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  • 2002
  • In 2002, a technique called handmade cloning was introduced, which is cheaper and simpler, without the need for micromanipulation and also works better. (i-sis.org.uk)
  • iPSCs
  • We also generated novel human iPSCs (hiPSCs) with "mouse ESC-like" characteristics, which can be surprisingly maintained in culture in the presence of MEK inhibitor and ALK5 inhibitor. (springer.com)
  • In 2006, the landscape of stem cell research changed when the creation of induced pluripotent stem cells (iPSCs) were first announced. (spusa.org)
  • With previous derivation of induced pluripotent stem cells (iPSCs) this problem has been overcome, however current perspectives regarding clinical translation of iPSCs still remain. (medsci.org)
  • Dolly
  • The first cloned animal Dolly the sheep was created in 1996 using expensive and time-consuming cell surgery with a micromanipulator. (i-sis.org.uk)
  • This technique is currently the basis for cloning animals (such as the famous Dolly the sheep ), and in theory could be used to clone humans. (bootstrike.com)
  • Researchers
  • Researchers have discovered that chemotherapy provides the perfect backdrop for 'sleeping' cancer to churn out deadly cancer stem cells. (stem-cells-news.com)
  • Researchers found that modifying blood stem cells to raise their levels of a T cell-blocking protein called PD-L1 reversed hyperglycemia in diabetic mice. (stem-cells-news.com)
  • The researchers extracted the egg cell from the ovary of the domestic cow and the skin cell from the skin of the gaur. (asu.edu)
  • In November 2007, Masato Nakagawa, along with a number of other researchers including Kazutoshi Takahashi, Keisuke Okita, and Shinya Yamanaka, published "Generation of Induced Pluripotent Stem Cells without Myc from Mouse and Human Fibroblasts" (abbreviated "Generation") in Nature. (asu.edu)
  • In 2000 ACT researchers in the United States cloned a gaur (Bos gaurus), an Asian ox with a then declining wild population. (asu.edu)
  • The researchers used cryopreserved gaur skin cells combined with an embryo of a domestic cow (Bos taurus). (asu.edu)
  • Around the world, researchers and politicians have struggled to develop guidelines that will allow for ethical and socially responsible stem cell research. (spusa.org)
  • In recent years, researchers have been exploring the potential of Induced Pluripotent Stem Cells (iPS cells) as possible substitutes or supplements to embryonic stem cells. (spusa.org)
  • At this time researchers are still uncertain of what clinical differences may exist between iPS cells and embryonic stem cells, meaning that, at this time, further research on both kinds of stem cells is necessary to fully understand the medical potential of these new discoveries. (spusa.org)
  • However, most researchers believe that in the foreseeable future it will not be possible to use this technique to produce a human clone that will develop to term. (bootstrike.com)
  • Stem cells have raised tremendous expectations among the medical doctors, researchers, patients, and the general public due to their capacity to differentiate into a broad range of cell types. (medsci.org)
  • Using wildtype or engineered stem cell lines, researchers may use this technique to uncover the various mechanisms or treatments that may affect early brain infection and resulting microcephaly in Zika virus-infected embryos. (jove.com)
  • scientists
  • But even he concedes that over time there could be pressure to change the law to allow the cloning of people and that scientists may still be pushing to do this. (newsweekly.com.au)
  • Cloning" is an umbrella term traditionally used by scientists to describe different processes for duplicating biological material. (nhmrc.gov.au)
  • The use of differentiated cells from human pluripotent cell lines would allow scientists to test new medications on a wider range of cell types. (spusa.org)
  • Although the possibility of cloning humans had been the subject of speculation for much of the 20th century, scientists and policy makers began to take the prospect seriously in the mid-1960s. (wikipedia.org)
  • Many nations outlawed it, while a few scientists promised to make a clone within the next few years. (wikipedia.org)
  • In the United States, scientists at the Harvard Stem Cell Institute,the University of California San Francisco, Stemagen (La Jolla, CA) and possibly Advanced Cell Technology are currently researching a technique to use somatic cell nuclear transfer to produce embryonic stem cells. (bootstrike.com)
  • This review offers stem cell scientists, clinicians and patient's useful information and could be used as a starting point for more in-depth analysis of ethical and safety issues related to clinical application of stem cells. (medsci.org)
  • Our hope is that stem cell scientists and clinicians will use the information presented herein as a starting point for more in-depth analysis of ethical and safety issues related to clinical translation of stem cells since controversial regulation and application of stem cell therapy has been falsely celebrated not only in countries with lax medical regulations but also in many developed countries. (medsci.org)
  • genome
  • Are there potential discriminatory implications that might result from the human genome project? (temple.edu)
  • Molecular
  • Molecular basis of the first cell fate determination in mouse embryogenesis. (biomedsearch.com)
  • Barwy Pasażowanie ludzkich embrionalnych komórek macierzystych linii Trypsyna Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard W tym filmie pokazujemy, jak w naszym laboratorium rutynowo fragmenty barwy linii ludzkich zarodkowych komórek macierzystych, z trypsyny. (jove.com)
  • Zamrażanie komórek ES człowieka Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Tutaj pokazujemy, jak w naszym laboratorium zawiesza barwy linii ludzkich zarodkowych komórek macierzystych. (jove.com)
  • Człowieka komórek ES: Kultura Od mrożone komórki Erin Trish 1 , John Dimos 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Tutaj pokazujemy, jak w naszym laboratorium rozpoczyna odcienie ludzkich zarodkowych komórek macierzystych kultury linii mrożonych ręki. (jove.com)
  • Transfer jądra do komórki jajowej myszy Dieter Egli 1 , Kevin Eggan 1 1 Department of Molecular and Cell Biology, Harvard Ten film i protokół mają pomóc nauki transfer jądra. (jove.com)
  • Dnmt1 Overexpression Causes Genomic Hypermethylation, Loss of Imprinting, and Embryonic Lethality Molecular and Cellular Biology. (jove.com)
  • destruction
  • In this article the author focuses on the court ruling which emphasized the preclusion of an embryonic stem cell research project from receiving federal fundings by the Dickey-Wicker Amendment if one step of the project results in the destruction of an embryo in the U.S. (ebscohost.com)
  • It is safe to say that, despite a host of other concerns about where science was leading us in the future, the ethical discourse over stem cell research for the past decade has been characterized predominantly by the debate over embryo destruction. (jci.org)
  • However, since the gold standard stem cells, embryonic stem cells, require the destruction of a human embryo, great controversy has arisen regarding the ethics of stem cell research. (spusa.org)
  • regulation
  • The definition proposed in this paper was subsequently adopted by the Australian Parliament in the Prohibition of Human Cloning for Reproduction and Regulation of Human Embryo Research Amendment Act 2006 to replace the previously used definition. (nhmrc.gov.au)
  • diseases
  • On the other hand proponents for change argue instead that embryos may have to be sacrificed for the sake of research which could lead to major breakthroughs in a host of diseases and ailments. (newsweekly.com.au)
  • Because stem cells have the potential to generate fresh, healthy cells of nearly any type, there is interest in exploring their use to treat and cure various diseases. (stem-cells-news.com)
  • An essay is presented on the delay of the progress of embryonic stem cell research for the treatment of various diseases due to debates regarding the use of human embryos in the research. (ebscohost.com)
  • The regulatory regimes of USA and EU based their false claim that the cloned animals are true clones on the baseless assumption that the mitochondrial genomes do not count when in fact the mitochondria play crucial roles in in a number of diseases of the nervous system, in cell suicide and in aging. (i-sis.org.uk)
  • In "Generation," the authors point to dedifferentiation of somatic cells as an avenue for generating pluripotent stem cells useful for treating specific patients and diseases. (asu.edu)
  • The generation of patient-specific embryonic stem cells would revolutionize our understanding of human diseases (1). (blogspot.com)
  • ethical
  • These ethical objections cannot be over-ridden by the claim that the embryo is entitled to a "special respect" but that this respect can be violated if there is sufficient benefit for others. (blogspot.com)
  • Nor can the ethical issues be side-stepped by calling the blastocyst a "pre-embryo. (blogspot.com)
  • From that point forward, hES cell research has been steeped in ethical controversy. (jci.org)
  • Against this background dystopian view of science, a pro-life ideology rapidly emerged as a main driving force behind stem cell ethical debate and policy. (jci.org)
  • By using this technique, we could establish pluripotent cell lines easily and circumvent ethical problems. (omicsonline.org)
  • These ethical concerns have prompted several nations to pass laws regarding human cloning and its legality. (wikipedia.org)
  • However, clinical application of stem cells raises numerous ethical and safety concerns. (medsci.org)