Sodium dependent neutral amino acid transporter sodium dependent amino acid transporter amino acids neutral. Medical search. Frequent questions

ATB 0+ (SLC6A14) is a transporter for numerous dipolar and cationic amino acids and thus has a much broader substrate specificity than the glycine transporters alongside which it is grouped on the basis of structural similarity [ 10 ]. (guidetopharmacology.org)
Cationic amino acid transporters are 14 TM proteins, which mediate pH- and sodium-independent transport of cationic amino acids (system y + ), apparently as an exchange mechanism. (guidetopharmacology.org)

In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. (nih.gov)
A family of sodium chloride-dependent neurotransmitter symporters that transport the amino acid GLYCINE. (childrensmercy.org)

Subsequent to our kinetic identification of the transport process, significant advances have been achieved in the genetic and protein identification and characterization of the X AG - transporter class as EAATs (excitatory amino acid transporters). (biomedcentral.com)

In this review, I describe the molecular mechanism underlying the extreme stability of unboiled NAD-dependent glutamate dehydrogenase from the hyperthermophile Pyrobaculum islandicum . (go.jp)
Moreover, we identified metabolic compensation mediated by the glutamate/aspartate transporters SLC1A2 and SLC1A3 under glutamine-limiting conditions. (life-science-alliance.org)
In other cells (predominantly excitable tissue cells), EAAC1 has been reported to function as a glutamate transporter rather than as an aspartate transporter. (biomedcentral.com)
The identification of EAAC1 as the high-affinity L-aspartate transporter now permits studies to elucidate the mechanism of hormonal regulation of EAAC1 gene expression, and to investigate the mechanism by which the cellular environment effects the functioning of EAAC1 as an aspartate transporter or as a glutamate transporter. (biomedcentral.com)
The kinetic properties are representative of the Na+- dependent high-affinity glutamate-aspartate transporters referred to as the X AG - class of amino acid transporters. (biomedcentral.com)

However, US/MW pretreatment and enzymatic extraction did not improve the yields of proteins and free amino acids. (bvsalud.org)
In contrast to the influx of amino acids, the degradation of proteins is also the important intracellular mechanism for releasing free amino acids both under steady-state conditions and during cellular stresses. (spandidos-publications.com)

This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. (nih.gov)
Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. (life-science-alliance.org)

The env gene maintained an ORF coding for a 538-amino acid polypeptide that has all the characteristic features of env proteins and mediates intercellular fusion in vitro [ 11 - 13 ]. (ecancer.org)
This study investigated the multiproduct (fucoidans, ß-glucans, proteins, carotenoids, fatty acids, amino acids and polyphenols) valorization of the invasive macroalgae Ascophyllum nodosum within a green biorefinery concept using ultrasound (US), microwave (MW) treatment followed by supercritical CO2 (SC-CO2) with co-solvent and enzymatic extraction. (bvsalud.org)

Among the transporters identified, we characterized the cationic amino acid transporter SLC7A3 as a gene that, when up-regulated, overcame low availability of arginine and lysine by increasing their uptake, whereas SLC7A5 was able to sustain cellular fitness upon deprivation of several neutral amino acids. (life-science-alliance.org)

Mutations in the SLC6A19 gene, which encodes the SLC6A19 (B 0 AT1) neutral amino acid transporter, causes a failure of the transport of neutral (ie, monoaminomonocarboxylic) amino acids in the small intestine and the renal tubules. (medscape.com)

[ 10 , 11 ] In an animal model of Hartnup disorder, mice lacking SLC6A19 (B 0 AT1) transporter general neutral aminoaciduria were observed, as well as the decreased body weight, demonstrating the essential role of epithelial amino acid uptake in optimal growth and bodyweight regulation. (medscape.com)
This study shows that EAAC1 functions as the high-affinity L-aspartate transporter that is responsible for the uptake and accumulation of aspartate in prostate cells. (biomedcentral.com)

Branched-chain fatty acids (BCFAs) consist of a wide variety of fatty acids with alkyl branching of methyl group. (bvsalud.org)
The characterization of SC-CO2 extracts revealed that pretreatment with US and MW improved the 2-fold yield of carotenoids, total phenolics and fatty acids. (bvsalud.org)

The LAT1 transporter is acknowledged as a pharmacological target of tumours since it is strongly overexpressed in many human cancers. (ucy.ac.cy)

SGK3-sensitive transporters contribute to a variety of physiological and pathophysiological processes, such as maintaining calcium and phosphorus homeostasis, hydro-salinity balance and acid-base balance, cell proliferation, muscle action potential, cardiac and neural electrophysiological disturbances, bone density, intestinal nutrition absorption, immune function, and multiple substance metabolism. (cqmu.edu.cn)
One-by-one depletion of 13 amino acids required for cell proliferation enabled gain-of-function genetic screens using a SLC-focused CRISPR/Cas9-based transcriptional activation approach to uncover transporters relieving cells from growth-limiting metabolic bottlenecks. (life-science-alliance.org)

The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). (nih.gov)

The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. (aspetjournals.org)

A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. (aspetjournals.org)
first, organic anions are transported from the peritubular plasma by basolateral organic anion transporter(s) and subsequently effluxed into the tubular lumen by luminal transporter(s). (aspetjournals.org)
Belongs to the class of organic compounds known as l-alpha-amino acids. (cannabisdatabase.ca)

Unbiased classification of gene expression profiles and subsequent gene ontology analyses revealed that the majority of Olig2-astrocytes belonged to an astrocytic cluster that is enriched for transporter-related genes. (biomedcentral.com)
SLC7A10 (also known as ASC-1) was one of the representative neutral amino acid transporter genes in the cluster. (biomedcentral.com)

In earlier kinetic studies we identified the existence of a unique Na+-dependent high-affinity L-aspartate transport process in rat prostate secretory epithelial cells. (biomedcentral.com)

Given its particular distribution in normal human tissues and its potential roll as an immune modulator and in amino acid transport, tissue tolerance and protection against retroviral infection, syncytin could be a potential target for immune therapy using specific inhibitors. (ecancer.org)

The maintenance of the intracellular level of amino acids is crucial for cellular homeostasis. (spandidos-publications.com)
Therefore, the shortage of the intracellular amino acid pool appears to determine the sensitivity to GEF. (spandidos-publications.com)
Intracellular levels of amino acids are maintained by the balance between their influx, utilization and recycling ( 1 ). (spandidos-publications.com)

Recent research has shown that GPNA can inhibit multiple other amino acid transporters and that GPNA's inhibition of cell viability is likely due to off-target effects from the activity of the γ-Glutamyltransferase enzyme rather than the disruption of glutamine metabolism [ 12 ] . (encyclopedia.pub)
Transporters in the APC superfamily influence ferroptosis which may inhibit bone formation and promote bone absorption through oxidative stress, thus leading to osteoporosis. (tcdb.org)

Two gene products, GlyT1 and GlyT2, are known that give rise to transporters that are predominantly located on glia and neurones, respectively. (guidetopharmacology.org)

This is achieved by the existence of a Na+-dependent high-affinity L-aspartate transport process with kinetic properties that result in cellular accumulation of aspartate from circulation [ 5 - 7 ]. (biomedcentral.com)
An important unresolved issue was the identification of the putative prostate high-affinity L-aspartate transporter. (biomedcentral.com)
OAT1 is a PAH/dicarboxylate exchanger and mediates the high-affinity transport of PAH in a sodium-independent manner. (aspetjournals.org)

Cloning and expression of the mouse SLC6A19 gene demonstrated that this transporter has all the properties of the amino acid transport system B 0 AT1. (medscape.com)
As an example, Wood and colleagues (pp. 2695-2710) present the sialic acid gene repressor NanR (PDB-6WFG), where cryo-EM revealed the DNA-binding mode. (silverchair.com)

Normal alanine metabolism, like that of other amino acids, is highly dependent upon enzymes that contain vitamin B6. (cannabisdatabase.ca)
The ASCT2 transport system catalyses a sodium-dependent antiport of glutamine and other neutral amino acids which is involved in amino acid metabolism. (ucy.ac.cy)

In one case, the presence of several kinds of glutamine transporters in the plasma membrane made it difficult to accomplish selective blocking of glutamine absorption [ 5 ] . (encyclopedia.pub)

Hartnup disease is an autosomal recessive disorder caused by impaired neutral (ie, monoaminomonocarboxylic) amino acid transport in the apical brush border membrane of the small intestine and the proximal tubule of the kidney. (medscape.com)
SLC6A19 is a sodium-dependent and chloride-independent neutral amino acid transporter, expressed predominately in the kidneys and intestine. (medscape.com)

The present report is concerned with the identification of this putative L-aspartate transporter in rat and human prostate cells. (biomedcentral.com)

The size of the central cavity of CadB and PotE is dependent on the angle of transmembrane helix 6 (TM6) against the periplasm. (tcdb.org)

In contrast, in citrate-producing prostate cells, aspartate is an essential amino acid that must be derived from circulation. (biomedcentral.com)

Functions as a sodium-dependent neutral amino acid transporter. (nih.gov)
L-Arginine is an amino acid that has numerous functions in the body. (cannabisdatabase.ca)

Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. (nih.gov)

Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)

have presented the crystal structure of apo-ApcT, a proton-coupled broad-specificity amino acid transporter, at 2.35 Å resolution. (tcdb.org)

Overall, this gain-of-function approach using human cells uncovered functional transporter-nutrient relationships and revealed that transport activity up-regulation may be sufficient to overcome environmental metabolic restrictions. (life-science-alliance.org)
Understanding the regulation of acid-base balance requires appreciation of the fundamental definitions and principles underlying this complex physiologic process. (medscape.com)

Rapid methods for amino acid determination are desired to reduce running times, and the main factors involved in the rapid separation of these compounds in HPLC are the columns, solvents, and gradient. (bvsalud.org)
Alanine and derivatives are compounds containing alanine or a derivative thereof resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. (cannabisdatabase.ca)

Amino acids are essential for cellular homeostasis, growth and proliferation via their contribution to a diverse range of cellular processes. (spandidos-publications.com)

The present study refers to a method optimization to rapidly analyze 19 amino acids in RP-HPLC/DAD with pre-column derivatization using o-phthalaldehyde. (bvsalud.org)

The members of the L-type amino acid transporter (LAT) family are Na + -independent transporters that deliver neutral amino acids into cells ( 2 ). (spandidos-publications.com)
SLC7 family members may be divided into two major groups: cationic amino acid transporters (CATs) and glycoprotein-associated amino acid transporters (gpaATs). (guidetopharmacology.org)
The deduced amino acid sequence of hOAT3 showed 36 to 51% identity to those of other members of the OAT family. (aspetjournals.org)

L-Alanine or Alanine, abbreviated Ala or A, is a non-essential amino acid made in the body from either the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. (cannabisdatabase.ca)
The addition of essential amino acids, but not non-essential amino acids to the cell culture medium resulted in the cancellation of this pronounced cytotoxicity. (spandidos-publications.com)
and, therefore is a non-essential amino acid. (biomedcentral.com)
In these specialized prostate cells, aspartate is an essential amino acid that is derived from circulation. (biomedcentral.com)
Arginine or l-arginine, abbreviated Arg or R, is an essential amino acid that is physiologically active in the L-form. (cannabisdatabase.ca)
In mammals, arginine is formally classified as a semi-essential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. (cannabisdatabase.ca)

Plasma alanine is often decreased when the BCAA (branched-chain amino acids) are deficient. (cannabisdatabase.ca)
The transport of serum amino acids into cells is an active process that is facilitated by plasma membrane-localized amino acid transporters. (spandidos-publications.com)

[ 14 ] The most common mutation in Hartnup disorder is c.517G→A, resulting in the amino acid substitution p.D173N, and it can be found in 43% of patients. (medscape.com)
They proposed that Lys158 is central to proton-coupled transport and that the amine group serves the same functional role as the Na2 ion in LeuT, thus demonstrating common principles among proton- and sodium-coupled transporters. (tcdb.org)

Various anionic drugs have been indicated to be taken up into the proximal tubular cells by the classic p -aminohippurate (PAH) transporter. (aspetjournals.org)

Arginine is a basic amino acid as its side chain contains a positively charged guanidinium group, which is highly polar, at the end of a hydrophobic¬†aliphatic¬†hydrocarbon chain. (cannabisdatabase.ca)
With a pKa of 12.48, the guanidinium group is positively charged in neutral, acidic, and even most basic environments. (cannabisdatabase.ca)

May have a role as transporter for neurotransmitter precursors into neurons. (nih.gov)
Here we described the role of Si and its transporters in mitigating abiotic stress condition in horticultural plants. (researchsquare.com)

However, an analysis of the synonymous and non-synonymous substitutions indicated a relatively high degree of amino acid change in hominoids [ 15 ], which could be consistent with a low degree of selective pressure. (ecancer.org)

It is highly concentrated in muscle and is one of the most important amino acids released by muscle, functioning as a major energy source. (cannabisdatabase.ca)

Thus, buffers work as a first-line of defense to blunt the changes in pH that would otherwise result from the constant daily addition of acids and bases to body fluids. (medscape.com)

In living organisms, if the temperature exceeds the normal range (thermo-neutral zone), it disturbs the normal physiological functioning and induces cell injury. (frontiersin.org)

It is an important amino acid for lymphocyte reproduction and immunity. (cannabisdatabase.ca)

Anatomy10

Organisms3

Diseases5

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes22

Information Science4

Cationic amino acids2

Chloride-dependent2

Identification and characterization1

Glutamate5

Free amino acids2

Solute2

Proteins2

SLC7A31

Renal1

Uptake2

Fatty acids2

LAT11

Cell proliferation2

PMID1

Protein1

Organic3

Genes2

Epithelial1

Retroviral1

Intracellular3

Inhibit2

Predominantly1

Affinity3

Gene2

Metabolism2

Absorption1

Intestine2

Putative1

Transmembrane1

Contrast1

Functions2

Mediates1

Receptor1

Specificity1

Regulation2

Compounds2

Homeostasis1

Rapidly1

Family3

Essential6

Plasma2

Common2

Cells1

Basic2

Role2

High1

Major1

Addition1

Normal1

Important1