• Solute carrier family 16 member 12 is a protein that in humans is encoded by the SLC16A12 gene. (wikipedia.org)
  • Consistently down-regulated genes included were bone morphogenetic phosphatase kinase (BMP2K), solute carrier family 12, member 1 (SLC12A1), solute carrier family 7 (SLC7A2), paternally expressed 10 (PEG10) and protein phosphatase 1 regulatory (inhibitor unit) (PPP1R1C). (nih.gov)
  • DnaJ heat shock protein family (Hsp. (gsea-msigdb.org)
  • guanylate binding protein family me. (gsea-msigdb.org)
  • Functionally, barrier loss was linked to the adenosine 3',5'-cyclic monophosphate (cAMP)/protein kinase A-cAMP response element-binding protein signaling pathway. (bvsalud.org)
  • The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
  • While the entire Slc gene family is typically involved with the uptake of small molecules into cells, there are 52 sub-families reported and the specificity of what each protein can transport varies widely, even within sub-families. (prohealth.com)
  • The etiopathogenesis of the zinc deficiency occurs as a result of loss-of-function mutations of the zinc-ligand binding protein ZIP4 encoded by the SLC39A4 ( solute carrier 39A) gene located on band 8q24.3. (medscape.com)
  • ZIP4 is a member of the Zrt-/Irt-like protein (ZIP) family, and it is a histidine-rich transmembrane protein that is specifically expressed on the apical side of enterocytes in the small intestine, as well as in the kidney, and is responsible for zinc absorption. (medscape.com)
  • Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
  • The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)
  • Thirty-seven significantly up-regulated genes and 40 down-regulated genes were commonly expressed in all 3 groups of patients with worsening of renal functions. (nih.gov)
  • Up-regulated genes included major histocompatibility complex (HLA-C), complement component 3a receptor 1 (C3AR1), solute carrier family 16, member 3 (SLC16A3) and solute carrier family 9 (sodium/hydrogen exchanger) (SLC9A8). (nih.gov)
  • Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
  • 3] "Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (tcdb.org)
  • Dicarboxylate carriers (DIC) and voltage-dependent anion channels (VDAC) control succinate release from mitochondria to cytosol. (haematologica.org)
  • 1 Similarly, succinate may derive from the γ-aminobutyric acid shunt pathway that correlates with levels of expression of the γ-aminobutyric acid transporters solute carrier family 6 members 12 and 13 (SLC6A12, SLC6A13). (haematologica.org)
  • Acrodermatitis enteropathica is an autosomal recessive disorder occurring as a result of mutations in the SLC39A4 ( solute carrier family 39 member A4) gene located on band 8q24.3. (medscape.com)
  • Rattus norvegicus solute carrier family 4 member 11 (Slc4a11), mRNA. (genscript.com)
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • The epidemiology of OA is very complex due to various factors such as genetic and biomechanical components [ 3 ], and the molecular mechanisms underlying OA are still not completely understood. (biomedcentral.com)
  • Genetic counseling is recommended for family members of parents with the congenital form of acrodermatitis enteropathica. (medscape.com)
  • Families with confirmed Pelizaeus-Merzbacher disease must be referred to a geneticist or neurogeneticist for education about the disease and, especially, for genetic counseling. (medscape.com)
  • It is caused by a point mutation (G→T) at nucleotide position 559 of the gene, bovine solute carrier family 35 member 3 (SLC35A3). (researchgate.net)
  • Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1). (tcdb.org)
  • 3] "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1). (tcdb.org)
  • 12] "The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha. (tcdb.org)
  • Elevated levels of solute carrier family 14 member 1 expression induced mitochondrial reactive oxygen species accumulation, diminished the intracellular adenosine triphosphate level, and destroyed both mitochondrial membrane potential integrity and mitochondrial morphology. (biomedcentral.com)
  • We evaluated muscle mitochondrial function and associated transcriptional profiles in nonobese humans after 12 months of CR. (medscape.com)
  • [ 12 ] The activity of key mitochondrial enzymes of the tricarboxylic acid cycle, β-oxidation, and the electron transport system, conversely, were unchanged, [ 12 ] leaving many unanswered questions regarding the effects of CR on muscle-specific mitochondrial function in humans. (medscape.com)
  • We conducted an ancillary study to the CALERIE 2 randomized controlled trial to examine the effects of 12 months of 25% CR on in vivo skeletal muscle mitochondrial energetics, mitochondrial content, and markers of oxidative stress. (medscape.com)
  • cytohesin 3 [Source:HGNC Symbol;Acc. (gsea-msigdb.org)
  • The nomenclature system begins with the root symbol Slc, followed by a number that indicates the family, then by a letter designating the sub-family (however, only 'a' is used when the family has not been subdivided), and lastly another number that defines the individual transporter gene. (prohealth.com)
  • However, it is surprising that no phenotypic effects were observed in the carrier bull, necessitating further studies to fully elucidate the effects of these novel homozygous mutations. (researchgate.net)
  • Transient receptor potential channel melastatin subtype 6 (TRPM6) was detected by immunohistochemistry in paraffin-embedded renal biopsy sections of 12 GS patients. (nih.gov)
  • The results elucidate a mechanism wherein the solute carrier family 14 member 1 gene participates in the occurrence and development of hypoxia-induced renal cell carcinoma in a mitochondria-dependent manner. (biomedcentral.com)
  • There are three main histological subtypes of RCC, including clear cell RCC (ccRCC), papillary RCC, and chromophobe RCC, which jointly represent over 85% of all primary renal malignancies [ 3 ]. (biomedcentral.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Solute Carrier Family 1, Member 5 (SLC1A5) in Tissue homogenates, cell lysates and other biological fluids. (glideruniversity.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Solute Carrier Family 1, Member 5 (SLC1A5) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (glideruniversity.org)
  • Description: A sandwich ELISA kit for detection of Solute Carrier Family 1, Member 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (glideruniversity.org)
  • Hypoxia was found to induce A498 cell invasion, migration, and the release of inflammatory cytokines, while repressing human solute carrier family 14 member 1 gene expression. (biomedcentral.com)
  • Human immunology 2004 Dec 65 (12): 1437-42. (cdc.gov)
  • Solute carrier family 11 member A1 gene polymorphisms in reactive arthritis. (cdc.gov)
  • 3 2 Under physiological hypoxia, low oxygen levels lead to reduced activity of succinate dehydrogenase (SDH), which metabolizes succinate, and other oxygen-dependent enzymes in the electron transport chain, causing succinate accumulation. (haematologica.org)
  • 6 3 In fact, one of the first pieces of evidence for a role of succinate in cancer development was provided by the discovery of pseudohypoxia, which refers to activation of hypoxia signaling pathways under normal oxygen levels. (haematologica.org)
  • Overexpression of the solute carrier family 14 member 1 gene could abolish hypoxia-induced invasion, reduce the migration of A498 cells, inhibit the hypoxia-induced release of inflammatory cytokines, and arrest the cell cycle at the G1/S checkpoint. (biomedcentral.com)
  • Statistical tools are required to analyze the large and hybridized as described previously (3, 10, 11) and according to standard amount of expression data generated by this methodology. (lu.se)
  • 14] "The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells. (tcdb.org)
  • Gene expression profile of GSE105027, including 12 OA serum samples (OA group) and 12 healthy serum samples (ctrl group), was downloaded. (biomedcentral.com)
  • Alterations in other a lot more than 18 lysine residues distributed amongst a minimum of four different subtypes of histones, i. e, histone 2A, 2B, 3 and 4, may well arise, but weren't examined. (mirnaarray.com)
  • Transports dehydroepiandrosterone sulfate, estrone-3-sulfate, and pregnenolone sulfate with Km values of 30, 12 and 11 μM, respectively. (tcdb.org)
  • Ensembl chr 3:89,842,399. (mcw.edu)
  • High affinity monosaccharide (KM ≈ 20 µM):H+ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose. (lbl.gov)
  • Progressive loss of photoreceptor cells was observed in WNIN/GR-Ob rats with an onset as early as 3 months. (molvis.org)
  • Individuals from an ancillary study of the CALERIE 2 randomized controlled trial were assessed at baseline and 12 months after a 25% CR or ad libitum (control) diet. (medscape.com)
  • This study included 12 months of a 25% CR or ad libitum (control) diet. (medscape.com)
  • In vivo ATPmax and P/O were unaffected by 12 months of CR. (medscape.com)
  • NAD+ is also involved with regulating the family of proteins called sirtuins , which play a central role in longevity and the aging process. (prohealth.com)
  • His laboratory tests were normal preoperatively, but the following values are obtained 12 hours after surgery: Arterial pH 7.53, PCO 2 50 mmHg, and bicarbonate - 40 mmol/L. (abdominalkey.com)
  • To obtain an independent test set, the remaining 11 of the 58 tumors were selected from an ongoing clinical trial and used here as a blinded sion via ER,3 however the details of the estrogen effect on down- test set. (lu.se)