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AdenocarcinomaMucinsMucin 5ACLung NeoplasmsErigeronRespiratory MucosaMucin-2LungAdenocarcinoma, MucinousCarcinoma, MucoepidermoidMucin-5BGoblet CellsGastric MucinsAdenocarcinoma, Bronchiolo-AlveolarPseudomyxoma PeritoneiReceptor, Epidermal Growth FactorVanadium CompoundsCell Line, TumorAdenocarcinoma, PapillaryMetaplasiaPancreatic NeoplasmsEsophageal NeoplasmsImmunohistochemistryCarcinoma, Non-Small-Cell LungMucusTumor Markers, BiologicalGene Expression Regulation, NeoplasticTransforming Growth Factor alphaBarrett EsophagusLeukocyte ElastaseEpithelial CellsCarcinoma, Pancreatic DuctalStomach NeoplasmsPrognosisRNA, MessengerNeoplasm StagingLung DiseasesCardiaColonic NeoplasmsTumor Cells, CulturedCarcinoma, Squamous CellMutationUp-RegulationNeoplasm InvasivenessGenes, rasInterleukin-13Genes, erbB-1Keratin-7Signal TransductionAntineoplastic AgentsGene Expression ProfilingReverse Transcriptase Polymerase Chain ReactionImmunoenzyme Techniquesras ProteinsQuinazolinesCell ProliferationPrecancerous ConditionsMice, NudeMucin-1Esophagogastric JunctionNeoplasm MetastasisPhosphorylationPleural Effusion, MalignantDNA, NeoplasmNeoplasm ProteinsNeoplasm TransplantationOligonucleotide Array Sequence AnalysisCells, CulturedSmokingSurvival RateSurvival AnalysisTissue Array AnalysisGene Expression RegulationKaplan-Meier EstimateLung InjuryMolecular Sequence DataEndometrial NeoplasmsLymphatic MetastasisCarcinoma, Signet Ring CellAntigens, NeoplasmDisease ProgressionNeoplasms, Multiple PrimaryBlotting, WesternIntestinal NeoplasmsMucin-4ApoptosisDNA Mutational AnalysisRetrospective StudiesCarcinoma, AdenosquamousCarcinoma, Small CellTreatment OutcomeAdenomaProstatic NeoplasmsLung TransplantationCarcinoma, Large CellProto-Oncogene ProteinsMammary Neoplasms, ExperimentalDrug Resistance, NeoplasmPolymerase Chain ReactionTumor Suppressor Protein p53
International Multidisciplinary Classification of Lung AdenocarcinomaTumorsDuctalSuggested for a malCancersPancreaticPapillaryPoorly-differentiatedEpithelial tumorGenes associatedDisulfideCarcinomaHistologicalPulmonaryMolecularTumor suppressorVariantCommonlyCancerMucusProteinImplicationsAirwayBackgroundTypeHeartRare
International Multidisciplinary Classification of Lung Adenocarcinoma2
  • According to the International Multidisciplinary Classification of Lung Adenocarcinoma (LAD) by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) in 2011, the diagnosis of LAD is changing from simple morphology into a comprehensive multidisciplinary classification. (biomedcentral.com)
  • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. (radiopaedia.org)
Tumors7
  • Adenocarcinomas are most often highly heterogeneous peripheral tumors, and are thought to arise from malignant transformation of primitive cells that can exhibit differentiation characteristics of Club cells, Type II pneumocytes, bronchiolar surface cells, bronchial gland cells, or goblet cells. (wikipedia.org)
  • 1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
  • What makes the response of PDAC to immunotherapy different from the responses of other solid tumors is the specific host tissue. (biomedcentral.com)
  • Although individualized targeted therapies are routinely used for patients with lung and breast tumors, personalized medicine has not achieved the same degree of success in the pancreas. (coek.info)
  • Triphasic pancreatic-protocol computed tomography is the best initial diagnostic test for pancreatic cancer, and on this modality these tumors appear as a hypodense solid mass. (coek.info)
  • A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
  • Tumors or cancer of the LUNG. (lookformedical.com)
Ductal6
  • Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death and is one of the most difficult-to-treat cancers. (biomedcentral.com)
  • PANCREATIC DUCTAL ADENOCARCINOMA CLINICAL FEATURES Ductal adenocarcinoma of the pancreas is the most common malignant neoplasm of the pancreas. (coek.info)
  • PATHOLOGY Ductal adenocarcinomas are firm to hard mass lesions that are often poorly defined grossly. (coek.info)
  • Histologically, most ductal adenocarcinomas are composed of glandlike structures embedded in an abundant desmoplastic stroma. (coek.info)
  • In spite of their aggressive biologic behavior, some ductal adenocarcinomas show bland nuclear features, making the distinction of benign lesion from an invasive carcinoma difficult, particularly on small biopsy specimens (Fig. 1). (coek.info)
  • The compact extracellular matrix (ECM) of pancreatic ductal adenocarcinoma (PDAC) is the major physical barrier that hinders the delivery of anti-tumor drugs, leading to strong inherent chemotherapy resistance as well as establishing an immunosuppressive tumor microenvironment (TME). (biomed.news)
Suggested for a mal1
  • The term mesonephric-like adenocarcinoma (MLA) has been suggested for a malignant tumor arising in the uterine corpus and the adnexa. (iiarjournals.org)
Cancers4
  • FA is a rare tumor, with a relative incidence estimated to be no more than 0.5% of all lung cancers. (wikipedia.org)
  • Non-small cell lung cancer (NSCLC) accounts for 70%-80% in lung cancer, and among them, lung adenocarcinoma (LAD) accounting for almost half of lung cancers, was one of the most common histologic subtype. (biomedcentral.com)
  • Non-small cell lung cancer (NSCLC) represents a heterogeneous group of lung cancers that do not have "small cells" on histology. (radiopaedia.org)
  • Five-year lung cancer screening experience: CT appearance, growth rate, location, and histologic features of 61 lung cancers. (radiopaedia.org)
Pancreatic1
  • Indeed, while the risks of breast, ovarian, pancreatic and prostate cancer have been documented for years, recent data show an increased risk of gastric cancer, and suggest an association with lung cancer. (cdc.gov)
Papillary3
  • More interestingly, the expression of Notch-1 protein was often observed to be negative in solid predominant adenocarcinoma (SPA) tissues, but highly expressed in papillary predominant adenocarcinoma (PPA) and micropapillary predominant adenocarcinoma (MPA) tissues. (biomedcentral.com)
  • 1. Adenocarcinoma: papillary, mucoid, trabecular (well-differentiated). (poznayka.org)
  • Microscopically, fungating or polypoid carcinomas are well-differentiated adenocarcinomas, commonly papillary type. (poznayka.org)
Poorly-differentiated2
Epithelial tumor1
  • FA is an epithelial tumor whose cells and architecture resemble that of fetal lung tissues in the pseudoglandular stage of development (which occurs at about 10-16 weeks gestation in the human), with complex glandular structures and morules with cell nuclei that appear clear due to the accumulation of biotin. (wikipedia.org)
Genes associated2
  • Using SENT-seq, we have identified cell subtypes that exhibit particularly high or low LNP uptake as well as genes associated with those subtypes. (biomed.news)
  • The identification of the genes associated with increased airway mucin production in humans should be useful in understanding the pathogenesis of airway mucus hypersecretion and identifying therapeutic targets. (biomedcentral.com)
Disulfide2
  • Despite small molecular mucolytics having the ability to break the disulfide bonds of mucins, offering a potential way to overcome the airflow obstruction and airway infection, these mucolytics have limited therapeutic effects in vivo. (biomed.news)
  • The positively charged nanogels effectively inhibit the formation of large aggregates of mucin in vitro, probably thanks to the formation of an ionic interaction between CS-Arg and mucin, as well as the breakage of disulfide bonds in mucin by the reductive TCEP. (biomed.news)
Carcinoma9
  • A case of combined small cell lung carcinoma featuring components of FA and cells resembling those from carcinoid tumor has been reported, illustrating the unique complexity and heterogeneity of divergent histogenesis and cell differentiation in lung cancer. (wikipedia.org)
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
  • Microscopically, early gastric carcinoma is a typical glandular adenocarcinoma, usually well-differentiated. (poznayka.org)
  • Microscopically, it may be an adenocarcinoma or signet-ring cell carcinoma, extensively infiltrating the stomach wall, but due to marked desmoplasia cancer cells may be difficult to find. (poznayka.org)
  • carcinoma contains abundant pools of mucin in which are seen a small number of tumor cells, sometimes having signet-ring appearance. (poznayka.org)
  • It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA . (lookformedical.com)
  • They are thus separated, as small cell carcinoma of the lung has distinctive management implications. (radiopaedia.org)
  • Integrated PET/CT of salivary gland type carcinoma of the lung in 12 patients. (radiopaedia.org)
  • Ovarian carcinoma is not a single disease entity and comprises various subtypes, each with distinct complex molecular landscapes that change during progression and therapy. (cdc.gov)
Histological2
  • The aim of this study is to detect the expression of Notch-1 and analyze its clinicopathological or prognostic significance in different histological subtypes of Lung Adenocarcinomas (LADs). (biomedcentral.com)
  • Notch-1 could be used as a predictable biomarker to be detected in different pathological and histological subtypes in LAD for diagnosis or prognosis. (biomedcentral.com)
Pulmonary2
  • Fetal adenocarcinoma (FA) of the lung is a rare subtype of pulmonary adenocarcinoma that exhibits tissue architecture and cell characteristics that resemble fetal lung tissue upon microscopic examination. (wikipedia.org)
  • Mucus hypersecretion contributes to the morbidity and mortality of smoking-related lung diseases, especially chronic obstructive pulmonary disease (COPD), which starts in the small airways. (biomedcentral.com)
Molecular1
  • The revealed key factors in the design and optimization of 3D DNA nanoframes for functional liposome production could benefit the fields of nanotechnology and molecular medicine. (biomed.news)
Tumor suppressor1
Variant1
Commonly1
  • Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)
Cancer4
  • FA can occur in combination with other forms of lung cancer, particularly other variants of adenocarcinoma. (wikipedia.org)
  • There also seems to be an association with clear cell lung cancer variants. (wikipedia.org)
  • Complete surgical resection is the treatment of choice in FA, as it is in nearly all forms of lung cancer. (wikipedia.org)
  • In the longer term, some might even take part in lung cancer screening programs. (cdc.gov)
Mucus5
  • Despite progress in animal studies, the genes and their expression pattern involved in mucus production and secretion in human airway epithelium are not well understood. (biomedcentral.com)
  • We hypothesized that comparison of the transcriptomes of the small airway epithelium of individuals that express high vs low levels of MUC5AC, the major macromolecular component of airway mucus, could be used as a probe to identify the genes related to human small airway mucus production/secretion. (biomedcentral.com)
  • This strategy identified both mucus production and secretion related genes under control of a network composed of multiple transcription factors. (biomedcentral.com)
  • This novel strategy enabled identification of a 73 "MUC5AC-associated core gene" list with 9 categories, which control a series of processes from mucin biosynthesis to mucus secretion. (biomedcentral.com)
  • The process of mucus production and secretion is central to the normal defense of the lung, with mucus an important component of the airway mucociliary escalator that continuously cleanses the lung of inhaled particulates, pathogens and xenobiotics [ 1 ]. (biomedcentral.com)
Protein2
  • SENT-seq quantifies how dozens of LNPs deliver DNA barcodes and mRNA into cells, the subsequent protein production and the transcriptome, with single-cell resolution. (biomed.news)
  • In mammals, the first protein with similar binding properties was purified from calf heart and lung protein extracts and was later named "galectin- 1" [2]. (fdocuments.net)
Implications1
Airway1
  • Little is known about the gene networks associated with the synthesis and secretion of mucins in the human small airway epithelium. (biomedcentral.com)
Background1
Type1
  • The superficial type may further be of flat, elevated to depressed subtypes. (poznayka.org)
Heart1
  • 2004). Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart (PDF). (wikipedia.org)
Rare1