ApoptosisFasLCytokinesSuperfamilyStimulationEpidermalLigandProteinsToll-like receInhibitory receptorsAntigen receptorType I transmembrane proteinCD95LAggregationMoleculesDecoy receptorTumorCD71LigationSystemic Lupus ErythemRecognizesAntagonistHerpesCytoplasmicInducesClusterAntibodyCellsCell deathResistanceDeathFlowActsProliferationResultsFunctionsLevelsFormRoleSignal
Apoptosis12
- Apoptosis-inducing Fas receptor is dubbed isoform 1 and is a type 1 transmembrane protein. (wikipedia.org)
- This and other factors-for example, eosinophil-apoptosis impairment through high levels of soluble CD95-might account for the persistent eosinophilia in active CSS. (medscape.com)
- The supernatants were collected and analyzed for the secretion of human Fas ligand, and cells were used to determine cell death and apoptosis, cell death receptor, and intracellular proteins expression. (unisi.it)
- Results suggest that soluble factors secreted by BeWo cells induce cell death and apoptosis in THP-1 cells, and Fas/CD95 can be involved in this process. (unisi.it)
- Caspases-9, -8 and -3 have been implicated in apoptosis-caspase-9 in the mitochondrial pathway, caspase-8 in the Fas/CD95 pathway, and caspase-3 more downstream, activated by multiple pathways. (bdbiosciences.com)
- deletion of an exon encoding the transmembrane domain results in a soluble FAS molecule that blocks apoptosis. (biolegend.com)
- The results of the present study suggest that P. vivax infection induces apoptosis of CD4 + T cells mediated by two types of signaling: by activation of the TNFR1 death receptor (extrinsic pathway), which is amplified by Bid, and by decreased expression of the anti-apoptotic protein Bcl-2 (intrinsic pathway). (biomedcentral.com)
- The exogenous pathway mediated by death receptors and death ligands is a very important pathway for cell apoptosis. (bvsalud.org)
- Pathways such as cytokine-cytokine receptor interaction, glycolysis/gluconeogenesis and apoptosis are closely related to sperm quality. (biomedcentral.com)
- Cytoflorymetric analysis of chosen markers of apoptosis CD95/CD95L (Fas/FasL) in thyroid tissues from young patients with Graves' disease and Hashimoto's thyroiditis. (edu.pl)
- Concentrations of soluble factors participating in regulation of apoptosis of lymphocyte from patients with chronic Lyme arthritis (preliminary report). (edu.pl)
- Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
FasL6
- Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external matrix metalloproteinase MMP-7. (wikipedia.org)
- DcR3: Decoy receptor 3 (DcR3) is a recently discovered decoy receptor of the tumor necrosis factor superfamily that binds to FasL, LIGHT, and TL1A. (wikipedia.org)
- DcR3 is a soluble receptor that has no signal transduction capabilities (hence a "decoy") and functions to prevent FasR-FasL interactions by competitively binding to membrane-bound Fas ligand and rendering them inactive. (wikipedia.org)
- Soluble FasL is less active than its membrane-bound counterpart and does not induce receptor trimerization and DISC formation. (wikipedia.org)
- RESULTS: Homozygous FASLG variants abrogated cytotoxicity and resulted in early-onset severe ALPS with elevated DNT, raised vitamin B12, and usually no soluble FasL. (bvsalud.org)
- Cytofluorymetryczna analiza wybranych marker w apoptozy Fas/FasL (CD95/CD95L) w tkance gruczo u tarczowego u m odocianych pacjent w z chorob Gravesa-Basedowa oraz zapaleniem tarczycy typu Hashimoto. (edu.pl)
Cytokines5
- Th1-type lymphocytes that secrete cytokines, such as interferon-gamma and soluble IL-2 receptor, are possible inducers of granuloma formation. (medscape.com)
- However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
- Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)
- Ligands for these receptors belong to the Tumor Necrosis Factor (TNF) superfamily of cytokines, which activate signaling pathways for cell survival, death, and differentiation that orchestrate the development, organization and homeostasis of lymphoid, mammary, neuronal and ectodermal tissues. (hycultbiotech.com)
- Continuous ligation of LILRB1 modulated cellular differentiation, conferred a unique phenotype upon the resultant cells, induced a profound resistance to CD95-mediated cell death, and inhibited secretion of cytokines IL-10, IL-12p70, and TGF-β. (ashpublications.org)
Superfamily4
- CD95 is a member of the TNF receptor superfamily that is ubiquitously expressed in healthy and pathological tissues. (researchgate.net)
- FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. (thermofisher.com)
- The monoclonal antibody 55R-170 recognizes the extracellular part of mouse Tumor Necrosis Factor Receptor superfamily member 1A (TNF-RI), also known as CD120a or p55. (hycultbiotech.com)
- FAS is a type I transmembrane protein and belongs to the TNF receptor superfamily. (biolegend.com)
Stimulation3
- Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the transduction of either apoptotic or non‐apoptotic signals. (researchgate.net)
- We investigated baseline surface marker expression and Syk phosphorylation kinetics upon B cell receptor (BCR) stimulation of peripheral B cells and specifically the CXCR5-CD19low subset using flow cytometry. (bmj.com)
- CD86 expression is modest in resting B cells, but it rises in response to BCR, CD40, IL-4R, LPS receptor, or 2-adrenergic receptor stimulation. (cusabio.com)
Epidermal2
- Triple-negative breast cancers (TNBC) are defined as negative for hormonal receptors and human epidermal growth factor receptors 2 and account for 15% of breast cancers. (researchgate.net)
- An increase in the number of epidermal growth factor and transferrin receptors (EGFR, TrfR) is induced by Ara-C on these cells. (cnr.it)
Ligand6
- Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. (wikipedia.org)
- Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. (wikipedia.org)
- Key players in the controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR activated by its cognate ligand CD95L triggering programmed cell death. (researchgate.net)
- The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
- Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
- Age related changes of soluble Fas, Fas ligand and Bcl-2 in autoimmune thyroid diseases. (edu.pl)
Proteins2
- Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)
- Active caspases can then cleave many proteins, including poly-ADP ribose polymerase (PARP), other caspases and other protein substrates en masse. (bdbiosciences.com)
Toll-like rece1
- 1 Activation of DCs through toll-like receptors (TLRs) for "infectious nonself" or other "danger" signals normally initiates a process of cellular differentiation resulting in "mature" DCs capable of stimulating T-cell and natural killer (NK)-cell responses. (ashpublications.org)
Inhibitory receptors2
- NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. (frontiersin.org)
- Ligation of these receptors results either in diminution of intracellular signaling by ITIM-associated phosphatase activity for inhibitory receptors with a long cytoplasmic tail or in ITAM-associated signaling through adaptor molecules recruited by activating receptors with a short cytoplasmic tail. (ashpublications.org)
Antigen receptor2
- Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. (nature.com)
- CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. (thermofisher.com)
Type I transmembrane protein1
- Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)
CD95L1
- As a consequence, alterations in the CD95/CD95L pathway have been involved in several disease co. (researchgate.net)
Aggregation2
- Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. (wikipedia.org)
- Caspase-8 is produced as a proenzyme (55/50 kDa doublet) which upon receptor aggregation is proteolytically cleaved into smaller subunits of 40/36 (doublet), and 23 kDa. (bdbiosciences.com)
Molecules1
- Recent studies have suggested a role for human leukocyte Ig-like receptors (LILRs, also known as ILT, LIR, or CD85) in regulating the function of myeloid cells, potentially implicating these molecules in the control of immune responses. (ashpublications.org)
Decoy receptor1
- Binding to the decoy receptor TNFRSF6B modulates its effects. (joplink.net)
Tumor1
- Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
CD711
Ligation1
- After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. (thermofisher.com)
Systemic Lupus Erythem1
- Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. (bmj.com)
Recognizes1
- The monoclonal antibody 55R-170 also recognizes the soluble receptor. (hycultbiotech.com)
Antagonist2
- Several cases of eosinophilic conditions including Churg-Strauss syndrome have been reported to be associated with zafirlukast, a cysteinyl leukotriene type 1 receptor antagonist. (lookformedical.com)
- Pulmonary eosinophilia developed while he was receiving treatment with montelukast, a chemically distinct cysteinyl leukotriene type 1 receptor antagonist. (lookformedical.com)
Herpes2
- TNF-RI belongs to the large TNF receptor family, among which TNF-RII (TNF-R p75-80), lymphotoxin-beta receptor (LTbetaR) and the Herpes virus entry mediator (HVEM). (hycultbiotech.com)
- Acts as a receptor for Herpes simplex virus. (joplink.net)
Cytoplasmic1
- FADD therefore acts as an adapter molecule, allowing caspase-8 to become recruited to the cytoplasmic region of Fas following receptor activation. (bdbiosciences.com)
Induces1
- Its binding with Fas receptor (FasR) induces programmed cell death in the FasR-carrying target cell. (wikipedia.org)
Cluster1
- 3-5 LILRs are encoded by a set of genes within the leukocyte receptor cluster on chromosome 19q13.4, adjacent to the killer Ig-like receptor ( KIR ) genes that are responsible for controlling NK- and CD8 T-cell survival and effector functions. (ashpublications.org)
Antibody1
- Most of these immunomodulatory antibodies are of IgG isotypes that have low, or no, binding to the Fc gamma receptors (FcγRs) that trigger cell-mediated cytotoxic effector functions such as antibody dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP). (bmj.com)
Cells2
- We suggest that an analysis of the apoptotic rate induced by serum in Jurkat cells and the levels of soluble CD95 in serum could be helpful during the prognosis and treatment of women detected with precancerous lesions or cervical cancer. (pdgfreceptor.com)
- γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)
Cell death1
- Glycosylation of classical death receptors fine-tunes cell death programs. (nature.com)
Resistance1
- In the last years higher attention focused on the role of immunoregulation both in the insulin production by β-cell of Langerhans-islets and in the insulin sensitivity (resistance) of insulin receptors. (biobran.org)
Death4
- FasR: The Fas receptor (FasR), or CD95, is the most intensely studied member of the death receptor family. (wikipedia.org)
- Unfolded Protein Response (UPR) and Death Receptor (DR) signalling are cellular stress pathways frequently activated towards pro-tumoral cellular outputs in cancer. (researchgate.net)
- TNF-RI contains a characteristic structural cassette termed death domain in its sequence that is conserved within a distinct subset of other TNF-R family members, such as CD95, DR3, DR4, and DR5. (hycultbiotech.com)
- Deletion of the death domain of the TNF-RI results in a non-functional receptor, indicating that the death domain is required for the signal transduction of the physiological functions of TNF-RI in vivo. (hycultbiotech.com)
Flow1
- To check the subset for its capability of secreting antibodies, cell cultures were performed and soluble immunoglobulins were detected using a bead-based flow cytometry assay. (bmj.com)
Acts1
- Microbial infection) Acts as a receptor for adenovirus subgroup B. (cusabio.com)
Proliferation1
- Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. (cusabio.com)
Results1
- Our results reveal a role for B7-2 as obligatory receptor for superantigens. (cusabio.com)
Functions1
- However, TNF-RI functions as the high affinity receptor for soluble TNF (sTNF). (hycultbiotech.com)
Levels1
- Addition ally, we were able to show higher levels of soluble CD95 in serum of women with cancer than in those of healthy controls. (pdgfreceptor.com)
Form2
- FAS also exists in a soluble form that weight approximately 26kDa. (thermofisher.com)
- TNF-RI is present as soluble form in body fluids (for instance plasma and CSF). (hycultbiotech.com)
Role1
- The role of TRAIL/TRAIL receptors in central nervous system pathology. (mdc-berlin.de)
Signal1
- Caspase-8 (FLICE/MACH-1) is a 55 kDa cytosolic protein with homology to the CD95/Fas-associated signal transducer, FADD/MORT-1, as well as to other caspase (ICE/Ced-3) cysteine proteases. (bdbiosciences.com)