Solid organ transplantation organ recipients organ transplanted. Medical search. Frequent questions

The positive effects of the immunosuppressive agents, obligatory for the prevention of organ rejection, have been tempered by the negative effects of these same therapies, leading to various infections that range in both frequency and severity. (medscape.com)
Newer immunomodulating agents have been developed, increasing the number of therapies that prevent organ rejection. (medscape.com)
Acute Renal Failure: Correlations Between Morphology and Function (1984) Kidney Transplant Rejection - Diagnosis and Treatment (1986) International Review of Experimental Pathology (multiple editions) Acute Renal Failure: Diagnosis, Treatment, Prevention (1991) Organ Transplantation: Long-Term Results (1992) Solid Organ Transplant Rejection: Mechanisms, Pathology, and Diagnosis (1996) National Kidney Foundation Fellowship, 1976-77. (wikipedia.org)
Whether the alternated microbiota in the gut contribute to the risk of allograft rejection (AR) and pulmonary infection (PI) in the setting of lung transplant recipients (LTRs) remains unexplored. (nature.com)
Severe allograft rejection (AR) and pulmonary infection (PI) are the most common complications within 1 year after the transplant. (nature.com)
11 , 12 Compelling evidences have also showed that the gut microbiome could modulate alloimmunity and rejection, directly implicating the gut microbiome as a therapeutic target in organ transplantation. (nature.com)
Kidney transplant recipients are advised to take immune-suppressive drugs (calcineurin inhibitors, antiproliferative agents, rapamycin inhibitors, and corticosteroids) in order to prevent rejection by the host immune system. (hindawi.com)
Transplantation of solid organs like kidney between donors and recipients of incompatible blood group is usually contraindicated because of the risk of ""hyper acute"" rejection. (apollohospitals.com)
This rejection occurs due to the presence of pre existing Anti-A or Anti B antibodies in the recipient that can destroy the incompatible donor organ. (apollohospitals.com)
Moreover, until 2004, HIV-infected patients were deemed unsuitable for renal transplantation owing to the lack of an ART programme, and the dangers of using immunosuppressive anti-rejection drugs in the absence of HAART. (scielo.org.za)
He uses (1) genetically-modified mouse models to study mechanisms underlying immune tolerance and rejection, (2) tissues from human transplant recipients to study immune protection from latent viral infection and tolerance and (3) immune responses to COVID19 in transplant recipients. (stanford.edu)
The Laboratory of Applied Precision Omics, led by Dr. Sean Agbor-Enoh, aims to develop novel approaches to detect and treat lung transplant rejection. (nih.gov)
APO aims develop novel approaches to detect and treat lung transplant rejection. (nih.gov)
Unfortunately, half of these patients will die within 5 - 6 years after transplant because of transplant rejection. (nih.gov)
Transplant rejection is detected by analyzing a biopsy of the transplanted organ. (nih.gov)
Could early detection and treatment of rejection save the transplanted organ from rejection? (nih.gov)
The focus of APO is to investigate whether early detection and treatment of rejection improves transplant survival. (nih.gov)
APO has developed an approach that picks up transplant rejection 2 - 3 months before biopsy. (nih.gov)
APO is also planning a clinical trial to assess whether early detection and treatment of rejection improves survival in lung transplant patients and also engaged in additional studies to understand molecular mechanisms of transplant rejection. (nih.gov)
Via genome sequencing of both lung transplant recipients and donors, we examine genetic ancestral markers that are associated with graft rejection and dysfunction. (nih.gov)
Maintenance of immunosuppression after solid-organ transplant is essential in order to prevent short-and long-term complications such as acute cellular rejection and chronic lung allograft dysfunction. (nih.gov)
3 As the patient's immune system is often significantly suppressed in the weeks to months following the transplant to prevent organ rejection, the risk of infection (viral, bacterial or fungal) is a concern and dental treatment during that time is recommended only on an emergency basis. (jcda.ca)
Although kidney transplantation is the most effective treatment for children with kidney failure, rejection of the transplanted organ by the recipient's immune system is a major concern. (medicalxpress.com)
Whether donor leukocytes persist within kidney transplants or play any role in rejection is unknown, however, in part because of limited techniques for distinguishing recipient and donor cells. (biorxiv.org)
The leukocyte donor to recipient ratio varied with rejection status for macrophages and with time post-transplant for lymphocytes. (biorxiv.org)
The immunological response of the multi-organ recipient, receiving multiple organs from the same donor, differs (the acute and chronic rejection are usually milder) than that in single organ transplantation. (frontiersin.org)
1.6 Consider Valganciclovir prophylaxis for at least 3 months after starting treatment for acute allograft rejection if either donor or recipient are CMV positive (D+/R-, D+/R+ or D-/R+) [2C]. (bts.org.uk)
Damage to your kidneys, liver, or other organs from anti-rejection medicines. (medlineplus.gov)

Clinical Outcomes of Administration of Rituximab for Desensitization in Liver Transplant Patients with Pref. (annalsoftransplantation.com)
Findings to date Detailed clinical and laboratory data in high granularity as well as patient-reported outcomes from transplant recipients and activities in Switzerland are available in the last decade. (bmj.com)
Drug development of immunosuppressive therapies (ISTs) for use in transplantation has historically focused on morbidity and mortality as the primary clinical outcomes of interest, with patient experiences often being an afterthought. (lww.com)
Increasing numbers of pregnancies are now occurring in recipients of non-renal solid organ transplants [1] , however, the published information is insufficient to assess with confidence the outcomes associated with these pregnancies. (ox.ac.uk)
This project will collect information about pregnancy outcomes amongst current non-renal solid organ transplant recipients in the UK and assess the role of immunosuppressive regimens and other factors in the outcomes of women and their infants. (ox.ac.uk)
Report from the national transplantation pregnancy registry (NTPR): outcomes of pregnancy after transplantation. (ox.ac.uk)
This concern has abated as good outcomes have been confirmed after transplantation in HIV-infected patients receiving HAART. (scielo.org.za)
In this study we seek to investigate the implications of loss of gut microbiota diversity by correlating them with long-term clinical outcomes in alloHSCT recipients. (mayo.edu)
We hypothesize that individuals of non-European ancestry experience inferior lung transplantation outcomes when compared to those of European ancestry. (nih.gov)
The goal of this research is to better inform pre- and post-transplant clinical management and further refine donor-recipient organ matching to improve long-term outcomes and survival in lung transplant patients. (nih.gov)
The Thomas E. Starzl Transplant Surgery State-of the-Art Lecture at this year's American Association for the Study of Liver Diseases (AASLD) annual meeting was devoted to the outcomes following solid organ transplantation in HIV-infected recipients. (hivandhepatitis.com)
Gastrointestinal (GI) complications occur in almost 40% of solid organ recipients, and similarly account for many of the non - allograft - related adverse outcomes in the HCT population. (elsevierpure.com)
Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)

Post‐transplant lymphoproliferative disease represents a spectrum of disorders resulting from lymphoid proliferations that occur as a result of immunosuppression following SOT. (b-s-h.org.uk)
1 The reported incidence varies according to patient age, transplant type and the degree of immunosuppression. (b-s-h.org.uk)
Immunosuppression after pediatric liver transplant: The parents' perspective. (nih.gov)
Solid organ transplant recipients (SOTRs) are on lifelong immunosuppression, which may interfere with adaptive immunity to COVID-19. (lu.se)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have made intermediate-term survival after lung transplantation an achievable goal. (ersjournals.com)
Over the last decade, improvements in surgical techniques, lung preservation, immunosuppression, and management of ischaemia/reperfusion injury and infections have contributed to increase the 1‐yr patient survival after lung transplantation (LTx) to 70-80% 1 . (ersjournals.com)
Mentioned above issues are exacerbated during the current Covid-19 pandemic, creating novel challenges in Covid-19 prevention, immunization, and adjusting or modifying the existing immunosuppression regimens in the multi-organ transplant recipients. (frontiersin.org)
GI disorders are frequently present prior to transplant and immunosuppression may augment symptoms. (elsevierpure.com)
After transplantation, high-dose steroid therapy and immunosuppression further promote bone loss and fracture development. (medscape.com)
However, some procedures (eg, hand, larynx, tongue, uterus, facial transplantation) enhance the quality of life but do not improve survival and have significant risks related to surgery and immunosuppression. (msdmanuals.com)

Participants Over 5500 solid organ transplant recipients have been enrolled in all six Swiss transplant centres by end of 2019, around three-quarter of them for kidney and liver transplants. (bmj.com)
Living donors are often used for kidney and hematopoietic stem cell transplants, less frequently for segmental liver transplants, and rarely for pancreas and lung transplants. (msdmanuals.com)
After approval by the Research Ethics Committee for the Santa Casa de Misericórdia de São Paulo, this study evaluated 33 prospective patients who were candidates for liver transplants and had been receiving treatment in a dentistry department for patients with special needs, during 3 years, according to the indication/medical records maintained by the liver transplant team. (bvsalud.org)

A prospective multicenter cohort of LTRs was identified in the four lung transplant centers. (nature.com)
Transplant centers having the capability of performing and managing multi-organ transplant surgeries are increasingly faced with the task of discerning how to address this scenario and balance the patient's needs with the availability of donor organs. (frontiersin.org)
Whilst addressing the topic of multi-organ transplants to provide insight on the current incidence and prevalence of multi-organ chronic disease and how transplant centers are addressing the needs of these very sick patients. (frontiersin.org)
Setting: Two Italian transplantation centers. (univr.it)
Cohort A was extracted from the United Network of Organ Sharing data set and cohort B from SOT recipients evaluated at 3 Mayo Clinic transplant centers. (elsevierpure.com)

Over the last several decades, the field of solid organ transplantation (SOT) science and practice has advanced significantly, only to be continually challenged by the risks for infection in SOT recipients. (medscape.com)
The diagnosis of infection is made more arduous since SOT recipients may present with more than one infection or at later stages in the disease process or may experience drug toxicity from immunosuppressive agents, as well as from antibiotics. (medscape.com)
A transplant using stem cells from a donor increases your risk for fungal infection more than a transplant that uses stem cells from your own body. (cdc.gov)
Aspergillosis is the most common type of fungal infection in stem cell transplant patients, followed by Candida infection and mucormycosis, but other types of fungal infections are also possible. (cdc.gov)
Two of the recipients died of West Nile Virus infection. (cdc.gov)
There is only sparse data on immunity against SARS-CoV-2 infection among renal transplant recipients. (hindawi.com)
Sternal wound infection with Mycoplasma salivarium following bilateral lung transplant. (stanford.edu)
HIV infection was previously an absolute contraindication to renal transplantation. (scielo.org.za)
Newswise - Skin cancer and skin infection are significantly more likely in solid organ transplant patients compared to patients with normal immune system function. (newswise.com)
3,4 As the patient moves into the stable post-transplantation period, risk of infection generally decreases and oral health care may be sought more routinely. (jcda.ca)
Clinicians should be aware that unusual illness or death in a transplant recipient may be due to an infection transmitted from the donor, and should rapidly alert their organ procurement organization (OPO) and public health authorities when this is suspected. (cdc.gov)
Blood samples from the donor and recipients were sent to CDC and all had evidence of LCMV infection. (cdc.gov)
LCMV infection in humans usually causes a self-limited meningitis, an inflammation of the lining surrounding the brain and spinal cord that resolves on its own and does not result in major complications, but organ transplant recipients can develop severe disease or death. (cdc.gov)
Recent infection with yellow fever virus was confirmed in all four organ recipients by identification of yellow fever virus RNA consistent with the 17D vaccine strain in brain tissue from one recipient and seroconversion after transplantation in three recipients. (cdc.gov)

1 Nevertheless, the overall survival after a lung transplant is still inferior compared to other solid-organ transplantation modalities. (nature.com)
12 These results supported that potential gut microbiome-targeted interventions could influence the survival of patients received solid organ transplantation. (nature.com)
However, chronic allograft dysfunction in the form of bronchiolitis obliterans remains a major hurdle that threatens both the quality of life and long-term survival of the recipients. (ersjournals.com)
After single LTx, survival after BOS onset is longer in recipients with emphysema compared with recipients with idiopathic pulmonary fibrosis 8 . (ersjournals.com)
Although the short-term survival of heart transplant recipients has improved, there is a steady decline in graft function over time. (rotrf.org)
Ischemia is an integral part in solid organ transplantation and is associated with impaired long-term graft survival. (rotrf.org)
1 Records from the United States show that, between 1999 and 2008, patient and graft survival improved for almost every organ type. (jcda.ca)
Solid organ transplantation (SOT) and hematopoietic cell transplantation (HCT) have dramatically improved the survival and quality of life in patients with a variety of malignancies and chronic end - organ disease. (elsevierpure.com)
The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
Long-term survival following organ transplantation has improved considerably. (medscape.com)
Almost always, transplantation is done to replace or restore the function of an end-stage diseased organ, thereby restoring an essential function and improving patient survival. (msdmanuals.com)

West Nile Virus transmission through tissue transplantation, for instance, skin, muscle, or connective tissues, has not been identified, and the risk for transmission by this route is not known. (cdc.gov)
none of the donor tissues were transplanted. (cdc.gov)
At many transplant centres, examination of both the hard and soft tissues of the oral cavity is often carried out by a dental professional to determine oral and dental health status before transplantation. (jcda.ca)
The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
Thus, the availability of and access to human tissues for transplantation remains essential. (who.int)
In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor. (cdc.gov)
Skin grafts Many different types of tissues can be transplanted, including skin, bone, cartilage, adrenal tissue, fetal thymus, corneas, and composite transplantation of tissues to restore the face or extremities. (msdmanuals.com)

Purpose The Swiss Transplant Cohort Study (STCS) is a prospective multicentre cohort study which started to actively enrol study participants in May 2008. (bmj.com)
Epidemiology of lower respiratory tract infections and community-acquired respiratory viruses in patients with bronchiolitis obliterans syndrome after hematopoietic cell transplant: a retrospective cohort study. (stanford.edu)
Incidence and clinical predictors of a subsequent nonmelanoma skin cancer in solid organ transplant recipients with a first nonmelanoma skin cancer: a multicenter cohort study. (univr.it)
In cohort A, the annual incidence rate was 12.78 per 100,000 in kidney-pancreas, 13.34 in liver, and 21.87 in heart-lung transplant recipients. (elsevierpure.com)
This large retrospective cohort analysis confirms that renal transplant recipients have a fivefold increased risk of developing malignant melanoma. (medscape.com)

Because stem cell transplants destroy and rebuild your immune system, they increase your risk for fungal infections. (cdc.gov)
Hence, we conclude that despite immune-suppressed status of transplant recipients, COVID-19 vaccination could protect them against severe illness. (hindawi.com)
In contrast, some studies have noted that solid organ transplant recipients achieve adaptive immune response similar to immune-competent individuals [ 12 ]. (hindawi.com)
In Nepal, immune response to SARS-CoV-2 in immune-compromised individuals, mainly in renal transplant recipients has not been reported till date and very less is known about neutralizing antibody response in them after vaccination. (hindawi.com)
In this study, we estimated circulating anti-SARS-CoV-2 antibody level after vaccination in three renal transplant patients who are concurrently receiving immune-suppressive drugs. (hindawi.com)
It was aimed to understand the humoral immune response in the recipients and the need for additional booster doses of COVID-19 vaccine in such patients. (hindawi.com)
The first ABO-incompatible kidney transplant at the Apollo hospitals Chennai was done by using the Immune adsorption columns to reduce the specific blood group antibody titer before the ABO-incompatible transplant. (apollohospitals.com)
This is achieved by removing the anti-A or Anti B from the recipient using antigen-specific immune adsorption by performing several sessions of plasmapheresis. (apollohospitals.com)
This procedure is supported by a protocol of pharmacological drug based immune suppression and the ABO incompatible kidney transplant is performed. (apollohospitals.com)
Jonathan Maltzman , MD-PhD studies immune responses relevant to solid organ transplantation. (stanford.edu)
Transplant recipients have a 60-100-fold increased risk of squamous cell carcinoma (SCC), the second most common skin cancer in the United States, compared to patients with normal immune systems. (newswise.com)
The second area of study is to understand the regulation of the immune response to cellular and solid organ grafts. (stanford.edu)
However, the same immunosuppressive medications that are required to prevent the child's immune system from attacking and rejecting the transplanted organ can predispose these individuals to developing a very serious cancer that is linked to Epstein-Barr virus (EBV). (stanford.edu)
High-dimensional profiling of pediatric immune responses to solid organ transplantation. (stanford.edu)
Human solid organ transplantation has evolved into a predictable therapeutic modality due to advances in medical and surgical care and improved understanding of the immune system. (jcda.ca)
In solid organ transplantation, donor derived immune cells are assumed to decline with time after surgery. (biorxiv.org)
The immune mechanisms responsible for the modified response in multi-organ recipients are still very vague and require additional studies. (frontiersin.org)
Forty-three renal transplant recipients with well-functioning allografts were immunized with H. influenzae type b vaccine in order to investigate the immune response. (scienceopen.com)
LMP-specific T-cells are special immune system cells trained to recognize proteins found on post-transplant lymphoproliferative disorder tumor cells if they are infected with Epstein-Barr virus. (stanford.edu)
Marwan Azar, MD, is an infectious diseases specialist with a focus on infections in patients with compromised immune systems, including organ transplant recipients and oncology patients. (yalemedicine.org)
Recipients of grafts containing immune cells (particularly bone marrow, intestine, and liver) are at risk of graft-vs-host disease, in which the donor immune cells attack recipient tissue. (msdmanuals.com)
Can immune checkpoint inhibitors, such as ipilimumab , be used safely in this high-risk population, [ 7 ] and is there a way to encourage the host's immune response to melanoma cells without risking organ failure? (medscape.com)

Effects of Preservation of Donor Liver Gastroduodenal Artery on Post-Transplant Biliary Complications in 18. (annalsoftransplantation.com)
A shift in the nature of complications from early to late graft dysfunction has been similarly observed after transplantation of other solid organs 2 . (ersjournals.com)
When solid organ transplant patients get skin cancers or infections, their risk of serious complications and death is significantly elevated. (newswise.com)
GI complications are a prevailing source of morbidity and mortality in solid organ and bone marrow transplant recipients. (elsevierpure.com)
Chandok, N & Watt, KDS 2010, Gastrointestinal complications of solid organ and hematopoietic cell transplantation . (elsevierpure.com)
Watt, Kymberly D.S. / Gastrointestinal complications of solid organ and hematopoietic cell transplantation . (elsevierpure.com)
Aim: To evaluate the invasive dental procedures for removing dental foci performed in patients scheduled for liver transplantation and its accompanying complications. (bvsalud.org)
Methods: The medical records of 33 preliver transplant recipients who were undergoing invasive dental procedures were reviewed, including their laboratory tests, special handling needs and resulting complications. (bvsalud.org)
Although no evidence-based guidelines for dental septic focal treatment exist, patients should be advised to have dental foci removed before undergoing organ transplants in order to avoid post-transplant systemic and local oral complications. (bvsalud.org)
This research aimed at evaluating invasive dental procedures for removing dental foci in patients scheduled for liver transplantation along with any accompanying complications. (bvsalud.org)

Traditionally ABO compatible donor organs are essential to achieve a successful organ transplant. (apollohospitals.com)

Do Patients with Solid Organ Transplants or Breast Implants Require Antibiotic Prophylaxis before Dental Treatment? (jcda.ca)
Evidence supporting the use of antibiotic prophylaxis among patients with solid organ transplants before dental treatment is extremely limited. (jcda.ca)

Isolated renal, corneal and bone marrow transplant recipients will be excluded. (ox.ac.uk)
We identified West Nile Virus RNA in spleen/lymph node homogenate, skin, fat, muscle, tendon, and bone marrow samples obtained postmortem from a donor associated with transmission of West Nile Virus through solid organ transplantation. (cdc.gov)
Bone Marrow Transplant. (nih.gov)
The purpose of this study is to evaluate the effects that psychological and health behavior factors have on quality of life, level if sickness, and death after blood and bone marrow transplantation. (mayo.edu)
Low bone mass is extremely common among patients awaiting solid organ transplantation. (medscape.com)
A large and rapid decrease in bone mineral density (BMD) occurs within the first year following virtually all forms of solid organ transplantation. (medscape.com)
Even before transplantation, bone homeostasis may be adversely influenced by the disease process or diseased organ itself (eg, liver, lung, or kidney failure). (medscape.com)
Because patients often wait 2 or more years before transplantation, this represents an opportunity to prevent further bone loss and to help restore what may already have been lost. (medscape.com)
The clinical focus should be to both optimize bone mass before transplantation and to prevent bone loss in the postoperative period. (medscape.com)
[ 6 ] In other words, only a minority of patients awaiting transplant had normal bone density. (medscape.com)
Ferrari et al also prospectively evaluated changes in bone mass in 21 consecutive lung transplant candidates and confirmed this increased osteoporosis prevalence. (medscape.com)
Cystic fibrosis, a common indication for transplantation, is itself associated with low bone mass and fragility fractures because of (1) delayed puberty and hypogonadism and (2) chronic malnutrition with pancreatic insufficiency causing calcium and vitamin D malabsorption. (medscape.com)
Later, many cases have been reported in heart, kidney, and bone marrow transplant recipients and patients with hematological malignancies. (medscape.com)
Diabetes , bone thinning, or high cholesterol levels from the medicines given after a transplant. (medlineplus.gov)

BACKGROUND: In 2021, four patients who had received solid organ transplants in the USA developed encephalitis beginning 2-6 weeks after transplantation from a common organ donor. (cdc.gov)

Allogeneic Hematopoietic Stem Cell Transplantation Can Improve Prognosis of Extramedullary Infiltration Pos. (annalsoftransplantation.com)
The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)

Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)
Corneal Transplantation Corneal transplantations are done for several reasons: To reconstruct the cornea (eg, replacing a perforated cornea) To relieve intractable pain (eg, severe foreign body sensation due to recurrent. (msdmanuals.com)

Interdisciplinary contributions in diverse fields of transplantation medicine such as infectious diseases, genomics, oncology, immunology and psychosocial science have resulted in approximately 70 scientific papers getting published in peer-review journals so far. (bmj.com)
This book is addressed to physicians and researchers working in the ever-expanding research and practice fields of transplantation medicine. (intechopen.com)

Occurrence of the subsequent NMSC was not related to any risk factor considered, including sex, age at transplantation, type of transplanted organ, type of immunosuppressive therapy, histologic type of the first NMSC, and time since diagnosis of the first NMSC. (univr.it)
Vaccination guidelines for transplant recipients include regular boosters of tetanus, diphtheria, and inactivated polio vaccine, but there are few published data on the efficacy of these vaccines in patients receiving immunosuppressive therapy. (scienceopen.com)
Solid organ transplantation, although lifesaving for patients with end-stage renal, liver, or heart disease, requires chronic immunosuppressive therapy that increases the risk for cancer, including lymphoma and skin cancer. (medscape.com)
In addition, melanomas appear to be more lethal in elderly and male transplant recipients, and those who continue immunosuppressive therapy with cyclosporine or sirolimus. (medscape.com)
Although not yet scientifically proven, evaluation and dental treatment during the pre-transplantation period is recommended in order to prevent infections and resultant odontogenic-origin sepsis during the post-transplant period, when patients receive immunosuppressive therapy. (bvsalud.org)

Catalan Society for Transplantation Gold Medal, 2017 American Society of Transplantation Fellowship, FAST designation 2020. (wikipedia.org)

Guidelines for the management of squamous cell carcinoma in organ transplant recipients. (newswise.com)

Patient education including reminders that regular use of sunscreens, as part of a UV-protection strategy which also includes sun avoidance and sun-protective clothing, decreases the rate of development of further precancerous lesions, invasive SCC and, to a lesser degree, BCC, in immunocompromised organ transplant recipients. (newswise.com)
The authors of the study reiterated that, at that time, there was no documentation of transient bacteremia from an invasive dental procedure posing another threat to the immunosuppressed organ transplant recipient. (jcda.ca)
In a recent article, Scully and colleagues 8 recommend administering antibiotic prophylaxis to organ transplant patients before invasive dental procedures (particularly during the 6 months after transplantation) without citing evidence-based research to support their recommendation. (jcda.ca)
Italian guidelines for diagnosis, prevention, and treatment of invasive fungal infections in solid organ transplant recipients. (cnr.it)
H. influenzae type b vaccination is safe and effective in patients with well-functioning renal allografts and should be recommended to renal transplant recipients who may have the risk of invasive disease on the basis of the immunosuppressive state. (scienceopen.com)

Finally, several areas related to infections in SOT recipients are unresolved and controversial. (medscape.com)
The September 2019 issue of the American Journal of Transplantation contains a comprehensive review of the various topics within the scope of infections in SOT recipients. (medscape.com)
As a result, practitioners are challenged to help solid organ transplantation (SOT) recipients retain their transplanted organs, prevent SOT-related infections, and improve their quality of life. (medscape.com)
Fungal infections can happen any time after your transplant. (cdc.gov)
Fungal infections can happen days, weeks, or months after the stem cell transplant. (cdc.gov)
Some types of fungal infections are more common than others in stem cell transplant patients. (cdc.gov)
In 6 clusters of organ transplant-transmitted West Nile Virus infections reported to public health agencies in the United States, 12 of 16 recipients were infected. (cdc.gov)
Since the 1990s, the risk of dying from infections after kidney transplantation has dropped by half, according to a recent analysis. (medicalxpress.com)
Oral-source infections are a potential threat for transplant candidates because oral diseases tend to be more severe and untreated in people who have received transplants. (bvsalud.org)

Studies have reported that vaccines show weak immunogenicity among kidney transplant recipients as they do not produce antibodies effectively [ 9 , 10 ]. (hindawi.com)
A study conducted among kidney transplant recipients in France has revealed that 10.8% of transplant recipients developed antibodies after 28 days of receiving COVID-19 vaccine and that multiple booster doses might be required to reach effective level [ 13 ]. (hindawi.com)

Solid organ transplantation is an important therapeutic option for children with a variety of end stage diseases. (stanford.edu)
Multi-organ transplantation also presents immunological and therapeutic challenges. (frontiersin.org)
These study findings also raise a therapeutic challenge, because renal transplant recipients with melanoma need to be treated. (medscape.com)

Objective Solid organ transplant (SOT) recipients have moderately increased risk of pancreatic adenocarcinoma (PAC). (elsevierpure.com)
Conclusions We report demographic and clinical risk factors for PAC after SOT, many of which were present before transplant and are common to sporadic pancreatic cancer. (elsevierpure.com)

Am J Transplant, 2017. (newswise.com)

Worldwide, an estimated 152,863 solid organ transplants were performed in 2019. (medscape.com)
Almost 40,000 organ transplants were performed in the United States in 2019, a 9% increase over 2018. (newswise.com)

We invite the research and review papers on the basic, preclinical, and clinical studies in the multi-organ transplantation field. (frontiersin.org)

As a stem cell transplant patient, you have new opportunities for a healthy and full life. (cdc.gov)
On September 27-28, 2018, the US Food and Drug Administration (FDA) and the Critical Path Institute's Transplant Therapeutics Consortium convened a public workshop to address drug development in the field of transplantation, titled "Evidence-based Treatment Decisions in Transplantation: The Right Dose & Regimen for the Right Patient/Individualized Treatment. (lww.com)
The total dose, based on the number of slices administered to the patient, is 5,000 to 22,000 mm² of RETHYMIC/m² recipient BSA. (rxlist.com)
The resources for the GRAfT-GTD study provide support at all clinical sites for patient recruitment, enrollment and bio-sample collection, while also supporting the laboratory of transplant genomics at NHLBI to perform measurements of ddcfDNA (donor derived - cell free DNA), computational analysis, host and manage the biorepository of clinical data and all bio-samples, and the data coordinating center for GRAfT at NHLBI. (nih.gov)
The oral health care provider plays an important role in overall management of the solid organ transplant patient. (jcda.ca)
In areas like anesthesia, a vital aspect of the transplant surgery, doctors prepare for hours to keep each patient stable during surgery, mitigate risk in cases of unexpected blood loss and respond to crucial physiological indicators throughout the 8-12 hour surgery. (financialcontent.com)
It is often difficult to ascertain which organ is the most critically in need of replacement or whether replacement of one organ would result in improvement of other organ function and whether a patient can survive or thrive with only one of the failing organs transplanted. (frontiersin.org)

[ 15 ] The focus of this article is adult populations, although infectious disease issues germane to the pediatric SOT recipient are discussed in Special Host Considerations. (medscape.com)
This document is an updated guideline and details the recommendations for the front‐line management of adult patients with an established diagnosis of post‐transplant lymphoproliferative disorder (PTLD) following solid organ transplantation (SOT). (b-s-h.org.uk)
1 In adult SOT recipients, PTLD is a common malignancy after skin cancer and is associated with a significant cancer‐related mortality. (b-s-h.org.uk)
For children and adult with advanced lung diseases, transplantation is often the only treatment. (nih.gov)
Routine immunizations in adult renal transplant recipients. (scienceopen.com)

Some research is ongoing in transplantation of non-human organs, such as heart, kidney and liver transplantation. (msdmanuals.com)

There are different reasons for receiving either type of transplant. (cdc.gov)
BO and its clinical correlate bronchiolitis obliterans syndrome (BOS) affect up to 50-60% of patients who survive 5 yrs after surgery, irrespective of the type of transplant procedure 1 , 4 - 6 . (ersjournals.com)
Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)

Cardiac transplantation is a standard therapy for many end-stage heart diseases and returns patients to normal life. (rotrf.org)
In relation to organ transplants, these guidelines recommend providing antibiotic prophylaxis before specific dental procedures in cardiac transplantation recipients with cardiac valvulopathy to prevent infective endocarditis. (jcda.ca)

In this case report, we present the level of anti-SARS-CoV-2 antibody of three kidney transplant recipients after vaccination against COVID-19 virus. (hindawi.com)
Neutralizing antibody and T cell responses to SARS-CoV-2 vaccination in hematopoietic cell transplant recipients. (nih.gov)
Kidney transplant recipients tend to mount impaired antibody responses against emerging SARS-CoV-2 variants after standard two-dose COVID-19 vaccination, according to new research published in CJASN. (medicalxpress.com)

Lung transplantation is a potentially curative therapy for patients with end-stage pulmonary disease. (nature.com)
The drug of choice for prevention of CMV disease in solid-organ transplant patients is valganciclovir. (medscape.com)
In 2011, the CDC assisted state and local health departments in an investigation of a cluster of West Nile Virus disease transmitted through solid organ transplantation. (cdc.gov)
Limitations in donor availability for organ transplantation makes ""living donor"" solid organ transplantation across the blood group barrier to become an alternative to ABO compatible transplantation for those with end stage renal disease facing long waiting times. (apollohospitals.com)
The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
The condition of chronic multi-organ disease is increasing with a significant number of patients reaching end-stage disease of more than one organ simultaneously. (frontiersin.org)
Shane and colleagues studied 70 patients awaiting transplant for end-stage lung disease and found osteoporosis in 30% at the lumbosacral (LS) spine and in 49% at the femur neck. (medscape.com)
Aris et al reported that nearly half (45%) of patients with end-stage lung disease awaiting transplant were at or below the fracture threshold. (medscape.com)
This is probably due to underdiagnosis and underreporting of this disease in patients with hematological malignancies or solid organ transplantation. (medscape.com)
Renal transplant recipients are up to 5 times more likely to develop malignant melanoma compared with the general population, [ 4 ] and those with melanoma are more likely to die of their disease. (medscape.com)
Lung transplants may be recommended for people under age 65 who have severe lung disease. (medlineplus.gov)

In a Cox proportional hazards regression model, age older than 50 years at the time of transplantation and male sex were significantly related to the first NMSC. (univr.it)

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem. (annalsoftransplantation.com)
Indications for liver transplantation include Cirrhosis (70% of transplantations. (msdmanuals.com)

The transplantation of HIV-positive donor kidneys to HIV-infected recipients is now a viable alternative to chronic dialysis or transplantation of HIV-negative donor kidneys. (scielo.org.za)
Some 550 000 individuals may be expected to require renal replacement therapy (RRT) comprising dialysis and transplantation, considerably more than the SA population currently receiving dialysis, and exceeding the health service renal replacement capacity. (scielo.org.za)
5 GSH has facilities for only 100 haemodialysis and 50 peritoneal dialysis patients in its chronic dialysis programme at any one time, with concomitant pressure to transplant patients and free dialysis space. (scielo.org.za)

The Packard Children's Pediatric Transplant Center is a national leader in the field of pediatric organ transplantation and a destination center for the most acute and complex cases, which require highly specialized care. (financialcontent.com)
Giving rituximab and LMP-specific T-cells may work better in treating pediatric organ recipients with post-transplant lymphoproliferative disorder than rituximab alone. (stanford.edu)

This is a post-hoc analysis from a clinical trial to study the area under curve (AUC) and the area under effect (AUE) profiles of calcineurin inhibition after tacrolimus administration in twenty-five renal transplant patients. (frontiersin.org)

For single lung transplants, the cut is made on the side of your chest where the lung will be transplanted. (medlineplus.gov)
For double lung transplants, the cut is made below the breast and reaches to both sides of the chest. (medlineplus.gov)
Sometimes, heart and lung transplants are done at the same time (heart-lung transplant) if the heart is also diseased. (medlineplus.gov)

In the transplant population, antigen assays or PCR is used (sometimes in conjunction with cytopathology) for diagnosis and treatment determinations. (medscape.com)
PURPOSE OF REVIEW: Fever is a common manifestation of both infectious and noninfectious processes in recipients of hematopoietic cell transplantation (HCT) and chimeric antigen receptor T-cell (CAR-T) therapy. (stanford.edu)
Recipient macrophages were characterized by inflammatory activation and donor macrophages by antigen presentation and complement signaling. (biorxiv.org)

The estimated incidence based on data from UK Transplant is 1 case per 29,000 pregnancies. (ox.ac.uk)

Collaboration between dermatologists and transplant physicians should be encouraged to ensure frequent, full body skin examinations by dermatologists, preferably in specialty clinics for high risk patients, both pre-and post- transplantation. (newswise.com)
Our results indicate that donor origin macrophages and T cells have distinct transcriptional profiles compared to their recipient counterparts and donor macrophages can persist for years post transplantation. (biorxiv.org)

Allocation to pediatric recipients around the world: An IPTA global survey of current pediatric solid organ transplantation deceased donation allocation practices. (nih.gov)
This number is expected to continue to rise as donations increase and innovations such as domino transplantation, hepatitis C positive organ donation, and improved organ preservation expand the pool of available organs. (newswise.com)
The cornerstone of transplant is organ donation. (financialcontent.com)
We can't ever say enough of the importance of organ donation," said Strichartz. (financialcontent.com)
In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
3 days before organ procurement, the organ donor received a blood transfusion from a donor who had received a yellow fever vaccine 6 days before blood donation. (cdc.gov)

Anatomy7

Organisms7

Diseases14

Chemicals and Drugs14

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes12

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Named Groups2

Health Care12

Rejection28

Outcomes13

Immunosuppression10

Liver transplants3

Centers5

Infection14

Survival12

Tissues8

Cohort5

Immune22

Complications10

Donor organs1

Patients with Solid Organ Transplants2

Bone14

20211

Hematopoietic Stem Cell Trans3

Corneal2

Fields of transplantation medicine2

Immunosuppressive therapy5

20201

Squamous cell carc1

Invasive5

Infections9

Among kidney transplant recipients2

Therapeutic3

Pancreatic2

20171

20192

Multi-Organ Transplantation1

Patient7

Adult5

Kidney and liver1

Type of transplant3

Cardiac2

Vaccination3

Disease11

Time of transplantation1

Cirrhosis2

Dialysis3

Pediatric organ2

Renal transplant patients1

Lung transplants3

Antigen3

Incidence1

Post-transplantation2

Donation6