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  • PIAS1
  • We demonstrate for the first time that PIAS1 protein expression is significantly higher in malignant areas of clinical prostate cancer specimens than in normal tissues, thus suggesting a growth-promoting role for PIAS1. (ox.ac.uk)
  • recombinant
  • If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production , custom recombinant protein production or custom antibody production . (mybiosource.com)
  • Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications. (mybiosource.com)
  • Apart from acting at the formulation level, the recombinant nature of protein drugs allows intervening at upstream stages through protein engineering, to produce analogue protein versions with higher stability and enhanced therapeutic values. (biomedcentral.com)
  • Despite aggregation as inclusion bodies might represent a source of relatively pure proteins for further refolding or extraction [ 29 - 33 ], or unexpectedly, a new type of nano-microparticulate biomaterials for biotechnological and biomedical applications [ 34 - 39 ], the use of recombinant proteins for most of biotechnological and biomedical applications requires fully soluble protein versions. (biomedcentral.com)
  • A particular issue in recombinant protein aggregation is the occurrence of soluble aggregates (less apparent that large aggregates), that are being progressively recognized in production processes. (biomedcentral.com)
  • covalent
  • In this reaction, a covalent bond is generated between its most COOH-terminal amino acid residue, a glycine, and one of the lysines in the modified protein ( 3 , 4 ). (aacrjournals.org)
  • genes
  • The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. (merckmillipore.com)
  • Multiple restenosis‑associated proteins and genes have been identified to account for this. (readbyqxmd.com)
  • Both genes give rise to proteins that have ( a ) entirely novel functions and ( b ) p53-related functions. (aacrjournals.org)
  • motility
  • These agents can decrease glucose production by the liver (metformin), stimulate insulin secretion (sulfonylureas and meglitinides), retard glucose absorption from the gastrointestinal tract (-glycosidase inhibitors), slow intestinal motility (amylin), reduce insulin resistance (thiazolidinediones (TZDs)), or replace gastrointestinal peptides known to be active in glucose metabolism (GLP-1 analogs or dipeptidyl peptase IV inhibitors). (hindawi.com)
  • stability
  • The role of XIAP on the regulation of Sox2 protein stability and ERK1-mediated phosphorylation of Sox2 signaling pathway were analyzed using immunoblotting, immunoprecipitation, immunofluorescence, phosphorylation mass spectrometry, siRNA silencing and plasmid overexpression. (thno.org)
  • IAPs, especially X chromosome-linked IAP (XIAP), were elevated in CSCs of NPC, and these proteins were critically involved in the maintenance of CSCs properties by enhancing the stability of Sox2. (thno.org)
  • Post-production protein aggregation is then a major concern in the pharmaceutical industry, as protein stability, pharmacokinetics, bioavailability, immunogenicity and side effects are largely dependent on the extent of aggregates formation. (biomedcentral.com)
  • modulate
  • It has since been discovered that the ROCK kinases actively phosphorylate a large cohort of actin-binding proteins and intermediate filament proteins to modulate their functions. (diff.org)
  • enables
  • Mitochondria undergo fusion to form elongated interconnected networks, a process which is orchestrated by the mitochondrial fusion proteins (Mfn1, Mfn2 and OPA1), and which enables the replenishment of damaged mitochondrial DNA. (springer.com)
  • family
  • p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3. (springer.com)
  • Characterization of a second member of the sentrin family of ubiquitin-like proteins. (wikipathways.org)
  • Belongs to the EGR C2H2-type zinc-finger protein family. (mybiosource.com)
  • Genomic organization is more complex in p63 and p73, largely the result of an alternative internal promoter generating NH 2 -terminally deleted dominant-negative proteins that engage in inhibitory circuits within the family. (aacrjournals.org)
  • Ubc9
  • Although Ubc9 is viewed as a promising anti-cancer drug target, the development of small-molecule Ubc9 inhibitors has proven to be very difficult. (nih.gov)
  • By X-ray crystallographic fragment screening, we have identified two small-molecule fragments that bind to Ubc9 at a location that is distal from its active site. (nih.gov)
  • nuclear receptor
  • The corepressor complex constitutes corepressor proteins, such as nuclear receptor corepressor (NCoR) and silencing mediator of retinoid and thyroid hormone receptors, histone deacetylases (HDACs) and transducin -like protein 1 (TBL1). (hindawi.com)
  • Estrogen-related receptor alpha is a nuclear receptor protein related to the Estrogen receptor. (merckmillipore.com)
  • activity
  • Moreover, in the current presence of CX-4945 biological activity 3-methyladenine (3-MA), an inhibitor in the first stage of autophagy, the consequences of overexpression or silencing appearance of PIASy on HCV replication had been largely obstructed. (tech-strategy.org)
  • cascades
  • For example, K48-type chains are branched and required for protein degradation in proteasomes, whereas Lys 63 -type chains are more linear and used in cytokine signaling cascades for instance. (aacrjournals.org)
  • zinc finger
  • The study also suggests that the RNA-binding zinc finger CCCH-type containing 11A (ZC3H11A) protein takes part in a mechanism that facilitates nuclear export of mRNA, particularly under cellular stress, a mechanism that has been "hijacked" by several nuclear-replicating viruses to promote their replication. (pnas.org)
  • phosphorylation
  • It is well established that global cellular morphology, as modulated by the three cytoskeletal networks: actin filaments, intermediate filaments and microtubules, is regulated by a variety of accessory proteins whose activities are dependent on their phosphorylation by the Rho-kinases. (diff.org)
  • functions
  • Crucial proteins involved in the control of such diverse functions are modified by ubiquitin and are frequently altered during oncogenesis. (aacrjournals.org)
  • In the present study, the functions of ubiquitin‑specific peptidase 39 (USP39) were investigated in the context of two vascular remodeling models (a mouse common carotid artery ligation and a pig bilateral saphenous vein‑carotid artery interposition graft). (readbyqxmd.com)
  • accumulation
  • PIASy-enhanced accumulation of SUMO1-conjugated proteins might donate to its inducing aftereffect of autophagy. (tech-strategy.org)
  • Cellular processes that contribute to cold acclimation include protection and stabilization of cellular membranes, enhancement of antioxidative mechanisms, and synthesis and accumulation of cryoprotectant solutes and unique cryoprotective proteins ( Mahajan and Tuteja, 2005 ). (plantcell.org)
  • fragment
  • In the past decade, fragment-based drug design has emerged as a powerful approach to identify ligands for challenging protein targets that can provide excellent starting points for the development of potent inhibitors. (nih.gov)
  • undergo
  • Mitochondrial health is critically dependent on the ability of mitochondria to undergo changes in mitochondrial morphology, a process which is regulated by mitochondrial shaping proteins. (springer.com)
  • Mitochondria undergo fission to generate fragmented discrete organelles, a process which is mediated by the mitochondrial fission proteins (Drp1, hFIS1, Mff and MiD49/51), and is required for cell division, and to remove damaged mitochondria by mitophagy. (springer.com)
  • histone
  • Several proteins involved in processes as different as endocytosis and trafficking of cargos (such as epsins, Hrs, Eps15), transcription (e.g., histone H2B), or response to different DNA damages (such as PCNA or FANCD2) are monoubiquitylated. (aacrjournals.org)
  • isopeptide
  • Recently produced Ub is normally C-terminally fused to various other proteins, such as for example other Ub substances, and should be cleaved by DUBs for its terminal glycine residue to become shown for isopeptide connection development. (cura-cancer.com)