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  • glutamine
  • Moreover, through a complex array of exchange fluxes, involving other amino acid transporters, and of metabolic reactions, such as the synthesis of glutamate from glutamine, SNAT2 activity influences the cell content of most amino acids, thus determining the overall size and the composition of the intracellular amino acid pool. (biomedsearch.com)
  • The rapamycin-induced transcriptional profile is distinct from those induced by glucose, glutamine, or leucine deprivation but is most similar to that induced by amino acid deprivation. (asm.org)
  • Interestingly, lymphocytes are more dependent than other cell types on amino acids, particularly glutamine, for biosynthesis and energy production ( 28 ), and a decrease in blood glutamine levels causes immunosuppression in humans and mice ( 6 , 19 ). (asm.org)
  • The purpose of the current study was to determine how nutrient perfusion alters sodium-dependent glucose and glutamine transport activity and their regulation at the cellular level during hypoperfusion. (physiology.org)
  • intracellular
  • In cultured human fibroblasts incubated under hypertonic conditions, the specific silencing of SNAT2 expression, obtained with anti-SNAT2 siRNAs, prevents the increase in system A transport activity, hinders the expansion of intracellular amino acid pool, and significantly delays cell volume recovery. (biomedsearch.com)
  • ASCT2
  • The receptor for the rabbit syncytin-Ory1 was found to be the same as that for human syncytin-1, i.e. the previously identified ASCT2 transporter. (biomedcentral.com)
  • mammalian
  • Recent studies indicate that the levels of ATP and phosphatidic acid may regulate the TOR pathway in mammalian cells ( 11 , 13 ), but the connection to nutrient signaling is not clear. (asm.org)
  • Symptoms
  • Daily intake of 50-300mg Nicotinamide and Nicotinic acid has been found to provide relief if neurological symptoms or skin problems arise at any time. (primehealthchannel.com)