Loading...
  • interactions
  • RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. (nih.gov)
  • In yeast, this bridging involves interactions between the WW domains in the splicing factor PRP40 and a proline-rich domain in the branchpoint binding protein, BBP. (embl.de)
  • microscopy
  • All small nuclear RNAs (snRNAs) of the [U4/U6.Utri-snRNP localize transiently to nucleoli, as visualized by microscopy after injection of fluorescein-labeled transcripts into Xenopus laevis oocyte nuclei. (nih.gov)
  • functional
  • The wild-type U4 transcripts used here are functional: they exhibit normal nucleocytoplasmic traffic, associate with Sm proteins, form the [U4/Udi-snRNP, and localize to nucleoli and Cajal bodies. (nih.gov)
  • methylation
  • Protein arginine methylation, one of the most abundant and important posttranslational modifications, is involved in a multitude of biological processes in eukaryotes, such as transcriptional regulation and RNA processing. (pnas.org)
  • motifs
  • Sequence comparison has shown that all the known Sm proteins share two evolutionarily conserved structural sequence motifs, a possible explanation for their immunological cross-reactivity. (arodia.com)
  • arginine
  • PRMT5 is a type II protein arginine methyltransferase that catalyzes the formation of monomethylarginine and symmetric ω- N G , N ′ G -dimethylarginine (SDMA) ( 1 ). (pnas.org)
  • Mutation
  • Even mutation of just five nucleotides, essential for binding this protein, impaired U4 nucleolar localization. (nih.gov)
  • Transcripts encoding the pathogenesis-related PR1 and PR2 proteins were elevated in At GRP7-ox plants but not in plants overexpressing At GRP7 with a point mutation in the RNA-binding domain, indicating that the regulation involves RNA binding activity of At GRP7. (biomedcentral.com)
  • Binding
  • U4 snRNA nucleolar localization requires the NHPX/15.5-kD protein binding site but not Sm protein or U6 snRNA association. (nih.gov)
  • Neither the 5'-cap nor the 3'-region of U4, which includes the Sm protein binding site, are essential for nucleolar localization. (nih.gov)
  • The only region in U4 snRNA required for nucleolar localization is the 5'-proximal stem loop, which contains the binding site for the NHPX/15.5-kD protein. (nih.gov)
  • Here we show that AtPRMT5 methylates a wide spectrum of substrates, including some RNA binding or processing factors and U snRNP AtSmD1, D3, and AtLSm4 proteins, which are involved in RNA metabolism. (pnas.org)
  • RBM10 is an RNA binding motif (RBM) protein expressed in most, if not all, human and animal cells. (readbyqxmd.com)
  • RNA-binding motif protein 5 (RBM5), also known as LUCA-15/H37, is a gene that maps to human chromosome 3p21.3, a critical region that is deleted in a large number of human cancers, of which the majority are lung cancers, and that is predicted to contain one or more tumor suppressor genes (TSGs). (readbyqxmd.com)
  • GO annotations related to this gene include identical protein binding and RNA binding . (genecards.org)
  • At GRP7 ( Arabidopsis thaliana glycine-rich RNA-binding protein 7) is an RNA-binding protein with an N-terminal RNA recognition motif and a C-terminal glycine-rich domain. (biomedcentral.com)
  • RNA-binding proteins are involved in almost all aspects of RNA metabolism. (biomedcentral.com)
  • Using a proline-rich domain derived from formin (a product of the murine limb deformity locus), we have identified a family of murine formin binding proteins (FBP's), each of which contains one or more of a special class of tyrosine-rich WW domains. (embl.de)
  • vesicles
  • We identified highly mobile SmB protein-trafficking vesicles in neural cells, which are dependent on the cellular levels of SMN and SmB for their morphology and mobility. (st-andrews.ac.uk)
  • We previously identified microtubule-dependant mobile vesicles rich in SMN and the splicing factor SmB, a member of the Sm protein family, in neural cells. (st-andrews.ac.uk)
  • pathways
  • What pathways are this gene/protein implicaed in? (cancer-genetics.org)
  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem The ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses. (nih.gov)