• The Env proteins of the Avian Sarcoma and Leukosis virus (ASLV) and the Murine Leukemia Virus (MLV) are both trimers of SU-TM heterodimers. (wikipedia.org)
  • Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)
  • The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. (lookformedical.com)
  • Proteins synthesized by HUMAN IMMUNODEFICIENCY VIRUSES such as the HIV-1 and HIV-2 . (lookformedical.com)
  • The tropism of the virus is determined by the SU protein domain because it is responsible for the receptor-binding function of the virus. (wikipedia.org)
  • The Env protein of Human Immunodeficiency Virus (HIV) also has a trimeric structure of heterodimers. (wikipedia.org)
  • External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
  • Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. (lookformedical.com)
  • Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
  • Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. (lookformedical.com)
  • She conducts research in infectious disease pathogenesis, diagnostics and vaccine development, with a focus on feline viruses. (gla.ac.uk)
  • Viral culture is also related, with cells as hosts for the viruses. (wikipedia.org)
  • Margaret Hosie is Professor of Comparative Virology at the MRC-University of Glasgow Centre for Virus Research. (gla.ac.uk)
  • Prof Hosie has served as a member of the Editorial Boards of Virus Genes and BMC Veterinary Research and has acted as a guest editor for Viruses Special Issues on companion animal virology. (gla.ac.uk)
  • p47v-crk (v-Crk) is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. (bdbiosciences.com)
  • It is becoming clear that vectors based upon adeno-associated virus (AAV) are the vectors of choice for certain gene therapy applications such as muscle delivery. (justia.com)
  • In particular embodiments, the chimeric viruses of the invention have enhanced transduction capability (e.g., transduction of skeletal muscle, cardiac muscle, glial cells, astrocytes, liver, retina and/or lung, etc.), enhanced levels of transgene expression and/or earlier onset of transgene expression. (justia.com)
  • Growing viruses in cell cultures allowed preparation of purified viruses for the manufacture of vaccines . (wikipedia.org)
  • This vaccine was made possible by the cell culture research of John Franklin Enders , Thomas Huckle Weller , and Frederick Chapman Robbins , who were awarded a Nobel Prize for their discovery of a method of growing the virus in monkey kidney cell cultures. (wikipedia.org)
  • A veterinarian, she completed her Ph.D. studies on feline immunodeficiency virus in 1991 and subsequently she has pursued an academic research and teaching career in Glasgow, collaborating with colleagues in Europe, US, Australia and Japan. (gla.ac.uk)
  • The surge in Human Immunodeficiency Virus (HIV) research in order to identify new therapeutic targets has led to a better understanding of the retroviral life cycle. (biomedcentral.com)
  • In this study, a novel slightly-soluble selenium (Se) fertilizer (SSF) was successfully applied to address the problems of Cd pollution in paddy soil and rice, and Se deficiency in human beings. (bvsalud.org)
  • As in many other cases of single-locus resistance, resistance to type B avian leukosis viruses is due to the lack of a functional receptor for the viruses. (omia.org)
  • Resistance to the B subgroup of avian sarcoma and leukosis viruses is a single-locus trait, with susceptibility being dominant and resistance recessive (Crittenden et al. (omia.org)
  • 2. Two different molecular defects in the Tva receptor gene explain the resistance of two tvar lines of chickens to infection by subgroup A avian sarcoma and leukosis viruses. (nih.gov)
  • 5. Model of the TVA receptor determinants required for efficient infection by subgroup A avian sarcoma and leukosis viruses. (nih.gov)
  • 8. The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily. (nih.gov)
  • 10. Identification of two residues within the LDL-A module of Tva that dictate the altered receptor specificity of mutant subgroup A avian sarcoma and leukosis viruses. (nih.gov)
  • Molecular identification of avian leukosis virus subgroup E loci and tumor virus B locus in Chinese indigenous chickens. (omia.org)
  • Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup B. J Virol 83:4835-43, 2009. (omia.org)
  • A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo. (omia.org)
  • 1. Analysis of the subgroup A avian sarcoma and leukosis virus receptor: the 40-residue, cysteine-rich, low-density lipoprotein receptor repeat motif of Tva is sufficient to mediate viral entry. (nih.gov)
  • 3. The spacing between cysteines two and three of the LDL-A module of Tva is important for subgroup A avian sarcoma and leukosis virus entry. (nih.gov)
  • 4. Characterization of determinants for envelope binding and infection in tva, the subgroup A avian sarcoma and leukosis virus receptor. (nih.gov)
  • 6. The receptor for the subgroup A avian leukosis-sarcoma viruses binds to subgroup A but not to subgroup C envelope glycoprotein. (nih.gov)
  • 7. Identification of key residues in subgroup A avian leukosis virus envelope determining receptor binding affinity and infectivity of cells expressing chicken or quail Tva receptor. (nih.gov)
  • 9. Residue Trp-48 of Tva is critical for viral entry but not for high-affinity binding to the SU glycoprotein of subgroup A avian leukosis and sarcoma viruses. (nih.gov)
  • 11. A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor. (nih.gov)
  • 12. Characterization of the LDL-A module mutants of Tva, the subgroup A Rous sarcoma virus receptor, and the implications in protein folding. (nih.gov)
  • 13. Genetic mapping of the cloned subgroup A avian sarcoma and leukosis virus receptor gene to the TVA locus. (nih.gov)
  • 15. Residues L55 and W69 of Tva Mediate Entry of Subgroup A Avian Leukosis Virus. (nih.gov)
  • 17. Soluble forms of the subgroup A avian leukosis virus [ALV(A)] receptor Tva significantly inhibit ALV(A) infection in vitro and in vivo. (nih.gov)
  • 18. Receptor-induced conformational changes in the subgroup A avian leukosis and sarcoma virus envelope glycoprotein. (nih.gov)
  • we have recently cloned avian genes encoding receptors for a subgroup of Rous sar- coma virus (RSV) and shown that the receptors resemble the receptor for low-density lipoproteins (LDL). (nih.gov)
  • Recently, the receptor for ecotropic murine leukemia virus (MLV) was shown to be a very different type of protein, an amino acid permease with fourteen transmembrane domains. (nih.gov)
  • Survey of endogenous virus and TVB* receptor status of commercial chicken stocks supplying specific-pathogen-free eggs. (omia.org)
  • 20. Novel monoclonal antibody directed at the receptor binding site on the avian sarcoma and leukosis virus Env complex. (nih.gov)
  • The tropism of the virus is determined by the SU protein domain because it is responsible for the receptor-binding function of the virus. (wikipedia.org)
  • The SU domain therefore determines the specificity of the virus for a single receptor molecule. (wikipedia.org)
  • The need to understand these and other aspects of retroviruses has become more urgent with the dis- covery that AIDS is caused by a retrovirus, the hu- man immunodeficiency virus (HIV). (nih.gov)
  • In a somewhat analogous way there was also a general feeling that viruses did not cause human cancers, and that retroviruses, in particular, did not exist in human beings. (science-connections.com)
  • This is a major difference between retroviruses and other viruses, which we tend to think are transmitted while a person is sick or in the early phase of incubation, which can be a few days, a few weeks, or at the most a few months. (science-connections.com)
  • Often, a virus is completely eliminated by the immune system . (wikidoc.org)
  • [9] In the late 18th century, Edward Jenner observed and studied Miss Sarah Nelmes, a milkmaid who had previously caught cowpox and was found to be immune to smallpox , a similar, but devastating virus. (wikidoc.org)
  • simian virus 40 expression vectors contain- ing the chicken M1 PK cDNA (RL142PK10X, RL18PK8X, and RL18PK12X, which differ by the reading frame at a * Corresponding author. (nih.gov)
  • The present invention is in the field of recombinant adeno-associated virus vectors. (justia.com)
  • Both cell bound and soluble forms of modified segments are made available, as are methods for assays using them, allowing for screening of ligand analogues. (everypatent.com)
  • Viruses infect cellular life forms and are grouped into animal, plant and bacterial types, according to the type of host infected. (wikidoc.org)
  • Preparation of pyrrolidine derivatives useful in treatment of hepatitis C virus infection ((3 D Gene Pharma, Fr. (nih.gov)
  • [10] Dimitri Ivanovski used this filter to study an infection of tobacco plants, now known as tobacco mosaic virus . (wikidoc.org)
  • As its name implies, AAV is dependent upon the presence of a helper virus, such as an adenovirus or herpes virus, for active replication. (justia.com)
  • Human TIymphotropic (leukemia) virus type I (HTL V -I) was found by Gallo and coworkers in the late 1970s and first reported in 1980. (science-connections.com)
  • Morphology Of Angioinvasive T-Cell Lymphoma Reproduced In Rabbits Inoculated With Human T-Cell Leukemia Virus Type-1 Transformed T-Cells. (nih.gov)
  • The English plural form of virus is viruses . (wikidoc.org)
  • At the other end of the spectrum, MMTV (Mouse Mammary Tumor Virus has only 4 sites for oligosaccharide addition (two on gp52 and two on gp37). (wikipedia.org)
  • For example, unlike most organisms, viruses do not have cells . (wikidoc.org)
  • Adeno-associated virus (AAV) is a 4.7 kb, single stranded DNA virus that contains two open reading frames, rep and cap. (justia.com)
  • This study has the potential to shed light on the evolution and genome biology of reptiles, avians, and modern vertebrate taxa by allowing a better understanding of the diversity and divergence of the ERVs that may be present in these taxa. (biomedcentral.com)
  • The present invention provides mutant adeno-associated virus (AAV) that exhibit altered capsid properties, e.g., reduced binding to neutralizing antibodies in serum and/or altered heparin binding and/or altered infectivity of particular cell types. (justia.com)
  • Phenol in turn is more soluble in waxes and lipids such as those present on tubercle bacilli. (microrao.com)
  • It is used as a model for PULMONARY ALVEOLI function and virus infections, as a TRANSFECTION host, and for PRECLINICAL DRUG EVALUATION. (nih.gov)
  • A virus (from the Latin virus meaning "toxin" or "poison"), is a sub-microscopic infectious agent that is unable to grow or reproduce outside a host cell . (wikidoc.org)