AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
1-OctanolOctanolsAlcoholsOctanesHexanolsHeptanol2-PropanolAnestheticsGap JunctionsGlycyrrhetinic Acid1-ButanolPentanolsLiquid Phase MicroextractionCarbenoxoloneWaterSolventsMultiple Chemical Sensitivity
SolubilityEtherAqueousPropylene glycolAlcoholEthanolOrganicFreely solubleTolueneCoefficientsSubstanceSlightlyVapour densityCompoundsLogPSolubilitiesAlcoholsCarboxylateSurfactantEsterBufferWater partitionAlkylChemicalsChemicallyPolarMeltingDeterminationMethylSubstancesSolventBiodegradableSUSPECTED ADVERSE REACTIONSDissolvesConstantSodiumReceptorPhaseConcentrationsAccordanceZaleplonCompoundAcuteGoodMixtureCapsules
Solubility6
  • Previous and present solubility tests showed that pyridine, nicotine, THF and aniline are completely soluble in liquid PEG200 and PEG400. (aston.ac.uk)
  • This study confirmed and extended the previous discoveries that PEG can adjust its polarity and may be soluble with both polar and non-polar compounds as well as that the addition of a methyl group dramatically reduces the solubility of PEG with arenes. (aston.ac.uk)
  • The lower alcohols are readily soluble in water but the solubility decreses with the rise in the molecular weight. (brainmass.com)
  • The important physicochemical properties of three novel bioactive hybrid compounds with different groups (-CH3, -F and -Cl) were studied, including kinetic and thermodynamic solubility in pharmaceutically relevant solvents (buffer solutions and 1-octanol) as well as partition coefficient in system 1-octanol/buffer pH 7.4. (bvsalud.org)
  • The aqueous solubility of these chemicals is poor and ranged from 0.67 × 10-4 to 1.98 × 10-3 mol·L-1. (bvsalud.org)
  • At 25 °C, toluene has a solubility in water of 526 mg l−1, an estimated vapor pressure of 28.4 mm Hg and a Henry's Law Constant of 6.64 × 10−3 atm-m3 mol−1(USEPA, 2011). (yourprofoundinfo.com)
Ether5
  • Isomeric ether carboxylate is highly soluble and has excellent wetting power. (tatayoung.com)
  • Dipropylene Glycol Methyl Ether is soluble in water and many organic solvents. (actionext.com)
  • Chlorthalidone is practically insoluble in water, ether and chloroform and soluble in methanol and also slightly soluble in alcohol. (biomedres.info)
  • It is very soluble in water, soluble in isopropranolol and in chloroform, and practically insoluble in ether and in glycerine. (drugs-library.com)
  • Octanol Polyoxyethylene Ether: Octanol polyoxyethylene is a type of non-ionic detergent, soluble in aqueous solutions without gel phase. (cookingmamacookoff.com)
Aqueous4
  • A value in the range 31.8 mN/m to ca. 66.5 mN/m at ca. 90% saturated aqueous solution is estimated by read-across from undecan-1-ol and (Z)-octadec-9-enol. (europa.eu)
  • The surface tension of undecan-1-ol is 31.8 mN/m at 22.5°C and ca. 90% saturated aqueous solution. (europa.eu)
  • Good dispersion, 1% aqueous liquid is milky, white liquid. (actionext.com)
  • It is freely soluble in water and both basic and acidic aqueous solutions. (hipaaspace.com)
Propylene glycol1
  • Zaleplon is a white to off-white powder that is practically insoluble in water and sparingly soluble in alcohol or propylene glycol. (rxlist.com)
Alcohol4
  • It is very slightly soluble in water and soluble in alcohol. (wikipedia.org)
  • Oxycodone hydrochloride dissolves in water (1 g in 6 to 7 mL) and is considered slightly soluble in alcohol (octanol water partition coefficient is 0.7). (prescriptiondrugs.com)
  • About Sec-Octyl alcohol ethoxylates;2-Octanol ethoxylates: Good dispersion, 1% solution in water is a white milky liquid. (actionext.com)
  • It is slightly soluble in alcohol (octanol water partition coefficient 0.7). (globalsourcechem.com)
Ethanol4
  • Due to higher molecular weight octanol has a higher viscous nature as compared to ethanol . (brainmass.com)
  • It is a white to white powder that is soluble in water and ethanol. (dmcha.com)
  • It is readily soluble in water and ethanol and has a pKa of 9.41. (prescriptiondrugs.com)
  • PPG series is soluble in toluene ethanol trichloroethylene, and other organic solvants. (cookingmamacookoff.com)
Organic4
  • boiling point, 110.6° C [231.1° F]) is a colourless, flammable, toxic liquid, insoluble in water but soluble in all common organic solvents. (yourprofoundinfo.com)
  • It is soluble in toluene and other organic solvants. (cookingmamacookoff.com)
  • Water comes to mind but most organic compounds are not soluble in it. (biotage.com)
  • To highlight the importance of choosing the correct dissolution solvent, I developed a reversed-phase method to separate five organic-soluble compounds of various polarities (methyl paraben, butyl paraben, naphthalene, 1-nitronaphthalene, 3,5-dibenzyloxyacetophenone). (biotage.com)
Freely soluble1
  • It is a white crystalline powder which is practically insoluble in water but freely soluble solvents like methanol, dimethyl sulfoxide and dimethyl formamide, soluble in acetic acid, slightly soluble in acetone and Acetonitrile and very slightly soluble in Tetra Hydro furan and 1-octanol. (biomedres.info)
Toluene2
Coefficients2
  • Chemicals having log octanol/water partition coefficients between 1 and 2 are well absorbed. (cdc.gov)
  • The temperature dependencies of partition coefficients of new hybrids in the model system 1-octanol/buffer pH 7.4 as a surrogate lipophilicity were measured by the shake flask method. (bvsalud.org)
Substance4
  • There are no impurities present at or above 1% which are not category members or which would affect the properties of the substance. (europa.eu)
  • As the test item and the hydrolysis products are only poorly soluble in water it is expected that after shaking with n-octanol, the residue in the aqueus phase is below the limit of quantitation of 1 mg/L. A determination of the partition coefficient is therefore not possible.The substance hydrolyses rapidly with a half life of 7.7 hours. (europa.eu)
  • Acid Brown 348 is a soluble substance in water (36.97 g/l at 20 °C) and logPow was calculated as -1.2593, showing a greater affinity with the water phase, than the octanol phase (REACH&Colours Kft, 2013). (europa.eu)
  • The risk seems entirely insignificant for the highly water-soluble substance rosuvastatin. (janusinfo.se)
Slightly4
  • Slightly soluble materials are not well absorbed. (cdc.gov)
  • 2-ethylhexanol is a colorless liquid with a characteristic odor and is slightly soluble in water. (vivochem.com)
  • Isovaleric acid is slightly soluble in water. (guidechem.com)
  • More fat-soluble statins (simvastatin, atorvastatin) may be quite potent and (together with ezetimibe) represent a slightly higher risk than the others, but the levels in the environment are probably well below the concentrations that give rise to effects. (janusinfo.se)
Vapour density1
  • The relative vapour density and the relative vapour air/mixture of MTBE being above 1, it means that this mixture would tend to remain at the sea level. (memac-rsa.org)
Compounds4
  • The compounds studied are more soluble in the buffer pH 2.0, simulating the gastrointestinal tract environment (by an order of magnitude) than in the buffer pH 7.4 modelling plasma of blood. (bvsalud.org)
  • In silico analyses by molecular docking to model ligand-protein interactions, and by SwissADME and ADMET webservers to establish the pharmacokinetic profile of the four investigated compounds in interaction with the angiogenesis target protein HIF-1α/breast cancer (PDB ID: 3KCX) and human androgen receptor/prostate cancer (PDB ID: 1E3G) were performed. (springeropen.com)
  • This study aimed to examine the interaction of four cytotoxic compounds isolated from Madagascar endemic medicinal plants Diospyros quercina and Salacia leptoclada with both angiogenesis target protein HIF-1α and human androgen receptor (HAR) by evaluating binding affinity energy of formed complex and defining the amino residues involved in such interaction. (springeropen.com)
  • Reversed-phase chromatography is typically used when you need to separate several milligrams of relatively polar compounds that either are not soluble in normal-phase solvents or are not compatible with bare silica because they react, stick, or both. (biotage.com)
LogP1
Solubilities1
  • Nevertheless, experimental Pow values have been obtained, usually as quotients of solubilities in octanol and in water. (europa.eu)
Alcohols1
  • 2,2,6,6-Tetramethyl-1-piperidinyloxy or 2,2,6,6-Tetramethylpiperidine 1-oxyl free radical or TEMPO is a catalyst employed in the oxidation of primary alcohols to aldehydes with NaOCl. (mubychem.com)
Carboxylate1
  • Azilsartan Medoxomil ( Figure 1 ) is an Angiotensin II receptor antagonist which has the chemical name (5-Methyl-2-oxo-1,3- dioxol-4-yl) methyl 2-ethoxy-1-{ [2'-(5-oxo-4,5-dihydro 1,2,4- oxadiazol-3-yl) biphenyl-4-yl] methyl}-1H-benzimidazole-7- carboxylate monopotassium salt. (biomedres.info)
Surfactant2
  • U-CAT SA 1 is an extensively tested safe and effective surfactant. (dmcha.com)
  • U-CAT SA 1 is a safe and effective surfactant. (dmcha.com)
Ester1
Buffer1
  • The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is -1.25. (hipaaspace.com)
Water partition1
Alkyl1
  • All members of the alkyl sulfates category are well soluble in water. (europa.eu)
Chemicals1
  • not soluble according to NOAA Cameo chemicals - http://cameochemicals.noaa.gov/ ) which means that any spillage in water would initially float and rapidly evaporate (and/or possibly dissolve). (memac-rsa.org)
Chemically1
  • Chlorthalidone ( Figure 2 ) is chemically 2-Chloro-5-(1- hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1- yl)benzenesulfonamide. (biomedres.info)
Polar1
  • The EN difference between hydrogen and sulfur is 0.4, so hydrogen and sulfur form non-polar bonds. (yourprofoundinfo.com)
Melting1
  • Methadone hydrochloride has a melting point of 235°C, a pKa of 8.25 in water at 20°C, a solution (1 part per 100) pH between 4.5 and 6.5, a partition coefficient of 117 at pH 7.4 in octanol/water. (drugs-library.com)
Determination1
  • Determination of the partition coefficient octanol/water for any of the active substances, the Predicted No Effect Concentration (PNEC) calculation and lower values of assessment factors should be re-assessed. (janusinfo.se)
Methyl1
  • The chemical name for tramadol hydrochloride is (±)cis-2-[(dimethylamino)methyl]-1-(3methoxyphenyl) cyclohexanol hydrochloride. (prescriptiondrugs.com)
Substances2
  • In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, 'information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met. (europa.eu)
  • With respect to the effect on the marine environment, IBAL has no GESAMP profile which could suggest it is not soluble as soluble substances are usually targeted in priority by the IMO Group of Experts. (memac-rsa.org)
Solvent1
  • 2-ethyl-1-hexanol is a solvent with a low volatility. (vivochem.com)
Biodegradable1
  • U-CAT SA 1 is also biodegradable. (dmcha.com)
SUSPECTED ADVERSE REACTIONS1
  • To report SUSPECTED ADVERSE REACTIONS, contact Amryt Pharmaceuticals DAC at 1-855-303-2347 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. (drugs.com)
Dissolves1
Constant1
  • Its partition coefficient in octanol/water is constant (log PC = 1.23) over the pH range of 1 to 7. (rxlist.com)
Sodium1
Receptor2
  • Other nonclinical studies have also shown that Zaleplon binds selectively to the brain omega-1 receptor situated on the alpha subunit of the GABAA /chloride ion channel receptor complex and potentiates t-butyl-bicyclophosphorothionate (TBPS) binding. (healthyplace.com)
  • Studies of binding of Zaleplon to recombinant GABAA receptors (α1β1γ2[omega-1] and α2β1γ2 [omega-2]) have shown that Zaleplon has a low affinity for these receptors, with preferential binding to the omega-1 receptor. (healthyplace.com)
Phase1
  • Zaleplon was rapidly absorbed with a time to peak concentration (tmax) of approximately 1 hour and a terminal-phase elimination half-life (t1/2) of approximately 1 hour. (healthyplace.com)
Concentrations2
  • Peak plasma concentrations are attained within approximately 1 hour after oral administration. (healthyplace.com)
  • Well, I have found that at high sample concentrations (~1 g /mL) and with small injection volumes (~0.5% of a column volume), you can get good results. (biotage.com)
Accordance2
  • U-CAT SA 1 should be disposed of in accordance with local, state, and federal regulations. (dmcha.com)
  • 1. Data must be provided in accordance with § 158.320 . (cornell.edu)
Zaleplon5
  • The chemical name of zaleplon is N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide. (rxlist.com)
  • The blood to plasma ratio for Zaleplon is approximately 1, indicating that Zaleplon is uniformly distributed throughout the blood with no extensive distribution into red blood cells. (healthyplace.com)
  • After oral administration, Zaleplon is extensively metabolized, with less than 1% of the dose excreted unchanged in urine. (healthyplace.com)
  • After either oral or IV administration, Zaleplon is rapidly eliminated with a mean t1/2 of approximately 1 hour. (healthyplace.com)
  • The oral-dose plasma clearance of Zaleplon is about 3 L/h/kg and the IV Zaleplon plasma clearance is approximately 1 L/h/kg. (healthyplace.com)
Compound2
  • U-CAT SA 1 is a compound with the formula C10H17NO2. (dmcha.com)
  • Five stock samples were prepared at 1 gram of each compound in 5-mL of each of the solvents (~20% solution). (biotage.com)
Acute3
  • ABSTRAL ® is contraindicated in opioid non-tolerant patients ( 1 ) and in management of acute or postoperative pain, including headache/migraines ( 4 , 5.1 ). (drugs.com)
  • Due to the risk of fatal respiratory depression, SUBSYS is contraindicated in opioid non-tolerant patients ( 1 ) and in management of acute or postoperative pain, including headache/migraines. (nih.gov)
  • With respect to the effect on the marine environment, according to the IMO Group of Experts on Scientific Aspects of Marine Environmental Protection (GESAMP) hazard profiles, MTBE does not bio-accumulate and has a low aquatic acute toxicity (rated 1 in 0-6 scale, 0 being the lowest) and very low chronic toxicity (rated 0, 1 in 0-4 scale, 0 being the lowest). (memac-rsa.org)
Good2
  • Based on the H-bonding interaction, ligands 1 and 2 displayed a good pharmacophore profiles to both protein targets 3KCX and 1E3G. (springeropen.com)
  • U-CAT SA 1 is also a good emulsifier and can be used to prepare stable emulsions. (dmcha.com)
Mixture1
  • Chlorine adds to 1,3-butadiene to afford a mixture of 3,4-dichlorobut-1-ene and 1,4-dichlorobut-2-ene. (antareschem.com)
Capsules1
  • The active ingredient in gabapentin capsules, USP is gabapentin, which has the chemical name 1-(aminomethyl)cyclohexaneacetic acid. (hipaaspace.com)