It forms the U5 snRNP (small nuclear ribonucleoprotein) by associating with several proteins including Prp8 - the largest and most conserved protein in the spliceosome, Brr2 - a helicase required for spliceosome activation, Snu114, and the 7 Sm proteins. (wikipedia.org)
Component1
U5 snRNA is a small nuclear RNA (snRNA) that participates in RNA splicing as a component of the spliceosome. (wikipedia.org)
MFDM1
The EFTUD2 gene mutations that cause MFDM result in the production of little or no functional enzyme from one copy of the gene in each cell. (medlineplus.gov)
SnRNA4
U5 snRNA is a small nuclear RNA (snRNA) that participates in RNA splicing as a component of the spliceosome. (wikipedia.org)
U5 snRNA forms a coaxially-stacked series of helices that project into the active site of the spliceosome. (wikipedia.org)
RNA polymerase II (RNAPII) transcribes small nuclear RNA (snRNA) genes in close proximity to Cajal bodies, subnuclear compartments that depend on the SUMO isopeptidase USPL1 for their assembly. (bvsalud.org)
We show here that overexpression of USPL1 as well as of another nuclear SUMO isopeptidase, SENP6, alters snRNA 3'-end cleavage, a process carried out by the Integrator complex. (bvsalud.org)
Spliceosome2
It forms the U5 snRNP (small nuclear ribonucleoprotein) by associating with several proteins including Prp8 - the largest and most conserved protein in the spliceosome, Brr2 - a helicase required for spliceosome activation, Snu114, and the 7 Sm proteins. (wikipedia.org)
Pre-mRNA splicing is catalyzed by the spliceosome, a multi-megadalton ribonucleoprotein machine. (bvsalud.org)
Sequences1
A 35-residue fragment of the ATPase/helicase Prp22 latches onto Prp8, and the quaternary exon junction complex (EJC) recognizes upstream 5'-exon sequences and associates with Cwc22 and the GTPase Snu114 . (nih.gov)