This protein family consists of various potassium transport proteins (Trk) and V-type sodium ATP synthase subunit J or translocating ATPase J (EC). (wikipedia.org)
The SMF is generated by primary sodium pumps (e.g. sodium/potassium ATPases, sodium translocating respiratory chain complexes) or via the action of sodium/proton antiporters. (embl.de)
We sought to directly monitor cAMP in a microdomain formed around sodium-potassium ATPase (NKA) in healthy and failing cardiomyocytes and to better understand alterations of cAMP compartmentation in heart failure. (dundee.ac.uk)
Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. (childrensmercy.org)
Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. (childrensmercy.org)
Below are the most recent publications written about "Sodium-Potassium-Exchanging ATPase" by people in Profiles. (childrensmercy.org)
SGLTs transport sodium and glucose into cells using the sodium gradient created by sodium/potassium ATPase pumps at the basolateral cell membranes. (bjcardio.co.uk)
Glucose and galactose share the same carrier, SGLT-1, which transports one molecule of the monosaccharide and one molecule of sodium (Na) in a secondarily active transport, energized by Na-activated and potassium (k)-activated adenosine triphosphatase (NaK ATPase). (medscape.com)
Subunit2
We measured dopamine regulation of ouabain-sensitive 86 Rb uptake and Na + -K + -ATPase α1 subunit phosphorylation in wild-type opossum kidney (OK) (OK-WT) cells, OKH cells (NHERF-1-deficient), and OKH cells stably transfected with full-length human NHERF-1 (NF) or NHERF-1 constructs with mutated PDZ-1 (Z1) or PDZ-2 (Z2) domains. (elsevierpure.com)
Treatment with 1 μM dopamine decreased ouabain-sensitive 86 Rb uptake, increased phosphorylation of Na + -K + -ATPase α1-subunit, and enhanced association of NHERF-1 with D1 receptor in OK-WT cells but not in OKH cells. (elsevierpure.com)
Synthase1
The other important classes of ATPase in eukaryotic systems are the vacuolar H+ -ATPases and the F0F1 ATP synthase, and, in bacteria, the anion-translocating ATPases, responsible for resistance to arsenicals and antimonials, and the (Na+ -Mg2+) -ATPase of Acholeplasma. (elsevier.com)
Exchanger2
The current experiments explore the role of Na + /H + exchanger regulatory factor 1 (NHERF-1) in dopamine-mediated regulation of Na + -K + -ATPase. (elsevierpure.com)
The intestine expresses three presumably apical sodium-hydrogen exchanger (NHE) isoforms: NHE2, NHE3, and NHE8. (bvsalud.org)
Electrochemical sodium gradient2
Thereby the energy stored in an inwardly directed electrochemical sodium gradient (sodium motive force, SMF) is used to drive solute accumulation against a concentration gradient. (embl.de)
SGLT2 binds to sodium and glucose in the filtrate and these compounds are translocated across the apical cell membrane, an active process driven by the electrochemical sodium gradient between tubular filtrate and the cell. (bjcardio.co.uk)
Proteins3
These proteins are involved in active sodium uptake utilizing ATP in the process. (wikipedia.org)
Conclusions: IBD-associated diarrhea may be due to a coordinated downregulation of multiple Na + transporter and related regulatory proteins, including NHE1,3, Na + /K + - ATPase, and ENaC, as well as NHERF1,2, and ClC-5, all of which are involved directly or indirectly in intestinal Na + absorption. (johnshopkins.edu)
Volume 5 of Biomembranes covers an important group of membrane proteins, the ATPases. (elsevier.com)
Ouabain-sensitive2
Examination of the enzymatic properties of the pineal gland α3 isoform suggests that this enzyme is a ouabain-sensitive ATPase whose activity is dependent upon Na + and K + . This ATPase exhibited a lower apparent K m for Na + than the kidney α1 isoenzyme and did not show positive cooperative Na + activation. (psu.edu)
Examination of the enzymatic properties of the pineal gland α3 isoform suggests that this enzyme is a ouabain-sensitive ATPase whose activity is dependent upon Na+ and K+. (psu.edu)
Transporters1
Almost all of this is re-absorbed into the circulation via sodium glucose co-transporters (SGLTs). (bjcardio.co.uk)
Renal3
Na + -K + -ATPase activity in renal proximal tubule is regulated by several hormones including parathyroid hormone (PTH) and dopamine. (elsevierpure.com)
Renal sodium reabsorption depends on the activity of the Na + ,K + -ATPase α/β heterodimer. (pucv.cl)
Role of Renal Aminopeptidases and Angiotensin Type-2 (AT2) Receptors in Sodium Excretion and Hypertension -- 12. (nshealth.ca)
Epithelial1
Finally, free amino acids are taken up by enterocytes through specific Na-linked carrier systems (5 carriers with selective affinities for groups of amino acids are described), whereas dipeptides and tripeptides are translocated into the absorptive epithelial cells by the peptide transporter 1 (PEPT1), which is a carrier with a broad specificity linked to H entry. (medscape.com)
Binds2
An ordered binding model of sodium/substrate transport suggests that sodium binds to the empty transporter first, thereby inducing a conformational alteration which increases the affinity of the transporter for the solute. (embl.de)
The cardiac steroid ouabain binds to Na + , K + -ATPase and inhibits its activity. (huji.ac.il)
Reabsorption1
Thus, we describe a novel molecular mechanism of sodium pump modulation that may contribute to the effects of mineralocorticoids on sodium reabsorption. (pucv.cl)
Transporter2
Substrate and sodium are released and the empty transporter re-orientates in the membrane allowing the cycle to start again. (embl.de)
SGLT2, a high-capacity, low-affinity transporter of glucose and sodium is found in high concentration at the brush border membrane of the S1 and S2 segment of the proximal convoluted tubule (PCT). (bjcardio.co.uk)
Apical1
Heterogeneously expressed Flag-tagged rat (r)Nhe8 and human (h)NHE8 translocated to the apical membrane of Caco2Bbe cells. (bvsalud.org)
Plasma membrane3
Included are the plasma membrane and muscle sarcoplasmic reticulum Ca2+ -ATPases, the (Na+ -K+) -ATPase, the gastric (H+ -K+) -ATPase, the plasma membrane H+ -ATPase of fungi and plants, the Mg2+ - transport ATPase, the Salmonella typhimurium, and the K+ -ATPase of Escherichia coli, KdpB. (elsevier.com)
The Plasma Membrane H + -ATPase of Fungi and Plants (F. Portillo, P. Eraso, and R. Serrano). (elsevier.com)
The very steep gradient is maintained by an energy-driven calcium pump, known as the plasma membrane Ca 2+ ATPase (PMCA). (abdominalkey.com)
Complexes2
All such systems are multisubunit complexes with at least 3 dissimilar subunits embedded as a complex in the membrane (F 0 , a:b:c = 1:2:~12) and (usually) at least 5 dissimilar subunits attached to F 0 (F 1 , α:β:γ:δ:ε = 3:3:1:1:1 for F-type ATPases). (tcdb.org)
The functional motors are multiprotein complexes that translocate viral DNA into a capsid shell, powered by a packaging ATPase, and are among the most powerful molecular motors in nature. (nih.gov)
Eukaryotic3
Sodium/substrate symport (or co-transport) is a widespread mechanism of solute transport across cytoplasmic membranes of pro- and eukaryotic cells. (embl.de)
F-type ATPases are found in eukaryotic mitochondria and chloroplasts as well as in bacteria. (tcdb.org)
All eukaryotic F-type ATPases pump 3-4 H + out of mitochondria, or into thylakoids of chloroplasts, per ATP hydrolyzed. (tcdb.org)
Pump4
Bacterial F-type ATPases pump 3-4 H + and/or Na + (depending on the system) out of the cell per ATP hydrolyzed. (tcdb.org)
V-type ATPases may pump 2-3 H + per ATP hydrolyzed, and these enzymes cannot catalyze pmf-driven ATP synthesis. (tcdb.org)
In vitro functional analysis of Na, K-ATPase pump activity revealed that sTECE had significantly high pump function compared to SKPs or control 3T3 cells. (elsevierpure.com)
Our results suggest that the activity of the Na + ,K + -ATPase α3 isoenzyme may be adapted to function under conditions of hyperpolarizing transmembrane potentials. (psu.edu)
The Na + -K + -ATPase (NKA)-specific activity in the gills of tilapia exposed to 0.2 mg/L Cu 2+ significantly decreased over 48-72 h and was restored to the control level after 96 h, but was again depressed during 120-144 h. (ntnu.edu.tw)
Aldosterone stimulates Na + ,K + -ATPase activity and may modulate α 1 /β 1 expression. (pucv.cl)
Aldosterone stimulates Na+,K+-ATPase activity and may modulate α1/β1 expression. (pucv.cl)
Finally, kinetic studies demonstrate that assembly of the ring tetramer is directly linked to activation of the packaging ATPase activity of the motor, thus providing a direct link between structure and function. (nih.gov)
The majority of the ATPase activity on everted membrane vesicles prepared from strain 184 grown at alkaline pH was sensitive to azide and N , N ′-dicyclohexylcarbodiimide (DCCD), but ATPase was less sensitive to these inhibitors when Na + was present. (microbiologyresearch.org)
Blebbing, apoptotic body formation and protein release during early apoptosis are dependent on ROCK and myosin ATPase activity to drive actomyosin contraction. (nature.com)
Bacteria1
V-type ATPases are found in vacuoles of eukaryotes and in bacteria. (tcdb.org)
Escherichia1
The KDP-ATPase of Escherichia Coli (K. Altendorf and W. Epstein). (elsevier.com)
Respiration1
Effect of inhibitors and uncouplers on P/O ratio, trypsin-induced ATPase and ADP-stimulated respiration. (microbiologyresearch.org)
NHE21
Results: NHE1,3 (but not NHE2), β-ENaC, Na + /K + -ATPase-α, ClC-5, and NHERF1 were all downregulated in sigmoid mucosal biopsies from most cases of active UC and/or CD compared to controls. (johnshopkins.edu)
Tubular1
We hypothesized that the β 3 isoform of the Na + ,K + -ATPase is expressed in tubular cells of the distal nephron, and modulated by mineralocorticoids. (pucv.cl)
Protein2
Expression of major corneal endothelial markers were confirmed by Reverse transcription polymerase chain reaction (RT-PCR) and quantitative Real time polymerase chain reaction (qRT-PCR).Western blots confirmed the expression of Na, K-ATPase protein, the major functional marker of corneal endothelial cells. (elsevierpure.com)
Marked changes in serum sodium concentration also affect the protein binding of calcium. (abdominalkey.com)
Regulation2
Transfection with wild-type, full-length, or PDZ-1 domain-mutated NHERF-1 into OKH cells restored dopamine-mediated regulation of Na + -K + -ATPase and D1-like receptor association with NHERF-1. (elsevierpure.com)
These results suggest that NHERF-1 mediates Na + -K + -ATPase regulation by dopamine through its PDZ-2 domain. (elsevierpure.com)
Functional1
This protomer assembles into a functional higher-order complex that excises a unit length genome from a concatemeric DNA precursor (genome maturation) and concomitantly translocates the duplex into a preformed procapsid shell (genome packaging). (nih.gov)
Cells1
Dopamine did not regulate Na + -K + -ATPase or increase D1-like receptor association with NHERF-1 in OKH cells transfected with mutated PDZ-2 domain. (elsevierpure.com)
Expression4
Immunohistochemistry revealed the expression of zonular occludens-1 and Na, K-ATPase in cellcell junctions. (elsevierpure.com)
We have used immunoblotting and biochemical techniques to analyze expression of Na + ,K + -ATPase α and β subunits in rat pineal glands. (psu.edu)
Influence of inhaled nitric oxide and hyperoxia on Na,K-ATPase expression and lung edema in newborn piglets. (childrensmercy.org)
CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. (thermofisher.com)
Major1
This graph shows the total number of publications written about "H(+)-K(+)-Exchanging ATPase" by people in this website by year, and whether "H(+)-K(+)-Exchanging ATPase" was a major or minor topic of these publications. (umassmed.edu)