Soluble golgi n ethylmaleimide sensitive proteins. Medical search. Frequent questions

Platelet secretion requires Soluble N-ethylmaleimide Sensitive Attachment Protein Receptors (SNAREs). (bvsalud.org)
An abundance of soluble N-ethylmaleimide-sensitive factor adaptor protein receptors. (kegg.jp)
In the trans-Golgi network (TGN), phosphorylated lysosomal enzymes bind to M-6-P receptors, which direct the enzymes into clathrin-coated vesicles. (biomedcentral.com)
Vesicle-associated membrane proteins 721 and 722 (VAMP721/722) are secretory vesicle-localized arginine-conserved soluble N -ethylmaleimide-sensitive factor attachment protein receptors (R-SNAREs) to drive exocytosis in plants. (molcells.org)
Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. (lookformedical.com)
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
The first layer of immunity, known as pathogen-associated molecular pattern- (PAMP-) triggered immunity (PTI), is activated following recognition of the fungal pattern molecule chitin, by four lysin motif- (LysM-) containing protein (LYP) receptors, i.e., chitin elicitor binding protein (CEBiP), chitin elicitor receptor kinase (CERK1), LYP4 and LYP6 (Shimizu et al. (biomedcentral.com)

This crucial function was ascribed to a minimal Munc13 region called the MUN domain, which likely participates in soluble N-ethylmaleimide sensitive factor attachment protein receptor complex (SNARE) assembly and is also found in Ca 2+ -dependent activator protein for secretion. (elsevierpure.com)
This antibody provides a valuable tool for investigating intracellular membrane trafficking, vesicle fusion, and the role of STX6 in cellular processes such as protein sorting, secretion, and endocytosis. (affigen.com)
In contrast, chemokine secretion and trafficking of plasma membrane proteins, transported via the constitutive secretory pathway, are unaffected by the lack of WASp. (aai.org)
New insights into protein secretion: TANGO1 runs rings around the COPII coat. (uchicago.edu)

Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. (wikipedia.org)
In some cases, the exocytotic vesicles derive from the Golgi apparatus and consist of newly synthesized materials, while in others the vesicles derive from the plasma membrane and cycle locally. (sdbonline.org)

The size of the trans-Golgi network and DCVs was decreased, and the speed of DCV cargo flux through Golgi was increased in tomosyn-deficient neurons, suggesting a role for tomosyns in DCV biogenesis. (bvsalud.org)
STX6 is primarily localized to the trans-Golgi network (TGN) and endosomes, where it plays a role in regulating membrane fusion and cargo trafficking. (affigen.com)

Platelet exocytosis uses a molecular mechanism similar to that used by other secretory cells, such as neurons, although the proteins used by the platelet and their modes of regulation may be quite different. (wikipedia.org)
Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. (bvsalud.org)
Taken together, our findings argue against an inhibitory role of tomosyns in neuronal DCV exocytosis and suggests an evolutionary conserved function of tomosyns in the packaging of secretory cargo at the Golgi. (bvsalud.org)
In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory pathway in CD4 + T cells. (aai.org)
The exocyst complex, a set of eight proteins first identified from secretory mutants in yeast, is an attractive candidate for mediating directed traffic. (sdbonline.org)

Previously, we reported the structure of the yeast Dsl1 complex, the simplest known MTC, which is essential for coat protein I (COPI) mediated transport fromthe Golgi to the endoplasmic reticulum(ER). (princeton.edu)
Precursors of lysosomal enzymes are synthesized in the rough endoplasmic reticulum (rER) and then migrate to the cis-Golgi, where mannose residues on the oligosaccharide chain are phosphorylated to form mannose-6-phosphate (M-6-P), an important sorting signal for lysosomal enzymes. (biomedcentral.com)

In plants, three groups of regulatory proteins such as Sec1/Munc18 (SM), small GTPase and synaptotagmin (SYT) have been studied for modulating the trafficking functionality of SNAREs. (molcells.org)
They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)

According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. (wikipedia.org)
Platelets contain some of the same proteins, including NSF, p115/TAP, alpha-SNAP (this protein), gamma-SNAP, and the t-SNAREs syntaxin-2 and syntaxin-4, that are used in many vesicular transport processes in other cell types. (wikipedia.org)
Vesicle SNAREs/Vesicle-Associated Membrane Proteins (v-SNAREs/VAMPs) on granules and t-SNAREs in plasma membranes mediate granule release. (bvsalud.org)
The specificity of vesicle trafficking: coat proteins and SNAREs. (kegg.jp)

Clathrin also interacts with cytoskeletal proteins. (lookformedical.com)
Chemotaxis of neutrophils involves movement of pseudopodia and polymerization of cytoskeletal proteins or actin. (medscape.com)

STX6 is a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) protein family and is involved in intracellular membrane trafficking and vesicle fusion events. (affigen.com)

Systematic analysis of SNARE molecules in Arabidopsis: dissection of the post-Golgi network in plant cells. (kegg.jp)

We found weak yet significant sequence similarities between the MUN domain and a set of protein subunits from several related vesicle tethering complexes, such as Sec6 from the exocyst complex and Vps53 from the Golgi-associated retrograde protein complex. (elsevierpure.com)

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells. (wikipedia.org)
Vesicular transport proteins are distinguished from MEMBRANE TRANSPORT PROTEINS, which move molecules across membranes, by the mode in which the molecules are transported. (uchicago.edu)

750 kDa), conserved macromolecular machines that are essential for soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-mediated membrane fusion in all eukaryotes.MTCs are thought to organizemembrane trafficking by mediating the initial long-range interaction between a vesicle and its target membrane and promoting the formation of membrane-bridging SNARE complexes. (princeton.edu)
These findings further unify the mechanism of neurotransmitter release with those of other types of intracellular membrane traffic and, in turn, support a role for tethering complexes in soluble N-ethylmaleimide sensitive factor attachment protein receptor complex assembly. (elsevierpure.com)

Although 271 genes linked to hereditary retinal diseases have already been identified, these genes encode diverse functions, including phototransduction, retinol metabolism, and intracellular protein transport. (oist.jp)

Eye proteins are the biological molecules that make up the various structures of the eye and are essential for its proper function. (lookformedical.com)

It interacts with other SNARE proteins and vesicle-associated membrane proteins (VAMPs) to mediate membrane fusion events during intracellular transport processes. (affigen.com)

A total of 257 differentially expressed proteins (DEPs) were identified by iTRAQ, which provided a comprehensive overview on the functional protein profile changes of tuber development regulated by JA. (biomedcentral.com)
Neurons generate their polarity by directing membrane traffic to growing neurites and growth cones, and by sorting proteins differentially between the axon and dendrites. (sdbonline.org)

[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)

2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there for both auto- and Rab substrate phosphorylation. (stanford.edu)

Alpha- and gamma-SNAP are found in a wide range of tissues and act synergistically in intra-Golgi transport. (wikipedia.org)
The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively. (wikipedia.org)
VAMP (Vesicle-associated membrane protein), SNAP-25 (Synaptosome associated protein of 25 kDa) and Syntaxin constitute the basic SNARE complex. (biomedcentral.com)
Seeking ovarian cancer related SNAP proteins may help to reveal new mechanisms of invasion and metastasis of ovarian cancer, and provide new ideas for clinical diagnosis and treatment. (biomedcentral.com)

Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)

We focus on zebrafish mutants, in which photoreceptor degeneration is caused by defects in protein synthesis in ER, protein transport from ER to the apical photoreceptive membrane region, and phototransduction. (oist.jp)
The function of the SEDL protein is not known although it is speculated that it may participate in the ER-to-Golgi transport as part of a novel highly conserved multiprotein TRAPP complex. (nature.com)
We also study the NPC1 protein that is essential for cholesterol transport in humans and can lead to Niemann Pick C disease when mutated. (stanford.edu)
Within neurons, multiple pathways are known to transport proteins and transmitters to the cell surface. (sdbonline.org)
Another distinction that has been drawn contrasts the constitutive and the regulated pathways to distinguish the ongoing transport of protein and lipid to the cell surface from the ability to secrete hormones and transmitters in response to specific stimuli. (sdbonline.org)
The main structural coat protein of COATED VESICLES which play a key role in the intracellular transport between membranous organelles. (lookformedical.com)
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport. (lookformedical.com)
Vesicular Transport Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
A broad category of proteins involved in the formation, transport and dissolution of TRANSPORT VESICLES. (uchicago.edu)
This graph shows the total number of publications written about "Vesicular Transport Proteins" by people in this website by year, and whether "Vesicular Transport Proteins" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Vesicular Transport Proteins" by people in Profiles. (uchicago.edu)

sec5 mutations have been identified and characterized in Drosophila in order to delineate the role of the protein in neurons and particularly at synapses. (sdbonline.org)
This protein is required for many aspects of membrane traffic within neurons, including the elaboration of neurites, but the release of neurotransmitter at the synapse is independent of this exocyst component (Murthy, 2003). (sdbonline.org)

The long term goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific and distinct compartments. (stanford.edu)

Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)

The results revealed that the levels of a number of proteins involved in various cellular processes were regulated by JA during tuber development. (biomedcentral.com)

The mature miRNAs are loaded onto ARGONAUTE (AGO) proteins, forming a miRNA-induced gene silencing complex (miRISC). (biomedcentral.com)

Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. (biomedcentral.com)

Several isoforms of the protein with molecular sizes of 47 kDa and 52 kDa exist due to multiple ALTERNATIVE SPLICING. (lookformedical.com)

Such an evolutionary relationship allows structure prediction of the MUN domain and suggests functional similarities between MUN domain-containing proteins and multisubunit tethering complexes such as exocyst, conserved oligomeric Golgi complex, Golgi-associated retrograde protein complex, and Dsl1p. (elsevierpure.com)
strongly suggests that at least one regulatory protein should control the SNARE complex formation of VAMP721/722 with a specific Qa-SNARE in a particular biological process in plants. (molcells.org)

However, no clear similarity between Munc13s and protein families generally involved in membrane traffic has been reported, despite the essential nature of Munc13s for neurotransmitter release. (elsevierpure.com)
Such processes require membrane traffic to particular domains of the cell surface, in order to insert proteins at restricted regions of the membrane, to enlarge particular regions of the cell membrane, or to signal asymmetrically to neighboring cells. (sdbonline.org)

Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)
Soluble N-Acetylgalactosamine-Modified Antigens Enhance Hepatocyte-Dependent Antigen Cross-Presentation and Result in Antigen-Specific CD8+ T Cell Tolerance Development. (uchicago.edu)

A 48-Kd protein of the outer segment of the retinal rods and a component of the phototransduction cascade. (lookformedical.com)

A purplish-red, light-sensitive pigment found in RETINAL ROD CELLS of most vertebrates. (lookformedical.com)

They share a common structure and signal through HETEROTRIMERIC G-PROTEINS. (lookformedical.com)

And, a large number of protein biosynthesis, degradation and assembly-related were up-regulated by JA to promote tuber protein biosynthesis and maintain strict protein quality control during tuber development. (biomedcentral.com)

Anatomy1

Chemicals and Drugs1

Receptors11

Secretion4

Apparatus2

Trans-Golgi n2

Secretory5

Endoplasmic Reticulum2

Regulatory proteins2

SNAREs4

Cytoskeletal proteins2

Involved in intracellular membrane1

Arabidopsis1

Exocyst complex1

Membranes2

Attachment2

Intracellular protein transport1

Molecules1

VAMPs1

Differentially2

Cytokines1

20171

SNAP4

Kinase2

Transport11

Neurons2

Mechanisms1

Synthesis1

Cellular processes1

Gene1

Tumor1

Molecular1

Complex2

Membrane traffic2

Cell2

Outer1

Cells1

Structure1

Large1