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  • transport
  • Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and NRF2 pathway . (genecards.org)
  • Transport inhibited by BCH (2-aminobicyclo-[2.2.heptane-2-carboxylic acid). (genecards.org)
  • Fetal growth is dependent on nutrient availability, which in turn is related to the capacity of the placenta to transport these nutrients. (hindawi.com)
  • The activity of a range of nutrient transporters has been reported to be decreased in placentas of growth restricted fetuses, whereas at least some studies indicate that placental nutrient transport is upregulated in fetal overgrowth. (hindawi.com)
  • In this paper we will focus on recent studies of regulatory mechanisms that modulate placental transport of amino acids, fatty acids, and glucose. (hindawi.com)
  • Fetal growth is largely determined by nutrient supply, which is dependent upon placental nutrient transport. (hindawi.com)
  • A wide range of nutrients (e.g., amino acids, phosphorus, and lactate) are transported across the placenta mediated by secondary active transport, utilizing energy provided by ion gradients such as sodium, chloride, and protons [ 14 - 16 ]. (hindawi.com)
  • Both RDR and ATB0 serve as retrovirus receptors and both show specific transport of neutral amino acids. (tcdb.org)
  • Infection of cells with RD114/type D retroviruses results in impaired amino acid transport, suggesting a mechanism for virus toxicity and immunosuppression. (tcdb.org)
  • Surprisingly, however, rapamycin had effects opposite from those of amino acid starvation on the expression of a large group of genes involved in the synthesis, transport, and use of amino acids. (asm.org)
  • We hypothesized that adiponectin regulates placental amino acid transport. (diabetesjournals.org)
  • As a result, fAd inhibits insulin-stimulated amino acid transport, which may have important implications for placental nutrient transport and fetal growth in pregnancy complications associated with altered maternal adiponectin levels. (diabetesjournals.org)
  • however, the primary determinant of fetal growth is nutrient supply, which is dependent on placental nutrient transport. (diabetesjournals.org)
  • The neuronal system A2 has been reported to transport Asn and Gln with higher affinity than for other neutral amino acids. (tcdb.org)
  • Variants that cause the disease disrupt amino acid transport across the cell membrane, leading to the build-up of relatively insoluble cystine, resulting in formation of stones. (biomedcentral.com)
  • The various transporters have different properties both with respect to their transport functions and with respect to their ability to act as ion channels. (frontiersin.org)
  • placental
  • Detailed information on the mechanisms by which placental nutrient transporters are regulated will therefore help us to better understand how important pregnancy complications develop and may provide a foundation for designing novel intervention strategies. (hindawi.com)
  • In human pregnancies complicated by either intrauterine growth restriction (IUGR) or fetal overgrowth many key placental nutrient transporters are specifically regulated (Table 1 ). (hindawi.com)
  • Changes in BM or MVM activity or placental expression of nutrient transporters and lipases in pregnancies complicated by abnormal fetal growth. (hindawi.com)
  • In this paper, we will focus on circulating and placental factors as well as placental signaling pathways regulating key placental macronutrient transporters. (hindawi.com)
  • Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL,Leibach FH, Ganapathy V. Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bofrom a human placental choriocarcinoma cell line.J Biol Chem. (tcdb.org)
  • Decreased placental mTOR activity causes down-regulation of placental system A activity by shifting SNAT-2 trafficking towards proteasomal degradation, thereby contributing to decreased fetal amino acid availability and restricted fetal growth in IUGR. (antibodies-online.com)
  • Placental mRNA expression of system A transporter isoforms SLC38A1 and -2 was lower in teenagers than in adults which may underlie their susceptibility to delivering small-for-gestational-age infants. (antibodies-online.com)
  • lysine
  • Effect of abomasal administration of lysine and methionine or lysine alone on nitrogen balance and plasma free amino acid concentrations in early-weaned calves fed a corn and soybean meal diet. (azabu-u.ac.jp)
  • leucine
  • Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. (nih.gov)
  • Hartnup
  • Diagnosis of Hartnup disease is made by showing the characteristic amino acid excretion pattern in the urine. (merckmanuals.com)
  • Bröer reviews Hartnup disease, an autosomal disease first discovered in 1956, characterized by a neutral aminoaciduria accompanied by a photo-sensitive rash and cerebellar ataxia. (medbullets.com)