GalactoseBinding proteinInhibited C-type lectinAntigenProteinsPlant lectinsDietary lectinsComplementMannoseReceptorsInnateImmunityImmune systemLeptinInflammationMoleculesAdditionallyGeneInteractionsReceptorInteractionRecognitionBelongsTypeSusceptibleBloodWaterDomainFunctionCriticalProductMouseStudiesProvideFoundContentPlatform
Galactose2
- Soluble bovine galactose-binding lectin. (wikipedia.org)
- Goose Lectin-Galactose Binding-Soluble three ELISA Equipment from MYBIOSOURCE INC. Product Identify Goose Lectin-Galactose Binding-Soluble three ELISA Equipment Description Assay Sort: Sandwich. (bioinfor.me)
Binding protein4
- Do not miss to order the product Human Mannma binding protein/mannan binding lectin,MBP/MBL ELISA Kit at this promotional price until the end of December 2017. (assayspro.com)
- After delivery, the specialists from Gentaur/Genprice recommend you to store the Human Mannma binding protein/mannan binding lectin,MBP/MBL ELISA Kit between two and eight degrees Celsius to keep the quality and activity of the reagents included in the kit. (assayspro.com)
- C4b-binding protein (C4BP) is the major soluble inhibitor of the classical and lectin pathways whereas factor H (FH) inhibits the alternative route. (lu.se)
- One soluble factor modulating the interplay between immune cells and microbes is galectin-3 (gal-3), a carbohydrate-binding protein that regulates a wide variety of neutrophil functions. (lu.se)
Inhibited C-type lectin1
- High glucose inhibited C-type lectin binding to high-mannose glycoprotein and binding of DC-SIGN to fucosylated ligand (blood group B) was abrogated in high glucose. (nih.gov)
Antigen2
- Positive tests for antinuclear antibodies (ANAs) and anti-smooth-muscle antibodies (ASMAs): Tests for antibodies to liver-kidney microsome type 1 (anti-LKM-1), soluble liver antigen (anti-SLA), and liver cytosol type 1 (anti-LC1) may be helpful if ANA and ASMA test results are negative. (medscape.com)
- Peanut agglutinin binds preferentially to the T-antigen, a galactosyl (β-1,3) N -acetylgalactosamine structure present in many glycoconjugates such as M and N blood groups, gangliosides, and many other soluble and membrane-associated glycoproteins and glycolipids. (vectorlabs.com)
Proteins9
- At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
- This work identifies Drosophila S2 cells as a clinically-relevant platform suited for the production of 'difficult-to-make' proteins from Plasmodium parasites, and identifies a PfRH5 sequence variant that can be used for clinical production of a non-glycosylated, soluble full-length protein vaccine immunogen. (nature.com)
- We have previously shown that hemocyanins are internalized by APCs through receptor-mediated endocytosis with proteins that contain C-type lectin domains, such as mannose receptor (MR). However, the contribution of other innate immune receptors to the proinflammatory signaling pathway triggered by hemocyanins is unknown. (exeter.ac.uk)
- Lectins are proteins that bind to carbohydrates or glycoproteins (carb-protein mixture) [ 1 ]. (selfhack.com)
- Proteins termed lectins (from the Latin legere, "to select") have the ability to bind to specific carbohydrate molecules. (selfhack.com)
- Plants also use lectins to communicate with their environment, for cell organization, and as reserve proteins, among other functions [ 3 ]. (selfhack.com)
- Lectins are carb-binding proteins found in all living organisms. (selfhack.com)
- On average, 15% percent of a bean's proteins are lectins. (selfhack.com)
- water-soluble proteins, found specifically in aqueous extracts of mistletoe, have been shown to support healthy blood sugar levels. (essential-vitamins.com)
Plant lectins3
- Some plant lectins, such as castor bean ricin and white kidney bean agglutinins, are very toxic to humans and rats. (selfhack.com)
- Other plant lectins are less toxic, but they can cause damage in other ways. (selfhack.com)
- Some plant lectins are extremely toxic, while others do milder harm. (selfhack.com)
Dietary lectins1
- In the present review, we provide evidence for how the interaction of dietary lectins with enterocytes and lymphocytes may facilitate the translocation of both dietary and gut-derived pathogenic antigens to peripheral tissues, which in turn causes persistent peripheral antigenic stimulation. (cambridge.org)
Complement4
- Complement activation via the lectin pathway was inhibited in high glucose and also in high trehalose - a nonreducing sugar with glucoside stereochemistry. (nih.gov)
- These interactions activate complement via the lectin and classical pathways, respectively. (le.ac.uk)
- 2008). Genetic Heterogeneity of Lectin Complement Activation Pathway Defects See also LCAPD2 (613791), caused by variation in the MASP2 gene (605102) on chromosome 1p36, and LCAPD3 (613860), caused by variation in the FCN3 gene (604973) on chromosome 1p36. (nih.gov)
- Invading pathogens activate complement either spontaneously due to differences in envelope/membrane composition compared to host (alternative and lectin pathways) or through antibody binding (classical pathway). (lu.se)
Mannose8
- A number of C-type lectins recognise oligosaccharides rich in mannose and fucose - sugars with similar structures to glucose. (nih.gov)
- Mannose-binding lectin, soluble DC-SIGN and DC-SIGNR, and surfactant protein D, were tested for carbohydrate binding in the presence of glucose concentrations typical of diabetes, via surface plasmon resonance and affinity chromatography. (nih.gov)
- Mannose binding lectin protein is a member of collectin family and important for innate immunity . (lu.se)
- Mannose-binding lectin (MBL) deficiency, defined as MBL protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. (nih.gov)
- Mannose-binding lectin deficiency is a condition that affects the immune system. (nih.gov)
- People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood. (nih.gov)
- People with mannose-binding lectin deficiency can develop infections of the upper respiratory tract and other body systems. (nih.gov)
- Infants and young children with mannose-binding lectin deficiency seem to be more susceptible to infections than affected adults, but adults can also develop recurrent infections. (nih.gov)
Receptors1
- In the Brown Group, we are interested in a superfamily of receptors called C-type lectin receptors (CLRs). (exeter.ac.uk)
Innate2
- Soluble human lectins are critical components of innate immunity. (bvsalud.org)
- SP-A is an innate host defense, large molecular, hydrophilic (water soluble) lectin coded on human chromosome 10 that regulates lung inflammation. (medscape.com)
Immunity2
- Intracellular lectins and glycan-modifying enzymes mediate autophagy and control host immunity and inflammation. (nature.com)
- How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)
Immune system3
- Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin. (nih.gov)
- In the blood, lectins may stimulate the immune system and modify hormone functions, or get deposited in blood and lymphatic walls [ 9 , 10 ]. (selfhack.com)
- Previous studies have suggested that Ply interacts with various soluble molecules of the immune system, including L-ficolin and IgG. (le.ac.uk)
Leptin1
- Do not confuse lectins with leptin, lactose, or pectin . (selfhack.com)
Inflammation1
- This post covers low-lectin and high-lectin foods, as well as other plant substances that may cause inflammation. (selfhack.com)
Molecules2
- Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
- Chimeric molecules resulting from the fusion of recombinant soluble CD4 to the Fc portion of immunoglobulins. (bvsalud.org)
Additionally2
- Additionally, oyster mushrooms contain bioactive compounds like lectin and antioxidants like phenolic acid. (healthifyme.com)
- Additionally, water-soluble lectins have been shown to support both relaxation and nerve health. (essential-vitamins.com)
Gene1
- The protein encoded by this gene is an S-type lectin. (thermofisher.com)
Interactions1
- We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
Receptor5
- A platform to screen for C-type lectin receptor-binding carbohydrates and their potential for cell-specific targeting and immune modulation. (mpg.de)
- Using this co-culture model, bacterial CpG DNA (a Toll like receptor 9 ligand) combined with NDO was found to effectively drive away from the allergic phenotype of the underlying immune cells by increasing epithelial release of galectin-9, a soluble type lectin known to neutralize IgE and instruct regulatory T-cells. (uu.nl)
- With certain exceptions, the receptor sequence for PNA is normally sialylated which prevents the lectin from binding to its receptor oligosaccharide (see Jacalin). (vectorlabs.com)
- Lectin-like Oxidized Low-density Lipoprotein Receptor 1 (LOX-1), also known as Oxidized Low-density Lipoprotein Receptor 1 (OLR1), is a type II transmembrane receptor belonging to the class E scavenger receptor (SR-E) subfamily of the C-type lectin family. (rndsystems.com)
- Tienen un empleo potencial en el tratamiento del SIDA ya que poseen propiedades de unión a gp120 y de bloqueo del VIH de rCD4 así como una gran semivida plasmática y funcioones de unión al receptor Fc de la inmunoglobulina. (bvsalud.org)
Interaction1
- Defining the interaction of human soluble lectin ZG16p and mycobacterial phosphatidylinositol mannosides. (mpg.de)
Recognition2
- Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
- Using the gal-3 inhibitor GB0139 (TD139) and gal-3C we found that the gal-3-induced inhibitory effect on ROS production was dependent on the carbohydrate recognition domain of the lectin. (lu.se)
Belongs1
- CD206 belongs to the C-type lectin family. (fishersci.com)
Type2
- We conclude that high glucose disrupts C-type lectin function, potentially illuminating new perspectives on susceptibility to infectious and inflammatory disease in diabetes. (nih.gov)
- I'm interested in soluble fiber, in the type of fiber that our gut flora can actually consume and ferment. (marksdailyapple.com)
Susceptible1
- Plant agglutinins have the ability to clump blood cells of certain blood types, which suggests that people with certain blood types may be more susceptible to health problems due to lectins than others [ 6 ]. (selfhack.com)
Blood1
- Although lectins were already known because of their ability to agglutinate red blood cells, 3 the involvement of lectins and glycans in PCD had not been elucidated. (nature.com)
Water1
- Typical extraction methods may focus on either the water-soluble or lipid-based fractions, but often fail to gather the fullest spectrum of the plant's active constituents. (essential-vitamins.com)
Domain1
- Cell surface LOX-1 can also be cleaved to release the soluble LOX-1 extracellular domain. (rndsystems.com)
Function1
- By eliminating dietary elements, particularly lectins, which adversely influence both enterocyte and lymphocyte structure and function, it is proposed that the peripheral antigenic stimulus (both pathogenic and dietary) will be reduced and thereby result in a diminution of disease symptoms in certain patients with RA. (cambridge.org)
Critical1
- Endogenous lectins and glycans are critical signals in the resolution of cell death. (nature.com)
Product1
- Accompanying each fluorescent lectin is an analysis data sheet summarizing the results of our quality control tests and providing pertinent information on the product. (vectorlabs.com)
Mouse1
- A soluble form of CD206 is generated by cleavage of the full-length protein, and it can be detected in in vitro macrophage cell culture supernatants and in mouse serum. (fishersci.com)
Studies1
- The emergence of functional studies on animal lectins during the 1990s has provided the appropriate framework to better understand their roles in cell death. (nature.com)
Provide1
- Cy5 labeled Peanut agglutinin has an appropriate number of fluorochromes bound to provide the optimum staining characteristics for this lectin. (vectorlabs.com)
Found2
- Cucurbitaceae lectins , found in the sap or juice of cucumber, melon, and squash. (selfhack.com)
- Prolamins , such as gluten and gliadin, are the alcohol-soluble lectins found in cereal grains. (selfhack.com)
Content1
- The sialic acid content of VWF was investigated using a modified ELISA to measure elderberry bark lectin, specific for sialic acid residues, binding to VWF. (imperial.ac.uk)
Platform1
- However it has proved challenging to identify a heterologous expression platform that can produce a soluble protein-based vaccine in a manner compliant with current Good Manufacturing Practice (cGMP). (nature.com)