Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene. (wikipedia.org)
Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (t3db.ca)
Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1). (tcdb.org)
2] "Cloning and functional expression of a human liver organic cation transporter. (tcdb.org)
3] "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1). (tcdb.org)
7] "Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). (tcdb.org)
9] "Regulation of the human organic cation transporter hOCT1. (tcdb.org)
11] "Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1. (tcdb.org)
12] "The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha. (tcdb.org)
15] "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences. (tcdb.org)
16] "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. (tcdb.org)
17] "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions. (tcdb.org)
18] "Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1). (tcdb.org)
A polyspecific transporter for organic cations found primarily in the kidney. (nih.gov)
2013) Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology. (guidetopharmacology.org)
However, their relevance for investigations of drug-drug and drug-organic anion (e.g., bile acid, steroid hormone) interactions at the transporter level remains to be established. (cancerindex.org)
Pombrio JM, Giangreco A, Li L, Wempe MF, Anders MW, Sweet DH, Pritchard JB, Ballatori N. Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1. (ucdenver.edu)
1] "Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (tcdb.org)
This gene encodes a liver-specific member of the organic anion transporter family. (antibodypedia.com)
Reduced hepatic uptake of unconjugated bilirubin due to a mutation in the solute carrier organic anion transporter protein SLCO1B1. (medscape.com)
LOCUS BC034384 2545 bp mRNA linear HUM 09-JUN-2008 DEFINITION Homo sapiens solute carrier family 22 (organic anion/urate transporter), member 11, mRNA (cDNA clone MGC:34282 IMAGE:5190509), complete cds. (nig.ac.jp)
We selected two transmembrane metal transporters investigated in my laboratory (a primary active Cu(I) P-type ATPase pump, CopA, and a ferrous iron solute carrier-like transporter, IroT) as a proof of principle to showcase the potential generalizability of the approach. (nature.com)
Transporters14
1] "Cloning and characterization of two human polyspecific organic cation transporters. (tcdb.org)
8] "Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides. (tcdb.org)
13] "Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. (tcdb.org)
Therefore, uptake transporters, e.g., members of the organic anion transporting polypeptide (OATP) family are important determinants of drug pharmacokinetics. (aspetjournals.org)
The goal of this study is to investigate whether these dicationic drugs are substrates for human organic cation transporters (hOCTs, solute carrier family 22A1-3) and whether hOCTs play a role in their tissue distribution, elimination, and toxicity. (aspetjournals.org)
Organic cation transporters (OCT) are electrogenic, Na + -independent and reversible. (guidetopharmacology.org)
Corticosterone and quinine are able to inhibit all three organic cation transporters. (guidetopharmacology.org)
Koepsell H. (2013) The SLC22 family with transporters of organic cations, anions and zwitterions. (guidetopharmacology.org)
Koepsell H. (2020) Organic Cation Transporters in Health and Disease. (guidetopharmacology.org)
2014) SLC22, SLC44, and SLC47 transporters--organic anion and cation transporters: molecular and cellular properties. (guidetopharmacology.org)
4. Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H. (2002) Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. (guidetopharmacology.org)
Solute carrier organic anion (SLCO) transporters (OATP transporters) are involved in cellular uptake of drugs and hormones. (bvsalud.org)
The members of the MFS are secondary active, ion-coupled transporters of sugars, amino acids, drugs, nucleosides as well as organic and inorganic cations and anions (13). (kentlandsinitiative.org)
OATP1
The disposition of digoxin and the influence of the organic anion transporting polypeptide (Oatp)2 inhibitor rifampicin and the P-glycoprotein (P-gp) inhibitor quinidine on its hepatic disposition were examined in the isolated perfused rat liver. (aspetjournals.org)
The SLC (solute carrier) family transport a wide range of different solutes across biological membranes using diverse energy coupling mechanisms 1 . (cyprotex.com)
Membrane Proteins1
In addition, to mimic the native lipid bilayer environment and generate a barrier that separates milieus of different solute compositions, membrane proteins can be reconstituted in artificial lipid bilayer vesicles of controlled size, called proteoliposomes, which allow investigating molecular processes like cargo translocation and generation of electrochemical gradients across the bilayer. (nature.com)
Superfamily1
The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). (guidetopharmacology.org)
Anion Transport Protein3
Organic Anion Transport Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
This graph shows the total number of publications written about "Organic Anion Transport Protein 1" by people in this website by year, and whether "Organic Anion Transport Protein 1" was a major or minor topic of these publications. (ucdenver.edu)
Below are the most recent publications written about "Organic Anion Transport Protein 1" by people in Profiles. (ucdenver.edu)
Translocation1
Mitochondrial carriers catalyse the translocation of numerous metabolites across the inner mitochondrial membrane, playing a key role in different cell functions. (cancerindex.org)
Anions2
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. (t3db.ca)
Loss of glomerular function (associated with decreased glomerular filtration rate [GRF]) results in the retention of many end products of metabolism, including the anions of various organic and inorganic acids and urea. (medscape.com)
Polypeptides1
2001). "Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver" (PDF). (wikipedia.org)
Olmesartan, also known as DE-092, belongs to the class of organic compounds known as biphenyls and derivatives. (hmdb.ca)
These are organic compounds containing to benzene rings linked together by a C-C bond. (hmdb.ca)
This compound belongs to the class of organic compounds known as monoalkylamines. (drugbank.com)
These are organic compounds containing an primary aliphatic amine group. (drugbank.com)
Metabolites1
A key physiological role for OAT1/3 is the transport of over 35 uremic toxins and solutes, with varying preferences, including the gut-derived metabolites indole-3-acetic acid, 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) and phenylsulfate [9, 10]. (solvobiotech.com)
Plasma membrane1
CLN7 belongs to a group of atypical solute carriers of MFS type which are located at the plasma membrane and/or in intracellular compartments (14). (kentlandsinitiative.org)
Mediates1
It mediates the coupled exchange of alpha-ketoglutarate with organic ions such as P-AMINOHIPPURIC ACID . (nih.gov)
Exchange1
NMR, water molecules can be monitored selectively in systems of arbitrary complexity and the single-molecule rotational correlation time t can be accurately determined from spin relaxation experiments.7 Provided that solute-water hydrogen exchange is not an issue, 2H NMR can be used in the same way. (lu.se)
Energy1
Liquid water has an exceptionally high cohe- sive energy density which tends to minimize the effect of solutes on its H-bonded network structure. (lu.se)
Cation1
From NCBI Gene: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. (nih.gov)
Protein1
The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. (medlineplus.gov)
Uptake2
2001). "Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver" (PDF). (wikipedia.org)
It is generally accepted that rOatps, such as rOatp1 ( Oatp1a1 ), rOatp2 ( Oatp1a4 ), and rOatp4 ( Oatp1b2 ), play major roles in the hepatic uptake of amphipathic organic anions and certain types of cationic compounds in the rat liver. (aspetjournals.org)
Anion-transporting1
The hepatic organic anion transporting polypeptides (OATPs) influence the pharmacokinetics of several drug classes and are involved in many clinical drug-drug interactions. (nih.gov)
Polypeptide1
Organic Anion Transporting Polypeptide 2B1 in Human Fetal Membranes: A Novel Gatekeeper for Drug Transport During Pregnancy? (tamu.edu)
Sodium-dependent1
These carriers maintain the enterohepatic circulation of bile acids by sodium-dependent bile acid reabsorption in the gut via ASBT and sodium-dependent bile acid transport into hepatocytes via NTCP [ 2 ]. (biomedcentral.com)
Mitochondrial4
2. The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. (nih.gov)
3. A key role of the mitochondrial citrate carrier (SLC25A1) in TNFα- and IFNγ-triggered inflammation. (nih.gov)
5. The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond. (nih.gov)
8. The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe Hypoxia. (nih.gov)
Proteins1
27/09/2023 - Abstract Carrier proteins that provide an effective and long-term immune response to weak antigens has become a real breakthrough in the disease prevention, making it. (softvt.com)
Liver1
These carriers maintain the enterohepatic circulation of bile acids between the liver and the gut. (biomedcentral.com)