com)
During the preparation of our manuscript, another group reported that Sirt6 knockout ES cells skewed towards neuroectoderm differentiation [ 20 ]. (biomedcentral.com)
But the exact role of Sirt6 in mouse somatic reprogramming and iPS cell differentiation remains unrevealed. (biomedcentral.com)
Cell proliferation ceased, and differentiation into electrophysiologically active neurons and other CNS cell types in vivo ensued upon transplantation into rats, both during development and after adult injury--with functional improvement and without neoplasia, overgrowth, deformation, emergence of non-neural cell types, phenotypic or genomic instability, or need for immunosuppression. (nih.gov)
Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells. (wikipedia.org)
This meant that the cells can change their differentiation pathway. (wikipedia.org)
In Drosophila imaginal discs, cells have to choose from a limited number of standard discrete differentiation states. (wikipedia.org)
The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
Furthermore, protein-iPS cells possessed in vivo differentiation (well-differentiated teratoma formation) and development (chimeric mice generation and a tetraploid blastocyst complementation) potentials. (ewha.ac.kr)
Derivation and differentiation of haploid human embryonic stem cells. (nature.com)
Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. (nih.gov)
Qualitative Dynamical Modelling of T-Helper Cell Differentiation and Reprogramming. (routledge.com)
Tracing Stem Cell Differentiation with Single-Cell Resolution. (routledge.com)
This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)
Stem cells are not specialized and the process of their specialization is called differentiation. (benthamscience.com)
In addition, researchers must develop methods to efficiently direct the differentiation of embryonic stem cells to specific stable cell types. (scienceblog.com)
The topics covered include nuclear reprogramming, regulation of stem cell self-renewal and differentiation, the stem cell niche, and signaling and gene regulation in stem cells. (cshlpress.com)
For the first time researchers can now compare iPSC differentiation to the same process an egg goes through after the transfer of a somatic cell genome. (the-scientist.com)
This could help researchers identify abnormalities in iPSC differentiation, correct them, and develop pluripotent stem cells that don't harbor tumorigenic qualities and do not require the use of human embryos. (the-scientist.com)
Here, we employed a human pancreatic differentiation platform complemented with an shRNA screen in human pluripotent stem cells (PSCs) to identify potential drivers of early endoderm and pancreatic development. (mdpi.com)
Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity. (springer.com)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
Factors that alter the differentiation of the primordial germ cell, resulting in the presence of an embryonal stem cell, can increase the risk of NSGCT. (medscape.com)
Stem cells can divide into two cells identical to the original stem cell or into differentiated cell types, depending on their origin and differentiation potency. (bvsalud.org)
By definition, adult stem cells are capable of differentiation into at least two lineages and have the property of self-renewal. (bvsalud.org)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
Firstly, we present a robust 2-week protocol for the differentiation of human pluripotent stem cells (PSCs) into forebrain neural progenitor cells. (lu.se)

Induced totipotent cells can be obtained by reprogramming somatic cells with somatic-cell nuclear transfer (SCNT). (wikipedia.org)
hESCs can be generated by SCNT using dermal fibroblasts nuclei from both a middle-aged 35-year-old male and an elderly, 75-year-old male, suggesting that age-associated changes are not necessarily an impediment to SCNT-based nuclear reprogramming of human cells. (wikipedia.org)
The make use of of the AZD-2461 manufacture HDAC inhibitor valproic acidity (VPA) and trichostatin A (TSA) frequently enhances the effectiveness of both iPSCs and SCNT.79C82 Another HDAC inhibitor butyrate also takes on a positive part in SCNT and cell blend.83,84 According to the effects mentioned above, a model of histone modification included in chromatin decondensation in somatic reprogramming is summarized in Fig. (mindunwindart.com)
Last week's newspapers carried the news of what was widely described as a significant "breakthrough" in stem cell science: the first successful human use of a technology known as Somatic Cell Nuclear Transfer (also referred to as SCNT). (intlstemcell.com)
I realize that I could be accused of bias because I am one of the founders of International Stem Cell, but, in fact, our company also owns license rights to some of the key intellectual property that is required to create cells through SCNT technology and our scientists are very familiar with its promise and its limitations. (intlstemcell.com)
Like embryonic stem cells and SCNT cells, these cells can be converted into almost any cell in the human body and thus have enormous potential for human therapy. (intlstemcell.com)
Unlike SCNT cells, parthenogenetic stem cells require no genetic manipulation or insertion of foreign DNA. (intlstemcell.com)
The cell lines that are produced from this method, unlike cell lines from embryonic stem cells or from SCNT, can potentially be matched to millions of people in the same way that an organ transplant is matched between donor and patient. (intlstemcell.com)
This approach could become an alternative to somatic cell nuclear transfer (SCNT), a method that is currently used to produce human stem cells. (news-medical.net)
SCNT involves transferring the nuclei of adult cells, called somatic cells, into oocytes in which scientists have removed the nuclei. (news-medical.net)
This method is called "somatic cell nuclear transfer" or SCNT. (scienceblog.com)
체세포 핵 치환 (Somatic-cell nuclear transfer, SCNT)은 난자 의 핵 을 제거한 후에, 체세포 의 핵을 이식하여 복제 를 하는 기술을 말한다. (wikipedia.org)

RNA sequencing was measured to identify the differential expressed genes due to loss of Sirt6 in somatic and pluripotent cells. (biomedcentral.com)

This could allow us to create cells that are useful for transplantation for a variety of diseases without the problem of immunological rejection," said Noggle in a press briefing. (the-scientist.com)
Some in vivo transplantation studies have reported robust (35-50%) levels of transdifferentiation, which makes it unlikely that the results are due to cell fusion events. (i-sis.org.uk)
Transplantation of living nuclei from blastula cells into enucleated frogs' eggs. (springer.com)
Human pluripotent stem cells harbor the potential to provide an inexhaustible supply of donor cells or tissues or organs for transplantation," Wu wrote in an email. (the-scientist.com)
Allogeneic hematopoietic stem cell transplantation is curative but it requires a histocompatible donor and is associated with significant morbidity and mortality, so it is reserved for severe cases of PNH with aplastic anemia or transformation to leukemia. (medscape.com)
Treatment of adenosine deaminase deficiency is by bone marrow or stem cell transplantation and enzyme replacement therapy. (msdmanuals.com)
Treatment of purine nucleoside phosphorylase deficiency is with bone marrow or stem cell transplantation. (msdmanuals.com)
Kinetics and Risk Factors of Relapse after Allogeneic Stem Cell Transplantation in Children with Leukemia: A Long-Term Follow-Up Single-Center Study. (cdc.gov)
Donor characteristics and hematopoietic stem cell transplantation outcome: experience of a single center in Southern Brazil. (cdc.gov)
The influence of glucocorticoid receptor single nucleotide polymorphisms on outcome after haematopoietic stem cell transplantation. (cdc.gov)
Donor-recipient killer immunoglobulin like receptor (KIR) genotype matching has a protective effect on chronic graft versus host disease and relapse incidence following HLA-identical sibling hematopoietic stem cell transplantation. (cdc.gov)
Chain Predicts Risk of Graft-versus-Host Disease and Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. (cdc.gov)
Chronic graft-versus-host disease could ameliorate the impact of adverse somatic mutations in patients with myelodysplastic syndromes and hematopoietic stem cell transplantation. (cdc.gov)

Germline mutations are more harmful than mutations in somatic cells? (physicsforums.com)
And cells get mutations in their DNA, including the parts they don't use/express, right? (physicsforums.com)
And what about mutations in germline cells? (physicsforums.com)
Mutations can kill or not kill the cells they are in, depending on the details of the mutation and the cell. (physicsforums.com)
Mutations in somatic cells can have a relatively quick negative effect on an organism, possibly including death. (physicsforums.com)
Cancer is due to somatic mutations in the cells that are cancerous. (physicsforums.com)
Mutations in germline cells may not kill the germline cells immediately, but could have negative effects on an offspring generated from a germline cell carrying a mutation. (physicsforums.com)
Suggested for: Germline mutations are more harmful than mutations in somatic cells? (physicsforums.com)
Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. (nih.gov)
Patient Stratification from Somatic Mutations. (routledge.com)
Your cells undergo trillions of point mutations daily, most of which don't cause any changes. (healthline.com)
While iPSCs avoid the ethical issues surrounding embryonic stem cells, the methods used to derive them sometimes induce mutations in cancer causing genes, making them unsuitable for therapeutic purposes. (the-scientist.com)
PNH is caused by somatic mutations in PIGA (which encodes phosphatidylinositol N-acetylglucosaminyltransferase subunit A) in one or more HSC clones. (medscape.com)
Clinical manifestations of PNH occur when a HSC clone carrying somatic PIGA mutations acquires a growth advantage and differentiates, generating mature blood cells that are deficient of GPI-anchored proteins. (medscape.com)

However, whether and how other sirtuins, especially nuclear epigenetic regulator Sirt6, regulate mouse somatic reprogramming still remains exclusive. (biomedcentral.com)
hPSC-enriched essential genes mainly encode transcription factors and proteins related to cell-cycle and DNA-repair, revealing that a quarter of the nuclear factors are essential for normal growth. (nature.com)
Mouse nuclear transfer embryonic stem cells (NT-ESCs) were first established in 2000, and then proved to be able to differentiate either in vivo or in vitro, and give rise to individual tissues through germ line transmission or tetraploid complementation. (benthamscience.com)
Scientists have isolated the first human embryonic stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various ages, suffering from disease or spinal cord injury. (scienceblog.com)
Each of the 11 new human embryonic stem cell lines was created by transferring the nuclear genetic material from a non-reproductive cell of a patient into a donated egg, or "oocyte," whose nucleus had been removed. (scienceblog.com)
Currently, the procedure for isolating non-reproductive cells for the nuclear transfer method involves animal enzymes and serum. (scienceblog.com)
From the 185 donated oocytes, endowed with the genetic material from a different person (or in one case, the same person), the researchers report development of 31 hollow balls of cells called "human nuclear-transfer blastocysts. (scienceblog.com)
From the 31 nuclear-transfer blastocysts, the scientists derived 11 stem cell lines. (scienceblog.com)
The single cell line generated in the 2004 Science paper resulted from nuclear transfer in which the oocyte and non-reproductive ("somatic") cell came from the same healthy female. (scienceblog.com)
The ten additional new lines resulted from nuclear transfer with skin cells of males or females and oocytes from biologically-unrelated females. (scienceblog.com)
A breakthrough in somatic cell nuclear transfer opens the possibility of producing human embryonic stem cells with a patient's own genes. (the-scientist.com)
The first pluripotent human embryonic stem cells (hESCs) have been generated from somatic cell nuclear transfer, according to a study published today (October 5) in Nature . (the-scientist.com)
The advance here is the proof that somatic cell nuclear transfer can work [in human cells] and can fully reset the donor cell genome to a pluripotent state," said Harvard Medical School's George Daley , who was not affiliated with the study. (the-scientist.com)
Somatic cell nuclear transfer typically involves the transfer of genomic information from a somatic cell into an unfertilized egg cell whose nucleus has been removed. (the-scientist.com)
Somatic cell nuclear transfer has shown limited success in animal studies, which have successfully isolated pluripotent cells. (the-scientist.com)
In humans, somatic transfer has been less fruitful-the egg cell quits dividing and often dies after nuclear transfer. (the-scientist.com)
Instead of removing the egg genome prior to nuclear transfer, he and his colleagues added the somatic cell nucleus directly to the intact egg. (the-scientist.com)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)

Moreover, for genes that are expressed in multiple tissues or at multiple stages of development, the use of tissue-specific expression of the Cre recombinase allows gene function to be perturbed in specific cell types and/or at specific times. (elifesciences.org)
There appear to be defects in the stem cells in all the tissues that we tested, including the brain," said Michael Clarke, MD, Stanford's Karel H. and Avice N. Beekhuis Professor in Cancer Biology. (sciencedaily.com)
In the somatic tissues, the stem cells expressed telomerase-associated RNA, but no proliferation activity. (nih.gov)
Depending on the source, stem cells can be classified into two broad categories i.e. embryonic stem cells that are derived from embryos and non-embryonic stem cells that are derived from adult and fetal tissues. (benthamscience.com)
They may instead be fusing with existing cells, creating genetically mixed-up tissues with unknown health effects" [1]. (i-sis.org.uk)
Telomere shortening in somatic tissues largely reflects stem cell replication. (columbia.edu)
We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate. (columbia.edu)
Their team focuses on using human induced pluripotent stem cells to grow human tissues inside pigs. (the-scientist.com)
This can range from the relatively pedestrian, such as a person who received a bone marrow transplant, to creatures that seem more at home in science fiction, such as animals containing cells or tissues belonging to other species. (the-scientist.com)
Moreover, the field is only inching forward scientifically as it is proving very hard to harness cells meant to create differentiated tissues in gestating embryos and fetuses. (nationalrighttolifenews.org)
The key functions of adult stem cells are to maintain and repair the specific tissues where they reside (e.g. skin or blood). (bvsalud.org)
Many studies have shown the utility of embryonic or adult stem cells for forming teeth and for regeneration of bone and soft tissues. (bvsalud.org)
Adult stem cells are classified as pluripotent and are undifferentiated cells that remain quiescent in tissues until stimulated, when they can create cell types that are compatible with the tissue in which they reside. (bvsalud.org)
Additionally, they can form specialized cell types from other tissues if they are transplanted 6 . (bvsalud.org)
Stromal cells are a mixed population that can create bone, cartilage and fat and also fibrous and connective tissues. (bvsalud.org)

if a germline cell have a mutation that mutation will end up in the cells of the baby and at least one type of the baby's cells will express the mutated gene and the mutation can have an impact on the baby. (physicsforums.com)
Generally, yes, because, as you said, a mutation in the germline would be passed on to every cell in the offspring. (physicsforums.com)
So a mutation that degrades ATP production would harm only a single somatic cell, whereas in germline cells it can cause systemic, chronic, and potentially lethal birth defects in offspring. (physicsforums.com)
Wutz, A. Haploid mouse embryonic stem cells: rapid genetic screening and germline transmission. (nature.com)
We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. (ncl.ac.uk)

So when a somatic cell get a mutation on a gene it doesn't use can it have an impact on the cell? (physicsforums.com)
So a mutation on germ cell have more chance of causing harm to the baby than the chance of the same mutation on somatic cell (that doesn't express the mutated gene) to cause harm to a person? (physicsforums.com)
During the process, gene expression and epigenetic status were converted from somatic to ES-equivalent status. (ewha.ac.kr)
We identified both gene and protein markers for three temporally distinct ProSG cell subsets, including a migratory cell population with a transcriptome distinct from the previously defined T1- and T2-ProSG stages. (biologists.com)
The defects in stem cell growth and self-renewal observed by the researchers can be alleviated by reducing the expression of just one gene on chromosome 21, they found. (sciencedaily.com)
The fact that people with Down syndrome have three copies of chromosome 21 and the Usp16 gene "accelerates the rate at which stem cells are used during early development, which likely exhausts stem cell pools and impairs tissue regeneration in adults with Down syndrome. (sciencedaily.com)
This gene is clearly regulating processes that are central to aging in mice and humans," said Clarke, "and stem cells are severely compromised. (sciencedaily.com)
A 2017 study showed that as many as two-thirds of cancers occurred due to random gene changes during cell replication. (healthline.com)
If a mutation causes a tumor suppression gene to turn off, it can no longer control cell growth. (healthline.com)
As scientific understanding of stem cells, gene editing, and organism development improved, Garry felt that her career path was clear. (the-scientist.com)
In people with PNH, variants of the PIGA gene occur during a person's lifetime and are present only in certain cells. (medlineplus.gov)
However, for the condition to occur, they need to also acquire a somatic variant that deletes the other copy of the PIGT gene and other genes around it. (medlineplus.gov)
PNH occurs when a somatic variant of the PIGA gene or PIGT gene occurs in a blood-forming cell called a hematopoietic stem cell. (medlineplus.gov)
Induced pluripotent stem (iPS) cells have great potential for regenerative medicine and gene therapy. (stemcell.com)
Somatic cell gene therapy is being evaluated as well. (msdmanuals.com)
First, we looked at LIN28B, a gene recognized as the master regulator of fetal blood cell formation. (lu.se)

The process involves sucking out the nucleus of a somatic (body) cell and injecting it into an oocyte that has had its nucleus removed Using an approach based on the protocol outlined by Tachibana et al. (wikipedia.org)
This can be finished in few hours43,44 and can be required for the decondensation of chromatin and reactivation of the pluripotency genetics April4 and SOX2 in human being and mouse cells.45 Importantly, the same alternative occurs after normal fertilization fertilization (IVF),49 recommending its role in facilitating reprogramming of somatic nucleus. (mindunwindart.com)
The long term goal for this experiment was to do cell fusion in a way that would allow the elimination of the embryonic stem cell nucleus to create an embryonic stem cell from the somatic cell," said Melton. (news-medical.net)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)

Some types of mature, specialized adult cells can naturally revert to stem cells. (wikipedia.org)
The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells. (news-medical.net)
Our assays showed that the hybrid cells, unlike adult cells, showed the development potential of embryonic stem cells," said Eggan. (news-medical.net)
Furthermore, Eggan noted that genetic analyses of the fused cells revealed that the somatic cell genes characteristic of adult cells had all been switched off, while those characteristic of embryonic cells had been switched on. (news-medical.net)
The finding that adult cells can fuse with ES cells is therefore irrelevant to the debate, and the fact that it was used in an attempt to discredit adult stem cells is itself revealing, particularly in view of other recent findings on ES cells. (i-sis.org.uk)
They found that the spontaneous mutation frequency in ES cells is 100-fold lower than that in mouse embryonic fibroblasts (a somatic cell line), which is similar to adult cells in vivo . (i-sis.org.uk)

Neither the title of the paper, nor the abstract mentioned that in the experiment, five out of 25 rats receiving the transplant died with "teratoma-like tumors" in their brains, a well-known hazard of ES cells. (i-sis.org.uk)
article{4b5db5d0-c1b6-463c-9ca2-f61b01429744, abstract = {{Cellular reprogramming is a new and rapidly emerging field in which somatic cells can be turned into pluripotent stem cells or other somatic cell types simply by the expression of specific combinations of genes. (lu.se)

We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)
Telomerase, an enzyme associated with cellular immortality, is expressed by malignant tumor and stem cells, especially germ cells. (nih.gov)
By experimenting on germ cells, cytologist Nettie Maria Stevens collected evidence to support the connection between heredity and the sex of offspring. (asu.edu)

Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. (biomedcentral.com)
Particularly, by performing transcriptome analysis, we observed that several pluripotent transcriptional factors increase in knockout cell line, which explains the underlying loss of pluripotency in Sirt6-null iPS-like cell line. (biomedcentral.com)
Differentiated somatic cells can be reprogrammed into a pluripotent-like state through four defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc (OSKM) [ 1 , 2 ]. (biomedcentral.com)
They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
The stem cell field witnessed a genuine breakthrough when a combination of solely four transcription factors ( Oct3 / 4 , Sox2 , Klf4 and c-Myc, OSKM ) proved enough to revert, in vitro, the differentiated status of a variety of cell types back to pluripotency, giving rise to so-called induced pluripotent stem (iPS) cells. (springer.com)
Automatically expanded hiPSCs exhibit normal growth characteristics, and show sustained expression of the pluripotency associated stem cell marker TRA-1-60 over at least 5 weeks (10 passages). (frontiersin.org)

After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
In the malignant tumor, deregulation of telomerase is thought to facilitate tumorigenesis and cellular immortality by providing cancer cells unlimited proliferation capacity. (nih.gov)
When the proliferation activity of the stem cells increased, however, the telomerase-associated expressions decreased. (nih.gov)
These cells are classified as totipotent and they can form any of the tissue types found in the adult body, in addition to having unlimited proliferation potential 6 . (bvsalud.org)

Genetic analysis with human--mouse somatic cell hybrids. (ox.ac.uk)
However, during the generation process of induced pluripotent stem (iPS) cells, genetic manipulation of certain factors may cause tumorigenicity, which limits further application. (ewha.ac.kr)
Genetic modification and screening in rat using haploid embryonic stem cells. (nature.com)
To understand further the genetic factors influencing red blood cells, we carried out a genome-wide association study of haemoglobin concentration and related parameters in up to 135,367 individuals. (natureasia.com)
Stem cells also provide a model system in which researchers can study the causes of genetic disease and the basis of embryonic development. (news-medical.net)
Eggan, Melton and their colleagues decided to pursue their alternative route after other researchers had shown that genetic reprogramming can occur when mouse somatic cells are fused to mouse embryonic stem cells. (news-medical.net)
The researchers demonstrated that they had achieved fusion of the two cell types by searching the fused cells for two distinctive genetic markers present in the somatic fibroblast and stem cells. (news-medical.net)
In their new paper, Science author Woo Suk Hwang from Seoul National University in Seoul, Korea and colleagues replaced the nuclei from donated oocytes with nuclei from skin cells from male and female patients, ranging in age from 2 to 56, who had spinal cord injuries, juvenile diabetes and the genetic disease "congenital hypogamma-globulinemia. (scienceblog.com)
The findings validate this controversial method, and may one day allow therapeutic stem cells to be created from a patient's own genetic material. (the-scientist.com)
Noggle said the findings may also pave the way for better induced pluripotent stem cells (iPSCs), which form when somatic cells are regressed to a pluripotent state through the use of genetic factors. (the-scientist.com)
While human induced pluripotent stem cells (hiPSCs) provide novel prospects for disease-modeling, the high phenotypic variability seen across different lines demands usage of large hiPSC cohorts to decipher the impact of individual genetic variants. (frontiersin.org)
Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)
Olariu V, Manesso E, commitment and Peterson C. 2017 A deterministic method for estimating free energy genetic network reprogramming paths landscapes with applications to cell commitment and reprogramming paths. (lu.se)
The common denominator in the disease, a biochemical defect, appears to be a genetic mutation leading to the inability to synthesize the glycosyl-phosphatidylinositol (GPI) anchor that binds these proteins to cell membranes. (medscape.com)

Induced stem cells (iSC) are stem cells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming. (wikipedia.org)
Here, we developed CellAgeClock, a new epigenetic clock that measures subtle ageing changes in primary human cells in vitro . (biorxiv.org)
The CellAgeClock outperforms other epigenetic clocks in measuring subtle ageing changes in primary human cells in culture. (biorxiv.org)

In this study, we provide evidence that Sirt6 is involved in mouse somatic reprogramming. (biomedcentral.com)
Since the discovery of induced pluripotent stem (iPS) cells, the molecular mechanism underlying the reprogramming process has been an active area of research. (biomedcentral.com)
And later both our group and others reported that Sirt1 can promote the efficiency of reprogramming and maintain characteristics of iPS cell [ 15 , 16 , 17 ]. (biomedcentral.com)
In this study, we sought to determine the role of Sirt6 in mouse somatic reprogramming. (biomedcentral.com)
We found that Sirt6 is highly expressed in pluripotent stem cells and also it regulates the efficiency of somatic reprogramming. (biomedcentral.com)
In the field of induced potency and fate reprogramming, it remains unclear what the best starting cell might be and to what extent a cell need be transported back to a more primitive state for translational purposes. (nih.gov)
Reprogramming a committed cell back to pluripotence to then instruct it toward a particular specialized cell type is demanding and may increase risks of neoplasia and undesired cell types. (nih.gov)
phosphorylation of multiple histone L3 in interphase cells and acetylation of Lys-14 in histone L3 activated by NPM are related with chromosome decondensation.11 Meanwhile, many researchers present that some elements included in an influence be had by the histone modifications in these reprogramming systems. (mindunwindart.com)
The concept of reprogramming of somatic cells has opened a new era in regenerative medicine. (ewha.ac.kr)
We report that that a single transfer of embryonic stem (ES) cell-derived proteins into primarily cultured adult mouse fibroblasts, rather than repeated transfer or prolonged exposure to materials, can achieve full reprogramming up to the pluripotent state without the forced expression of ectopic transgenes. (ewha.ac.kr)
We verified that protein-based reprogramming was neither by the contamination of protein donor ES cell nor by DNA/RNA from donor ES cell. (ewha.ac.kr)
Our results provide an alternative and safe strategy for the reprogramming of somatic cells that can be used to facilitate pluripotent stem cell-based cell therapy. (ewha.ac.kr)
Induced pluripotent stem cells, another types of pluripotent stem cells derived from any tissue by reprogramming and are the homologous source of stem cells. (benthamscience.com)
Thus, a much higher grade of parallelization, and throughput in the production of hiPSCs is needed, which can only be achieved by implementing automated solutions for cell reprogramming, and hiPSC expansion. (frontiersin.org)
We have developed a feeder-free, Sendai virus-mediated reprogramming protocol suitable for cell culture processing via a robotic liquid handling unit that delivers footprint-free hiPSCs within 3 weeks with state-of-the-art efficiencies. (frontiersin.org)
those of cell reprogramming, thereby avoiding exhaustive trial- energy landscape, deterministic models, and-error simulations with rate equations for different stem cell commitment, reprogramming parameter sets. (lu.se)
We explore the method on three circuits for haematopoiesis and embryonic stem cell development for commitment and reprogramming scenarios and illustrate how the method can be used to determine sequential steps for onsets of external factors, essential for efficient reprogramming. (lu.se)
Cellular reprogramming is a new and rapidly emerging field in which somatic cells can be turned into pluripotent stem cells or other somatic cell types simply by the expression of specific combinations of genes. (lu.se)
Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)

Systems Biology Approach to Study Heterogeneity and Cell Communication Networks in the Tumour Microenvironment. (routledge.com)
The study of biology of stem cells is the hallmark of the recent emerging field of regenerative medicine and medical biotechnology. (benthamscience.com)
Based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in research on the control and regulation of stem cells. (cshlpress.com)
The REPLI-g Cell WGA & WTA Kit is intended for molecular biology applications. (qiagen.com)

It is possible, with informed consent from the IVF patient, to hold back some unfertilized eggs for creation of parthenogenetic stem cells, all at no additional risk to the donor. (intlstemcell.com)
Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders. (the-scientist.com)
Clinical outcomes of HLA-DPB1 mismatches in 10/10 HLA-matched unrelated donor-recipient pairs undergoing allogeneic stem cell transplant. (cdc.gov)

Precursor/progenitor cells from the organ of therapeutic concern typically lack only one critical attribute--the capacity for sustained self-renewal. (nih.gov)
We have used patient-derived, typically resistant, glioma stem-like cells (GSCs) in combination with the previously validated preclinical Inovitro™ TTFields system together with a number of therapeutic DDRi. (nature.com)
Kuldip S. Sidhu , " Frontiers in Pluripotent Stem Cells Research and Therapeutic Potentials Bench-to-Bedside ", Bentham Science Publishers (2012). (benthamscience.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
One of the next preclinical steps, according to the authors, is to evaluate, in the lab, differentiated patient-specific human embryonic stem cell lines for immune-system tolerance, therapeutic efficacy and safety. (scienceblog.com)
In the best case, an early embryo consisting of a few cells may form, but these are not capable of giving rise to human life, nor hESCs for therapeutic purposes. (the-scientist.com)
The triploid cells aren't suitable for therapeutic purposes, and future efforts will be focused on trying to eliminate the [egg cell] genome," said Daley, who wrote an accompanying News & Views in Nature . (the-scientist.com)
Britain s House of Lords final approval of therapeutic human cloning and embryonic stem cells research has intensified the battle for ascendancy between adult and embryonic stem cells. (i-sis.org.uk)
The advent of the human induced pluripotent stem cells (hiPSCs) technology offers unprecedented opportunities for disease modeling, personalized medicine, and the development of new therapeutic interventions. (frontiersin.org)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)

can be the protein of the high flexibility group (HMG) mainly from the receiver cytoplasm that are integrated into the nuclei rather than the somatic nuclei protein.39,42 HMG protein such as the highly cellular oocyte-specific linker histone H1foo or its counterpart B4 in the oocyte are AZD-2461 manufacture integrated into somatic nuclei in place of the somatic H1. (mindunwindart.com)
The second type of displacement is normally the dietary supplement of somatic elements from the oocyte, such as heterochromatin proteins 1 (Horsepower1).50 Similarly, some chromatin remodelers in undifferentiated cells, including Chd110 and BAF (Brg1/Brm-associated factor) complex members Baf155 and Brg1,51,52 can accelerate the generation of iPSCs by promoting the opening of chromatin. (mindunwindart.com)
Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. (nature.com)
Oocyte donors and patients who donated non-reproductive cells were all unpaid volunteers. (scienceblog.com)
In a Science "Policy Forum" related to the team's latest findings, David Magnus and Mildred Cho from Stanford University in Palo Alto, CA discuss international oversight and ethical issues in oocyte donation, including the need to promote realistic expectations of the outcomes of stem cell research. (scienceblog.com)

Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. (nature.com)
A couple of studies show some success in generating early microscopic embryos, but this [study] is the first successful pluripotent stem cell line," said Daley. (the-scientist.com)
The hybrid cells carrying four sets of chromosomes (instead of the usual two) behaved as stem cells when injected into mouse embryos. (i-sis.org.uk)
Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. (springer.com)
Establishment in culture of pluripotential cells from mouse embryos. (springer.com)

They are classified as either totipotent (iTC), pluripotent (iPSC) or progenitor (multipotent - iMSC, also called an induced multipotent progenitor cell - iMPC) or unipotent - (iUSC) according to their developmental potential and degree of dedifferentiation. (wikipedia.org)

2017 . DOI : 10.1002/stem.2719. (epfl.ch)
2017 . DOI : 10.1016/j.stem.2017.07.004. (epfl.ch)

The work also moves scientists one step closer to the goal of transplanting healthy cells into humans to replace cells damaged by diseases such as Parkinson's and diabetes. (scienceblog.com)

The developmental capacity of nuclei taken from differentiating endoderm cells of Xenopus laevis. (springer.com)
The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. (springer.com)

One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
Studies of embryonic stem cells and adult stem cells are covered, along with research shedding light on the roles of these cells in regeneration and cancer. (cshlpress.com)
Stem cells are nonspecific cells with powerful self-regeneration properties and they are capable of organizing other cell types in the body. (bvsalud.org)

This strategy of inducing self-renewal might be applied to progenitors from other organs and may prove to be a safe, effective, efficient, and practical method for optimizing insights gained from the ability to reprogram cells. (nih.gov)
Regulatory microRNA sequences may stimulate self-renewal of these muscle cells. (natureasia.com)
Clarke's past research has focused on how normal stem cells and cancer stem cells regenerate themselves, and Adorno was searching for genes that could inhibit a specific molecular pathway involved in the self-renewal of these cells. (sciencedaily.com)
A stem cell is an undifferentiated unit with powerful self-renewal properties that is capable of organizing other cell types in the body. (bvsalud.org)
Stem cells are defined as undifferentiated cells that have precursor properties, are capable of forming many different cell types and have the property of unlimited self-renewal 5 . (bvsalud.org)

Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide loss-of-function library targeting 18,166 protein-coding genes to define the essential genes in hPSCs. (nature.com)
studies on cell cycle regulation and genome instability. (ncl.ac.uk)
The REPLI-g Cell WGA & WTA Kit uniquely enables uniform whole genome amplification (WGA) and whole transcriptome amplification (WTA) in parallel reactions, allowing direct correlation of the genome with the transcriptome from very small samples (25-1000 cells). (qiagen.com)
The REPLI-g Cell WGA & WTA Kit contains the novel REPLI-g SensiPhi DNA Polymerase, as well as an optimized set of buffers and reagents for parallel whole genome amplification (WGA) and whole transcriptome amplification (WTA) from 25-1000 cells, or equivalently small samples. (qiagen.com)

Finally, we demonstrate that CySCs secrete the Dilp-binding protein ImpL2, the Drosophila homolog of IGFBP7, into the stem cell niche, which blocks InR activation in CySCs. (ucl.ac.uk)
They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
Protein-iPS cells were biologically and functionally very similar to ES cells and differentiated into 3 germ layers in vitro. (ewha.ac.kr)
In the second report [3], mouse bone marrow cells marked with green fluorescent protein were found to fuse with ES cells in culture in the presence of the cytokine, interleukin-3, which is known to encourage cell fusion. (i-sis.org.uk)
Most type II PNH cells (total lack of GPI-linked protein) are due to a frame shift mutation occurring in the early hematopoietic progenitor cells, resulting in same mutation in all blood cell lines. (medscape.com)
We show that human and chimpanzee cells differentiate in a similar man¬ner and that the difference in interspecies protein abundance is higher than transcript-level differences, suggesting that post-transcriptional mechanisms play a role in the difference between human and chim¬panzee brain development. (lu.se)

These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)
The advent of iPSCs has opened up the possibility to graft patient-specific cells which most likely would circumvent the need for immunosuppression. (lu.se)

As a result, International Stem Cell will benefit from the development of either technology, but it is important that the public and the scientific community be fully aware of all alternatives in the field of regenerative medicine, not just the ones that capture public imagination at any particular time. (intlstemcell.com)
Stem cells are emerging as an important source of material for diseases in regenerative medicine. (benthamscience.com)
Induced pluripotent stem cell technology has attracted enormous interest for potential application in regenerative medicine. (ca.gov)
Stem cells and regenerative medicine - future perspectives. (springer.com)
Stem cells in regenerative medicine: introduction. (springer.com)

Viable offspring derived from fetal and adult mammalian cells. (springer.com)
Células madre de un tejido específico (también denominadas células madre somáticas) que aparecen durante el desarrollo fetal y permanecen en el cuerpo durante toda la vida. (bvsalud.org)
Tissue-specific stem cells (also known as Somatic Stem Cells) that appear during fetal development and remain in the body throughout life. (bvsalud.org)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)

Pluripotent teratocarcinoma-thymus somatic cell hybrids. (springer.com)

Heart muscle cells die en masse after injury, yet the adult mammalian heart retains little capacity to regenerate them. (natureasia.com)

For example, if the mutation changes the base pairs in such a way as to form a start codon, then the cell can accidentally translate and produce proteins from the wrong portion of the DNA molecule. (physicsforums.com)
The proteins produced from both genes are involved in a multistep process that connects particular proteins to the surface of cells. (medlineplus.gov)
These proteins are attached to the cell by a specialized molecule called GPI anchor and are known as GPI-anchored proteins. (medlineplus.gov)
Anchored proteins have a variety of roles, including sticking cells to one another, relaying signals into cells, and protecting cells from destruction. (medlineplus.gov)
This classification was abandoned because of the observation that surface proteins were missing not only in the RBC membrane but also in all blood cells, including the platelet and white cells. (medscape.com)
Due to its location on the X chromosome, and due to X inactivation in female somatic cells, only one mutation is required in either males or females to abolish the expression of GPI-linked proteins. (medscape.com)

2018 . DOI : 10.1016/j.cell.2018.01.028. (epfl.ch)
Hematology, transfusion and cell therapy 2018 7 40 (2): 136-142. (cdc.gov)

We speculated that this could be induced in a regulatable manner such that cells proliferate only in vitro and differentiate in vivo without the need for promoting pluripotence or specifying lineage identity. (nih.gov)
For example, the stem cells can differentiate into cells that display characteristics of skin and retina cells, muscle cell bundles, bone matrix cells and cells of the gastrointestinal and respiratory lining. (scienceblog.com)
Neither report cited a paper published last year in the journal Blood [4], where a group from the Stem Cell Institute, Department of Medicine, and Cancer Center, University of Minnesota Medical School, Minneapolis, reported the most comprehensive experiments proving that a single adult stem cell can differentiate into all cell types in culture. (i-sis.org.uk)
The cells could be made to differentiate into bone forming cells, cartilage forming cells, fat cells, skeletal muscle cells and endothelial cells. (i-sis.org.uk)
Human pluripotent stem cells, with their ability to proliferate indefinitely and to differentiate into virtually all cell types of the human body, provide a novel resource to study human development and to implement relevant disease models. (mdpi.com)
The key to these cells' utility is their ability to differentiate into many different cell types depending on the stimulus received and they have been used in treatments for diseases such as cancer and neural degeneration, in rehabilitation of tetraplegic and paraplegic patients and even in dentistry 1 . (bvsalud.org)
Hematopoietic stem cells are cells isolated from blood and bone marrow that can differentiate into a variety of different specialized cells and suffer apoptosis 1 . (bvsalud.org)

In the studies published in Science, the researchers combined human fibroblast cells with human embryonic stem cells in the presence of a detergent-like substance that caused the two cell types to fuse. (news-medical.net)
Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. (springer.com)

For underage donors of non-reproductive cells, both parents signed informed-consent agreements. (scienceblog.com)

Embryonic stem cell lines derived from human blastocysts. (springer.com)
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells' (2007), by Junying Yu et al. (asu.edu)
On 2 December 2007, Science published a report on creating human induced pluripotent stem (iPS) cells from human somatic cells: "Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. (asu.edu)

It is more likely that the new technique will see immediate use in helping to accelerate understanding of how embryonic cells "reprogram" somatic cells to an embryonic state. (news-medical.net)

In the end, the egg cell contained three sets of chromosomes-two from the diploid somatic cell, and one from the haploid egg. (the-scientist.com)

The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
And, since these cell types are derived from three different parts of the embryo, this really demonstrated the ability of these cells to give rise to a variety of different cell types. (news-medical.net)
Hwang and colleagues report that the cells are chromosomally normal, self-renewing and "pluripotent" - meaning they have the ability to form the three major types of cells in the early embryo that give rise to all other cells in the body. (scienceblog.com)
The fusion ultimately gives rise to a microscopic embryo, from which embryonic stem cells can theoretically be derived. (the-scientist.com)
The resulting clone developed into a microscopic embryo, which survived long enough for pluripotent stem cell lines to be derived. (the-scientist.com)
We think that the developmental cues that exist in the pig will help to guide the human cells inside the porcine embryo. (the-scientist.com)
Dr. Shinya Yamanaka of Japan and others have turned adult skin cells into human embryonic stem cells, without using an embryo. (nationalrighttolifenews.org)

A balance between elongation and trimming regulates telomere stability in stem cells. (sens.org)

The researchers also performed fusion experiments using pelvic bone cells as the somatic cells and a different human embryonic cell line, to demonstrate that their technique was not restricted to one adult cell type or embryonic cell line. (news-medical.net)

Using single-cell RNA sequencing (RNAseq), we studied the development of ProSG, their SG descendants and testicular somatic cells during the perinatal period in mice. (biologists.com)
Of the three main types of testicular cancer, nonseminomatous germ cell tumors (NSGCTs) are second only to seminomas in terms of frequency. (medscape.com)

In fact, by some estimates, as few as 100 parthenogenetic stem cell lines could provide immune-matched cells to over 50 percent of the world's population, and could accelerate disease therapies and treatments for severe chronic conditions, including diabetes, spinal cord injuries, liver diseases, blinding diseases such as macular degeneration, and neural diseases such as Parkinson's and Alzheimer's. (intlstemcell.com)
The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)

Cell Stem Cell 19 , 569-572 (2016). (nature.com)
2016 . DOI : 10.1016/j.stem.2015.09.019. (epfl.ch)

Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. (ca.gov)
To our knowledge, this is the first time that human iPS cells have been generated from somatic cells without exogenous Sox2 expression. (ca.gov)

In newts, muscle tissue is regenerated from specialized muscle cells that dedifferentiate and forget the type of cell they had been. (wikipedia.org)
The disparate functions of different cell types are coordinated by a wide array of mechanisms, including direct cell-cell contacts within a tissue, shared access to nutrient pools, and both local (paracrine) and longer-range trafficking of small molecule and peptide signals. (elifesciences.org)
Understanding how normal stem cells regenerate themselves could help to repair tissue and organ damage from disease, and understanding how cancer stem cells maintain themselves could help explain why they are unusually resistant to chemotherapy or radiation therapy -- often resulting in a patient's relapse after seemingly successful treatment. (sciencedaily.com)
Two reports appeared as advance online publications in the top British journal Nature , accompanied by a news report that begins, "The hyped ability of adult stem cells to sprout replacement tissue types is being called into question. (i-sis.org.uk)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)

Furthermore, neural progenitor cells (those self-renewing cellular factories responsible for the development and maintenance of many of the cell types in the brain) were less able to form balls of cells called neurospheres -- a laboratory test that reflects the number and robustness of nerve stem cells in a culture. (sciencedaily.com)

or movements in a free energy landscape such that lineage choices are paths between stable cell states. (lu.se)

These researchers pointed out that the spontaneous fusion rate (without interleukin-3) was extremely low, between 2-11 per million bone marrow cells, and is unlikely to account for all the findings with adult stem cells. (i-sis.org.uk)
Example: In Japan, scientists have discovered the chemical that induces bone marrow to produce healing cells. (nationalrighttolifenews.org)
The chemical which summons stem cells from bone marrow to the site of a wound has been discovered by scientists in the UK and Japan. (nationalrighttolifenews.org)
Scientists at Osaka University and King's College London gave mice bone marrow cells that glow green - which can be tracked while moving round the body. (nationalrighttolifenews.org)
Stem cells can be found in bone marrow and blood. (bvsalud.org)
Bone marrow appears to contain three stem cell populations: hematopoietic stem cells, stromal stem cells and endothelial precursor cells. (bvsalud.org)

For instance, multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant adult human stem cells that can self-renew. (wikipedia.org)
I am talking about human stem cells derived from a process called, "Parthenogenesis", developed and first announced in 2007 by a company called International Stem Cell Corporation, whose discoveries were first published in the peer reviewed journal, Cloning and Stem Cells, edited by the scientist who first created "Dolly", the first cloned animal. (intlstemcell.com)

Characteristics and risk of chronic graft-versus-host disease of liver in allogeneic hematopoietic stem cell transplant recipients. (cdc.gov)

The scientists knew that if their studies were successful, it would provide the research community with a new option for producing reprogrammed cells using embryonic stem cells, which are more plentiful and easier to obtain than unfertilized human eggs. (news-medical.net)
Other scientists, including Jun Wu, a stem cell biologist at the University of Texas Southwestern Medical Center, are also studying chimeras with the ultimate goal of one day being able to grow enough human organs to meet the enormous need for transplants, potentially saving hundreds of thousands of lives. (the-scientist.com)

Anatomy51

Organisms16

Diseases10

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes43

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science2

Named Groups1

Health Care1

Differentiation37

SCNT12

Expressed genes1

Transplantation13

Mutations14

Nuclear22

Tissues15

GERMLINE5

Gene16

Nucleus4

Adult cells6

Abstract2

Germ cells3

Pluripotency6

Proliferation4

Genetic14

Epigenetic3

Reprogramming20

Biology4

Donor3

Therapeutic10

Oocyte5

Embryos5

Progenitor cell1

20172

Humans1

Nuclei taken2

Regeneration3

SELF-RENEWAL5

Genome4

Protein6

IPSCs2

Regenerative5

Fetal4

Hybrids1

Mammalian1

Proteins6

20182

Differentiate7

Fibroblast2

Reproductive1

Lines derived3

Reprogram1

Diploid1

Embryo7

Regulates1

Embryonic cell line1

Testicular2

Therapies2

20162

SOX22

Tissue5

Neural progenitor1

Lineage1

Bone6

Human stem cells2

Allogeneic1

Scientists2