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  • assemble snRNPs
  • Because Gemin2 is an essential component of complexes that assemble snRNPs, this finding suggests that Smn might serve additional functions in axons of motoneurons. (rupress.org)
  • The Dreyfuss team previously showed that loss of SMN, a protein that helps assemble snRNPs and is deficient in individuals with the common neurodegenerative disease spinal muscular atrophy (SMA), results in altered snRNP levels and abnormal splicing. (scienceblog.com)
  • snRNP
  • A comprehensive analysis of snRNP dynamics in the cell nucleus enabled us to determine snRNP diffusion throughout the nucleoplasm as well as the interaction rates of individual snRNPs with pre-mRNA. (rupress.org)
  • Since we recently identified U1 snRNP components in the insoluble fraction in sporadic AD [ 3 ], we first wanted to determine whether U1 snRNPs were also localized to the insoluble fraction in familial AD (FAD) cases. (biomedcentral.com)
  • They probably provide storage sites for snRNPs or function in snRNP recycling ( Lamond and Spector, 2003 ). (biologists.org)
  • form
  • During metaphase and anaphase, two populations of U-snRNPs can be identified: those associated with the chromosome surface and a 'free' form distributed throughout the cytoplasm. (cshl.edu)
  • Thus, hPrp31 and hPrp6 form an essential connection between the U4/U6 and U5 snRNPs in vivo . (embopress.org)
  • individual
  • This model is based on numerous in vitro observations that demonstrated the sequential association of individual snRNPs with pre-mRNA ( Reed, 2000 ). (rupress.org)
  • model
  • According to the step-wise model, snRNPs sequentially interact with the pre-mRNA transcript. (rupress.org)
  • factors
  • Other studies have independently identified the functions of numerous auxiliary factors that co-purify with different snRNPs. (frontiersin.org)
  • human
  • U1-70k and other snRNPs were biochemically enriched in the insoluble fraction of human brain from subjects with presenilin 1 (PS1) mutations. (biomedcentral.com)