Sodium phosphate cotransporter proteins type iib. Medical search. Frequent questions

SLC34A2 gene mutations are thought to impair the activity of the type IIb sodium-phosphate cotransporter, resulting in the accumulation of phosphate in the alveoli. (medlineplus.gov)
2016). Characterizing and evaluating the expression of the type IIb sodium-dependent phosphate cotransporter (slc34a2) gene and its potential influence on phosphorus utilization efficiency in yellow catfish (Pelteobagrus fulvidraco). (tcdb.org)
2017). Characterization of the isoforms of type IIb sodium-dependent phosphate cotransporter (Slc34a2) in yellow catfish, Pelteobagrus fulvidraco, and their vitamin D3-regulated expression under low-phosphate conditions. (tcdb.org)

Vascular smooth muscle cells are sensitive to changes in inorganic phosphate (Pi) levels. (revistanefrologia.com)
The PNaS family includes several functionally characterized, sodium-dependent, inorganic phosphate (P i ) transporter (NPT2 or NptA) proteins from mammals. (tcdb.org)
Mammalian porters of the PNaS family may catalyze cotransport of 3 Na + with 1 inorganic phosphate. (tcdb.org)
In response to parathyroid hormone and dietary inorganic phosphate, the renal cotransporter is rapidly inserted into and retrieved from the renal brush border membrane in a fashion similar to that by which the glucose transporter (Glut4) (TC# 2.A.1.1) is regulated by insulin, and aquaporins 1 and 2 (TC# 1.A.8.1) are regulated by vasopressin (Levi et al. (tcdb.org)

Pulmonary alveolar microlithiasis is a disorder in which many tiny fragments (microliths) of a compound called calcium phosphate gradually accumulate in the small air sacs (alveoli) located throughout the lungs. (medlineplus.gov)
Vascular calcification is a pathology characterized by the deposition of calcium-phosphate in cardiovascular structures, mainly in the form of hydroxyapatite crystals, resulting in ectopic calcification. (revistanefrologia.com)

For instance the wheat HKT1 transporter shows two modes of transport by the same protein. (wikipedia.org)

This gene provides instructions for making a protein called the type IIb sodium-phosphate cotransporter, which plays a role in the regulation of phosphate levels (phosphate homeostasis). (medlineplus.gov)

Cotransporters can be classified as antiporters and symporters. (wikipedia.org)
Here, since both glucose and sodium are transported in the same direction across the membrane, they would be classified as symporters. (wikipedia.org)
Antiporters and symporters both transport two or more different types of molecules at the same time in a coupled movement. (wikipedia.org)
In one conformation the protein will have the binding site (or sites in the case of symporters) exposed to one side of the membrane. (wikipedia.org)

Here we describe the results of administering a potent and selective inhibitor of Protein Kinase C (PKC) family members PKCα and PKCß, Cmpd 1, in the ZSF1 obese rat model of hyperphagia-induced, obesity-driven T2D. (bvsalud.org)

In mammals, glucose is transported through sodium dependent glucose transporters, which use energy in this process. (wikipedia.org)

His experience in the areas of glucose-6-phosphate biochemistry, carbon dioxide fixation, hexokinase and phosphate studies led him to hypothesize cotransport of glucose along with sodium through the intestine. (wikipedia.org)

Defects in epithelial functional differentiation at parturition were accompanied by a profound reduction in expression of the STAT5-regulated milk genes casein beta and whey acidic protein . (silverchair.com)

Cotransporters are a subcategory of membrane transport proteins (transporters) that couple the favorable movement of one molecule with its concentration gradient and unfavorable movement of another molecule against its concentration gradient. (wikipedia.org)
Uniporters are also transporters but move only one type of molecule down its concentration gradient and are not classified as cotransporters. (wikipedia.org)
This type of transport is known as secondary active transport and is powered by the energy derived from the concentration gradient of the ions/molecules across the membrane the cotransporter protein is integrated within. (wikipedia.org)
Cotransporters undergo a cycle of conformational changes by linking the movement of an ion with its concentration gradient (downhill movement) to the movement of a cotransported solute against its concentration gradient (uphill movement). (wikipedia.org)
Variations in serum protein alter proportionately the concentration of the protein-bound and total serum calcium. (abdominalkey.com)
An increase in serum albumin concentration of 1 g/dL increases protein-bound calcium by 0.8 mg/dL, whereas an increase of 1 g/dL of globulin increases protein-bound calcium by 0.16 mg/dL. (abdominalkey.com)
Marked changes in serum sodium concentration also affect the protein binding of calcium. (abdominalkey.com)

Pictured right is of Dr. Crane and his drawing of the cotransporter system he proposed in 1960, at the international meet on membrane transport and metabolism. (wikipedia.org)
This cycle of conformational changes only transports one substrate ion at a time, which results in a fairly slow transport rate (100 to 104 ions or molecules per second) when compared to other transport proteins like ion channels. (wikipedia.org)
2012). Functional Interaction between CFTR and the Sodium-Phosphate Co-Transport Type 2a in Xenopus laevis Oocytes. (tcdb.org)

These cells produce and recycle surfactant, which is a mixture of certain phosphate-containing fats (called phospholipids) and proteins that lines the lung tissue and makes breathing easy. (medlineplus.gov)

Although this protein can be found in several organs and tissues in the body, it is located mainly in the lungs, specifically in cells in the alveoli called alveolar type II cells. (medlineplus.gov)
The well-characterized mammalian proteins are found in renal (IIa isoform) and intestinal (IIb isoform) brush border membranes and are about 640 amino acyl residues long with 8-12 putative TMSs. (tcdb.org)

The ERBB family of type 1 receptor tyrosine kinases and their ligands have crucial functions during mammopoiesis, but the signaling networks that ultimately regulate ERBB activity in the breast have remained elusive. (silverchair.com)

Dystrophin associates with a number of proteins to form a large oligomeric complex named the dystrophin-glycoprotein complex (DGC), which bridges across the sarcolemma and connects the extracellular matrix and the actin cytoskeleton (Allamand and Campbell, (2000) Human Molecular Genetics 9:2459-2467). (justia.com)

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)

Although this protein can be found in several organs and tissues in the body, it is located mainly in the lungs, specifically in cells in the alveoli called alveolar type II cells. (medlineplus.gov)
This protein is expressed in alveolar type II cells and its mutation results in disordered phosphate homeostasis and clearance from the alveoli. (rcpjournals.org)
12. Expression of type II Na-P(i) cotransporter in alveolar type II cells. (nih.gov)
These analyses revealed that in addition to pulmonary inflammation and fibrosis, intratracheal silica challenge induced osteoclast-like differentiation of alveolar macrophages and recruited monocytes, driven by induction of the osteoclastogenic cytokine, receptor activator of nuclear factor-κB ligand (RANKL) in pulmonary lymphocytes and alveolar type II cells. (bvsalud.org)

[ 5 ] A low phosphorus diet and 1,25(OH) 2 vitamin D 3 are the two most important positive regulators of the intestinal isoform (NaPi-IIb). (medscape.com)
Metabolic acidosis, estrogen and epidermal growth factor (EGF) enhance expression of NaPi-IIb. (medscape.com)
Serum and glucocorticoid-inducible kinase 1 stimulates phosphate transport, at least in part, by phosphorylating Nedd4-2, thereby inhibiting binding of this ubiquitin ligase to NaPi-IIb. (medscape.com)
[ 10 ] NaPi-IIb is not ubiquitinated and its expression in the membrane is increased. (medscape.com)
8. Expression of NaPi-IIb in rodent and human kidney and upregulation in a model of chronic kidney disease. (nih.gov)
9. The vitamin D analog ED-71 is a potent regulator of intestinal phosphate absorption and NaPi-IIb. (nih.gov)
11. Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation. (nih.gov)
15. Upregulation of the Na⁺-coupled phosphate cotransporters NaPi-IIa and NaPi-IIb by B-RAF. (nih.gov)

A large proportion of dietary phosphate is absorbed from the gastrointestinal tract and excreted in urine. (medscape.com)

[ 8 , 9 ] A novel signaling pathway in regulation of intestinal phosphate transport involves serum and glucocorticoid-inducible kinase 1, and the ubiquitin ligase Nedd4-2. (medscape.com)
3. Regulation of intestinal phosphate transport. (nih.gov)

This gene provides instructions for making a protein called the type IIb sodium-phosphate cotransporter, which plays a role in the regulation of phosphate levels (phosphate homeostasis). (medlineplus.gov)
The protein encoded by this gene is involved in phosphate homeostasis and alveolar surfactant metabolism. (rcpjournals.org)

They are present primarily in the KIDNEY and SMALL INTESTINE and are responsible for renal and small intestinal epithelial transport of phosphate. (reference.md)

PAM is a rare autosomal recessive disease characterised by the accumulation of innumerable calcium phosphate deposits known as microliths in the lungs. (rcpjournals.org)

Cotransporters can be classified as antiporters and symporters. (wikipedia.org)
Here, since both glucose and sodium are transported in the same direction across the membrane, they would be classified as symporters. (wikipedia.org)
Antiporters and symporters both transport two or more different types of molecules at the same time in a coupled movement. (wikipedia.org)
In one conformation the protein will have the binding site (or sites in the case of symporters) exposed to one side of the membrane. (wikipedia.org)

Cotransporters undergo a cycle of conformational changes by linking the movement of an ion with its concentration gradient (downhill movement) to the movement of a cotransported solute against its concentration gradient (uphill movement). (wikipedia.org)

Pulmonary alveolar microlithiasis is a disorder in which many tiny fragments (microliths) of a compound called calcium phosphate gradually accumulate in the small air sacs (alveoli) located throughout the lungs. (medlineplus.gov)
The accumulated phosphate forms the microliths that cause the signs and symptoms of pulmonary alveolar microlithiasis. (medlineplus.gov)
The single cell transcriptomic analysis of a pulmonary alveolar microlithiasis lung explant showing a robust osteoclast gene signature in alveolar monocytes and the finding that calcium phosphate microliths contain a rich protein and lipid matrix that includes bone resorbing osteoclast enzymes and other proteins suggested a role for osteoclast-like cells in the host response to microliths. (bvsalud.org)

A family of sodium-phosphate cotransporter proteins with eight transmembrane domains. (reference.md)

A Proton gradient moves the ions into the vacuole by proton-sodium antiporter or the proton-calcium antiporter. (wikipedia.org)
The serum assay measures inorganic orthophosphates, of which 10% are bound to protein, 5% are complexed with calcium and magnesium, and 85% are H 2 PO 4 - and HPO 4 2- . (medscape.com)

[ 11 ] Three sodium-phosphorus cotransporters are expressed in proximal tubule cells. (medscape.com)
WK TPM values with a β superscript signify non-proximal tubule cell type selective markers with rat proximal tubule RPKM values >10 in at least one proximal tubule subsegment. (nih.gov)

1. Intestinal and renal adaptation to a low-Pi diet of type II NaPi cotransporters in vitamin D receptor- and 1alphaOHase-deficient mice. (nih.gov)
6. Age, phosphorus, and 25-hydroxycholecalciferol regulate mRNA expression of vitamin D receptor and sodium-phosphate cotransporter in the small intestine of broiler chickens. (nih.gov)
7. Intestinal Na-P(i) cotransporter adaptation to dietary P(i) content in vitamin D receptor null mice. (nih.gov)
18. Role of the vitamin D receptor in FGF23 action on phosphate metabolism. (nih.gov)
A Fab fragment of the chimeric monoclonal antibody 7E3 that binds to the glycoprotein IIb-IIIa receptor of human platelets, and blocks PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX, potently inhibiting PLATELET AGGREGATION. (nih.gov)

Cotransporters are a subcategory of membrane transport proteins (transporters) that couple the favorable movement of one molecule with its concentration gradient and unfavorable movement of another molecule against its concentration gradient. (wikipedia.org)
In general, cotransporters consist of two out of the three classes of integral membrane proteins known as transporters that move molecules and ions across biomembranes. (wikipedia.org)
Pictured right is of Dr. Crane and his drawing of the cotransporter system he proposed in 1960, at the international meet on membrane transport and metabolism. (wikipedia.org)
This type of transport is known as secondary active transport and is powered by the energy derived from the concentration gradient of the ions/molecules across the membrane the cotransporter protein is integrated within. (wikipedia.org)
Ubiquitination of target proteins tags them for removal from the cell membrane and for degradation in PROTEASOMES. (medscape.com)

These cells produce and recycle surfactant, which is a mixture of certain phosphate-containing fats (called phospholipids) and proteins that lines the lung tissue and makes breathing easy. (medlineplus.gov)
The recycling of surfactant releases phosphate into the alveoli. (medlineplus.gov)

4. Expression of renal and intestinal Na/Pi cotransporters in the absence of GABARAP. (nih.gov)
5. Segment-specific expression of sodium-phosphate cotransporters NaPi-IIa and -IIc and interacting proteins in mouse renal proximal tubules. (nih.gov)
13. Renal expression of the sodium/phosphate cotransporter gene, Npt2, is not required for regulation of renal 1 alpha-hydroxylase by phosphate. (nih.gov)
17. Expression and regulation of the renal Na/phosphate cotransporter NaPi-IIa in a mouse model deficient for the PDZ protein PDZK1. (nih.gov)

14. Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate. (nih.gov)

Phosphate uptake is increased at lower pH. (nih.gov)

I. Segmental expression and adaptation to low-P(i) diet of the type IIb Na(+)-P(i) cotransporter in mouse small intestine. (nih.gov)

In mammals, glucose is transported through sodium dependent glucose transporters, which use energy in this process. (wikipedia.org)
Transepithelial phosphate transport across intact intestinal epithelium is driven by an active sodium-dependent process. (medscape.com)
2. Vitamin D and type II sodium-dependent phosphate cotransporters. (nih.gov)

This database provides mean TPM values for the cell type selective markers expressed in mouse whole kidney (WK) samples. (nih.gov)
Representation and relative abundance of cell-type selective markers in whole-kidney RNA-Seq data. (nih.gov)

https://nhtsa.gov/Driving-Safety/Aggressive-Driving) HN - 2019 MH - Alefacept UI - D000077944 MN - D12.776.124.486.485.114.619.393.131 MN - D12.776.124.790.651.114.619.393.131 MN - D12.776.377.715.548.114.619.393.131 MN - D12.776.395.550.34.500 MN - D12.776.543.550.158.500 MN - D12.776.828.300.100 MS - A recombinant human fusion protein of LFA-3 antigen and immunoglobulin IGG1 that binds to CD2 ANTIGENS on memory T-LYMPHOCYTES, preventing their activation and proliferation. (nih.gov)

AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)

Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)

A carcinoma originating in the lung and the most common lung cancer type in never-smokers. (nih.gov)
HN - 2019 (1985) MH - Adenocarcinoma of Lung UI - D000077192 MN - C4.557.470.200.25.22 MN - C4.588.894.797.520.55 MS - A carcinoma originating in the lung and the most common lung cancer type in never-smokers. (nih.gov)

NaPi-II expression in both cell types is controlled by hormones and metabolic factors in response to homeostatic needs. (medscape.com)

HN - 2006(1981) BX - Actin-Capping Proteins MH - Actin Depolymerizing Factors UI - D051339 MN - D5.750.78.730.212 MN - D12.776.220.525.212 MS - A family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. (nih.gov)

The rate at which this cycle of conformational changes occurs is called the turnover rate (TOR) and is expressed as the average number of complete cycles per second performed by a single cotransporter molecule. (wikipedia.org)

with Pubmed ID, gene symbol/accession number and parasite interacting protein. (polygenicpathways.co.uk)

HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)

When levels of dietary phosphorus are normal and parathyroid function is intact, about 80% of filtered phosphate is reabsorbed. (medscape.com)
It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain. (nih.gov)

Some studies show that cotransporters can function as ion channels, contradicting the classical models. (wikipedia.org)
His experience in the areas of glucose-6-phosphate biochemistry, carbon dioxide fixation, hexokinase and phosphate studies led him to hypothesize cotransport of glucose along with sodium through the intestine. (wikipedia.org)
His studies were confirmed by other groups and are now used as the classical model to understand cotransporters. (wikipedia.org)

First, mesangial expansion is directly induced by hyperglycemia, perhaps via increased matrix production or glycation of matrix proteins. (medscape.com)

In urine, phosphate is an effective buffer, a function of its relatively high tubular concentration and PKa of 6.8, which is close to the pH of urine under normal conditions. (medscape.com)

HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)

Gene symbols marked with an α superscript are listed as markers in multiple cell types. (nih.gov)

Anatomy11

Organisms4

Diseases7

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes13

Technology, Industry, Agriculture4

Information Science3

Health Care2

SLC34A23

Inorganic phosphate4

Calcium phosphate2

Transporter1

Gene1

Symporters4

Inhibitor1

Mammals1

Cotransport1

Genes1

Concentration7

Transport3

Tissue1

Found2

Family1

Form1

Results1

Alveolar type II cells4

NAPI-IIb8

Dietary phosphate1

Intestinal phosphate transport2

Homeostasis2

Epithelial1

Accumulation1

SYMPORTERS4

Solute1

Microliths3

Transmembrane1

Calcium2

Proximal tubule2

Receptor5

Membrane5

Surfactant2

Renal4

Regulation1

Uptake1

Adaptation1

Dependent3

Kidney2

Antigen1

Regulate1

Binds2

Lung2

Expression1

Family1

Occurs1

Gene Symbol1

Role1

Levels2

Studies3

Matrix1

Function1

Complex1

Cell types1