AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
AdenocarcinomaAdenocarcinoma, MucinousLung NeoplasmsPancreatic NeoplasmsEsophageal NeoplasmsAdenocarcinoma, PapillaryBarrett EsophagusCarcinoma, Pancreatic DuctalStomach NeoplasmsAdenocarcinoma, Bronchiolo-AlveolarCardiaImmunohistochemistryColonic NeoplasmsTumor Markers, BiologicalEsophagogastric JunctionNeoplasm StagingPrognosisCell Line, TumorGene Expression Regulation, NeoplasticKeratin-7Carcinoma, Squamous CellEndometrial NeoplasmsNeoplasms, Multiple PrimaryPrecancerous ConditionsIntestinal NeoplasmsTumor Cells, CulturedProstatic NeoplasmsDuodenal NeoplasmsCarcinoma, Signet Ring CellMammary Neoplasms, ExperimentalNeoplasm InvasivenessCarcinoma, EndometrioidCecal NeoplasmsAdenocarcinoma, Clear CellMetaplasiaImmunoenzyme TechniquesColorectal NeoplasmsRectal NeoplasmsGenes, rasAmpulla of VaterCommon Bile Duct NeoplasmsTissue Array AnalysisAdenomaKeratin-20Ileal NeoplasmsNeoplasm MetastasisAntineoplastic AgentsPancreaticoduodenectomyDNA, NeoplasmNeoplasm TransplantationSurvival RateNeoplasm ProteinsCarcinoma, Non-Small-Cell LungLymphatic MetastasisJejunal NeoplasmsCarcinoma, Acinar CellCarcinoma, AdenosquamousCarcinoembryonic AntigenDisease ProgressionMice, NudeRetrospective StudiesEsophagusSurvival AnalysisTreatment OutcomeRNA, MessengerMutationGastrectomyReceptor, Epidermal Growth FactorAntigens, NeoplasmCarcinoma in SituPancreatectomyBiopsyReverse Transcriptase Polymerase Chain ReactionParanasal Sinus NeoplasmsKaplan-Meier EstimateFatal OutcomeCell ProliferationUterine Cervical NeoplasmsGastrointestinal NeoplasmsMucinsDeoxycytidineTumor Suppressor Protein p53Gene Expression ProfilingNeoplasms, ExperimentalOvarian NeoplasmsPancreatic DuctsAppendiceal NeoplasmsGallbladder NeoplasmsCell Transformation, NeoplasticKeratinsNeoplasmsSigmoid NeoplasmsEsophagectomyTime FactorsEndometrial HyperplasiaFluorouracilras ProteinsPolymerase Chain ReactionProstatic Intraepithelial NeoplasiaApoptosis
Squamous cell carcDuctal adenocarcinomaTumorsPrognosisCancersIncidence of esophageal adenocarcinomaCarcinomaGastroesophageal junctionNSCLCEpidermal growth fMammary adenocarcinomaGastric or gastroesophagealSubtypeAcinarColorectal cancerMelanomaGlandularMalignantEsophagusRisk of adenocarcinomaPatients with adenocarcinomaLUADCOADMetastatic gastricPancreasCysticLesionsHistologyLiquidsStomachSurvivalHistologicDistalEpithelialForms of lung cancerCellsLung cancerLepidic2023MutationsTissuePrognosticIncreasesCommonClassificationOrgan transplantSubtypesAriseOccurCommonlyMolecular
Squamous cell carc5
Ductal adenocarcinoma3
Tumors8
  • Determinants of drug delivery and transport to solid tumors. (springer.com)
  • Participant must have at least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 criteria (by local Investigator) (Eisenhauer, 2009). (uclahealth.org)
  • 1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
  • These results establish HO-1 as a mediator of ATF4-dependent anoikis resistance and tumor metastasis and suggest ATF4 and HO-1 as potential targets for therapeutic intervention in solid tumors. (jci.org)
  • It is a subtype of carcinoma, the most common form of cancer, and typically forms solid tumors. (shakuhachi.net)
  • Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
  • MAX-4 is under development for the treatment of myelodysplastic syndrome, acute myelocytic leukemia, metastatic colorectal cancer, relapsed/refractory acute myeloid leukemia, solid tumors, gastric cancer, small-cell lung cancer and adenocarcinoma of the gastroesophageal junction. (pharmaceutical-technology.com)
  • We identified rare cases on our next generation sequencing panel of solid tumors with off-target, high quality reads that aligned to the TSPyV genome. (cdc.gov)
Prognosis3
Cancers7
  • Like many lung cancers, adenocarcinoma of the lung is often advanced by the time of diagnosis. (wikipedia.org)
  • No new cancers have been discovered in solid nodules in follow-up since the baseline screening in 1998, Dr. Henschke reported. (cancernetwork.com)
  • As the most predominant subtype of NSCLC, lung adenocarcinoma (LUAD) accounts for approximately 50% of the total lung cancers [ 3 ]. (biomedcentral.com)
  • We have sampled 29 tissue samples in total derived from head and neck cancers and 29 samples of their clear surgical margins, 33 breast adenocarcinomas and 33 clear surgical margins. (nel.edu)
  • Adenocarcinoma of the gastroesophageal junction (GEJ or GE junction, a specific part of the esophagus where the esophagus and stomach meet) is a specific subset of esophagus cancers . (medicinenet.com)
  • Adenocarcinoma of the GE junction describes cancers that arise either in the lower esophagus or upper stomach, very close to the GE junction. (medicinenet.com)
  • It represents 1.64% of intervention could reduce the risk for amination using a long forward viewing all cancers in Egypt, according to the adenocarcinoma of the distal stomach instrument (Fuji, EG 250D video). (who.int)
Incidence of esophageal adenocarcinoma2
Carcinoma2
  • This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status. (uclahealth.org)
  • The aim of our study was to evaluate the MT expression in head and neck squamous cells carcinoma and breast adenocarcinoma and their histologically healthy adjacent tissue. (nel.edu)
Gastroesophageal junction3
  • FRIDAY, Sept. 1, 2023 -- For patients with human epidermal growth factor receptor 2 (HER2)-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction (mG/GEJ) adenocarcinoma, zolbetuximab, a monoclonal antibody that. (medworm.com)
  • MAX-4 is under clinical development by Maxinovel Pharmaceuticals and currently in Phase II for Adenocarcinoma Of The Gastroesophageal Junction. (pharmaceutical-technology.com)
  • According to GlobalData, Phase II drugs for Adenocarcinoma Of The Gastroesophageal Junction have a 51% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
NSCLC3
  • The present study evaluated the prognostic value of the epidermal growth factor receptor (EGFR) mutation status, and excision repair cross-complementation group 1 (ERCC1) and thymidylate synthase (TS) expression following intercalated tyrosine kinase inhibitor (TKI) therapy and platinum- and pemetrexed-based chemotherapies (subsequent second-line treatment) for patients with adenocarcinoma non-small-cell lung cancer (AC-NSCLC). (medsci.org)
  • More than 80% of NSCLC cases are of the adenocarcinoma subtype (AC-NSCLC), whose incidence rate has steadily increased over the past decade. (medsci.org)
  • Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
Epidermal growth f1
  • The standard therapies for lung adenocarcinoma include epidermal growth factor receptor (EGFR) mutation targeted therapy and conventional chemotherapy, such as platinum- and pemetrexed-based chemotherapies. (medsci.org)
Mammary adenocarcinoma3
Gastric or gastroesophageal1
  • On January 15, 2021, the Food and Drug Administration approved fam-trastuzumab deruxtecan-nxki (Enhertu, Daiichi Sankyo) for adult patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal (GEJ) adenocarcinoma who have received a prior trastuzumab-based regimen. (ecancer.org)
Subtype3
  • Overall, our research proposes several potential entry points to improve the immunosuppressive TME of solid LUADs, thereby synergistically potentiating their immunotherapeutic efficacy, and may provide precise therapeutic strategies for LUAD patients of distinct histologic subtype constitution. (nih.gov)
  • The three nonsolid nodules that were eventually diagnosed as adenocarcinoma, mixed subtype, took 3 to 4 years to diagnose. (cancernetwork.com)
  • The size of the malignant lesions differed by subtype, she noted, typically being about 3 mm for solid nodules, 10 mm for part-solid, and 7 mm for non-solid. (cancernetwork.com)
Acinar1
  • Prostate xanthomas may mimic high-grade prostatic acinar adenocarcinoma with foamy cytoplasm, as well as adenocarcinoma with posthormonal therapy effect, particularly androgen deprivation therapy. (medscape.com)
Colorectal cancer1
Melanoma1
  • found that pyroptosis-related genes can be used for prognostic prediction of skin cutaneous melanoma and lung adenocarcinoma, respectively. (nature.com)
Glandular2
  • Adenocarcinoma forms in glandular epithelial cells, which secrete mucus, digestive juices or other fluids. (shakuhachi.net)
  • Coexisting foamy and nonfoamy adenocarcinoma with glandular differentiation devoid of basal cell lining is helpful in clarifying their malignant nature. (medscape.com)
Malignant8
  • As long as there are not excrescences with areas of irregular solid mixed with cystic, this is still unlikely to be a malignant process. (wdxcyber.com)
  • Almost all of the part-solid nodules larger than 10 mm were malignant, she said. (cancernetwork.com)
  • In contrast to its value in solid nodules, growth assessment discriminates poorly between malignant and benign subsolid nodules, Dr. Henschke said. (cancernetwork.com)
  • The sebaceous adenocarcinomas are malignant and are red, ulcerated and solid. (vetinfo.com)
  • Background/Aim: Uterine mesonephric-like adenocarcinoma (MLA) is a rare malignant tumor of the female genital tract. (iiarjournals.org)
  • Mesonephric adenocarcinoma (MA) is a rare malignant tumor of the female genital tract. (iiarjournals.org)
  • The term mesonephric-like adenocarcinoma (MLA) has been suggested for a malignant tumor arising in the uterine corpus and the adnexa. (iiarjournals.org)
  • Differentiation of benign from malignant solid renal lesions with MRI-based radiomics and machine learning. (cdc.gov)
Esophagus4
Risk of adenocarcinoma3
Patients with adenocarcinoma1
  • Less than 1% of patients with adenocarcinoma of the lung will exhibit this finding, but when it does occur, it is a poor prognostic factor. (wikipedia.org)
LUAD1
COAD2
Metastatic gastric1
  • Efficacy was evaluated in a multicenter, open-label, randomised trial (DESTINY-Gastric01, NCT03329690) in patients with HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma who had progressed on at least two prior regimens, including trastuzumab, a fluoropyrimidine- and a platinum-containing chemotherapy. (ecancer.org)
Pancreas2
  • Gross section of an adenocarcinoma of the pancreas measuring 5 × 6 cm resected from the pancreatic body and tail. (medscape.com)
  • This study from South Australia using the state's Cancer Registry data provides compelling evidence for a significant increase in the incidence of young-onset (18-50 years) gastrointestinal (oesophageal, stomach, colon and rectum, and pancreas) adenocarcinomas over the last three decades. (mdpi.com)
Cystic2
  • If an ovary is not distinctly seen on an imaging study but there is a mixed cystic and solid mass in the adnexal region, it is most likely to be a benign lesion. (wdxcyber.com)
  • Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Lesions3
Histology2
  • Key clinical point: Predominantly solid tumor histology predicted earlier recurrence and poorer postrecurrence survival (PRS) in surgically. (the-hospitalist.org)
  • SCC is the most common histology in Eastern Europe and Asia, while adenocarcinoma is most common in North America and Western European countries. (medscape.com)
Liquids1
  • The condition results from impeded transport of liquids, solids, or both from the pharynx to the stomach. (msdmanuals.com)
Stomach1
  • Most cases of paraneoplastic AN involve an adenocarcinoma,[5] most commonly one arising in the gastrointestinal tract (stomach or liver[3] ) and less commonly in the lungs, ovaries, uterus, breasts, kidneys, prostate or bladder. (medscape.com)
Survival3
  • This resistance makes surgery the best option for pancreatic adenocarcinoma (PAAD) treatment, and for 10-20% of patients who undergo surgery, the 5-year survival rate is still only 15-25% [ 8 ]. (hindawi.com)
  • Moreover, HO-1 expression correlated with reduced overall survival of patients with lung adenocarcinoma and glioblastoma. (jci.org)
  • A primary reason for the low survival rate for patients with pancreatic adenocarcinoma is the inability to diagnose this cancer during early stage disease. (ohsu.edu)
Histologic3
  • The diversity of histologic composition reflects the inter- and intra-tumor heterogeneity of lung adenocarcinomas (LUADs) macroscopically. (nih.gov)
  • We find that the hypoxic and acidic situation is the worst in the TME of solid LUADs compared to other histologic subtypes. (nih.gov)
  • The pathophysiology of adenocarcinoma is complicated, but generally follows a histologic progression from cells found in healthy lungs to distinctly dysmorphic, or irregular cells. (wikipedia.org)
Distal1
  • adenocarcinoma is the most common in the distal one third. (msdmanuals.com)
Epithelial1
  • Our cases comprised 1 patient with metastatic lung adenocarcinoma involving the brain (case 1), 1 patient with meningioma (case 2), and 1 patient with a metastatic perivascular epithelial cell tumor involving the liver ( Table ). (cdc.gov)
Forms of lung cancer3
  • Adenocarcinoma of the lung is the most common type of lung cancer, and like other forms of lung cancer, it is characterized by distinct cellular and molecular features. (wikipedia.org)
  • citation needed] Adenocarcinoma, like other forms of lung cancer, is usually advanced or metastatic at time of diagnosis. (wikipedia.org)
  • For instance, lung adenocarcinomas tend to metastasize more slowly than other forms of lung cancer. (shakuhachi.net)
Cells5
  • Remarkably, tumor cells from solid LUADs upregulate energy and substance metabolic activities, particularly the folate-mediated one-carbon metabolism and the key gene MTHFD2, which could serve as a potential therapeutic target. (nih.gov)
  • Immunologically, solid LUADs are characterized by a predominance of exhausted T cells and immunosuppressive myeloid cells, where the hypoxic, acidified and nutrient-deprived TME has a non-negligible impact. (nih.gov)
  • You get adenocarcinoma when cells in the glands that line your organs grow out of control. (shakuhachi.net)
  • When adenocarcinoma in a lung metastasizes, cancer cells typically spread to the other lung or to the adrenal glands, bones, brain, or liver. (shakuhachi.net)
  • If prostate biopsies are performed following hormonal therapy for prostatic adenocarcinoma, the appearance of residual tumor cells can mimic xanthoma cells. (medscape.com)
Lung cancer6
  • Lung cancer is the most common cause of global cancer-related mortality, leading to over a million deaths each year and adenocarcinoma is its most common histological type. (nature.com)
  • Adenocarcinoma is more common in patients with a history of cigarette smoking, and is the most common form of lung cancer in younger women and Asian populations. (wikipedia.org)
  • A modified adenocarcinoma classification approach significantly enhances reproducibility and may be an improvement on the existing World Health Organization classification system, according to research unveiled at the International Association for the Study of Lung Cancer (IASLC) 2023. (medworm.com)
  • If it's partially obscured, it's part-solid, and otherwise, it's nonsolid,' she said at the 7th International Conference on Screening for Lung Cancer. (cancernetwork.com)
  • Adenocarcinoma of the lung (a type of non-small cell lung cancer) is fairly aggressive. (shakuhachi.net)
  • 9) Lung adenocarcinoma tends to spread more slowly than other kinds of lung cancer. (shakuhachi.net)
Lepidic1
  • Comparative genomics between matched solid and lepidic portions of semi-solid lung adenocarcinomas. (ucsfhealth.org)
20231
  • WEDNESDAY, Sept. 20, 2023 -- Patients with nonerosive gastroesophageal reflux disease (GERD) do not have an increased risk for esophageal adenocarcinoma compared with the general population, according to a study published online Sept. 13 in The. (medworm.com)
Mutations1
  • However, most lung adenocarcinomas either lack an identifiable driver oncogene, or harbour mutations in KRAS and are therefore still treated with conventional chemotherapy. (nature.com)
Tissue1
  • The expression level of NEK6 in esophagitis tissue is similar to that in esophageal adenocarcinoma, and overexpression of the NEK6 gene increases in proportion to the severity of esophagitis [ 14 ]. (hindawi.com)
Prognostic2
  • Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
  • Prognostic impact of artificial intelligence-based volumetric quantification of the solid part of the tumor in clinical stage 0-I adenocarcinoma. (cdc.gov)
Increases1
  • The presence of solid components increases the likelihood of a neoplastic process rather than a physiologic process of the ovary. (wdxcyber.com)
Common1
  • Adenocarcinoma is more common than squamous cell cancer in western countries, including the U.S. The reason for this change has yet to be determined. (medicinenet.com)
Classification1
  • These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis. (nature.com)
Organ transplant3
  • Objective Solid organ transplant (SOT) recipients have moderately increased risk of pancreatic adenocarcinoma (PAC). (elsevierpure.com)
  • Solid organ transplant recipients are highly susceptible to infections that sometimes have uncommon clinical manifestations ( 1 - 3 ). (cdc.gov)
  • We report identifying a novel circovirus infecting humans, tentatively named human circovirus type 1 (HCirV-1), and its role in causing liver damage in a solid organ transplant recipient. (cdc.gov)
Subtypes3
  • Lung adenocarcinoma is further classified into several subtypes and variants. (wikipedia.org)
  • Five additional malignancies have been diagnosed in these subtypes, two in part-solid nodules and three in nonsolid. (cancernetwork.com)
  • With the additional diagnoses, Dr. Henschke reported, crude malignancy rates for the nodule subtypes are now 7% for solid nodules, 63% for part-solid nodules, and 29% for nonsolid nodules. (cancernetwork.com)
Arise1
  • Rarely, adenocarcinomas arise within endometrial polyps. (slideserve.com)
Occur1
  • Smoking is the major cause of lung adenocarcinoma but, as smoking rates decrease, proportionally more cases occur in never-smokers (defined as less than 100 cigarettes in a lifetime). (nature.com)
Commonly1
  • While it is possible that this represents a ovarian mass with mostly solid components, it is much more commonly a benign process involving the bowel, tube or adhesive disease around the ovary. (wdxcyber.com)
Molecular1
  • Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. (nature.com)