Small t lymphocytes. Medical search. Frequent questions

This putative preneoplastic lesion can be differentiated from lymphoma by the heterogeneous population of lymphocytes, mitotic rate, and lack of capsular invasion. (nih.gov)
Organic killer T (NKT) cells are a heterogeneous population of lymphocytes that recognize antigens presented by Compact disc1m and have attracted attention because of their potential role linking natural and adaptive immune system responses. (ap26113.com)
Apoptosis, or programmed cell death, regulates the population of lymphocytes and dysregulation of this process results in the prolonged activation of IL that occurs during inflammation. (uwaterloo.ca)

Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
We aimed to investigate the prognostic value of tumor-infiltrating lymphocytes (TILs) in a uniform cohort of patients with completely resected stage IIIA(N2) NSCLC. (oncotarget.com)

The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. (researchsquare.com)
This study retrospectively analyzed serum lymphocyte subsets and survival outcomes in intracranial germ cell tumors (iGCTs) patients. (researchsquare.com)
Serum from145 iGCTs patients were collected and lymphocyte subsets were analyzed by flow cytometry. (researchsquare.com)
Dynamic monitoring of serum lymphocyte subsets can be used as an auxiliary indicator for prognosis judgment. (researchsquare.com)

Physiologic dsDNA breaks are generated in a variety of normal cellular functions, including the RAG endonuclease-mediated rearrangement of antigen receptor genes during the normal development of lymphocytes. (biomedcentral.com)
These breaks are necessary to create the vast diversity seen in lymphocyte antigen receptors. (biomedcentral.com)
The small lymphocytes became hyperchromatic and enlarged 3 days after antigen administration, and pyanotic in 7 days, an effect enhanced by reserpine and LSD. (erowid.org)
It is suggested that CD8 + T-lymphocytes remain in the brain and spinal cord as tissue resident cells, which may focally propagate neuroinflammation, when they re-encounter their cognate antigen. (frontiersin.org)

Neutrophil to lymphocyte ratio (NLR) predicts overall survival (OS) in cancer patients (pts) treated with immune checkpoint inhibitors (ICI). (jnccn.org)
In the absence of similar research, we endeavored to investigate the prognostic usefulness of posttreatment neutrophil-to-lymphocyte ratio (NLR) in patients treated with definitive concurrent chemoradiotherapy (CCRT) for locally advanced pancreatic adenocarcinoma (LAPAC). (hindawi.com)
Increasing neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) define and grade systemic inflammation in lung cancer patients. (tgcd.org.tr)
An increasing neutrophil to lymphocyte ratio (NLR) is reported to define, as well indicate the degree, of systemic inflammation in patients with tumors [ 5 , 6 ]. (tgcd.org.tr)
Wang, X. (2014) Neutrophil to Lymphocyte Ratio in Relation to Risk of All-Cause Mortality and Cardiovascular Events among Patients Undergoing Angiography or Cardiac Revascularization: A Meta-Analysis of Observational Studies. (scirp.org)
Xue, P. (2014) Neutrophil-to-Lymphocyte Ratio for Predicting Palliative Chemotherapy Outcomes in Advanced Pancreatic Cancer Patients. (scirp.org)

Focal accumulations of lymphocytes in the bone marrow of SM are reactive in nature and could be termed lymphocytosis. (bmj.com)
Jessner lymphocytic infiltration of the skin is an uncommon skin disorder characterized by benign accumulations of lymphocytes by a "coat-sleeve"-like perivascular infiltration in the skin [1]. (who.int)

Volume regulation by human lymphocytes. (jci.org)
In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radiofrequency: studies of proliferation, apoptosis and mitochondrial membrane potential med. (emf-portal.org)

Although the protocol focuses on the small intestine, it is also suitable for analysis of the colon. (duke.edu)
Epithelium of small intestine contains approximately 1 IEL per 10 enterocytes. (wikipedia.org)
In diseases such as celiac sprue, IEL elevation throughout the small intestine is one of many specific markers. (wikipedia.org)
Histology slide of small intestine from a rabbit. (histology-world.com)
Tissue inflammation was determined by histology (H&E staining) on segments of mouse small and large intestine. (uwaterloo.ca)

Tumor cell spreading is established by angiogenesis and cancer cell proliferation [ 3 , 4 ] and the T and B lymphocytes and neutrophils are indicated to have a role in tumor inflammation (spreading). (tgcd.org.tr)
Wang, J. (2014) The Clinical Significance of Tumor-Infiltrating Neutrophils and Neutrophil-to-CD8+ Lymphocyte Ratio in Patients with Resectable Esophageal Squamous Cell Carcinoma. (scirp.org)

We have studied the ionic basis for this second or regulatory volume decrease (RVD) phase using lymphocytes from peripheral blood, tonsil, and thymus. (jci.org)
The increase in K+ permeability in response to hypotonic challenge was characteristic for T lymphocytes obtained from peripheral blood, tonsil, or thymus. (jci.org)
Thymus - Atypical hyperplasia, Lymphocyte in a female p53+/- (C57Bl/6) mouse from a subchronic study. (nih.gov)
Erowid.org: Erowid Reference 2931 : Cytotoxic Effects Induced by Various Agents in Rat Thymus Lymphocytes. (erowid.org)

These studies show that an increased pre-operative or pre-treatment NLR and platelet to lymphocyte ratio (PLR) (calculated from peripheral blood tests) have been found to be independent and easy, low cost prognostic biomarkers in patients with lung cancer, including small cell and non-small cell lung cancer [ 7 - 10 ]. (tgcd.org.tr)
Neutrophil lymphocyte (N/L) ratio was assessed before second line chemotherapy. (scirp.org)

Clinical studies are also underway to evaluate TIL in earlier stage cancers in combination with currently approved treatments, and to investigate Iovance peripheral blood lymphocyte (PBL) T cell therapy for blood cancers. (biospace.com)
Following exposure to hypotonic media, human peripheral blood lymphocytes swell initially but restore their isotonic volume within minutes. (jci.org)
The data confirm that the response of peripheral blood and tonsillar lymphocytes to a hypotonic environment can be accounted for by differences in the proportions of T and B cells, and the differential behaviour of B and T lymphocytes is based on differences in membrane permeability to K+ upon swelling. (jci.org)
A study of the effects of cigarette smoking and solvent exposure on sister chromatid exchange (SCE) frequency in peripheral lymphocytes of painters was conducted. (cdc.gov)
Peripheral venous blood samples were collected, the lymphocytes were isolated, and assayed for SCEs. (cdc.gov)
The authors conclude that chronic solvent exposure in painters is not associated with an increased frequency of SCEs in peripheral lymphocytes. (cdc.gov)

Groups of small, bean-shaped organs called lymph nodes are located throughout the body at different sites in the lymphatic system. (cancer.net)

Increase of bone marrow lymphocytes in systemic mastocytosis: reactive lymphocytosis or malignant lymphoma? (bmj.com)
To clarify the nature (reactive or neoplastic) of lesional, perifocally aggregated lymphocytes in bone marrow infiltrates of systemic mastocytosis (SM), the histopathology of which can resemble malignant lymphoma with focal bone marrow involvement, particularly low grade malignant B cell lymphoma of lymphoplasmacytic immunocytoma subtype, which frequently exhibits increased mast cell (MC) numbers. (bmj.com)
the bone marrow usually has more than 30% monoclonal lymphocytes and is either normocellular or hypercellular. (medscape.com)

They're also called CD4 T lymphocytes or "helper T cells. (medlineplus.gov)

The patient prognosis after complete resection for pathologic stage IIIA(N2) non-small cell lung cancer (NSCLC) remains a significant concern. (oncotarget.com)

We conducted a single-arm open-label phase 1 trial ( NCT03215810 ) of TILs administered with nivolumab in 20 patients with advanced non-small cell lung cancer following initial progression on nivolumab monotherapy. (nature.com)

We further studied its prognostic value in a more homogenous cohort of only metastatic Non-Small Cell lung cancer (NSCLC) pts who have received first-line pembrolizumab-based therapy over the first 3 cycles. (jnccn.org)
Addeo, A., Banna, G. L., Metro, G. & Di Maio, M. Chemotherapy in combination with immune checkpoint inhibitors for the first-line treatment of patients with advanced non-small cell lung cancer: a systematic review and literature-based meta-analysis. (nature.com)
In addition, the company's TIL therapy is being investigated in a registration-supporting study for the treatment of patients with locally advanced, recurrent or metastatic non-small cell lung cancer. (biospace.com)
Lung cancer is the second highest cause of worldwide deaths, inclusive of both high and low-income countries, and non-small cell cancer (NSCLC) is observed in approximately 85% of lung cancers [ 1 ]. (tgcd.org.tr)

We present here a simplified protocol for the isolation of lymphocytes from the small-intestinal lamina propria, intraepithelial layer, and Peyer's patches that is rapid, reproducible, and does not require laborious Percoll gradients. (duke.edu)
Intraepithelial lymphocytes (IEL) are lymphocytes found in the epithelial layer of mammalian mucosal linings, such as the gastrointestinal (GI) tract and reproductive tract. (wikipedia.org)
Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. (nature.com)
Shires, J., Theodoridis, E. & Hayday, A.C. Biological insights into TCRγδ + and TCRαβ + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). (nature.com)

Also stage, performance status, response to first-line therapy, LDH, and lymphocyte count were found to be prognostic for OS and PFS. (cu.edu.tr)

In addition to the oral presentation, three Iovance poster presentations at AACR will highlight the design of clinical trials in progress in solid tumors and chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). (biospace.com)
Hodgkins Lymphoma begins when a newly developed B-lymphocyte changes, becomes cancerous and goes on to multiply several folds to form tumors or lymphomas. (medindia.net)

Intestinal lymphocytes (IL) are immune cells that can participate in inflammation through the generation of cytokines and by causing direct cellular injury. (uwaterloo.ca)
Granulomatosis with Polyangiitis (GPA) Granulomatosis with polyangiitis is characterized by necrotizing granulomatous inflammation, small- and medium-sized vessel vasculitis, and focal necrotizing glomerulonephritis, often with crescent. (merckmanuals.com)

Atypical hyperplasia of the thymic lymphocytes is regarded as a proliferative change that may progress to lymphoma, although it may occur without progression. (nih.gov)
it was frequently categorized as diffuse small-cleaved cell lymphoma (by the International Working Formulation) or centrocytic lymphoma (by the Kiel classification). (medscape.com)
Primary Small Lymphocytic Lymphoma of the Renal Capsule: A Histopathological Case Report. (medindia.net)
Guideline] Chronic Lymphocytic Leukemia/ Small Lymphocytic Lymphoma. (medscape.com)

In some cases, T cells may present, as a result of residual autologous cells or transplacentally acquired maternal lymphocytes [ 1 ]. (hindawi.com)

B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. (jneurosci.org)
Antibodies are small molecules that find and bind to foreign materials so that Monocytes can find them. (earthlife.net)
B lymphocytes, the immune cells that secrete antibodies, follow this pattern. (sciencedaily.com)
A biopsy sent for routine haematoxylin and eosin staining revealed a normal epidermis with well-demarcated dense perivascular infiltrate and periadnexal infiltrate in the dermis composed of mature lymphocytes (Figure 2 ) and these lymphocytes showed immunoreactivity to CD4 antibodies with immunohistochemistry (IHC) staining ( Figure 3 ). (who.int)

Whether lymphocytes within the brain tissue of MS lesions have also regulatory functions is presently unknown. (frontiersin.org)
in chronic lesions, lymphocytes predominate. (merckmanuals.com)
These small lesions are solid, pink or red in colour and appear on the face, neck and back. (who.int)

Scholars@Duke publication: Isolation and Flow Cytometric Characterization of Murine Small Intestinal Lymphocytes. (duke.edu)
A repeat small intestinal biopsy was also performed and compared to biopsies from the referring hospital where possible. (wjgnet.com)
A lot of the testing we do is the differential diagnosis, and we're looking for comorbid conditions, treatment targets, and subgroups, like people with [small intestinal bacterial overgrowth] or mast cell activation. (medscape.com)

Lymph contains lymphocytes & monocytes & flows in a one-way direction to the heart. (studystack.com)

We discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. (jneurosci.org)

The two main types of lymphocytes are T cells and B cells , which function in the adaptive immune system . (newworldencyclopedia.org)
Other lymphocyte-like cells are commonly known as natural killer cells, or NK cells, and are part of the innate immune system . (newworldencyclopedia.org)
The NK cells are sometimes labeled "large granular lymphocytes," while the T cells and B cells are labeled as "small lymphocytes. (newworldencyclopedia.org)
While offering protection against millions of possible invaders, including viruses , bacteria , are cancer cells, lymphocytes allow normal body cells and helpful, symbiotic bacteria to flourish at the same time. (newworldencyclopedia.org)
A stained lymphocyte surrounded by red blood cells viewed using a light microscope. (newworldencyclopedia.org)
The two main categories of lymphocytes are the B lymphocytes ( B cells ) and T lymphocytes ( T cell ), both of which are involved in the adaptive immune system (Alberts 1989). (newworldencyclopedia.org)
In addition, lymphocyte-like cells called natural killer (NK) cells are involved in the immune system, albeit part of the innate immune system . (newworldencyclopedia.org)
Tumor infiltrating lymphocyte (TIL) therapy uses a patient's own immune cells to attack cancer. (biospace.com)
While the autoreactive cells displayed significantly reduced Tregs numbers, the alloreactive transplacentally acquired maternal lymphocytes had high functional Tregs. (hindawi.com)
The origin of the reactive cells in such patients are either thymic release of T-cells that expand at the periphery or transplacentally transfers of maternal T lymphocytes. (hindawi.com)
A distinctive feature of SCID patients, which sometimes can clinically resemble Omenn, [ 6 ] is the presence of alloreactive cells originated from transplacentally maternal T lymphocytes. (hindawi.com)
This type of changes in lymphocyte cells in the lung may predispose to allergic reactions as suggested in asthmatic human beings. (vin.com)
These cells have weakly acidophil and markedly vacuolated cytoplasm, without prominent nucleoli and little to no mitotic activity. (medscape.com)
Silencing of IL-15Ralpha by specific small interfering RNA in renal cell carcinoma had no effect on MbIL-15 production, indicating that the cytokine is not cross-presented by IL-15Ralpha in renal cell carcinoma cells but anchored to the membrane. (nih.gov)
50%), compact MC infiltrates are accompanied by perifocal clusters of lymphocytes containing a mixture of B and T cells. (bmj.com)
*Note - In addition to cells, one may also note small "cell-like" constituents called platelets. (uwyo.edu)
But a smaller group of T cells is preprogrammed to survive and to remember the invader. (sciencedaily.com)
No vaccine trial to date," he said, "has been able to produce significant numbers of memory T lymphocytes, which are important in killing HIV-infected or cancerous cells. (sciencedaily.com)
The lymphatic system carries lymph, a colorless fluid containing white blood cells called lymphocytes. (cancer.net)
Most of the cells were irradiated at the averaged E-field level with a small dispersion. (emf-portal.org)
It refers to breakdown of inflammatory cells that leaves small nuclear fragments (nuclear debris) in and around the vessels. (merckmanuals.com)
Nonspecific, granular, cytoplasmic staining was observed in a small number of background cells. (karger.com)
A central area of necrosis (called geographic necrosis) is rimmed by lymphocytes, plasma cells, macrophages, and giant cells. (msdmanuals.com)

We suggest that a high-tolerance capacity of the alloreactive transplacentally acquired maternal lymphocytes represents a toleration advantage, yet still associated with severe immunodeficiency. (hindawi.com)

small, spherical bodies composed of lymphoid tissue. (studystack.com)
Cutaneous Vasculitis Cutaneous vasculitis refers to vasculitis affecting small- or medium-sized vessels in the skin and subcutaneous tissue but not the internal organs. (merckmanuals.com)
The lungs are most likely to display the full spectrum of histopathologic abnormalities, but diagnostic features are not typically identified on the small tissue samples obtained by transbronchial biopsy. (msdmanuals.com)

The aim of this study was to investigate whether DAbR1 can be expressed on lymphocytes and used as a reporter gene as well as a suicide gene for therapy of immune-related adverse effects. (snmjournals.org)
While it is known that genotoxic agents, such as IR, activate transcriptional programs involved in maintaining the integrity of the genome, we also want to investigate whether or not the genotoxic breaks could affect lymphocyte-specific maturation transcriptional responses similar to those we observed following RAG-induced physiological DSBs. (biomedcentral.com)

There are reports of oligoclonal bands in the CSF of stroke patients, suggesting that in some people a B-lymphocyte response to stroke may occur in the CNS. (jneurosci.org)
A small percentage of these patients eventually develop retinochoroiditis , lymphadenitis , or, rarely, myocarditis and polymyositis . (medscape.com)

The validity of the fractionation method was supported by light microscope observations, Coulter Counter sizing, and in vivo and in vitro labeling of lymphocytes. (rupress.org)

lymphocytes have very little cytoplasm. (histology-world.com)

A method of zonal centrifugation was developed which separates rat thoracic duct lymphocytes (TDL) mainly according to size. (rupress.org)

The first is the focal bulk invasion of T- and B-lymphocytes with profound blood brain barrier leakage, which predominately affects the white matter, and which gives rise to classical active demyelinated plaques. (frontiersin.org)

We identified a central lymphocyte-specific transcriptional response common to both physiologic and genotoxic breaks, which includes many lymphocyte developmental processes. (biomedcentral.com)
In addition to physiologic breaks, lymphocytes are exposed to a variety of genotoxic damage from exogenous sources. (biomedcentral.com)

NLR = absolute neutrophil/lymphocyte count from complete blood count (CBC). (jnccn.org)
A lymphocyte is a type of white blood cell (leukocyte) in the vertebrate immune system . (newworldencyclopedia.org)
use for lymphocyte proliferation of platypus blood. (bio.net)
A health care professional will take a blood sample from a vein in your arm, using a small needle. (medlineplus.gov)
After the needle is inserted, a small amount of blood will be collected into a test tube or vial. (medlineplus.gov)
There is very little risk to having a blood test. (medlineplus.gov)

Atypical hyperplasia of the thymic lymphocytes has been described in chemically treated B6C3F1 and p53-deficient mice. (nih.gov)

When stimulated by an invader, T lymphocytes multiply and attack the infecting foreigner. (sciencedaily.com)

This lesion is characterized by depletion of small lymphocytes and a diffuse change with loss of the normal thymic corticomedullary junction. (nih.gov)

This process is initiated by RAG endonucleases while the lymphocytes are in the G1 phase of the cell cycle. (biomedcentral.com)
One requires two parallel tracks for cell-killing T lymphocytes. (sciencedaily.com)

This point was clearly established by fractionating homogenates of purified small lymphocytes by means of differential centrifugation and isopycnic density gradient centrifugation. (rupress.org)

This approach results in the isolation of large numbers of viable lymphocytes that can subsequently be used for flow cytometric analysis or alternate means of characterization. (duke.edu)
This result indicates that the large lymphocyte is not the sole bearer of either lysosomes or the large amount of soluble cathepsin D found in homogenates of TDL. (rupress.org)
vasculitis may be a small or large component of the disease. (msdmanuals.com)

Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. (mdpi.com)
Lymphocytes play an important and integral role in the body's defenses, and are part of a system of extraordinary complexity and coordination. (newworldencyclopedia.org)
These small constituents are important for clotting. (uwyo.edu)

Figure 2: Pathways involved in nutrient signaling in some lymphocytes. (nature.com)

Anatomy43

Organisms20

Diseases14

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes56

Disciplines and Occupations1

Information Science3

Health Care1

Population of lymphocytes3

Tumor-infiltratin2

Subsets5

Antigen4

Neutrophil-to-lymphocyte6

Accumulations of lymphocytes2

Human lymphocytes2

Intestine5

Neutrophils2

Thymus4

Ratio2

Peripheral6

Lymph nodes1

Bone marrow3

Helper T cel1

Prognosis1

TILs1

Lung cancer4

Intraepithelial4

Prognostic1

Tumors2

Inflammation2

Lymphoma4

Autologous1

Antibodies4

Lesions3

Intestinal3

Monocytes1

Infiltrate1

Cells23

Maternal1

Tissue3

Investigate2

Patients2

Vitro1

Cytoplasm1

Thoracic1

Focal1

Genotoxic2

Blood6

Mice1

Multiply1

Diffuse1

Cell2

Differential1

Large3

Important3

Pathways1