Smooth muscle remodeling. Medical search. Frequent questions

Background : Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. (le.ac.uk)
Key features of this process include a loss of the internal elastic lamina, myointimal hyperplasia, and ectopic distribution of vascular smooth muscle cells (VSMC) [ 14 ]. (biomedcentral.com)
In addition, a significant reduction in goblet cell hyperplasia, peribronchiolar collagen layer thickness and VEGF expression for airway remodeling was detected in the OVA + SEAC‑treated group compared with the OVA + vehicle‑treated group. (spandidos-publications.com)
The phenotypic transformation of proliferation and migration in vascular smooth muscle cells (VSMCs) from media to intima is the basic pathology of neointimal hyperplasia after angioplasty in hypertensive patients. (hindawi.com)
The rat thoracic aortic smooth muscle cells (A10 cells) stimulated by AngII were used as the in vitro neointimal hyperplasia model, where AngII significantly induced the proliferation and migration in A10 cells. (hindawi.com)
Increased airway smooth muscle (ASM) mass due to hyperplasia/hypertrophy contributes significantly to overall airway remodeling and correlates with decline in lung function. (harvard.edu)
Varying degrees of mononuclear cell and eosinophil infiltration, mucus hypersecretion, desquamation of the epithelium, smooth muscle hyperplasia, and airway remodeling are present. (medscape.com)

Since these early observations, fibrocytes have been implicated in the tissue remodelling that occurs in a variety of human diseases, including idiopathic pulmonary fibrosis, asthma, pulmonary hypertension, atherosclerosis and renal fibrosis [ 6 ]. (ersjournals.com)
In animal models of pulmonary hypertension, as in human disease, pulmonary vascular remodelling is associated with fibroproliferative changes in the media and adventitia. (ersjournals.com)
5213. R.T. Lee, H. Huang, "Mechanotransduction and arterial smooth muscle cells: new insight into hypertension and atherosclerosis," Ann. (nanomedicine.com)
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by lung endothelial cell dysfunction and vascular remodeling. (surrey.ac.uk)
Via AT1a receptor, AngII increased oxidative stress, which is a critical regulator of VSMC proliferation and migration in hypertension and vascular remodeling [ 6 - 8 ]. (hindawi.com)
Therefore, despite the existing anti-RAAS medicines, finding a novel downstream molecule exclusively targeting to inhibit neointimal formation and vascular remodeling may be a promising strategy for the treatment of vascular restenosis after angioplasty in hypertension. (hindawi.com)
Chronic hypertension induces vascular and cardiac remodeling. (nih.gov)
OW1 is a novel imperatorin derivative that was previously reported to inhibit vascular remodeling and improve kidney function affected by hypertension. (nih.gov)
In the present study, the effect of OW1 on the cardiac remodeling induced by hypertension was investigated. (nih.gov)
More importantly, it inhibited vascular and cardiovascular remodeling, which may reduce the risk of hypertension-induced cardiovascular diseases. (nih.gov)
However, MR is expressed in extrarenal tissues including endothelial and vascular smooth muscle cells, and its activation leads to vascular remodeling, vascular stiffness, and endothelial dysfunction leading to vascular damage, an important pathophysiological process in hypertension and other cardiovascular diseases. (intechopen.com)

Pulmonary vasculature is remodeled in COPD. (nih.gov)
An important step in evaluating the role of circulating fibrocytes in human disease will be to provide evidence for their presence in the remodelled vasculature. (ersjournals.com)
To avoid the side effects of conventional therapeutics, remodeling the tumor vasculature is a new approach that has been suggested to be an effective treatment strategy. (biomedcentral.com)

Targeting S1P or its receptors could be a novel treatment strategy for inhibiting airway remodelling in asthma. (le.ac.uk)
Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung associated with structural "remodeling" inappropriate to the maintenance of normal lung function. (nih.gov)
The clinically observed distinctions between asthma and COPD are reflected by differences in the remodeling process, the patterns of inflammatory cells and cytokines, and also the predominant anatomic site at which these alterations occur. (nih.gov)
In asthma the epithelium appears to be more fragile than that of COPD, the epithelial reticular basement membrane (RBM) is significantly thicker, there is marked enlargement of the mass of bronchial smooth muscle, and emphysema does not occur in the asthmatic nonsmoker. (nih.gov)
studies have shown that the R- and S-enantiomers of racemic albuterol, a β 2 -adrenergic receptor agonist used in asthma treatment, have differential effects on the contractile properties of airway smooth muscle. (scirp.org)
More important, people found that, during the pathogenesis of asthma, smooth muscle cells could differentiate into the migration phenotype. (scirp.org)
As a kind of well mature pharmaceutical for asthma treatment, it would be very important to distinguish the effect of two different isomers of albuterol on proliferation and migration activities of airway smooth muscle cells. (scirp.org)
The present study examined the therapeutic effects and action mechanism of a saponin-enriched extract of Asparagus cochinchinensis (SEAC) on airway inflammation and remodeling in an ovalbumin (OVA)-induced asthma model. (spandidos-publications.com)
These findings indicate that SEAC is a suppressor of airway inflammation and remodeling, and may therefore be useful as an anti-inflammatory drug for the treatment of asthma. (spandidos-publications.com)
Kistemaker LE , Oenema TA, Meurs H, Gosens R. Regulation of airway inflammation and remodeling by muscarinic receptors: Perspectives on anticholinergic therapy in asthma and COPD. (rug.nl)
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. (uni-muenchen.de)
Methods: Murine tracheal smooth muscle cells (MTSMC) from T- bet KO mice and human bronchial smooth muscle cells (HBSMC) incubated with IL-13 and IL-4 served as asthma models. (uni-muenchen.de)
Airway remodeling is not specifically targeted by current asthma medications, partly owing to the lack of understanding of remodeling mechanisms, altogether posing great challenges in asthma treatment. (harvard.edu)
Collectively, our data provide mechanisms of a novel function of IgE which may contribute, at least in part, to airway remodeling observed in allergic asthma by directly inducing HASM cell proliferation. (harvard.edu)
Dr Chris Brightling a Wellcome Senior Research Fellow and Clinical Professor in Respiratory Medicine, is currently working on understanding the interactions between mast cells and airway smooth muscle cells in the development of the asthmatic phenotype, airway smooth muscle migration and remodelling in asthma and COPD . (le.ac.uk)
G protein-coupled receptors, airway smooth muscle, asthma, pharmacology of airway diseases, non-coding RNAs in lung diseases. (jefferson.edu)
I was able to apply my knowledge of signal transduction and cell biology to airway remodeling in asthma. (scireq.com)
A: I began my pulmonary research in asthma, studying signal transduction and airway remodelling. (scireq.com)
Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, Abstract hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. (cdc.gov)
Pathophysiologically, asthma exert different effects at different concentrations, can is characterized by constriction of airway smooth synergize or antagonize the effects of other cytokines muscle, hyper secretion of mucus, edema and airway and regulated in a complex manner and function via hyper responsiveness (AHR),[3] mucus secretion and cytokine cascade. (cdc.gov)

Moreover, IL-17F is involved in airway remodeling and steroid resistance. (hindawi.com)

In COPD, there is epithelial mucous metaplasia, airway wall fibrosis, and inflammation associated with loss of surrounding alveolar attachments to the outer wall of small airways: bronchiolar smooth muscle is increased also. (nih.gov)
Kolahian S , Gosens R. Cholinergic regulation of airway inflammation and remodelling. (rug.nl)
Both genomic and non-genomic effects facilitate reactive oxygen species (ROS) production (particularly by the enzyme NADPH oxidase), inflammation, and fibrosis, which, in turn, promote tissue remodeling, vascular stiffening, and endothelial dysfunction. (intechopen.com)

Medial-to-intimal migration of SMCs is critical to atherosclerotic plaque formation and remodeling of injured arteries. (jci.org)
Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque. (stanford.edu)
Background: Smooth muscle cells (SMC) transition into a number of different phenotypes during atherosclerosis, including those that resemble fibroblasts and chondrocytes, and make up the majority of cells in the atherosclerotic plaque. (stanford.edu)

Similarly, CD34+ cells can be identified in human scar tissue, suggesting that these cells may contribute to tissue remodelling and repair [ 5 ]. (ersjournals.com)
third, whole tissue culture was also performed to further demonstrate the different effect of R- and S-albuterol on migration of airway smooth muscle cells. (scirp.org)
After removal of blood vessels, connective tissues and cartilage, pure airway smooth muscle tissue was rinsed with PBS twice and cut into small pieces. (scirp.org)
The role of endogenous H2S formation in reversible remodeling of lung tissue during hibernation in the Syrian hamster. (rug.nl)

In fact, in addition to their potent vasodilating effect, EETs have potent anti-inflammatory properties, inhibit platelet aggregation, promote fibrinolysis, and reduce vascular smooth muscle cell proliferation. (frontiersin.org)
Dekkers BG , Pehlic A, Mariani R, Bos IS, Meurs H, Zaagsma J. Glucocorticosteroids and beta2-Adrenoceptor Agonists Synergize to Inhibit Airway Smooth Muscle Remodeling. (rug.nl)
Existing studies have shown that there is crossover between Renin-Angiotensin-Aldosterone (RAAS) signaling pathway and TGF-β pathway, but little is known about whether ARB drug losartan can block Angiotensin-II (Ang-II) signaling pathway, inhibit the activation of Transforming Growth Factor- Beta (TGF-β) pathway, and regulate vascular remodeling. (ijpsonline.com)

In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)
The development of AD is also associated with vascular remodeling, according to pathological studies. (ijpsonline.com)
It is commonly believed that abnormal proliferation and migration of medial vascular smooth muscle cells (VSMCs) are the pathological causes of neointimal formation after intima injury [ 4 ]. (hindawi.com)
Pulmonary vascular remodeling is the defining pathological feature of PAH. (cincinnatichildrens.org)

OW1 inhibited vascular smooth muscle cell (VSMC) proliferation and the phenotypic modulation of VSMCs induced by angiotensin II (Ang II). (nih.gov)

Abnormal vascular remodeling is the core cause of neointimal formation, mediator degeneration and cell dysfunction, which leads to atherosclerosis and vascular dilatation and other diseases[ 3 ]. (ijpsonline.com)

Histologic assessment of patients with systemic sclerosis-associated PAH and the hypoxia/SU5416 mouse model identified the presence von Willebrand factor/α-smooth muscle actin-positive endothelial cells in up to 5% of pulmonary vessels. (surrey.ac.uk)
Induced EndoMT cells exhibited up-regulation of mesenchymal markers, including collagen type I and α-smooth muscle actin, and a reduction in endothelial cell and junctional proteins, including von Willebrand factor, CD31, occludin, and vascular endothelial-cadherin. (surrey.ac.uk)
The heart is a complex organ made of various cell types including cardiomyocytes, endothelial and smooth muscle cells, but also fibroblasts and inflammatory cells, which could all be implicated in the disease process. (escardio.org)

The extracellular remodeling and fibroblast transformation potential was evaluated by measuring collagen 1, alpha-smooth muscle actin, and TGF-B in PHF cells. (cdc.gov)

Developmental arteriogenesis and adult vascular remodeling require smooth muscle cells (SMCs). (yu.edu)
Smooth muscle cells (SMCs), the major cell type in atherosclerotic plaques, are vital in coronary artery diseases (CADs). (stanford.edu)

EYA3 is a druggable and mechanistically unique protein tyrosine phosphatase (PTP) present at elevated levels in pulmonary arterial smooth muscle cells isolated from PAH patients. (cincinnatichildrens.org)

Discovery of Transacting Long Noncoding RNAs That Regulate Smooth Muscle Cell Phenotype. (stanford.edu)
Atherosclerotic plaques consist mostly of smooth muscle cells (SMC), and genes that influence SMC phenotype can modulate coronary artery disease (CAD) risk. (stanford.edu)
Single-cell transcriptomic analyses revealed that loss of Smad3 altered SMC transition cell state toward two fates: a SMC phenotype that governs both vascular remodelling and recruitment of inflammatory cells, as well as a chondromyocyte fate. (stanford.edu)
Dekkers BG , Bos IS, Zaagsma J, Meurs H. Functional consequences of human airway smooth muscle phenotype plasticity. (rug.nl)

By monitoring migratory properties of airway smooth muscle cells in the presence of albuterol isomers, the different effect of albuterol on proliferation and migration of airway smooth muscle cells is probed. (scirp.org)
However, the different effects of R- and S-albuterol on smooth muscle cells proliferation and migration have never been tested. (scirp.org)

Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. (le.ac.uk)
Results : S1P potently regulated the expression of more than 80 genes in human ASM cells, including several genes known to be involved in the regulation of cell proliferation and airway remodelling (HBEGF, TGFB3, TXNIP, PLAUR, SERPINE1, RGS4). (le.ac.uk)
Conclusion : S1P induces a steroid-resistant, pro-remodelling pathway in ASM cells. (le.ac.uk)
Primary culture of rat airway smooth muscle cells was performed by enzyme digestion. (scirp.org)
The role and nature of smooth muscle cells," Pathol. (nanomedicine.com)
Together, the findings reveal that Smad3 expression in SMC inhibits the emergence of specific SMC phenotypic transition cells that mediate adverse plaque features, including outward remodelling, monocyte recruitment, and vascular calcification. (stanford.edu)
Oenema TA , Smit M, Smedinga L, Racke K, Halayko AJ, Meurs H, Gosens R. Muscarinic receptor stimulation augments TGF-beta1-induced contractile protein expression by airway smooth muscle cells. (rug.nl)
Pera T , Atmaj C, van der Vegt M, Halayko AJ, Zaagsma J, Meurs H. Role for TAK1 in cigarette smoke-induced proinflammatory signaling and IL-8 release by human airway smooth muscle cells. (rug.nl)
Vascular Smooth Muscle Cells (VSMCs) are highly specialized cells that maintain vascular tone and ensure vascular contractility under physiological conditions. (ijpsonline.com)
Furthermore, cell clustering analysis based on expression mapping provided a molecular signature of all the cell types present in the diseased hearts including cardiomyocytes, fibroblasts, smooth muscle cells, pericytes, inflammatory (myeloid and lymphoid) as well as neuronal and adipose cells, providing an incredible resource for future research in the field. (escardio.org)
Vascular remodeling is promoted by the survival and proliferation of pulmonary arterial vascular cells under conditions of oxidative stress and in the presence of DNA damage. (cincinnatichildrens.org)
Immunostained sections were assessed for airway smooth muscle (ASM) area, subepithelial basement membrane thickness, nerve fibers, and epithelial neuroendocrine cells. (lu.se)
The mechanisms involved include direct stimulation of airway smooth muscle and indirect stimulation by pharmacologically active substances from mediator-secreting cells such as mast cells or nonmyelinated sensory neurons. (medscape.com)

The non-stretched portion was fixed and immunohistologically stained with orcein (elastin) and immunostained for smooth muscle actin [SMA]. (bmj.com)

The principal objective of my laboratory is to understand mechanisms by which intracellular Ca 2+ signals regulate vascular smooth muscle (VSM) function, physiologically and in vascular disease. (amc.edu)
Smooth muscle cell (SMC) phenotypic transition, which leads to the formation of various cell types in atherosclerotic plaques, is regulated by a network of genetic and epigenetic mechanisms and governs the risk of disease. (stanford.edu)
The exact mechanisms of pulmonary arterial remodelling that lead to the onset and progression of PH are still largely unclear. (ersjournals.com)

I then learned about a rare genetic lung disease that had abnormal smooth muscle-like lesions and used LAM to study how abnormal smooth muscle grow, and now lymphangioleiomyomatosis (LAM) has been my lab's primary focus for the past several years. (scireq.com)

In proof of principle studies, we show that transgenic mice harboring an inactivating mutation in the EYA3 PTP domain are significantly protected from vascular remodeling in a chronic hypoxia model, and that inhibitors of EYA3 PTP activity reverse vascular remodeling in a rat model of experimental angio-obliterative PH. (cincinnatichildrens.org)

Histological examination demonstrated that OW1 exerted an inhibitory effect on vascular and cardiac remodeling. (nih.gov)
cGMP plays a role in the regulation of vascular tone, cardiac contractility, and cardiac remodeling. (medscape.com)

Histone Acetyltransferases p300 and CBP Coordinate Distinct Chromatin Remodeling Programs in Vascular Smooth Muscle Plasticity. (bvsalud.org)

Through collaborations, we are evaluating pro-inflammatory signaling pathways and molecules in VSM that contribute to vascular remodeling in response to injury and aortic aneurysmal disease. (amc.edu)

PON2 may be a potential therapeutic target to reduce arterial remodeling after angioplasty in hypertensive patients. (hindawi.com)

A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimulation of human ASM cell proliferation. (le.ac.uk)
After rinse with PBS, smooth muscle cell culture media (Cell Application Inc) was mixed and then seeded into 12 well culture plates coating with fibronectin (R & D, Minneapolis). (scirp.org)

The following synopsis defines and compares the key remodeling processes and proposes several hypotheses. (nih.gov)

I then began exploring other smooth muscle diseases and came across LAM. (scireq.com)

To investigate the effect of losartan on vascular remodeling and transforming growth factor-beta and phosphoinositide 3-kinase/protein kinase B pathway. (ijpsonline.com)

Ciliary muscle thickness in adults with down syndrome. (osu.edu)
Ciliary Muscle Thickness in Anisometropia. (osu.edu)
Region-specific Relationships Between Refractive Error and Ciliary Muscle Thickness in Children (2013). (osu.edu)
Changes in Ciliary Muscle Thickness During Accommodation in Children. (osu.edu)
Measuring Changes in Ciliary Muscle Thickness with Accommodation in Young Adults. (osu.edu)

Cernecka H , Veizerova L, Mensikova L, Svetlik J, Krenek P. Selective inhibitory action of Biginelli-type dihydropyrimidines on depolarization-induced arterial smooth muscle contraction. (rug.nl)

5215. A. Kadar, S. Bjorkerud, "Arterial remodeling following mechanical injury. (nanomedicine.com)

Specifically, does primary CMD lead to ventricular remodelling/diastolic dysfunction and HFpEF or do alterations in myocardial remodelling/diastolic dysfunction observed in HFpEF lead to secondary CMD, i.e. the chicken or the egg? (medscape.com)

How does this change trigger adverse remodeling of the chambers? (escardio.org)

Here we show that SMC-specific deletion of Smad3 in a murine atherosclerosis model resulted in greater plaque burden, more outward remodelling and increased vascular calcification. (stanford.edu)

By directly stimulating sGC, independently of and synergistically with NO, vericiguat augments levels of intracellular cGMP, leading to smooth muscle relaxation and vasodilation. (medscape.com)

Anatomy75

Organisms16

Diseases18

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes42

Disciplines and Occupations3

Information Science3

Hyperplasia7

Hypertension11

Vasculature3

Asthma20

Involved in airway1

Inflammation3

Atherosclerotic plaque3

Tissue4

Inhibit3

Pathological4

Phenotypic modulation1

Neointimal formation1

Endothelial3

Extracellular1

SMCs2

Arterial smooth muscl1

Phenotype4

Proliferation and migration2

Cells13

Actin1

Mechanisms3

Abnormal1

Chronic1

Cardiac2

Plasticity1

Aortic1

Therapeutic1

Cell2

Processes1

Diseases1

Pathway1

Thickness5

Contraction1

Injury1

Alterations1

Adverse1

Atherosclerosis1

Intracellular1