- UDP-glucuronate is used to conjugate bilirubin to a more water-soluble bilirubin diglucuronide. (wikipedia.org)
- Water-soluble ligands are believed to be new frontiers in the search of efficient Lns/Ans separation ligands to close the nuclear fuel cycles and dealing with current existing nuclear waste. (bvsalud.org)
- These reactions may be mediated by cytochrome P450 enzyme, aldehyde oxidase, glutathione-disulfide reductase, and glucuronate reductase. (bvsalud.org)
- UDP-D-galacturonic acid, the key building block of pectins, is produced from the precursor UDP-D-glucuronic acid by the action of glucuronate 4-epimerases (GAEs). (escholarship.org)
- Once olive derived molecules are consumed and absorbed, they are shuttled to the liver where they are attached to detoxification molecules (sulfate/glucuronate). (formula216.com)
- While these molecules are attached to detoxification molecules (sulfate and glucuronate) as they pass through the liver, rendering them too large to pass through cells walls and influence cellular or genetic machinery, an enzyme called glucuronidase that is abundant at sites of inflammation, infection and malignancy frees resveratrol so it is delivered at the right time and place as an unbound molecule. (resveratrolnews.com)
- The preferred form of thiamine in supplements should be benfotiamine , a fat-soluble form of vitamin B1 which is more readily absorbed. (resveratrolnews.com)
- Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. (lookformedical.com)
- UDP-glucuronate is used to conjugate bilirubin to a more water-soluble bilirubin diglucuronide. (wikipedia.org)
- Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE . (nih.gov)
- Next, unconjugated bilirubin gets conjugated with one or two molecules of glucuronic acid by the enzyme uridine diphospho-glucuronate glucuronosyltransferase (UGT1A1), which forms bilirubin monoglucuronide and bilirubin diglucuronide respectively. (statpearls.com)
- Following oral administration in healthy volunteers, approximately 60% of a single dose of radiolabelled fenofibrate appeared in urine, primarily as fenofibric acid and its glucuronate conjugate, and 25% was excreted in the feces. (nih.gov)
- Glucuronic acid is highly soluble in water. (wikidoc.org)
- The substances resulting from glucuronidation are known as glucuronides (or glucuronosides) and are typically much more water - soluble than the non-glucuronic acid-containing substance from which they were originally synthesised. (wikidoc.org)
- The human body uses glucuronidation to make a large variety of substances more water-soluble, and, in this way, allow for their subsequent elimination from the body upon urination . (wikidoc.org)
- 37. Increased antitumor activities of glypican-3-specific chimeric antigen receptor-modified T cells by coexpression of a soluble PD1-CH3 fusion protein. (nih.gov)