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  • funded embryonic stem-cel
  • In May 2005, the House of Representatives voted 238-194 to loosen the limitations on federally funded embryonic stem-cell research - by allowing government-funded research on surplus frozen embryos from in vitro fertilization clinics to be used for stem cell research with the permission of donors - despite Bush's promise to veto if passed. (wikipedia.org)
  • regenerative medicine
  • During the past years the field of regenerative medicine has been focusing on development of therapeutically useful cells from embryonic stem cells. (ung.si)
  • Another form of products where cells are directly involved is regenerative medicine and tissue engineering. (iberlibro.com)
  • The demonstration that fully differentiated cells can reverse their gene expression profile to that of a pluripotent cell, and the successful derivation and culture of human embryonic stem cells (ESCs) have fuelled hopes for applications in regenerative medicine. (bioscientifica.com)
  • I think Irving L. Weissman, MD, the Director of the Institute of Stem Cell Biology and Regenerative Medicine at Stanford University School of Medicine would be pretty well qualified to give an opinion on it. (rutgers.edu)
  • While there is much work to be done in developing safe and effective stem cell treatments, we believe this is a significant step forward in developing the cells that could be used in regenerative medicine. (myinfoline.com)
  • This allows embryonic stem cells to be employed as useful tools for both research and regenerative medicine, because they can produce limitless numbers of themselves for continued research or clinical use. (wikipedia.org)
  • Because of their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (wikipedia.org)
  • He is the founder and CEO of AgeX Therapeutics a startup focused on the field of interventional gerontology, and Co-CEO of its parent company, BioTime, Inc. (AMEX: BTX) of Alameda, California (San Francisco Bay Area), a biotechnology company regarded as a leader in the field of regenerative medicine with a focus on cell therapy. (wikipedia.org)
  • West organized the first collaborative effort to isolate human pluripotent (embryonic) stem cells for the purpose of manufacturing products in regenerative medicine in collaboration with James Thomson at the University of Wisconsin at Madison John Gearhart at Johns Hopkins School of Medicine and Roger Pedersen at the University of California, San Francisco. (wikipedia.org)
  • West has authored and co-edited books on topics such as animal cloning, aging, gerontology, stem cells, stem cell biology, and regenerative medicine. (wikipedia.org)
  • Pluripotent stem cells in regenerative medicine: challenges and recent progress. (wikipedia.org)
  • 1997
  • Gene, the first cloned calf in the world was born in 1997 at the American Breeders Service facilities in Deforest, Wisconsin, United States. (wikipedia.org)
  • derivation
  • While these cells hold a great potential, their ethicaly controversial derivation has revived research using adult stem cells. (ung.si)
  • This would allow for derivation of patient-specific, autologous cells for cell therapy. (ung.si)
  • However, the derivation of such cell types from ESs is not without obstacles and hence current research is focused on overcoming these barriers. (wikipedia.org)
  • 2000
  • In 2000, the NIH, under the administration of President Bill Clinton, issued "guidelines that allow federal funding of embryonic stem-cell research. (wikipedia.org)
  • Texas A&M University cloned a Black Angus bull named 86 Squared in 2000, after cells from his donor, Bull 86, had been frozen for 15 years. (wikipedia.org)
  • In 2000, Studer moved to New York City where he embarked on his own research program at Memorial-Sloan Kettering Cancer Center (MSKCC) with a focus on exploring stem cells and brain repair. (wikipedia.org)
  • sheep
  • Some in the press speculated that a contributing factor to Dolly's death was that she could have been born with a genetic age of six years, the same age as the sheep from which she was cloned. (wikipedia.org)
  • hESC
  • This second paper to produce so-called nuclear transfer hESC (NT-hESC) made the important advance to show that it could be done using adult and even old human somatic cells. (ipscell.com)
  • However, key challenges and concerns remain for human therapeutic cloning and for potential clinical application of NT-hESC. (ipscell.com)
  • If NT-hESC are only about the same as these other human pluripotent stem cells in terms of most key attributes then given the difficulty of making NT-hESC (even factoring in some anticipated improvements in technology) there would be little reason to make NT-hESC from a clinical perspective. (ipscell.com)
  • Human iPS cells were first reported in 2007 and thus have a 7-year head start on NT-hESC. (ipscell.com)
  • On the other hand, one might say that the regulatory and scientific hurdles cleared by both hESC-based products and human iPS cell products might pave the way for NT-hESC and speed their translation to the clinic. (ipscell.com)
  • When making iPS cells we start with proliferative somatic cells and can essentially use as many as we want (e.g. tens of millions), while in contrast when making NT-hESC each line must be derived using a separate human egg. (ipscell.com)
  • According to modern stem cell researchers, Spain is one of the leaders in stem cell research and currently has one of the most progressive legislations worldwide with respect to hESC research. (wikipedia.org)
  • In 1998, privately funded research led to the breakthrough discovery of human Embryonic stem cells (hESC). (wikipedia.org)
  • Based on meticulous mammalian study review, the researchers concluded that the rigorous procedures developed for mammalian reproduction held promise for practical application in human embryonic stem cell (hESC) line production. (wikipedia.org)
  • mesenchymal stem
  • I remember attending a luncheon for sponsors and speakers in which Weissman gave a talk attacking mesenchymal stem cells. (rutgers.edu)
  • He pointed out that there are no reliable markers for mesenchymal stem cells and that a majority of studies making claims about mesenchymal stem cells having beneficial effects on animals really did not document what cells they transplanted. (rutgers.edu)
  • He is right of course but this does not mean that mesenchymal stem cells do not exist and are not beneficial in certain conditions. (rutgers.edu)
  • totipotent
  • They are classified as either totipotent (iTC), pluripotent (iPSC) or progenitor (multipotent-iMSC, also called an induced multipotent progenitor cell-iMPC) or unipotent-(iUSC) according to their developmental potential and degree of dedifferentiation. (wikipedia.org)
  • In the strictest sense, this requires stem cells to be either totipotent or pluripotent-to be able to give rise to any mature cell type, although multipotent or unipotent progenitor cells are sometimes referred to as stem cells. (wikipedia.org)
  • Cells produced by the first few divisions of the fertilized egg are also totipotent. (wikipedia.org)
  • Technique
  • Dr Shoukhrat Mitalipov said: 'A thorough examination of the stem cells derived through this technique demonstrated their ability to convert just like normal embryonic stem cells, into several different cell types, including nerve cells, liver cells and heart cells. (myinfoline.com)
  • The technique takes the same sample of skin cells but converts them using proteins to 'induced pluripotent' stem cells. (myinfoline.com)
  • They are the first cloned primates produced by this technique. (wikipedia.org)
  • It is a technique for cloning in which the nucleus of a somatic cell is transferred to the cytoplasm of an enucleated egg. (wikipedia.org)
  • Garima-I, a buffalo calf cloned using an "Advanced Hand guided Cloning Technique" was born in 2009 at the NDRI. (wikipedia.org)
  • On 24 January 2018, two monkey clones were reported to have been created with the technique for the first time. (wikipedia.org)
  • Eggan's work as of 2007[update] has succeeded in developing a technique of merging stem and skin cells that has obtained considerable public attention as a possible avenue to avoid moral objections regarding stem cell research in the context of serious illness. (wikipedia.org)
  • Eggan's technique provides a window into exactly what happens to turn back the clock in cells during cloning--and, indeed, in the normal process of creating sperm, eggs and embryos. (wikipedia.org)
  • Prof. John Bertrand Gurdon used the same technique on the frog, Xenopus under Prof Michael Fischberg at Oxford and was later awarded the Noble Prize in 2012 for the discovery that mature cells can be reprogrammed to become pluripotent. (wikipedia.org)