• The solubility parameters are helpful for the prediction of the solubility in the binary solvent mixtures. (mdpi.com)
  • Mixtures of the reservoir fluid and injection gas are physically recombined in the same proportions as each of the swollen oil mixtures in the solubility-swelling study described above. (corelab.com)
  • There are a number of patterns in the data obtained from measuring the solubility of different salts. (purdue.edu)
  • Rank the solubility of different salts. (colorado.edu)
  • Revised and updated throughout, Hansen Solubility Parameters: A User's Handbook, Second Edition features the three Hansen solubility parameters for over 1200 chemicals and correlations for over 400 materials including polymers, inorganic salts, and biological materials. (routledge.com)
  • Dow has developed the AFFINISOL™ line of excipients to enable solubility enhancement.Hypromellose acetate succinate (HPMCAS) has proven effective at producing stable amorphous solid dispersions for poorly soluble APIs. (in-pharmatechnologist.com)
  • In my presentation, I will cover the following topics 1) Discovery formulations: changing the formulation paradigm 2) Impact of excipients and solubility on oral bioavailability 3) A novel, high throughput formulation screening method adapted to the discovery environment 4) The Impact of early formulation screening on Pharmacokinetic & Pharmacology. (selectbiosciences.com)
  • Production is set to commence early 2014 and the site will commercially manufacture solubility enabling excipients. (in-pharmatechnologist.com)
  • The Hildebrand's solubility parameters have been calculated for 18 ionic liquids from the inverse gas chromatography measurements of the activity coefficients at infinite dilution. (mdpi.com)
  • From the solubility parameters, the standard enthalpies of vaporization of ionic liquids were estimated. (mdpi.com)
  • Solubility may also strongly depend on the presence of other species dissolved in the solvent, for example, complex-forming anions ( ligands ) in liquids. (wikidoc.org)
  • Comparing gas solubility in liquids with the concept of vapor pressure highlights another important pattern: Increasing pressure increases the solubility of a gas in liquid. (dummies.com)
  • This means that solubility should be viewed as a result of two simultaneous and opposing processes: dissolution and precipitation. (wikidoc.org)
  • The solubility of a substance is an entirely different property from the rate of solution, which is how fast it dissolves. (wikipedia.org)
  • 1 MeV) at temperatures in the range of 250 to 300°C, have higher dissolution and precipitation solubilities compared to those measured on unirradiated material. (astm.org)
  • An enhancement of solid solubility has been found in many bulk nanocrystalline materials, for instance [ 1 , 2 ]. (hindawi.com)
  • However quantifying the impact of grain refinement on equilibrium solid solubility is important for understanding the behavior of nanocrystalline alloys upon thermal activation. (hindawi.com)
  • An experimental program has been carried out to measure the terminal solid solubility (TSS) of hydrogen in Zircaloy. (astm.org)
  • My presentation will comprise of two sections: the first section will focus on formulation development of solid dispersions to enhance drug solubility and the second section will be dedicated to understanding transcriptomic changes of drug transporters during permeability studies. (selectbiosciences.com)
  • Sufficient permeability, aqueous solubility and physicochemical stability of the drug are important for achieving adequate bioavailability and therapeutic outcome. (frontiersin.org)
  • The report estimated that only 5% of new molecular entities (NMEs) under development by industry had both high solubility and high permeability (BCS Class I), while another 5% were of BCS Class III. (frontiersin.org)
  • The way to use this model on the website http://www.ou.edu/ for the prediction of protein solubility is explained. (springer.com)
  • Diaz AA, Tomba E, Lennarson R et al (2009) Prediction of protein solubility in Escherichia coli using logistic regression. (springer.com)
  • Presenting a comprehensive survey of the theoretical and practical aspects of HSPs, Hansen Solubility Parameters, Second Edition concludes with a detailed discussion on the necessary research, future directions, and potential applications for which HSPs can provide a useful means of prediction in areas such as biological materials, controlled release applications, nanotechnology, and self-assembly. (routledge.com)
  • I shall review the reasons why computer modelling is still relatively un-exploited by the pharmaceutical sector, give details of the methods with selected applications including prediction of solid state properties such as solubility, and then give a perspective for the future. (selectbiosciences.com)
  • Here, we first present solubility data for a reference set of 41 Adnectins and use them to screen computational solubility/aggregation prediction methods. (uwaterloo.ca)
  • On the basis of these results, we select the CamSol prediction method for use in a protein engineering project that applies the principles of consensus design to enhance the solubility of the Adnectin scaffold. (uwaterloo.ca)
  • Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. (hindawi.com)
  • Solubility is a major challenge for formulation scientist. (hindawi.com)
  • Now in its sixth year, the Drug Formulation, Solubility and Bioavailability Summit continues to offer you the best learning and networking venue for improving drug performance and therapeutic impact through enabled formulations and more effective delivery methods. (bvents.com)
  • The role of aqueous-solubility of any new chemical entity (NCE) or a drug is crucial and decisive in the development of its formulation. (frontiersin.org)
  • Dow says the acquisition of partner Bend Research is "good news" and will strengthen its developments in solving solubility and bioavailability issues in drug formulation. (in-pharmatechnologist.com)
  • I have a problem regarding the solubility of my protein. (bio.net)
  • A method for expressing proteins as a fusion chimera with a domain of p26 or alpha crystallin type proteins to improve the protein stability and solubility when over expressed in bacteria such as E. coli is provided. (google.com)
  • The observation that protein solubility decreases as solution ionic strength increases at high co. (chegg.com)
  • We found that despite the fact that the total quantity of proteins within the cellular environment remains approximately constant during aging, protein aggregation sharply increases between days 6 and 12 of adulthood, after the worms have reproduced, as individual proteins lose their stoichiometric balances and the cellular machinery that maintains solubility undergoes functional decline. (pnas.org)
  • Improved protein solubility in two-dimensional electrophoresis using tributyl phosphine as reducing agent. (nih.gov)
  • Tributyl phosphine improves protein solubility during isoelectric focusing, which results in shorter run times and increased resolution. (nih.gov)
  • This vector suite allows the parallel cloning of the same PCR product into the 12 different expression vectors evaluating protein expression under different promoter strength, different fusion tags as well as different solubility enhancer proteins. (frontiersin.org)
  • Additionally, we propose the use of a new fusion protein which appears to be a useful solubility enhancer. (frontiersin.org)
  • We also propose a new solubility enhancer protein that can be included in the evaluation of the expression of RP that are insoluble in classical expression conditions. (frontiersin.org)
  • Adnectins are known to vary in aggregation propensity, sometimes despite exceptionally high amino acid sequence identity, and have been used as a basis for protein aggregation/solubility research. (uwaterloo.ca)
  • Aggregation of therapeutic proteins can provoke a protein-specific immune response, and the solubility of Adnectins is therefore of immediate practical interest. (uwaterloo.ca)
  • We describe a statistical model that uses binomial logistic regression for predicting the solubility of heterologous proteins expressed in E. coli . (springer.com)
  • Harrison R.G., Bagajewicz M.J. (2015) Predicting the Solubility of Recombinant Proteins in Escherichia coli . (springer.com)
  • More than a decade ago, we put forward the "life on the edge of solubility" hypothesis, according to which proteins are expressed in the cellular environment at levels close to their solubility limits. (pnas.org)
  • This observation was based on the analysis of a small number of proteins for which solubility and cellular concentration information was available at the time. (pnas.org)
  • We have been able to show in this way that the vast majority of proteins in a model organism are indeed expressed above their solubility limits, and to investigate the consequences of this phenomenon. (pnas.org)
  • To function effectively proteins must avoid aberrant aggregation, and hence they are expected to be expressed at concentrations safely below their solubility limits. (pnas.org)
  • By analyzing proteome-wide mass spectrometry data of Caenorhabditis elegans , however, we show that the levels of about three-quarters of the nearly 4,000 proteins analyzed in adult animals are close to their intrinsic solubility limits, indeed exceeding them by about 10% on average. (pnas.org)
  • Here we describe a new versatile vector suite dedicated to the expression improvement of recombinant proteins (RP) with solubility problems. (frontiersin.org)
  • and one or more solubility-modified high strength and/or high-toughness polymeric materials selected from polyamides, polyethers, and liquid crystal polymers. (google.com)
  • US Patent 20110201836 describes a new type of extraction based on silicone polymers having different solubilities, which allows for the customization of a menstruum to extract not only more active ingredient, but also narrower ranges of materials than has heretofore been possible. (cosmeticsandtoiletries.com)
  • Dendrimers, a new class of polymers, possess great potential for drug solubility improvement, by virtue of their unique properties. (frontiersin.org)
  • The solubility of sucrose in water at 20 degrees Celsius (60 degrees Fahrenheit) is 204 g sucrose/100 g water. (reference.com)
  • What is the solubility of N 2 in a glass of water at 20 degrees Celsius sitting on a coffee table within a beach house? (dummies.com)
  • Methods of Collection and Compilation of Solubility Data 5. (routledge.com)
  • Novel high/low solubility classification methods for new molecular entities. (nih.gov)
  • The present invention relates generally to the field of oilfield exploration, production, and testing, and more specifically to a material and soluble oilfield elements such as well operating elements and methods of using same, which exhibit a combination of rapid solubility and high strength and/or high toughness. (google.com)
  • In this work, the quaternary Sn 1− y Mn y Te 1− x Se x phase space serves as a relevant model system to explore how a combination of computational and combinatorial-growth methods can be used to study equilibrium and non-equilibrium solubility limits. (rsc.org)
  • The talk will cover simple drugability methods to evaluate solubility and in vitro and in vivo studies to clarify pharmaceutical developability. (selectbiosciences.com)
  • Many of the industry's early prospective methods for improving drug solubility have not succeeded at market. (bvents.com)
  • Aqueous solubility values for the 24 samples compared favorably with results obtained by other traditional methods. (thefreedictionary.com)
  • Plot the solubility curve of a salt on the basis of observed data. (prezi.com)
  • The gas liquefaction may result in small kinks in the calculated solubility curve (calculated by equilibrating a solution with a GAS_PHASE ), and one is visible in figure 27 at 65 atm and 25 °C. (usgs.gov)
  • 1.1 This test method covers the determination of the degree of solubility in trichloroethylene of asphalt materials having little or no mineral matter. (astm.org)
  • The fugacity coefficient is close to 1 when the total pressure of the gas phase is less than about 10 atm, and it can be neglected in the solubility calculation. (usgs.gov)
  • Calculating solubility products from molar solubilities, and vice versa. (chemguide.co.uk)
  • Calculating hydrocarbon components solubility of natural gases is known as one of the important issues for operational works in petroleum and chemical engineering. (easychair.org)
  • The oxygen addition increased the hydrogen solubility. (astm.org)
  • However, increasing the matrix strength in Zircaloy-2 by cold working did not increase hydrogen solubility. (astm.org)
  • Furthermore, we demonstrate that hydrogen/deuterium exchange by hydrogen bonded amides in the C-terminal β-strand of the original scaffold is induced by transient inter-Adnectin association, and that equivalent exchange is not observed in our solubility-enhanced scaffold. (uwaterloo.ca)