AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Solute Carrier Family 12, Member 4Solute Carrier Family 12, Member 3Membrane Transport ProteinsAnion Transport ProteinsNucleotide Transport ProteinsCation Transport ProteinsSymportersAntiportersOrganic Cation Transport ProteinsBiological TransportPolymorphism, Single NucleotideSolute Carrier Family 12, Member 1GenotypeSolute Carrier Family 12, Member 2Molecular Sequence DataMitochondrial ADP, ATP TranslocasesCarrier ProteinsGene Expression RegulationMitochondrial ProteinsPhenotypeMutationAmino Acid SequenceAmino Acid Transport Systems, NeutralGenetic Predisposition to DiseaseGene Expression ProfilingDicarboxylic Acid TransportersMitochondriaOrganic Anion TransportersCarrier StateMitochondrial Membrane Transport ProteinsGlycosuria, RenalPlasma Membrane Neurotransmitter Transport ProteinsAmino Acid Transport SystemsPhylogenyAntigens, CD98 Heavy ChainRNA, MessengerOrganic Anion Transporters, Sodium-IndependentSequence AlignmentChloride-Bicarbonate AntiportersDrug CarriersBase SequenceAmino Acid Transport System y+Oligonucleotide Array Sequence AnalysisMembrane ProteinsSodium-Bicarbonate SymportersMonocarboxylic Acid TransportersAcyl Carrier ProteinKidney Tubular Necrosis, AcuteHeterozygote DetectionSaccharomyces cerevisiaeOrganic Anion Transporters, Sodium-DependentXenopus laevisThiamineSaccharomyces cerevisiae ProteinsIon TransportHeterozygoteWaterReduced Folate Carrier ProteinOsmosisBetaineMultigene FamilySolutionsKineticsUreaModels, BiologicalATP-Binding Cassette TransportersReverse Transcriptase Polymerase Chain ReactionIntestine, SmallKidneyPolymorphism, GeneticCell LineHydrogen-Ion ConcentrationSequence Homology, Amino AcidTissue DistributionAmino Acids, DiaminoCell MembraneOsmotic PressureHaplotypesOocytesGene FrequencyMice, KnockoutDiffusionPeritoneumProtein TransportOsmolar Concentration
MemberProteinTransportersMitochondrialEncodesAnionHomologyMutationsSubfamilyOrganicPhosphateProteinsNomenclatureModelGeneticMembersExpressionTypeWorkResourcesServicesTransporterELISA KitSodiumProteinNeurotransmitterMutationsHumanTransmembraneSuperfamilyCellularMetabolismGenesExpressionDescriptionTranscription
Member23
  • Names of individual SLC members have the following format: SLCnXm {\displaystyle {\ce {SLCnXm}}} where: SLC is the root name (SoLute Carrier) n = an integer representing a family (e.g., 1-52) X = a single letter (A, B, C, ...) denoting a subfamily m = an integer representing an individual family member (isoform). (wikipedia.org)
  • An exception occurs with SLC family 21 (the organic anion transporting polypeptide transporters), which for historical reasons have names in the format SLCOnXm where n = family number, X = subfamily letter, and m = member number. (wikipedia.org)
  • This gene encodes a mitochondrial solute carrier protein family member. (nih.gov)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Solute Carrier Family 1, Member 5 (SLC1A5) in Tissue homogenates, cell lysates and other biological fluids. (glideruniversity.org)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Solute Carrier Family 1, Member 5 (SLC1A5) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (glideruniversity.org)
  • Description: A sandwich ELISA kit for detection of Solute Carrier Family 1, Member 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (glideruniversity.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Solute Carrier Family 30 Member 7 (SLC30A7) in samples from tissue homogenates or other biological fluids. (isogem.org)
  • Hypoxia was found to induce A498 cell invasion, migration, and the release of inflammatory cytokines, while repressing human solute carrier family 14 member 1 gene expression. (biomedcentral.com)
  • Elevated levels of solute carrier family 14 member 1 expression induced mitochondrial reactive oxygen species accumulation, diminished the intracellular adenosine triphosphate level, and destroyed both mitochondrial membrane potential integrity and mitochondrial morphology. (biomedcentral.com)
  • Overexpression of the solute carrier family 14 member 1 gene could abolish hypoxia-induced invasion, reduce the migration of A498 cells, inhibit the hypoxia-induced release of inflammatory cytokines, and arrest the cell cycle at the G1/S checkpoint. (biomedcentral.com)
  • The results elucidate a mechanism wherein the solute carrier family 14 member 1 gene participates in the occurrence and development of hypoxia-induced renal cell carcinoma in a mitochondria-dependent manner. (biomedcentral.com)
  • Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Solute Carrier Family 30 Member 7 (SLC30A7) were tested 20 times on one plate, respectively. (biomatik.com)
  • Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Solute Carrier Family 30 Member 7 (SLC30A7) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
  • This assay has high sensitivity and excellent specificity for detection of Solute Carrier Family 30 Member 7 (SLC30A7). (biomatik.com)
  • No significant cross-reactivity or interference between Solute Carrier Family 30 Member 7 (SLC30A7) and analogues was observed. (biomatik.com)
  • This gene encodes a member of the SLC26A/SulP transporter family. (nih.gov)
  • Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1). (tcdb.org)
  • Urea transporter 1, designated Solute Carrier family 14 member 1 (SLC14A1) is a 43-54 kDa multipass urea transporter mainly expressed in erythrocytes, but also found in kidney, mesenchymal stem cells, and some carcinomas. (rndsystems.com)
  • Synthetic peptides corresponding to SLC2A8 (solute carrier family 2, facilitated glucose transporter, member 8). (novusbio.com)
  • WF upregulated (1.4 to 1.7-fold) the mRNA transcripts for interferon-gamma (Ifng), inducible nitric oxide synthase (Nos2), matrix metalloproteinase 9 (Mmp9), dopamine D2 receptor (Drd2), and the solute carrier family 18 member A2 (Slc18a2 / Vmat2) in FCT after 1 d, suggestive of neuroinflammation and altered monoamine neurotransmitter signaling. (cdc.gov)
  • Acrodermatitis enteropathica is an autosomal recessive disorder occurring as a result of mutations in the SLC39A4 ( solute carrier family 39 member A4) gene located on band 8q24.3. (medscape.com)
  • ZIP4 is a member of the Zrt-/Irt-like protein (ZIP) family, and it is a histidine-rich transmembrane protein that is specifically expressed on the apical side of enterocytes in the small intestine, as well as in the kidney, and is responsible for zinc absorption. (medscape.com)
  • Solute carrier family 11 member A1 gene polymorphisms in reactive arthritis. (cdc.gov)
Protein2
  • Hence, the criteria for inclusion of a family into the SLC group is not evolutionary relatedness to other SLC families but rather functional (i.e., an integral membrane protein that transports a solute). (wikipedia.org)
  • The etiopathogenesis of the zinc deficiency occurs as a result of loss-of-function mutations of the zinc-ligand binding protein ZIP4 encoded by the SLC39A4 ( solute carrier 39A) gene located on band 8q24.3. (medscape.com)
Transporters2
  • The goal of this study is to investigate whether these dicationic drugs are substrates for human organic cation transporters (hOCTs, solute carrier family 22A1-3) and whether hOCTs play a role in their tissue distribution, elimination, and toxicity. (aspetjournals.org)
  • Phosphate transporters: a tale of two solute carrier families. (medscape.com)
Mitochondrial1
Encodes1
  • The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP-N-acetylglucosamine. (nih.gov)
Anion1
  • Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (t3db.ca)
Homology1
  • In contrast, the homology between SLC families is very low to non-existent. (wikipedia.org)
Mutations2
  • Pontocerebellar hypoplasia with spinal muscular atrophy (PCH1): identification of SLC25A46 mutations in the original Dutch PCH1 family. (nih.gov)
  • SLC25A46 Mutations Associated with Autosomal Recessive Cerebellar Ataxia in North African Families. (nih.gov)
Subfamily1
  • For example, SLC1A1 is the first isoform of subfamily A of SLC family 1. (wikipedia.org)
Organic1
  • Solutes that are transported by the various SLC group members are extremely diverse and include both charged and uncharged organic molecules as well as inorganic ions and the gas ammonia. (wikipedia.org)
Phosphate1
  • The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. (medscape.com)
Proteins1
Nomenclature1
  • By convention of the nomenclature system, members within an individual SLC family have greater than 20-25% sequence identity to each other. (wikipedia.org)
Model1
  • Learn about our patient and family-centred care model. (sickkids.ca)
Genetic3
  • Genetic counsellors translate genetic information in a way that's accessible for families. (sickkids.ca)
  • Genetic counseling is recommended for family members of parents with the congenital form of acrodermatitis enteropathica. (medscape.com)
  • Families with confirmed Pelizaeus-Merzbacher disease must be referred to a geneticist or neurogeneticist for education about the disease and, especially, for genetic counseling. (medscape.com)
Members1
  • Many SLC families are members of the major facilitator superfamily. (wikipedia.org)
Expression1
  • 14] "The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells. (tcdb.org)
Type1
  • The atypical SLCs of MFS type can, however, be subdivided into 15 Putative MFS Transporter Families (AMTF). (wikipedia.org)
Work1
  • Social work services and psychosocial interventions for children, adolescents and families. (sickkids.ca)
Resources2
  • Hospital-wide resources for the specific needs of patients and families. (sickkids.ca)
  • Support resources for your family after the loss of a child. (sickkids.ca)
Services1
  • On-site interpreter services for patients and families with limited English proficiency. (sickkids.ca)
Transporter5
  • The atypical SLCs of MFS type can, however, be subdivided into 15 Putative MFS Transporter Families (AMTF). (wikipedia.org)
  • The serotonin transporter ( SERT or 5-HTT ) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene . (wikipedia.org)
  • It belongs to the NE, DA, SERT monoamine transporter family. (wikipedia.org)
  • This gene is one member of a family of sulfate/anion transporter genes. (antibodies-online.com)
  • From NCBI Gene: This gene encodes a member of the triose-phosphate transporter protein family. (nih.gov)
ELISA Kit1
  • Description: A sandwich ELISA kit for detection of Solute Carrier Family 26, Member 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (noveoninc.com)
Sodium1
  • [7] It is a member of the sodium:neurotransmitter symporter family. (wikipedia.org)
Protein5
  • Hence, the criteria for inclusion of a family into the SLC group is not evolutionary relatedness to other SLC families but rather functional (i.e., an integral membrane protein that transports a solute). (wikipedia.org)
  • Solute carrier family 35 member E3 (Bladder cancer-overexpressed gene 1 protein). (tcdb.org)
  • Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. (antibodies-online.com)
  • The etiopathogenesis of the zinc deficiency occurs as a result of loss-of-function mutations of the zinc-ligand binding protein ZIP4 encoded by the SLC39A4 ( solute carrier 39A) gene located on band 8q24.3. (medscape.com)
  • ZIP4 is a member of the Zrt-/Irt-like protein (ZIP) family, and it is a histidine-rich transmembrane protein that is specifically expressed on the apical side of enterocytes in the small intestine, as well as in the kidney, and is responsible for zinc absorption. (medscape.com)
Neurotransmitter1
  • WF upregulated (1.4 to 1.7-fold) the mRNA transcripts for interferon-gamma (Ifng), inducible nitric oxide synthase (Nos2), matrix metalloproteinase 9 (Mmp9), dopamine D2 receptor (Drd2), and the solute carrier family 18 member A2 (Slc18a2 / Vmat2) in FCT after 1 d, suggestive of neuroinflammation and altered monoamine neurotransmitter signaling. (cdc.gov)
Mutations1
  • Acrodermatitis enteropathica is an autosomal recessive disorder occurring as a result of mutations in the SLC39A4 ( solute carrier family 39 member A4) gene located on band 8q24.3. (medscape.com)
Human3
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Solute Carrier Family 26, Member 4 (SLC26A4) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. (noveoninc.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Solute Carrier Family 16, Member 8 (SLC16A8) in Tissue homogenates, cell lysates and other biological fluids. (tuberculosistest.net)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Solute Carrier Family 30, Member 10 (SLC30A10) in samples from tissue homogenates or other biological fluids. (maracpe.org)
Transmembrane1
  • The SLC26 family shares a 7 + 7 transmembrane segments inverted repeat architecture (7TMIR) with the SLC4 and SLC23 families, but holds a regulatory STAS domain in addition. (cef-mc.de)
Superfamily1
  • Many SLC families are members of the major facilitator superfamily. (wikipedia.org)
Cellular1
  • Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. (nih.gov)
Metabolism1
  • Hereditary Disorders of Manganese Metabolism: Pathophysiology of Childhood-Onset Dystonia-Parkinsonism in SLC39A14 Mutation Carriers and Genetic Animal Models. (nih.gov)
Genes1
  • There were only 12 genes found to be commonly expressed in tumor endothelium from all three tumor types, and the majority of these were members of the collagen family. (medscape.com)
Expression3
  • Violin plots show distribution of expression levels for Solute carrier family 12 member 9 (SMED30009255) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Expression of Solute carrier family 12 member 9 (SMED30009255) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
  • Violin plots show distribution of expression levels for Solute carrier family 12 member 9 (SMED30009255) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
Description2
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Solute Carrier Family 30 Member 4 (SLC30A4) in samples from tissue homogenates or other biological fluids. (operatiebrp.nl)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Solute Carrier Family 30, Member 10 (SLC30A10) in Tissue homogenates, cell lysates and other biological fluids. (maracpe.org)
Transcription1
  • Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and its regulation. (antikoerper-online.de)