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  • SMD2
  • SmD was later discovered to be a mixture of three proteins, which were named SmD1, SmD2 and SmD3. (wikipedia.org)
  • They are a 6S pentamer complex of SmD1,SmD2, SmF, SmE and SmG with pICln, a 2-4S complex of SmB, possibly with SmD3 and pICln and the 20S methylosome, which is a large complex of SmD3, SmB, SmD1, pICln and the arginine methyltransferase-5 (PRMT5) protein. (wikipedia.org)
  • Antibodies
  • Search, Find and Buy Antibodies, ELISA Kits and Proteins. (antibodies-online.com)
  • The Sm proteins were first discovered as antigens targeted by so-called Anti-Sm antibodies in a patient with a form of Systemic lupus erythematosus (SLE), a debilitating autoimmune disease. (wikipedia.org)
  • However, Dr. Kunkel and Dr. Tan found in 1966 that Ms. Smith produced antibodies to a set of nuclear proteins, which they named the 'smith antigen' (Sm Ag). (wikipedia.org)
  • About 30% of SLE patients produce antibodies to these proteins, as opposed to double stranded DNA. (wikipedia.org)
  • In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins (autoantigens). (wikipedia.org)
  • These cells coordinate an immune response upon the detection of foreign proteins (antigens), producing antibodies that bind to these antigens. (wikipedia.org)
  • The ENAs consist of ribonucleoproteins and non-histone proteins, named by either the name of the donor who provided the prototype serum (Sm, Ro, La, Jo), or the name of the disease setting in which the antibodies were found (SS-A, SS-B, Scl-70). (wikipedia.org)
  • Mutation
  • Even mutation of just five nucleotides, essential for binding this protein, impaired U4 nucleolar localization. (nih.gov)
  • Yeast Prp8 mutation results in a U5 snRNP maturation defect. (wikipedia.org)
  • functional
  • The wild-type U4 transcripts used here are functional: they exhibit normal nucleocytoplasmic traffic, associate with Sm proteins, form the [U4/Udi-snRNP, and localize to nucleoli and Cajal bodies. (nih.gov)
  • In normal physiology, lymphocytes that recognise human proteins (autoantigens) either undergo programmed cell death (apoptosis) or become non-functional. (wikipedia.org)
  • interactions
  • The protein may act as a charged protein scaffold to promote SNRNP assembly or strengthen SNRNP-SNRNP interactions through nonspecific electrostatic contacts with RNA. (wikipedia.org)
  • In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. (embl.de)
  • It has been shown previously that a highly conserved Kinked-loop participates in specific protein interactions. (wikipedia.org)
  • HUMAN
  • The genome of Saccharomyces cerevisiae (Baker's Yeast) was sequenced in the mid-1990s, providing a rich resource for identifying homologs of these human proteins. (wikipedia.org)
  • yeast
  • Two of these WW domains, in the proteins FBP11 and FBP21, are strikingly similar to those found in the yeast splicing factor PRP40. (embl.de)
  • Fibrillarin is associated with U3, U8 and U13 small nuclear RNAs in mammals and is similar to the yeast NOP1 protein. (wikipedia.org)
  • SMD3
  • These three Sm proteins have repeated arginine-glycine motifs in the C-terminal ends of SmD1, SmD3 and SmB, and the arginine side chains are symmetrically dimethylated to ω-NG, NG'-dimethyl-arginine. (wikipedia.org)
  • folds
  • The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded beta-sheet. (embl.de)
  • Proteins with similar structures are grouped into a hierarchy of protein families, superfamilies, and folds. (wikipedia.org)
  • murine
  • Using a proline-rich domain derived from formin (a product of the murine limb deformity locus), we have identified a family of murine formin binding proteins (FBP's), each of which contains one or more of a special class of tyrosine-rich WW domains. (embl.de)